AR048857A1 - Pirazolopirimidinas - Google Patents
PirazolopirimidinasInfo
- Publication number
- AR048857A1 AR048857A1 ARP050100633A ARP050100633A AR048857A1 AR 048857 A1 AR048857 A1 AR 048857A1 AR P050100633 A ARP050100633 A AR P050100633A AR P050100633 A ARP050100633 A AR P050100633A AR 048857 A1 AR048857 A1 AR 048857A1
- Authority
- AR
- Argentina
- Prior art keywords
- substituted
- alkyl
- appropriate
- heterocyclyl
- cycloalkyl
- Prior art date
Links
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 229910052736 halogen Inorganic materials 0.000 abstract 5
- 150000002367 halogens Chemical class 0.000 abstract 5
- 125000004414 alkyl thio group Chemical group 0.000 abstract 4
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 4
- 125000000623 heterocyclic group Chemical group 0.000 abstract 4
- 125000003342 alkenyl group Chemical group 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000000304 alkynyl group Chemical group 0.000 abstract 3
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 3
- -1 if substituted Chemical group 0.000 abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- APXRHPDHORGIEB-UHFFFAOYSA-N 1H-pyrazolo[4,3-d]pyrimidine Chemical class N1=CN=C2C=NNC2=C1 APXRHPDHORGIEB-UHFFFAOYSA-N 0.000 abstract 2
- 125000004429 atom Chemical group 0.000 abstract 2
- 125000005017 substituted alkenyl group Chemical group 0.000 abstract 2
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 2
- 125000000041 C6-C10 aryl group Chemical group 0.000 abstract 1
- 101100203602 Hypocrea jecorina (strain QM6a) sor7 gene Proteins 0.000 abstract 1
- 239000003905 agrochemical Substances 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000004644 alkyl sulfinyl group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 125000005844 heterocyclyloxy group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 125000004426 substituted alkynyl group Chemical group 0.000 abstract 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
La presente trata sobre pirazolopirimidinas, un procedimiento para la obtencion de estos productos y su empleo para la lucha contra microorganismos indeseados. Reivindicacion 1: Pirazolopirimidinas de la formula (1), en la que los símbolos tienen los significados siguientes: R1 significa H, alquilo en caso dado substituido, alquenilo en caso dado substituido, alquinilo en caso dado substituido, cicloalquilo en caso dado substituido o heterociclilo en caso substituido, hidroxi, alcoxi en caso dado substituido, amino, alquilamino en caso dado substituido o dialquilamino en caso dado substituido; R2 significa H o alquilo; o R1 y R2 forman, junto con el átomo de N, con el que están enlazados, un anillo heterocíclico en caso dado substituido; R3 significa arilo en caso dado substituido, heterociclilo en caso dado substituido, alquilo en caso dado substituido, alquenilo en caso dado substituido, alquinilo en caso dado substituido, cicloalquilo en caso dado substituido, cicloalquenilo en caso dado substituido, aralquilo en caso dado substituido, halogeno, un grupo amino en caso substituido, alcoxi C1-8 en caso dado substituido, alquiltio C1-8 en caso dado substituido, ariloxi C6-10 en caso dado substituido, ariltio C6-10 en caso dado substituido, heterocicliloxi en caso dado substituido, arilo C6-10-alcoxi C1-4 en caso dado substituido, arilo C6-10-alquiltio C1-4 en caso dado substituido, heterociclilo-alcoxi C1-4 en caso dado substituido, o heterociclilo- alquiltio C1-4 en caso dado substituido, C(S)OR8, C(O)SR8 o C(S)SR8; R4 significa CONR6R7, CONR7-N(R7)2, CO-NR7-OR7, COOR8, C(S)OR7, C(O)SR7, C(S)SR7, heterociclilo con 5 o 6 miembros en el anillo parcial o completamente insaturado o aromático, substituido en caso dado, SR7, SOR7, SO2R7, SO3R7, SON(R7)2, SO2N(R7)2, P(O)(OR7)2, NR7OR7,-B(OR7)2, -(CR72)0-6-NR72 o -(CR72)0-6-NR7-NR72; R5 significa H, halogeno, alquilo substituido en caso dado por halogeno o cicloalquilo substituido en caso dado por halogeno, O-alquilo C1-4 o S(O)0-2-alquilo C1-4; X significa halogeno, ciano, hidroxi, alquilo en caso dado substituido, alcoxi en caso dado substituido, fenilo en caso dado substituido, alquiltio en caso dado substituido, alquilsulfinilo en caso dado substituido o alquilsulfonilo en caso dado substituido; R6 significa alquilo en caso dado substituido, alquenilo en caso dado substituido, alquinilo en caso dado substituido, cicloalquilo en caso dado substituido y cicloalquenilo en caso dado substituido; arilo en caso dado substituido y arilalquilo en caso dado substituido; R7 son iguales o diferentes y significan H, R6 o dos restos R7 o bien un resto R7 y un resto R6 forman conjuntamente un ciclo con 3 hasta 6 átomos de C, que está saturado o parcialmente insaturado y que contiene, en caso dado, 1 o 2 átomos más de N, S u O, no pudiendo ser contiguos los átomos de O; R8 significa H, un cation, alquilo substituido, alquenilo substituido en caso dado, alquinilo substituido en caso dado, cicloalquilo substituido en caso dado, cicloalquenilo substituido en caso dado o aralquilo substituido en caso dado; así como sus sales con actividad agroquímica.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102004008807A DE102004008807A1 (de) | 2004-02-20 | 2004-02-20 | Pyrazolopyrimidine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR048857A1 true AR048857A1 (es) | 2006-06-07 |
Family
ID=34832976
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP050100633A AR048857A1 (es) | 2004-02-20 | 2005-02-21 | Pirazolopirimidinas |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US7629294B2 (es) |
| EP (1) | EP1718652A2 (es) |
| JP (1) | JP2007524691A (es) |
| KR (1) | KR20070015386A (es) |
| CN (1) | CN1946293A (es) |
| AR (1) | AR048857A1 (es) |
| BR (1) | BRPI0507894A (es) |
| CA (1) | CA2556798A1 (es) |
| CR (1) | CR8559A (es) |
| DE (1) | DE102004008807A1 (es) |
| EA (1) | EA200601515A1 (es) |
| IL (1) | IL177510A0 (es) |
| MX (1) | MXPA06009311A (es) |
| TW (1) | TW200538044A (es) |
| WO (1) | WO2005082907A2 (es) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1938309B (zh) * | 2003-12-22 | 2011-11-09 | 史密斯克莱.比奇曼（科克）有限公司 | Crf受体拮抗剂及其相关方法 |
| GB0519957D0 (en) * | 2005-09-30 | 2005-11-09 | Sb Pharmco Inc | Chemical compound |
| DE102005007534A1 (de) * | 2005-02-17 | 2006-08-31 | Bayer Cropscience Ag | Pyrazolopyrimidine |
| US8188097B2 (en) | 2005-10-21 | 2012-05-29 | Mitsubishi Tanabe Pharma Corporation | Pyrazolo[1,5-A]pyrimidine compounds |
| JP4847275B2 (ja) * | 2005-10-21 | 2011-12-28 | 田辺三菱製薬株式会社 | ピラゾロ［１，５−ａ］ピリミジン化合物 |
| AR061793A1 (es) | 2006-07-05 | 2008-09-24 | Mitsubishi Tanabe Pharma Corp | Compuesto de pirazolo[1,5-a] pirimidina y composicion farmaceutica |
| TW201345908A (zh) * | 2006-07-05 | 2013-11-16 | Mitsubishi Tanabe Pharma Corp | 吡唑并〔１，５-ａ〕嘧啶化合物 |
| DE102006039255A1 (de) * | 2006-08-17 | 2008-02-21 | Bayer Cropscience Ag | Insektizide heterocyclische Carbonsäurederivate |
| WO2008046856A2 (de) * | 2006-10-18 | 2008-04-24 | Basf Se | Fungizide zusammensetzungen |
| JP4837701B2 (ja) * | 2007-04-20 | 2011-12-14 | 田辺三菱製薬株式会社 | 医薬組成物 |
| EP2014661A1 (de) * | 2007-06-13 | 2009-01-14 | Bayer CropScience AG | Heterocyclisch substituierte Heterocyclyl-carbonsäurederivate |
| US8507673B2 (en) * | 2008-12-11 | 2013-08-13 | Emory University | Process for preparing 5,7 diaminopyrazolo [1,5-A] pyrimidine compounds |
| US9023883B2 (en) | 2013-03-14 | 2015-05-05 | Epizyme, Inc. | PRMT1 inhibitors and uses thereof |
| US9133189B2 (en) | 2013-03-14 | 2015-09-15 | Epizyme, Inc. | Arginine methyltransferase inhibitors and uses thereof |
| US9447079B2 (en) | 2013-03-14 | 2016-09-20 | Epizyme, Inc. | PRMT1 inhibitors and uses thereof |
| EP2970220A2 (en) | 2013-03-14 | 2016-01-20 | Epizyme, Inc. | Arginine methyltransferase inhibitors and uses thereof |
| US20160039767A1 (en) | 2013-03-14 | 2016-02-11 | Epizyme, Inc. | Pyrazole derivatives as prmt1 inhibitors and uses thereof |
| US9365527B2 (en) | 2013-03-14 | 2016-06-14 | Epizyme, Inc. | Arginine methyltransferase inhibitors and uses thereof |
| CA2903264A1 (en) | 2013-03-14 | 2014-11-06 | Epizyme, Inc. | Pyrazole derivatives as arginine methyltransferase inhibitors and uses thereof |
| WO2014153208A1 (en) | 2013-03-14 | 2014-09-25 | Epizyme, Inc. | Arginine methyltransferase inhibitors and uses thereof |
| BR112015022785A2 (pt) | 2013-03-14 | 2017-07-18 | Epizyme Inc | composto; composição farmacêutica; kit ou artigo farmacêutico embalado; método de inibição de uma arginina metil transferase (rmt); método de modulação da expressão genética; método de modulação da transcrição; e método de tratamento de um distúrbio mediado por rmt |
| US9120757B2 (en) | 2013-03-14 | 2015-09-01 | Epizyme, Inc. | Arginine methyltransferase inhibitors and uses thereof |
| ES2994013T3 (en) * | 2017-07-28 | 2025-01-15 | Takeda Pharmaceuticals Co | Tyk2 inhibitors and uses thereof |
| AU2019360941B2 (en) * | 2018-10-15 | 2025-02-27 | Takeda Pharmaceutical Company Limited | TYK2 inhibitors and uses thereof |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS423174Y1 (es) * | 1964-01-17 | 1967-02-24 | ||
| JPS423173Y1 (es) * | 1964-01-24 | 1967-02-24 | ||
| US3515715A (en) | 1967-01-23 | 1970-06-02 | Eastman Kodak Co | Quaternized pyrazolylazo dyes |
| US3634391A (en) | 1969-07-25 | 1972-01-11 | Eastman Kodak Co | Pyrazolyl-azo-indole dyestuffs |
| DE3130633A1 (de) | 1981-08-01 | 1983-02-17 | Basf Ag, 6700 Ludwigshafen | 7-amino-azolo(1,5-a)pyrimidine und diese enthaltende fungizide |
| FR2537137B1 (fr) | 1982-12-03 | 1985-07-19 | Roussel Uclaf | Procede de preparation de derives de l'acide 2-thiophene acetique et produits intermediaires necessaires pour leur preparation |
| DE3338292A1 (de) * | 1983-10-21 | 1985-05-02 | Basf Ag, 6700 Ludwigshafen | 7-amino-azolo(1,5-a)-pyrimidine und diese enthaltende fungizide |
| DE3533050A1 (de) | 1985-09-17 | 1987-03-26 | Basf Ag | 7-amino-azolo(1,5-a)pyrimidine, verfahren zu ihrer herstellung und diese enthaltende fungizide, bzw. deren verwendung als fungizide |
| GB9510459D0 (en) | 1995-05-24 | 1995-07-19 | Zeneca Ltd | Bicyclic amines |
| FR2750048B1 (fr) * | 1996-06-21 | 1998-08-14 | Oreal | Compositions de teinture des fibres keratiniques contenant des derives pyrazolo-(1, 5-a)-pyrimidine, procede de teinture, nouveaux derives pyrazolo-(1, 5-a)-pyrimidine et leur procede de preparation |
| GB9624611D0 (en) | 1996-11-26 | 1997-01-15 | Zeneca Ltd | Bicyclic amine compounds |
| EA199900502A1 (ru) | 1996-11-26 | 2000-02-28 | Зенека Лимитед | 8-азабицикло[3.2.1]октан-, 8-азабицикло[3.2.1]окт-6-ен-, 9-азабицикло[3.3.1]нонан-, 9-аза-3-оксабицикло[3.3.1]нонан- и 9-аза-3-тиабицикло[3.3.1]нонанпроизводные, их получение и их применение в качестве инсектицидов |
| US6156925A (en) | 1998-09-25 | 2000-12-05 | American Cyanamid Company | Process for the preparation of halogenated phenylmaloates |
| US6552026B2 (en) * | 1999-06-14 | 2003-04-22 | Basf Aktiengesellschaft | 6-phenyl-pyrazolopyrimidines |
| JP2001019693A (ja) * | 1999-06-14 | 2001-01-23 | American Cyanamid Co | 殺菌・殺カビ性６−フェニル−ピラゾロピリミジン |
| DE60015817T2 (de) * | 2000-12-11 | 2005-03-17 | Basf Ag | 6-phenyl-pyrazolpyrimidine |
| EA006133B1 (ru) | 2001-07-26 | 2005-10-27 | Басф Акциенгезельшафт | 7-аминотриазолопиримидины, способ и промежуточные продукты для их получения, содержащие их средства, а также их применение для борьбы с фитопатогенными грибами |
| DE10223917A1 (de) | 2002-05-29 | 2003-12-11 | Bayer Cropscience Ag | Pyrazolopyrimidine |
| WO2004076458A1 (en) * | 2003-02-28 | 2004-09-10 | Teijin Pharma Limited | Pyrazolo[1,5-a]pyrimidine derivatives |
| AU2004242850A1 (en) | 2003-06-03 | 2004-12-09 | Basf Aktiengesellschaft | Substituted pyrazolopyrimidines, methods for the production thereof, use of the same for controlling pathogenic fungi, and agents containing said compounds |
| KR20060027809A (ko) * | 2003-06-27 | 2006-03-28 | 바이엘 크롭사이언스 아게 | 피라졸로피리미딘 |
-
2004
- 2004-02-20 DE DE102004008807A patent/DE102004008807A1/de not_active Withdrawn
-
2005
- 2005-02-18 MX MXPA06009311A patent/MXPA06009311A/es not_active Application Discontinuation
- 2005-02-18 CA CA002556798A patent/CA2556798A1/en not_active Abandoned
- 2005-02-18 CN CNA200580012454XA patent/CN1946293A/zh active Pending
- 2005-02-18 EA EA200601515A patent/EA200601515A1/ru unknown
- 2005-02-18 KR KR1020067019019A patent/KR20070015386A/ko not_active Withdrawn
- 2005-02-18 EP EP05715397A patent/EP1718652A2/de not_active Withdrawn
- 2005-02-18 WO PCT/EP2005/001694 patent/WO2005082907A2/de not_active Ceased
- 2005-02-18 JP JP2006553545A patent/JP2007524691A/ja not_active Withdrawn
- 2005-02-18 BR BRPI0507894-6A patent/BRPI0507894A/pt not_active IP Right Cessation
- 2005-02-21 TW TW094105131A patent/TW200538044A/zh unknown
- 2005-02-21 AR ARP050100633A patent/AR048857A1/es not_active Application Discontinuation
- 2005-02-22 US US11/063,191 patent/US7629294B2/en not_active Expired - Fee Related
-
2006
- 2006-08-14 CR CR8559A patent/CR8559A/es not_active Application Discontinuation
- 2006-08-16 IL IL177510A patent/IL177510A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA06009311A (es) | 2007-03-01 |
| DE102004008807A1 (de) | 2005-09-08 |
| US7629294B2 (en) | 2009-12-08 |
| WO2005082907A2 (de) | 2005-09-09 |
| WO2005082907A3 (de) | 2006-06-29 |
| CR8559A (es) | 2006-11-23 |
| US20050187224A1 (en) | 2005-08-25 |
| CA2556798A1 (en) | 2005-09-09 |
| JP2007524691A (ja) | 2007-08-30 |
| IL177510A0 (en) | 2006-12-10 |
| EP1718652A2 (de) | 2006-11-08 |
| TW200538044A (en) | 2005-12-01 |
| EA200601515A1 (ru) | 2006-12-29 |
| BRPI0507894A (pt) | 2007-07-24 |
| CN1946293A (zh) | 2007-04-11 |
| KR20070015386A (ko) | 2007-02-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |