AR044985A1 - Metodo y parche de inmunizacion por disposicion de microproyeccion - Google Patents
Metodo y parche de inmunizacion por disposicion de microproyeccionInfo
- Publication number
- AR044985A1 AR044985A1 ARP040102324A ARP040102324A AR044985A1 AR 044985 A1 AR044985 A1 AR 044985A1 AR P040102324 A ARP040102324 A AR P040102324A AR P040102324 A ARP040102324 A AR P040102324A AR 044985 A1 AR044985 A1 AR 044985A1
- Authority
- AR
- Argentina
- Prior art keywords
- microprojection
- amount
- patch
- provision
- members
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 230000003053 immunization Effects 0.000 title 1
- 238000002649 immunization Methods 0.000 title 1
- 230000000890 antigenic effect Effects 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 230000001939 inductive effect Effects 0.000 abstract 2
- 230000002787 reinforcement Effects 0.000 abstract 2
- 229960005486 vaccine Drugs 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 206010040914 Skin reaction Diseases 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 231100000430 skin reaction Toxicity 0.000 abstract 1
- 230000035483 skin reaction Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/20—Surgical instruments, devices or methods for vaccinating or cleaning the skin previous to the vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/20—Surgical instruments, devices or methods for vaccinating or cleaning the skin previous to the vaccination
- A61B17/205—Vaccinating by means of needles or other puncturing devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0046—Solid microneedles
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Dermatology (AREA)
- Medical Informatics (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Anesthesiology (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Materials For Medical Uses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Se describen miembros microproyección (fig.10) que tienen un reservorio que contiene un agente antigénico y métodos de uso de dichos miembros para vacunar mamíferos (por ejemplo seres humanos). Los miembros de microproyección se usan para liberar trnasdérmicamente un agente antigénico (por ejemplo un antígeno de vacuna) con reacciones de la piel sustancialmente reducidas. Esto se logra administrando una cantidad inductora y liberando a continuación una o más cantidades subsiguientes de refuerzo. La cantidad inductora es relativamente mayor que la cantidad de refuerzo. Esta tecnología tiene una amplia aplicabilidad para una amplia variedad de vacunas para mejorar la eficacia y conveniencia de uso.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US48493003P | 2003-07-02 | 2003-07-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR044985A1 true AR044985A1 (es) | 2005-10-12 |
Family
ID=33564036
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP040102324A AR044985A1 (es) | 2003-07-02 | 2004-07-01 | Metodo y parche de inmunizacion por disposicion de microproyeccion |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20050025778A1 (es) |
| EP (1) | EP1643918A1 (es) |
| JP (1) | JP2007521092A (es) |
| KR (1) | KR20060037320A (es) |
| CN (1) | CN1845708A (es) |
| AR (1) | AR044985A1 (es) |
| AU (1) | AU2004253571A1 (es) |
| BR (1) | BRPI0412202A (es) |
| CA (1) | CA2530954A1 (es) |
| PE (1) | PE20050288A1 (es) |
| TW (1) | TW200513280A (es) |
| UY (1) | UY28398A1 (es) |
| WO (1) | WO2005002453A1 (es) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020193729A1 (en) * | 2001-04-20 | 2002-12-19 | Cormier Michel J.N. | Microprojection array immunization patch and method |
| US6908453B2 (en) * | 2002-01-15 | 2005-06-21 | 3M Innovative Properties Company | Microneedle devices and methods of manufacture |
| KR101323980B1 (ko) | 2002-07-19 | 2013-10-30 | 쓰리엠 이노베이티브 프로퍼티즈 컴파니 | 마이크로 니들 장치, 마이크로 니들 장치를 사용하는 방법 및 마이크로 니들 장치를 송출하는 방법 |
| US7220422B2 (en) * | 2003-05-20 | 2007-05-22 | Allergan, Inc. | Methods and compositions for treating eye disorders |
| CA2530531A1 (en) * | 2003-06-30 | 2005-01-20 | Alza Corporation | Formulations for coated microprojections containing non-volatile counterions |
| AU2004268616B2 (en) * | 2003-08-25 | 2010-10-07 | 3M Innovative Properties Company | Delivery of immune response modifier compounds |
| BRPI0416042A (pt) * | 2003-11-13 | 2007-01-02 | Alza Corp | composição e aparelho para suprimento transdérmico |
| CA2552385C (en) * | 2003-12-29 | 2013-07-23 | 3M Innovative Properties Company | Medical devices and kits including same |
| JP2007523771A (ja) * | 2004-02-23 | 2007-08-23 | スリーエム イノベイティブ プロパティズ カンパニー | マイクロニードルアレイの成形方法 |
| JP2007537783A (ja) * | 2004-04-13 | 2007-12-27 | アルザ コーポレイション | 複数のワクチンを経皮送達するための装置及び方法 |
| AU2005306426B2 (en) * | 2004-11-18 | 2011-04-28 | 3M Innovative Properties Company | Masking method for coating a microneedle array |
| CN101060883B (zh) | 2004-11-18 | 2010-06-23 | 3M创新有限公司 | 低轮廓微针阵列施放器 |
| US8057842B2 (en) | 2004-11-18 | 2011-11-15 | 3M Innovative Properties Company | Method of contact coating a microneedle array |
| WO2006055844A2 (en) | 2004-11-18 | 2006-05-26 | 3M Innovative Properties Company | Method of contact coating a microneedle array |
| DE602005027397D1 (de) | 2004-11-18 | 2011-05-19 | 3M Innovative Properties Co | Mikronadelanordungsapplikator und halter |
| JP2008522875A (ja) | 2004-12-07 | 2008-07-03 | スリーエム イノベイティブ プロパティズ カンパニー | マイクロニードルの成形方法 |
| US7691298B2 (en) * | 2005-01-21 | 2010-04-06 | Wisconsin Alumni Research Foundation | Plastic cantilevers for force microscopy |
| TW200738252A (en) * | 2005-02-16 | 2007-10-16 | Alza Corp | Apparatus and method for transdermal delivery of Epoetin-based agents |
| WO2006089285A1 (en) * | 2005-02-16 | 2006-08-24 | Alza Corporation | Microprojection arrays with improved biocompatibility |
| US10035008B2 (en) | 2005-04-07 | 2018-07-31 | 3M Innovative Properties Company | System and method for tool feedback sensing |
| US8048017B2 (en) | 2005-05-18 | 2011-11-01 | Bai Xu | High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances |
| WO2007002523A2 (en) * | 2005-06-24 | 2007-01-04 | 3M Innovative Properties Company | Collapsible patch with microneedle array |
| CA2613114C (en) | 2005-06-27 | 2015-02-24 | 3M Innovative Properties Company | Microneedle cartridge assembly and method of applying |
| JP5144510B2 (ja) | 2005-06-27 | 2013-02-13 | スリーエム イノベイティブ プロパティズ カンパニー | マイクロニードルアレイ適用装置 |
| CA2619452A1 (en) * | 2005-09-12 | 2007-03-22 | Alza Corporation | Coatable transdermal delivery microprojection assembly |
| CA2629193C (en) * | 2005-11-18 | 2016-03-29 | 3M Innovative Properties Company | Coatable compositions, coatings derived therefrom and microarrays having such coatings |
| US20080262416A1 (en) * | 2005-11-18 | 2008-10-23 | Duan Daniel C | Microneedle Arrays and Methods of Preparing Same |
| US20110107473A1 (en) * | 2006-03-15 | 2011-05-05 | Wisconsin Alumni Research Foundation | Diamond-like carbon coated nanoprobes |
| US20080142709A1 (en) * | 2006-03-21 | 2008-06-19 | Anirudha Vishwanath Sumant | MONOLITHIC ta-C NANOPROBES AND ta-C COATED NANOPROBES |
| WO2007116409A2 (en) * | 2006-04-11 | 2007-10-18 | Yeda Research And Development Co. Ltd. At The Weizmann Institute Of Science | Improved vaccines comprising multimeric hsp60 peptide carriers |
| US9119945B2 (en) * | 2006-04-20 | 2015-09-01 | 3M Innovative Properties Company | Device for applying a microneedle array |
| US20080214987A1 (en) | 2006-12-22 | 2008-09-04 | Nanomed Devices, Inc. | Microdevice And Method For Transdermal Delivery And Sampling Of Active Substances |
| US10525246B2 (en) | 2006-12-22 | 2020-01-07 | Nanomed Skincare, Inc. | Microdevice and method for transdermal delivery and sampling of active substances |
| WO2008088922A2 (en) * | 2007-01-19 | 2008-07-24 | Genentech, Inc. | Prevention of hydrogel viscosity loss |
| WO2008091602A2 (en) * | 2007-01-22 | 2008-07-31 | Corium International, Inc. | Applicators for microneedle arrays |
| US8911749B2 (en) | 2007-04-16 | 2014-12-16 | Corium International, Inc. | Vaccine delivery via microneedle arrays |
| AU2008241470B2 (en) | 2007-04-16 | 2013-11-07 | Corium Pharma Solutions, Inc. | Solvent-cast microneedle arrays containing active |
| US9107815B2 (en) * | 2008-02-22 | 2015-08-18 | Allergan, Inc. | Sustained release poloxamer containing pharmaceutical compositions |
| JP5902390B2 (ja) * | 2008-12-26 | 2016-04-13 | 久光製薬株式会社 | マイクロニードルデバイス |
| KR101136739B1 (ko) * | 2009-06-15 | 2012-04-19 | 주식회사 라파스 | 다기능 하이브리드 마이크로구조체 및 그의 제조방법 |
| CA2784827C (en) * | 2009-12-16 | 2018-10-23 | Shasun Pharmaceuticals Limited | Composition of dexibuprofen transdermal hydrogel |
| AU2011248108B2 (en) | 2010-05-04 | 2016-05-26 | Corium Pharma Solutions, Inc. | Method and device for transdermal delivery of parathyroid hormone using a microprojection array |
| GB201120000D0 (en) * | 2011-11-20 | 2012-01-04 | Glaxosmithkline Biolog Sa | Vaccine |
| GB201119999D0 (en) * | 2011-11-20 | 2012-01-04 | Glaxosmithkline Biolog Sa | Vaccine |
| CA2896188C (en) | 2012-12-21 | 2021-02-23 | Corium International, Inc. | Microarray for delivery of therapeutic agent and methods of use |
| ES2921481T3 (es) | 2013-03-12 | 2022-08-26 | Corium Inc | Aplicadores para microproyecciones |
| CA2903763C (en) | 2013-03-15 | 2021-11-16 | Corium International, Inc. | Microarray with polymer-free microstructures, methods of making, and methods of use |
| US10195409B2 (en) | 2013-03-15 | 2019-02-05 | Corium International, Inc. | Multiple impact microprojection applicators and methods of use |
| US10384046B2 (en) | 2013-03-15 | 2019-08-20 | Corium, Inc. | Microarray for delivery of therapeutic agent and methods of use |
| US20160310412A1 (en) * | 2013-12-16 | 2016-10-27 | Takeda Pharmaceutical Company Limited | Microneedle |
| EP3188714A1 (en) | 2014-09-04 | 2017-07-12 | Corium International, Inc. | Microstructure array, methods of making, and methods of use |
| KR102169536B1 (ko) * | 2014-09-11 | 2020-10-23 | 히사미쓰 세이야꾸 가부시키가이샤 | 마이크로니들 디바이스 |
| KR101626053B1 (ko) * | 2014-09-19 | 2016-06-01 | 연세대학교 산학협력단 | 원터치 유체 채취용 디바이스 |
| SG11201702779PA (en) | 2014-10-27 | 2017-05-30 | Hisamitsu Pharmaceutical Co | Microneedle device containing recombinant follicle stimulating hormone |
| US10857093B2 (en) | 2015-06-29 | 2020-12-08 | Corium, Inc. | Microarray for delivery of therapeutic agent, methods of use, and methods of making |
| TW202247855A (zh) | 2016-09-13 | 2022-12-16 | 美商愛力根公司 | 非蛋白梭菌毒素組成物 |
| KR102225666B1 (ko) * | 2018-12-31 | 2021-03-11 | 서울시립대학교 산학협력단 | 핵산 기반 마이크로니들의 제조방법 및 이를 통해 제조된 핵산 기반 마이크로니들 |
| WO2020198785A1 (en) * | 2019-03-29 | 2020-10-08 | Vaxxas Pty Ltd | Vaccination using high-density microprojection array patch |
| AU2021258258A1 (en) * | 2020-04-22 | 2022-11-17 | Emergex USA Corporation | Transdermal active agent delivery devices having coronavirus vaccine coated microprotrusions |
| CN116407624B (zh) * | 2023-04-14 | 2024-04-09 | 吉林省农业科学院(中国农业科技东北创新中心) | 一种鸡传染性支气管炎细菌样颗粒疫苗的制备方法和应用 |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE25637E (en) * | 1964-09-08 | Means for vaccinating | ||
| US3136314A (en) * | 1960-08-01 | 1964-06-09 | Kravitz Harvey | Vaccinating devices |
| US3964482A (en) * | 1971-05-17 | 1976-06-22 | Alza Corporation | Drug delivery device |
| BE795384A (fr) * | 1972-02-14 | 1973-08-13 | Ici Ltd | Pansements |
| OA05448A (fr) * | 1975-10-16 | 1981-03-31 | Manufrance Manufacture Francai | Dispositif vaccinateur multipénétrant. |
| FR2474856A1 (fr) * | 1980-01-31 | 1981-08-07 | Merieux Inst | Dispositif scarificateur |
| EP0429842B1 (en) * | 1989-10-27 | 1996-08-28 | Korea Research Institute Of Chemical Technology | Device for the transdermal administration of protein or peptide drug |
| US5487726A (en) * | 1994-06-16 | 1996-01-30 | Ryder International Corporation | Vaccine applicator system |
| WO1996037155A1 (en) * | 1995-05-22 | 1996-11-28 | Silicon Microdevices, Inc. | Micromechanical device and method for enhancing delivery of compounds through the skin |
| DE69719761T2 (de) * | 1996-06-18 | 2003-12-18 | Alza Corp., Palo Alto | Vorrichtung zur verbesserung der transdermalen verabreichung von medikamenten oder der abnahme von körperflüssigkeiten |
| US5738728A (en) * | 1996-07-26 | 1998-04-14 | Bio Dot, Inc. | Precision metered aerosol dispensing apparatus |
| US5916524A (en) * | 1997-07-23 | 1999-06-29 | Bio-Dot, Inc. | Dispensing apparatus having improved dynamic range |
| US5743960A (en) * | 1996-07-26 | 1998-04-28 | Bio-Dot, Inc. | Precision metered solenoid valve dispenser |
| US5741554A (en) * | 1996-07-26 | 1998-04-21 | Bio Dot, Inc. | Method of dispensing a liquid reagent |
| US5983136A (en) * | 1996-09-17 | 1999-11-09 | Deka Products Limited Partnership | System for delivery of drugs by transport |
| US6918901B1 (en) * | 1997-12-10 | 2005-07-19 | Felix Theeuwes | Device and method for enhancing transdermal agent flux |
| KR100572539B1 (ko) * | 1997-12-11 | 2006-04-24 | 알자 코포레이션 | 경피성 작용제 유동률을 증진시키기 위한 장치 |
| WO1999029365A1 (en) * | 1997-12-11 | 1999-06-17 | Alza Corporation | Device for enhancing transdermal agent flux |
| KR100557261B1 (ko) * | 1997-12-11 | 2006-03-07 | 알자 코포레이션 | 경피성 작용제 유동률을 증진시키기 위한 장치 |
| US6091975A (en) * | 1998-04-01 | 2000-07-18 | Alza Corporation | Minimally invasive detecting device |
| US6203051B1 (en) * | 1999-03-23 | 2001-03-20 | Jeffrey P. Sabol | Safety rotatable snowboard boot binding |
| GB0017999D0 (en) * | 2000-07-21 | 2000-09-13 | Smithkline Beecham Biolog | Novel device |
| MXPA03001694A (es) * | 2000-08-24 | 2004-11-01 | Johnson & Johnson | Metodo para toma de muestra transdermal de acido nucleico. |
| WO2002019985A2 (en) * | 2000-09-08 | 2002-03-14 | Alza Corporation | Methods for inhibiting decrease in transdermal drug flux by inhibition of pathway closure |
| KR20030068136A (ko) * | 2000-10-13 | 2003-08-19 | 알자 코포레이션 | 미세 돌기부로 피부를 천공하기 위한 장치 및 방법 |
| CZ20031035A3 (cs) * | 2000-10-13 | 2004-02-18 | Alza Corporation | Nárazový aplikátor opatřený množinou mikročepelek |
| MXPA03003303A (es) * | 2000-10-13 | 2004-12-13 | Johnson & Johnson | Retenedor del miembro de microprotrusion para aplicador de impacto. |
| WO2002094368A1 (en) * | 2000-10-26 | 2002-11-28 | Alza Corporation | Transdermal drug delivery devices having coated microprotrusions |
| US6855372B2 (en) * | 2001-03-16 | 2005-02-15 | Alza Corporation | Method and apparatus for coating skin piercing microprojections |
| ATE444773T1 (de) * | 2001-04-20 | 2009-10-15 | Alza Corp | Mikroprojektionsanordnung mit einem überzug, der ein vorteilhaftes mittel enthält |
| US20020193729A1 (en) * | 2001-04-20 | 2002-12-19 | Cormier Michel J.N. | Microprojection array immunization patch and method |
| EP1485317A2 (en) * | 2001-11-30 | 2004-12-15 | Alza Corporation | Methods and apparatuses for forming microprojection arrays |
| RU2314760C2 (ru) * | 2001-12-20 | 2008-01-20 | Алза Корпорейшн | Микровыступы, пробивающие кожу, имеющие средство регулирования глубины пробивки |
| KR20050054483A (ko) * | 2002-06-28 | 2005-06-10 | 알자 코포레이션 | 코팅된 미세돌출부를 갖는 경피용 약물 전달 장치 |
| AR040819A1 (es) * | 2002-08-08 | 2005-04-20 | Alza Corp | Dispositivo de administracion transdermica de vacuna que tiene microproyecciones revestidas |
| WO2004030743A2 (en) * | 2002-09-30 | 2004-04-15 | Alza Corporation | Drug delivery device having coated microprojections incorporating vasoconstrictors |
| AR042815A1 (es) * | 2002-12-26 | 2005-07-06 | Alza Corp | Dispositivo de suministro de agente activo que tiene miembros compuestos |
| CA2530531A1 (en) * | 2003-06-30 | 2005-01-20 | Alza Corporation | Formulations for coated microprojections containing non-volatile counterions |
| JP2007508914A (ja) * | 2003-10-24 | 2007-04-12 | アルザ・コーポレーシヨン | 経皮薬剤送達を促進するための装置及び方法 |
| WO2005042054A2 (en) * | 2003-10-24 | 2005-05-12 | Alza Corporation | Pretreatment method and system for enhancing transdermal drug delivery |
-
2004
- 2004-07-01 TW TW093119875A patent/TW200513280A/zh unknown
- 2004-07-01 UY UY28398A patent/UY28398A1/es unknown
- 2004-07-01 EP EP04756609A patent/EP1643918A1/en not_active Withdrawn
- 2004-07-01 AR ARP040102324A patent/AR044985A1/es not_active Application Discontinuation
- 2004-07-01 WO PCT/US2004/021393 patent/WO2005002453A1/en not_active Ceased
- 2004-07-01 BR BRPI0412202-0A patent/BRPI0412202A/pt not_active IP Right Cessation
- 2004-07-01 JP JP2006518804A patent/JP2007521092A/ja active Pending
- 2004-07-01 KR KR1020067000059A patent/KR20060037320A/ko not_active Withdrawn
- 2004-07-01 PE PE2004000631A patent/PE20050288A1/es not_active Application Discontinuation
- 2004-07-01 CA CA002530954A patent/CA2530954A1/en not_active Abandoned
- 2004-07-01 CN CNA2004800251396A patent/CN1845708A/zh active Pending
- 2004-07-01 AU AU2004253571A patent/AU2004253571A1/en not_active Abandoned
- 2004-07-01 US US10/884,603 patent/US20050025778A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| TW200513280A (en) | 2005-04-16 |
| CN1845708A (zh) | 2006-10-11 |
| KR20060037320A (ko) | 2006-05-03 |
| CA2530954A1 (en) | 2005-01-13 |
| US20050025778A1 (en) | 2005-02-03 |
| JP2007521092A (ja) | 2007-08-02 |
| EP1643918A1 (en) | 2006-04-12 |
| BRPI0412202A (pt) | 2006-08-22 |
| UY28398A1 (es) | 2004-11-08 |
| AU2004253571A1 (en) | 2005-01-13 |
| PE20050288A1 (es) | 2005-04-29 |
| WO2005002453A1 (en) | 2005-01-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR044985A1 (es) | Metodo y parche de inmunizacion por disposicion de microproyeccion | |
| BR0209041A (pt) | Emplastro de imunização de disposição de microprojeção e método | |
| UY39060A (es) | Composiciones y métodos para prevenir y tratar la infección por coronavirus - vacunas sars-cov-2 | |
| ECSP066683A (es) | Vacuna para mejorar el crecimiento, a base de epítopes neutralizantes | |
| CY1118521T1 (el) | Συνθεση εμβολιου και μεθοδος χρησης αυτου | |
| ES2585810T3 (es) | Uso de un virus de la gripe y un adyuvante de emulsión de aceite en agua para inducir respuesta de células T CD4 y/o una respuesta de células B de memoria mejorada | |
| CR11122A (es) | Vacuna de influenza de emulsion de aceite en agua | |
| MX2018010586A (es) | Nanovacuna de activacion de "sting" para inmunoterapia. | |
| AR032597A1 (es) | Uso de antigenos del virus de la gripe inactivado, en la preparacion de vacunas de una sola dosis intranasal; metodo para la profilaxis de enfermedades o de infecciones gripales en pacientes; equipos que comprenden dichas vacunas en dosis unicas y metodo para fabricar vacunas para la gripe para apli | |
| GT200200138A (es) | Vacunacion en dosis unica con mycoplasma hyopneumoniae | |
| BR112022014830A2 (pt) | Formulações de vacina para coronavírus | |
| DE60012042D1 (de) | Entepneumovirus und entsprechendes impfstoff | |
| IL150602A (en) | Proteosome influenza vaccine, method for preparing such and use thereof | |
| NO20015073L (no) | Vaksiner | |
| MX9709870A (es) | Uso de esporocistos u occistos para preparar una vacuna contra coccidiosis. | |
| ES2195169T3 (es) | Vacunas contra calmidias y composiciones inmunogenicas que contienen un antigeno de membrana externa y metodos para su preparacion. | |
| BR112023019301A2 (pt) | Formulações de vacina de coronavírus | |
| ATE511855T1 (de) | Adjuvansformulierung zur scheimhaut-applikation | |
| AR054844A1 (es) | Vacuna contra lawsonia y metodos de uso de la misma | |
| NZ592713A (en) | Adjuvanted influenza vaccines including a cytokine-inducing agents other than an agonist of Toll-Like Receptor 9 | |
| AR116878A1 (es) | Vacuna de ibv h52 con proteína espicular heteróloga | |
| EP1301208A4 (en) | Vaccine | |
| AR065765A1 (es) | Composicion de vacuna para el tratamiento de enfermedades infecciosas respiratorias | |
| ES2106032T3 (es) | Vacuna para inmunizar gatos contra el desprendimiento de oocistos de toxoplasma. | |
| DE69720065D1 (de) | Therapeutische anwendungen von antigenen oder epitopen assoziert mit unvollständiger zellulärer peptidprozesierung , z.b.: exprimiert in rma-s zellen transfiziert mit b7-1 gen |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |