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AR042401A1 - Compuestos quimicos - Google Patents

Compuestos quimicos

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Publication number
AR042401A1
AR042401A1 ARP020102488A ARP020102488A AR042401A1 AR 042401 A1 AR042401 A1 AR 042401A1 AR P020102488 A ARP020102488 A AR P020102488A AR P020102488 A ARP020102488 A AR P020102488A AR 042401 A1 AR042401 A1 AR 042401A1
Authority
AR
Argentina
Prior art keywords
alkyl
optionally substituted
alkoxy
hydroxy
halogen
Prior art date
Application number
ARP020102488A
Other languages
English (en)
Inventor
Richard Evans
Matthew Perry
Brian Springthorpe
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0116179A external-priority patent/GB0116179D0/en
Priority claimed from GB0123037A external-priority patent/GB0123037D0/en
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of AR042401A1 publication Critical patent/AR042401A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/96—Sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P11/14—Antitussive agents
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  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
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Abstract

Compuesto derivado de piperidina que responde a la fórmula (1), donde: T es C(O) o S(O); W es C(O) o S(O)2; X es CG2, O o NH; Y es CRS o N; R1 es arilo opcionalmente sustituido o heterociclilo opcionalmente sustituido; R2 es hidrógeno o alquilo C1-6; R3 es hidrógeno o alquilo C1-6 opcionalmente sustituido; R4 es alquilo, arilo opcionalmente sustituido, aralquilo opcionalmente sustituido o heterociclilo opcionalmente sustituido; R5 es hidrógeno o alquilo C1-6; donde las porciones arilo y heterociclilo mencionadas opcionalmente se sustituyen por: halógeno, ciano, nitro, hidroxi, oxo, S(O)PR25, OC(O)NR6R7, NR8R9, NR10C(O)R11, NR12C(O)NR13R14, S(O)2NR15R16. NR17S(O)R218, C(O)NR19R20, C(O)R21, CO2R22, NR23, alquilo C1-6, CF3, (alcoxi C1-6)alquilo, alcoxi C1-6, OCF3, alcoxi(alcoxi C1-6); alquiltio C1-6, alquenilo C2-6, alquinilo C2-6, cicloalquilo C3-10 (a su vez opcionalmente sustituido por alquilo C1-4 oxo), metilendioxi, difluorometilendioxi, fenilo, fenil(alquilo C1-4), fenoxi, feniltio, fenil(alcoxi C1-4), heteroarilo, heteroaril(alquilo C1-4), heteroariloxi o heteroaril(alcoxi C1-4); donde cualquiera de las porciones fenilo y heteroarilo mencionados precedentemente se sustituyen opcionalmente con halógeno, hidroxi, nitro, S(O)q(alquilo C1-4), S(O)2NH2, ciano, alquilo C1-4, alcoxi C1-4, C(O)NH2, C(O)NH(alquilo C1-4), CO2H, CO2(alquilo C1-4), NHC(O)(alquilo C1-4), NHS(O)2(alquilo C1-4), C(O)(alquilo C1-4), CF3 o OCF3; p y q son independientemente, 0, 1 ó 2; R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, R18, R19, R20, R21, R22, y R23 son independientemente hidrógeno, alquilo (opcionalmente sustituido por halógeno, hidroxi o cicloalquilo C3-10), CH2(alquenilo C2-6), fenilo (a su vez opcionalmente sustituido por halógeno, hidroxi, nitro, NH2, NH(alquilo C1-4), N(alquil C1-4)2, S(O)2(alquilo C1-4), S(O)2NH2, S(O)2NH(alquilo C1-4), S(O)2N(alquil C1-4)2, ciano, alquilo C1-4, alcoxi C1-4, C(O)NH2, C(O)NH(alquilo C1-4), C(O)N(alquilo C14), CO2H, CO2(alquilo C1-4), NHC(O)(alquilo C1-4), NHS(O)2(alquilo C1-4), C(O)(alquilo C1-4), CF3 o OCF3) o heterociclilo (a su vez opcionalmente sustituido por halógeno, hidroxi, nitro, NH2, NH(alquilo C1-4), N(alquil C1-4)2, S(O)2(alquilo C1-4), S(O)2NH2, S(O)2NH(alquilo C1-4), S(O)2N(alquil C1-4)2, ciano, alquilo C1-4, alcoxi C1-4, C(O)NH2, C(O)NH(alquilo C1-4), C(O)N(alquil C1-4)2, CO2H, CO2(alquilo C1-4), NHC(O)(alquilo C1-4), NHS(O)2(alquilo C1-4), C(O)(alquilo C1-4), CF3 o OCF3); como alternativa NR6R7, NR8R9, NR13R14, NR15R16, NR19R20 o N(alquil C1-4)2 pueden formar, como alternativa, un anillo heterociclico de 4 a 7 miembros, azetidina, pirrolidina, piperidina, azepina 1,4-morfolina o 1,4-piperazina, esta última opcionalmente sustituida por alquilo C1-4 en el nitrógeno distal; R25, R18 y R24 son independientemente, alquilo C1-6 (opcionalmente sustituido por halógeno, hidroxi o cicloalquilo C3-10), CH2(alquenilo C2-6), fenilo (a su vez opcionalmente sustituido por halógeno, hidroxi, nitro, NH2, NH(alquilo C1-4), N(alquilo C1-4)2 (estos grupos alquilo pueden unirse para formar un anillo como el descripto para R6 y R7), S(O)2(alquilo C1-4), S(O)2NH2, S(O)2NH(alquilo C1-4), S(O)2N(alquil C1-4)2 (estos grupos alquilo pueden unirse para formar un anillo como el descripto para R6 y R7), ciano, alquilo C1-4, alcoxi C1-4, C(O)NH2, C(O)NH(alquilo C1-4), C(O)N(alquil C1-4)2 (estos grupos alquilo pueden unirse para formar un anillo como el descripto para R6 y R7), CO2H, CO2(alquilo C1-4), NHC(O)(alquilo C1-4), NHS(O)2(alquilo C1-4), C(O)(alquilo C1-4), CF3 o OCF3) o heterociclilo (a su vez opcionalmente sustituido por halógeno, hidroxi, nitro, NH2, NH(alquilo C1-4), N(alquil C1-4)2 (estos grupos alquilo pueden unirse para formar un anillo como el descripto para R6 y R7), S(O)2(alquilo C1-4), S(O)2NH2, S(O)2NH(alquilo C1-4), S(O)2N(alquil C1-4)2 (estos grupos alquilo pueden unirse para formar un anillo como el descripto para R6 y R7), ciano, alquilo C1-4, alcoxi C1-4, C(O)NH2, C(O)NH(alquilo C1-4), C(O)N(alquil C1-4)2 (estos grupos alquilo pueden unirse para formar un anillo como el descripto para R6 y R7), CO2H, CO2(alquilo C1-4), NHC(O)(alquilo C1-4), NHS(O)2(alquilo C1-4), C(O)(alquilo C1-4), CF3 o OCF3); o un N-óxido del mismo; o una sal aceptable para uso farmacéutico del mismo; o un solvato del mismo. También se describe el método para preparar estos compuestos, las composiciones farmacéuticas que los comprenden, y el uso de dichos compuestos en la fabricación de medicamentos. Estos compuestos, son moduladores de la actividad de la quimoquina ( especialmente CCR3) y son especialmente útiles en el tratamiento del asma y/o la rinitis.
ARP020102488A 2001-07-02 2002-07-02 Compuestos quimicos AR042401A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0116179A GB0116179D0 (en) 2001-07-02 2001-07-02 Chemical compounds
GB0123037A GB0123037D0 (en) 2001-09-25 2001-09-25 Chemical compounds

Publications (1)

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AR042401A1 true AR042401A1 (es) 2005-06-22

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ARP020102488A AR042401A1 (es) 2001-07-02 2002-07-02 Compuestos quimicos

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US (1) US7307090B2 (es)
EP (2) EP1604982A1 (es)
JP (1) JP3857270B2 (es)
KR (1) KR20040013090A (es)
CN (1) CN1545509A (es)
AR (1) AR042401A1 (es)
AT (1) ATE319703T1 (es)
BR (1) BR0210733A (es)
CA (1) CA2452597A1 (es)
CO (1) CO5540307A2 (es)
CY (1) CY1106095T1 (es)
DE (1) DE60209736T2 (es)
DK (1) DK1404667T3 (es)
ES (1) ES2258642T3 (es)
HU (1) HUP0401886A2 (es)
IL (1) IL159256A0 (es)
IS (1) IS7094A (es)
MX (1) MXPA03011722A (es)
NO (1) NO20035729L (es)
NZ (1) NZ530202A (es)
PL (1) PL368041A1 (es)
PT (1) PT1404667E (es)
RU (1) RU2004100839A (es)
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WO (1) WO2003004487A1 (es)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR033517A1 (es) * 2000-04-08 2003-12-26 Astrazeneca Ab Derivados de piperidina, proceso para su preparacion y uso de estos derivados en la fabricacion de medicamentos
GB0120461D0 (en) 2001-08-22 2001-10-17 Astrazeneca Ab Novel compounds
GB0122503D0 (en) 2001-09-18 2001-11-07 Astrazeneca Ab Chemical compounds
WO2003059965A1 (en) * 2002-01-10 2003-07-24 University Of Washington Hydrogels formed by non-covalent linkages
AU2003209388A1 (en) * 2002-01-29 2003-09-02 Merck And Co., Inc. Substituted imidazoles as cannabinoid receptor modulators
SE0200844D0 (sv) 2002-03-19 2002-03-19 Astrazeneca Ab Chemical compounds
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