AR049168A1 - Derivados de benzimidazol - Google Patents
Derivados de benzimidazolInfo
- Publication number
- AR049168A1 AR049168A1 ARP050101885A ARP050101885A AR049168A1 AR 049168 A1 AR049168 A1 AR 049168A1 AR P050101885 A ARP050101885 A AR P050101885A AR P050101885 A ARP050101885 A AR P050101885A AR 049168 A1 AR049168 A1 AR 049168A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkoxy
- alkyl
- hydroxy
- hydrogen
- amino
- Prior art date
Links
- HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical class C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 22
- 239000001257 hydrogen Substances 0.000 abstract 14
- 229910052739 hydrogen Inorganic materials 0.000 abstract 14
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 14
- 125000000217 alkyl group Chemical group 0.000 abstract 13
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 11
- -1 pyrrolidino, piperidino, piperazino Chemical group 0.000 abstract 10
- 229910052736 halogen Inorganic materials 0.000 abstract 9
- 150000002367 halogens Chemical group 0.000 abstract 9
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 9
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 8
- 125000004466 alkoxycarbonylamino group Chemical group 0.000 abstract 8
- 125000005196 alkyl carbonyloxy group Chemical group 0.000 abstract 6
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 6
- 125000003118 aryl group Chemical group 0.000 abstract 5
- 125000003830 C1- C4 alkylcarbonylamino group Chemical group 0.000 abstract 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 4
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 3
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000003302 alkenyloxy group Chemical group 0.000 abstract 2
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 2
- 125000004104 aryloxy group Chemical group 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 125000000000 cycloalkoxy group Chemical group 0.000 abstract 2
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 abstract 2
- 125000006656 (C2-C4) alkenyl group Chemical group 0.000 abstract 1
- 125000006650 (C2-C4) alkynyl group Chemical group 0.000 abstract 1
- 125000001399 1,2,3-triazolyl group Chemical group N1N=NC(=C1)* 0.000 abstract 1
- FJRPOHLDJUJARI-UHFFFAOYSA-N 2,3-dihydro-1,2-oxazole Chemical compound C1NOC=C1 FJRPOHLDJUJARI-UHFFFAOYSA-N 0.000 abstract 1
- LWTIGYSPAXKMDG-UHFFFAOYSA-N 2,3-dihydro-1h-imidazole Chemical compound C1NC=CN1 LWTIGYSPAXKMDG-UHFFFAOYSA-N 0.000 abstract 1
- ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical compound C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 abstract 1
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 abstract 1
- 125000004618 benzofuryl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 abstract 1
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 abstract 1
- 125000004428 fluoroalkoxy group Chemical group 0.000 abstract 1
- 125000003709 fluoroalkyl group Chemical group 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000002883 imidazolyl group Chemical group 0.000 abstract 1
- 125000001041 indolyl group Chemical group 0.000 abstract 1
- 125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 abstract 1
- CTAPFRYPJLPFDF-UHFFFAOYSA-N isoxazole Chemical compound C=1C=NOC=1 CTAPFRYPJLPFDF-UHFFFAOYSA-N 0.000 abstract 1
- 125000000842 isoxazolyl group Chemical group 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- WCPAKWJPBJAGKN-UHFFFAOYSA-N oxadiazole Chemical compound C1=CON=N1 WCPAKWJPBJAGKN-UHFFFAOYSA-N 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 125000003226 pyrazolyl group Chemical group 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
- 125000000168 pyrrolyl group Chemical group 0.000 abstract 1
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 150000003536 tetrazoles Chemical class 0.000 abstract 1
- 125000000335 thiazolyl group Chemical group 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/08—Radicals containing only hydrogen and carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Reivindicacion 1: Un nuevo compuesto de 6-bencimidazol substituido, caracterizado por la formula (1), donde: R1 es hidrogeno, alquilo C1-4, cicloalquilo C3-7, cicloalquil C3-7-alquilo C1-4, alcoxi C1-4, alcoxi C1-4-alquilo C1-4, alcoxi C1-4- carbonilo, alquenilo C2-4, alquinilo C2-4, fluoro-alquilo C1-4, hidroxi-alquilo C1-4, mono- o di-alquil C1-4-amino o alquil C1-4-carboniloxi-alquilo C1-4; R2 es hidrogeno, alquilo C1-4, arilo, cicloalquilo C3-7, cicloalquil C3-7-alquilo C1-4, alcoxi C1-4-carbonilo, mono- o di-alquil C1-4-amino-alquil C1-4-carbonilo, hidroxi-alquilo C1-4, fluoro-alquilo C2-4, aril C1-4-alcoxi C1-4-alquilo C1-4, hidroxi o alcoxi C1-4; R3 es hidrogeno, halogeno, fluoro-alquilo C1-4, carboxilo, -CO-alcoxi C1-4, hidroxi-alquilo C1-4, alcoxi C1-4-alquilo C1-4, alcoxi C1-4-alcoxi C1-4-alquilo C1-4, fluoro-alcoxi C1-4-alquilo C1-4, ciano, el grupo -CO-NR31R32, el grupo SO2-NR31R32 o el grupo Het; donde R31 es hidrogeno, hidroxilo, alquilo C1-7, hidroxi-alquilo C1-4, alcoxi C1-4-alquilo C1-4 o cicloalquilo C3-7, amino; y R32 es hidrogeno, alquilo C1-7, hidroxi-alquilo C1-4 o alcoxi C1-4-alquilo C1-4; o donde R31 y R32 tomados conjuntamente, incluyendo el átomo de nitrogeno al cual están ligados, son un grupo pirrolidino, piperidino, piperazino, N-alquil C1-4-piperazino, morfolino, aziridino o acetidino; y Het es un residuo heterocíclico, sustituido por R33, R34 y R35, seleccionado del grupo formado por oxadiazol, dihidrooxazol, dihidroimidazol, oxazol, imidazol, isoxazol, dihidroisoxazol, pirazol y tetrazol; donde R33 es hidrogeno, alquilo C1-4, hidroxi-alquilo C1-4, alcoxi C1-4, alqueniloxi C2-4, alquil C1-4-carbonilo, carboxi, alcoxi C1-4-carbonilo, carboxi-alquilo C1-4, alcoxi C1-4- carbonil-alquilo C1-4, halogeno, hidroxi, arilo, aril-alquilo C1-4, aril-oxi, aril-alcoxi C1-4, trifluorometilo, nitro, amino, mono- o di-alquil C1-4-amino, alquil C1-4-carbonilamino, alcoxi C1-4-carbonilamino, alcoxi C1-4-alcoxi C1-4-carbonilamino o sulfonilo; R34 es hidrogeno, alquilo C1-4, alcoxi C1-4, alcoxi C1-4-carbonilo, halogeno, trifluorometilo o hidroxi; R35 es hidrogeno, alquilo C1-4, alcoxi C1-4, alcoxi C1-4-carbonilo, halogeno, trifluorometilo o hidroxi; X es O (oxígeno) o NH; y Y o tiene el significado -CH2-Ar; donde Ar es un residuo aromático mono- o bicíclico, sustituido por R4, R5, R6 y R7, que es seleccionado del grupo formado por fenilo, naftilo, pirrolilo, pirazolilo, imidazolilo, 1,2,3-triazolilo, indolilo, bencimidazolilo, furilo, benzofurilo, tienilo, benzotienilo, tiazolilo, isoxazolilo, piridinilo, pirimidinilo, quinolinilo o isoquinolinilo; o Y significado el grupo de formula (2), donde Z tiene el significado -CHR8- o -CHR8-CHR9- donde en Ar y/o en el grupo de formula (2); R4 es hidrogeno, alquilo C1-4, hidroxi-alquilo C1-4, alcoxi C1-4, alqueniloxi C2-4, alquil C1-4-carbonilo, carboxi, alcoxi C1-4-carbonilo, carboxi-alquilo C1-4, alcoxi C1-4-carbonil-alquilo C1-4, halogeno, hidroxi, arilo, aril-alquilo C1-4, aril-oxi, aril-alcoxi C1-4, trifluorometilo, fluoro-alcoxi C1-4, nitro, amino, mono- o di-alquil C1-4-amino, alquil C1-4-carbonilamino, alcoxi C1-4-carbonilamino, alcoxi C1-4-alcoxi C1-4-carbonilamino o sulfonilo; R5 es hidrogeno, alquilo C1-4, alcoxi C1-4, alcoxi C1-4-carbonilo, halogeno, trifluorometilo o hidroxi; R6 es hidrogeno, alquilo C1-4 o halogeno; y R7 es hidrogeno, alquilo C1-4 o halogeno; R8 es hidrogeno, alquilo C1-7, alquenilo C2-7, hidroxilo, alcoxi C1-4, alcoxi C1-4, oxo-substituido, cicloalcoxi C3-7, cicloalquil C3-7-alcoxi C1-4, hidroxi-alcoxi C1-4, alcoxi C1-4-alcoxi C1-4, alcoxi C1-4-alcoxi C1-4-alcoxi C1-4, cicloalcoxi C3-7-alcoxi C1-4, cicloalquil C3-7-alcoxi C1-4-alcoxi C1-4, alquil C1-4- carboniloxi, halo-alcoxi