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AR042900A1 - N-ARIL-HETEROAROMATIC PRODUCTS, COMPOSITIONS THAT CONTAIN THEM AND ITS USE - Google Patents

N-ARIL-HETEROAROMATIC PRODUCTS, COMPOSITIONS THAT CONTAIN THEM AND ITS USE

Info

Publication number
AR042900A1
AR042900A1 ARP040100138A ARP040100138A AR042900A1 AR 042900 A1 AR042900 A1 AR 042900A1 AR P040100138 A ARP040100138 A AR P040100138A AR P040100138 A ARP040100138 A AR P040100138A AR 042900 A1 AR042900 A1 AR 042900A1
Authority
AR
Argentina
Prior art keywords
aryl
heteroaryl
alkyl
group
substituted
Prior art date
Application number
ARP040100138A
Other languages
Spanish (es)
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Publication of AR042900A1 publication Critical patent/AR042900A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Productos N-aril-heteroaromáticos, composiciones que les contienen, y su utilización como medicamento, en particular en oncología. Reivindicación 1: Producto que responde a la fórmula (1), en la cual: R1 y R2 se seleccionan independientemente del grupo constituido por arilo, heteroarilo, arilo sustituido y heteroarilo sustituido; R2 se puede igualmente elegir entre el grupo cicloalquilo C5-7; L se selecciona del grupo constituido por C(R7)(R8), C=O, C=S y C=N(R7); R3 se selecciona del grupo constituido por H, halógeno, CF3, alquilo, alquilo sustituido, alquileno, alquileno sustituido, alquinilo, alquinilo sustituido, cicloalquilo, cicloalquileno, heterociclilo, CO-R7, C[N-O(R8)](R7), COOH, CONH-arilo, CONH-heteroarilo, CONH-R7, CON(R7)(R8), CO-N(R7)-arilo, CO-N(R7)-heteroarilo, C(OR7)=NH, C[N(R7)(R8)]=NH, NH2, NH-arilo, NH-heteroarilo, NH(R7), N(R7)(R8), NH-CO-R7, N(R7)-CO-arilo, N(R7)-CO-heteroarilo, NH-SO2-R7, NH-SO2-arilo, NH-SO2-heteroarilo, NH-CH2-CO2R7, NH-CH2-arilo, NH-CH2-heteroarilo, N(R7)-N(R8)(R10), N-N=C(R7)(R8), CN, O-R7, S-R7, SO2-R7, SO2-R7, arilo, heteroarilo, cicloalquilo sustituido, arilo sustituido y heteroarilo sustituido; R4 se selecciona del grupo constituido por H, alquilo C1-3, ciclopropilo, alquileno C1-3, alquinilo C1-3, O-alquilo C1-3, S-alquilo C1-3, F, Cl y Br; R5 y R6 se seleccionan independientemente del grupo constituido por H, alquilo C1-3, oxo y halógeno; R7, R8 y R10 se seleccionan independientemente del grupo constituido por H, alquilo C1-3 y alquilo C1-3 sustituido; L-G-R1 se selecciona del grupo constituido por un resto de grupo de fórmula (2), con L y R1 son tales como se definen precedentemente, y R9 es igual a alquilo C1-3, bajo forma racémica, enriquecida con un enantiómero, enriquecida con un diastereoisómero, sus tautómeros, sus fármacos y sus sales farmacéuticamente aceptables, bajo reserva que el producto de fórmula (1) no sea uno de los compuestos de fórmula (3).N-aryl-heteroaromatic products, compositions containing them, and their use as a medicine, particularly in oncology. Claim 1: Product that responds to formula (1), in which: R1 and R2 are independently selected from the group consisting of aryl, heteroaryl, substituted aryl and substituted heteroaryl; R2 can also be chosen from the C5-7 cycloalkyl group; L is selected from the group consisting of C (R7) (R8), C = O, C = S and C = N (R7); R3 is selected from the group consisting of H, halogen, CF3, alkyl, substituted alkyl, alkylene, substituted alkylene, alkynyl, substituted alkynyl, cycloalkyl, cycloalkylene, heterocyclyl, CO-R7, C [NO (R8)] (R7), COOH , CONH-aryl, CONH-heteroaryl, CONH-R7, CON (R7) (R8), CO-N (R7) -aryl, CO-N (R7) -heteroaryl, C (OR7) = NH, C [N ( R7) (R8)] = NH, NH2, NH-aryl, NH-heteroaryl, NH (R7), N (R7) (R8), NH-CO-R7, N (R7) -CO-aryl, N (R7 ) -CO-heteroaryl, NH-SO2-R7, NH-SO2-aryl, NH-SO2-heteroaryl, NH-CH2-CO2R7, NH-CH2-aryl, NH-CH2-heteroaryl, N (R7) -N (R8 ) (R10), NN = C (R7) (R8), CN, O-R7, S-R7, SO2-R7, SO2-R7, aryl, heteroaryl, substituted cycloalkyl, substituted aryl and substituted heteroaryl; R4 is selected from the group consisting of H, C1-3 alkyl, cyclopropyl, C1-3 alkylene, C1-3 alkynyl, O-C1-3 alkyl, S-C1-3 alkyl, F, Cl and Br; R5 and R6 are independently selected from the group consisting of H, C1-3 alkyl, oxo and halogen; R7, R8 and R10 are independently selected from the group consisting of H, C1-3 alkyl and substituted C1-3 alkyl; LG-R1 is selected from the group consisting of a group moiety of formula (2), with L and R1 being as defined above, and R9 is equal to C1-3 alkyl, in racemic form, enriched with an enantiomer, enriched with a diastereoisomer, its tautomers, its drugs and pharmaceutically acceptable salts, subject to the reservation that the product of formula (1) is not one of the compounds of formula (3).

ARP040100138A 2003-01-28 2004-01-19 N-ARIL-HETEROAROMATIC PRODUCTS, COMPOSITIONS THAT CONTAIN THEM AND ITS USE AR042900A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0300894A FR2850379B1 (en) 2003-01-28 2003-01-28 N-ARYL-HETEROAROMATIC PRODUCTS, COMPOSITIONS CONTAINING SAME AND USE THEREOF

Publications (1)

Publication Number Publication Date
AR042900A1 true AR042900A1 (en) 2005-07-06

Family

ID=32669255

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP040100138A AR042900A1 (en) 2003-01-28 2004-01-19 N-ARIL-HETEROAROMATIC PRODUCTS, COMPOSITIONS THAT CONTAIN THEM AND ITS USE

Country Status (9)

Country Link
AR (1) AR042900A1 (en)
CL (1) CL2004000045A1 (en)
FR (1) FR2850379B1 (en)
GT (1) GT200300267A (en)
PA (1) PA8594301A1 (en)
PE (1) PE20040766A1 (en)
SV (1) SV2004001710A (en)
TW (1) TW200504026A (en)
UY (1) UY28173A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2017310529B2 (en) * 2016-08-12 2021-08-19 Edwin J. Iwanowicz Protein kinase regulators

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3449350A (en) * 1968-06-24 1969-06-10 Ciba Geigy Corp Certain pyrazole-3-carboxylic acid hydrazide derivatives
US3778433A (en) * 1969-04-18 1973-12-11 Sumitomo Chemical Co Process for producing benzodiazepine derivatives
JPS61129129A (en) * 1984-11-28 1986-06-17 Kureha Chem Ind Co Ltd Antitumor agent
TW312694B (en) * 1994-09-26 1997-08-11 Daiichi Seiyaku Co
EA005934B1 (en) * 2001-07-05 2005-08-25 Х. Лундбекк А/С Substituted anilinic piperidines as mch selective antagonists

Also Published As

Publication number Publication date
SV2004001710A (en) 2004-03-19
FR2850379B1 (en) 2006-11-17
GT200300267A (en) 2004-02-24
PE20040766A1 (en) 2004-12-14
PA8594301A1 (en) 2004-08-31
UY28173A1 (en) 2004-08-31
FR2850379A1 (en) 2004-07-30
TW200504026A (en) 2005-02-01
CL2004000045A1 (en) 2005-01-07

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