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AR047461A1 - Formacion, purificacion y uso de n-formilolanzapina - Google Patents

Formacion, purificacion y uso de n-formilolanzapina

Info

Publication number
AR047461A1
AR047461A1 ARP050100260A ARP050100260A AR047461A1 AR 047461 A1 AR047461 A1 AR 047461A1 AR P050100260 A ARP050100260 A AR P050100260A AR P050100260 A ARP050100260 A AR P050100260A AR 047461 A1 AR047461 A1 AR 047461A1
Authority
AR
Argentina
Prior art keywords
salt
olanzapine
formula
acid
formilolanzapine
Prior art date
Application number
ARP050100260A
Other languages
English (en)
Inventor
Rolf Keltjens
Theodorus Hendricus Ant Peters
Original Assignee
Synthon Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthon Bv filed Critical Synthon Bv
Publication of AR047461A1 publication Critical patent/AR047461A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Reivindicacion 1: Un proceso, caracterizado porque comprende hacer reaccionar una despiperazinolanzapina de formula (1) o una sal de la misma, con una N-formilpiperazina de formula (2), para formar una N-formilolanzapina de formula (3) o una de la misma. Reivindicacion 19: Un proceso para formar una sal de olanzapina, caracterizado porque comprende: reducir una N-formilolanzapina de formula (3) o una sal de la misma con un agente reductor en un solvente para formar olanzapina o una sal de la misma disuelta en dicho solvente; hacer reaccionar dicha olanzapina disuelta o una sal de la misma con un ácido para formar una sal de adicion con ácido de olanzapina; y precipitar dicha sal de adicion con ácido de olanzapina de dicha solucion.
ARP050100260A 2004-01-27 2005-01-26 Formacion, purificacion y uso de n-formilolanzapina AR047461A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US53912004P 2004-01-27 2004-01-27
US56222504P 2004-04-15 2004-04-15
US56960704P 2004-05-11 2004-05-11

Publications (1)

Publication Number Publication Date
AR047461A1 true AR047461A1 (es) 2006-01-18

Family

ID=34812083

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP050100260A AR047461A1 (es) 2004-01-27 2005-01-26 Formacion, purificacion y uso de n-formilolanzapina
ARP050100259A AR047460A1 (es) 2004-01-27 2005-01-26 Proceso para la fabricacion de acetato de 2-metil-4-(4-metil-1-piperazinil)-10h-tieno[2,3-b][1,5]benzodiazepina (acetato de olanzapina)

Family Applications After (1)

Application Number Title Priority Date Filing Date
ARP050100259A AR047460A1 (es) 2004-01-27 2005-01-26 Proceso para la fabricacion de acetato de 2-metil-4-(4-metil-1-piperazinil)-10h-tieno[2,3-b][1,5]benzodiazepina (acetato de olanzapina)

Country Status (3)

Country Link
EP (2) EP1711503A1 (es)
AR (2) AR047461A1 (es)
WO (2) WO2005070937A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI21850A (sl) * 2004-07-28 2006-02-28 Krka, Tovarna Zdravil, D.D., Novo Mesto Soli olanzapina in njihova pretvorba v prosto bazo olanzapina
PL377084A1 (pl) * 2005-09-15 2007-03-19 Koźluk Tomasz Nobilus Ent Nowe związki olanzapiny i sposób ich wytwarzania
WO2007096895A1 (en) * 2006-02-27 2007-08-30 Lee Pharma Limited Preparation of anhydrous olanzapine of form-1
JP6085900B2 (ja) * 2012-04-02 2017-03-01 大日本印刷株式会社 オランザピンの製造方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU629879A3 (ru) * 1974-11-26 1978-10-25 Лилли Индастриз Лимитед, (Фирма) Способ получени тиено(1,5) бензодиазепинов или их солей
GB9009229D0 (en) * 1990-04-25 1990-06-20 Lilly Industries Ltd Pharmaceutical compounds
US5631250A (en) * 1995-03-24 1997-05-20 Eli Lilly And Company Process and solvate of 2-methyl-thieno-benzodiazepine
WO1999016312A1 (en) * 1997-09-30 1999-04-08 Eli Lilly And Company Method for treating sexual dysfunction
NZ519926A (en) * 1999-12-28 2004-02-27 Cipla Ltd New polymorphic forms of olanzapine
JP2004507548A (ja) * 2000-08-31 2004-03-11 ドクター・レディーズ・ラボラトリーズ・リミテッド オランザピン水和物の調製方法、及びこれを結晶形態のオランザピンに変換する方法
EP2108651A1 (en) * 2001-12-24 2009-10-14 Sun Pharmaceuticals Industries Ltd. Crystalline form I of 2-methyl-4-(4-methyl-1-piperazinyl) 10H thieno[2,3-B][1,5] benzodiazepine
PL196814B1 (pl) * 2002-05-17 2008-02-29 Inst Farmaceutyczny Sposób wytwarzania odmiany polimorficznej I olanzapiny i jej solwaty
DE60336226D1 (de) * 2002-05-31 2011-04-14 Sandoz Ag Verfahren zur herstellung von olanzapin form i
PL199016B1 (pl) * 2002-06-20 2008-08-29 Adamed Sp Z Oo Sposób wytwarzania olanzapiny
SI21270A (sl) * 2002-07-15 2004-02-29 Krka, Tovarna Zdravil, D.D., Novo Mesto Kristalne oblike olanzapina in postopki za njihovo pripravo

Also Published As

Publication number Publication date
WO2005070937A1 (en) 2005-08-04
EP1711503A1 (en) 2006-10-18
EP1720885A1 (en) 2006-11-15
WO2005070939A1 (en) 2005-08-04
AR047460A1 (es) 2006-01-18

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Legal Events

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