C1-4, amino, mono- o di-alquil C1-4-amino, alquil C1-4-carbonilamino, alcoxi C1-4-carbonilamino, mono- o di-alquil C1-4-amino-alquil C1-4-carboniloxi, alcoxi C1-4-alcoxi C1-4-carbonilamino o alcoxi C1-4-alquil C1-4- carboniloxi; R9 es hidrogeno, alquilo C1-7, alquenilo C2-7, hidroxilo, alcoxi C1-4, alcoxi C1-4 oxo-sustituido, cicloalcoxi C3-7, cicloalquil C3-7-alcoxi C1-4, hidroxi-alcoxi C1-4, alcoxi C1-4-alcoxi C1-4, alcoxi C1-4-alcoxi C1-4-alcoxi C1-4, cicloalcoxi C3-7-alcoxi C1-4, cicloalquil C3-7-alcoxi C1-4-alcoxi C1-4, alquil C1-4-carboniloxi, halo-alcoxi C1-4, amino, mono- o di-alquil C1-4-amino, alquil C1-4-carbonilamino, alcoxi C1-4-carbonilamino, mono- o di-alquil C1-4-amino-alquil C1-4- carboniloxi, alcoxi C1-4-alcoxi C1-4-carbonilamino o alcoxi C1-4-alquil C1-4-carboniloxi; y donde arilo es fenilo o fenilo sustituido por uno, dos o tres sustituyentes iguales o diferentes del grupo formado por alquilo C1-4, alcoxi C1-4, carboxi, alcoxi C1-4-carbonilo, halogeno, trifluorometilo, nitro, trifluorometoxi, hidroxi y ciano, y sus sales.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04102191 | 2004-05-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR049168A1 true AR049168A1 (es) | 2006-07-05 |
Family
ID=34929111
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP050101885A AR049168A1 (es) | 2004-05-18 | 2005-05-10 | Derivados de benzimidazol |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1756067A1 (es) |
| JP (1) | JP2007538047A (es) |
| AR (1) | AR049168A1 (es) |
| AU (1) | AU2005243434A1 (es) |
| CA (1) | CA2566821A1 (es) |
| TW (1) | TW200600502A (es) |
| WO (1) | WO2005111000A1 (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007023135A1 (en) * | 2005-08-22 | 2007-03-01 | Nycomed Gmbh | Isotopically substituted benzimidazole derivatives |
| WO2007031860A1 (en) * | 2005-09-15 | 2007-03-22 | Pfizer Japan Inc. | Indane substituted benzimidazoles and their use as acid pump inhibitors |
| WO2007072142A2 (en) * | 2005-12-19 | 2007-06-28 | Pfizer Japan Inc. | Benzimidazole-5-carboxamide derivatives |
| CN102321077A (zh) | 2005-12-19 | 2012-01-18 | 拉夸里亚创药株式会社 | 经色原烷取代的苯并咪唑类和它们作为酸泵抑制剂的用途 |
| KR20190057569A (ko) * | 2017-11-20 | 2019-05-29 | 제일약품주식회사 | 7-아미노-1h-인돌-5-카르복사미드 유도체 및 이의 용도 |
| WO2024087155A1 (zh) * | 2022-10-28 | 2024-05-02 | 深圳市华先医药科技有限公司 | 一种合成4-羟基-n,n,2-三甲基苯并咪唑-6-甲酰胺的方法 |
| WO2024210689A1 (ko) * | 2023-04-07 | 2024-10-10 | 제이더블유중외제약 주식회사 | 벤즈이미다졸 유도체의 염 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE8604566D0 (sv) * | 1986-10-27 | 1986-10-27 | Haessle Ab | Novel compunds |
| IL108520A (en) * | 1993-02-15 | 1997-09-30 | Byk Gulden Lomberg Chem Fab | 2, 3, 8-TRISUBSTITUTED IMIDAZO £1, 2-a| PYRIDINE DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| WO1996004251A1 (en) * | 1994-08-03 | 1996-02-15 | Fujisawa Pharmaceutical Co., Ltd. | Heterocyclic compound |
| SE9602286D0 (sv) * | 1996-06-10 | 1996-06-10 | Astra Ab | New compounds |
| AR043063A1 (es) * | 2002-12-13 | 2005-07-13 | Altana Pharma Ag | Bencimidazoles 6-sustituidos y su uso como inhibidores de secreciones gastricas |
-
2005
- 2005-05-10 AR ARP050101885A patent/AR049168A1/es unknown
- 2005-05-13 EP EP05747188A patent/EP1756067A1/en not_active Withdrawn
- 2005-05-13 JP JP2007517241A patent/JP2007538047A/ja not_active Withdrawn
- 2005-05-13 CA CA002566821A patent/CA2566821A1/en not_active Abandoned
- 2005-05-13 AU AU2005243434A patent/AU2005243434A1/en not_active Abandoned
- 2005-05-13 WO PCT/EP2005/052196 patent/WO2005111000A1/en not_active Ceased
- 2005-05-17 TW TW094115928A patent/TW200600502A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2005243434A1 (en) | 2005-11-24 |
| CA2566821A1 (en) | 2005-11-24 |
| TW200600502A (en) | 2006-01-01 |
| WO2005111000A1 (en) | 2005-11-24 |
| EP1756067A1 (en) | 2007-02-28 |
| JP2007538047A (ja) | 2007-12-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |