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AR044963A1 - Aparato y metodo para recubrir microproyecciones de perforacion de la piel - Google Patents

Aparato y metodo para recubrir microproyecciones de perforacion de la piel

Info

Publication number
AR044963A1
AR044963A1 ARP040102299A ARP040102299A AR044963A1 AR 044963 A1 AR044963 A1 AR 044963A1 AR P040102299 A ARP040102299 A AR P040102299A AR P040102299 A ARP040102299 A AR P040102299A AR 044963 A1 AR044963 A1 AR 044963A1
Authority
AR
Argentina
Prior art keywords
microprojections
coating
skin piercing
coating skin
skin perforation
Prior art date
Application number
ARP040102299A
Other languages
English (en)
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Publication of AR044963A1 publication Critical patent/AR044963A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/20—Surgical instruments, devices or methods for vaccinating or cleaning the skin previous to the vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/20—Surgical instruments, devices or methods for vaccinating or cleaning the skin previous to the vaccination
    • A61B17/205—Vaccinating by means of needles or other puncturing devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053—Methods for producing microneedles

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Medical Informatics (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
  • Media Introduction/Drainage Providing Device (AREA)

Abstract

Se proveen un aparato y método para aplicar selectivamente un recubrimiento líquido conteniendo un agente a microproyecciones de perforación de la piel extremadamente pequeñas. La solución de recubrimiento se aplica a las microproyecciones de perforación de la piel utilizando una técnica de recubrimiento que recubre selectivamente sólo porciones predeterminadas de las microproyecciones de perforación de la piel. Mediante el uso de diversas fotorresistencias y recubrimiento hidrofóbicos, se puede recubrir una porción definida y precisa de las microproyocciones con una formulación de agente.
ARP040102299A 2003-06-30 2004-06-30 Aparato y metodo para recubrir microproyecciones de perforacion de la piel AR044963A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US48414203P 2003-06-30 2003-06-30

Publications (1)

Publication Number Publication Date
AR044963A1 true AR044963A1 (es) 2005-10-12

Family

ID=34062028

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP040102299A AR044963A1 (es) 2003-06-30 2004-06-30 Aparato y metodo para recubrir microproyecciones de perforacion de la piel

Country Status (18)

Country Link
US (1) US20040265365A1 (es)
EP (1) EP1638468B1 (es)
JP (1) JP5174347B2 (es)
KR (1) KR20060029162A (es)
CN (1) CN100586385C (es)
AR (1) AR044963A1 (es)
AT (1) ATE369802T1 (es)
AU (1) AU2004255228A1 (es)
BR (1) BRPI0412021A (es)
CA (1) CA2530520A1 (es)
DE (1) DE602004008278T2 (es)
DK (1) DK1638468T3 (es)
ES (1) ES2290738T3 (es)
MX (1) MXPA06000283A (es)
PL (1) PL1638468T3 (es)
PT (1) PT1638468E (es)
TW (1) TW200514591A (es)
WO (1) WO2005004729A1 (es)

Families Citing this family (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0210397D0 (en) 2002-05-07 2002-06-12 Ferring Bv Pharmaceutical formulations
CA2530531A1 (en) * 2003-06-30 2005-01-20 Alza Corporation Formulations for coated microprojections containing non-volatile counterions
AU2004268616B2 (en) 2003-08-25 2010-10-07 3M Innovative Properties Company Delivery of immune response modifier compounds
BRPI0416042A (pt) * 2003-11-13 2007-01-02 Alza Corp composição e aparelho para suprimento transdérmico
JP2007537783A (ja) * 2004-04-13 2007-12-27 アルザ コーポレイション 複数のワクチンを経皮送達するための装置及び方法
JP5007427B2 (ja) * 2004-05-13 2012-08-22 アルザ コーポレイション 副甲状腺ホルモン剤の経皮送達のための装置および方法
US20060030811A1 (en) * 2004-08-03 2006-02-09 Wong Patrick S Method and device for enhancing transdermal agent flux
TW200616660A (en) * 2004-08-11 2006-06-01 Alza Corp Apparatus and method for transdermal delivery of natriuretic peptides
SE0402100D0 (sv) * 2004-08-30 2004-08-30 Bonsens Ab Molded micro-needles
WO2006055844A2 (en) * 2004-11-18 2006-05-26 3M Innovative Properties Company Method of contact coating a microneedle array
US8057842B2 (en) * 2004-11-18 2011-11-15 3M Innovative Properties Company Method of contact coating a microneedle array
CN101106979A (zh) * 2005-01-21 2008-01-16 阿尔扎公司 具有改善的稳定性的含有至少一种反离子的用于涂覆微针的治疗性的肽试剂
AU2006211176A1 (en) * 2005-01-31 2006-08-10 Alza Corporation Coated microprojections having reduced variability and method for producing same
TW200738252A (en) * 2005-02-16 2007-10-16 Alza Corp Apparatus and method for transdermal delivery of Epoetin-based agents
AU2006230308A1 (en) * 2005-03-28 2006-10-05 Alza Corporation Microprojections with capillary control features and method
WO2006138719A2 (en) 2005-06-17 2006-12-28 Georgia Tech Research Corporation Coated microstructures and method of manufacture thereof
US20070078414A1 (en) * 2005-08-05 2007-04-05 Mcallister Devin V Methods and devices for delivering agents across biological barriers
CA2619452A1 (en) * 2005-09-12 2007-03-22 Alza Corporation Coatable transdermal delivery microprojection assembly
CA2629193C (en) * 2005-11-18 2016-03-29 3M Innovative Properties Company Coatable compositions, coatings derived therefrom and microarrays having such coatings
EP1957145A4 (en) * 2005-11-30 2011-03-23 3M Innovative Properties Co MICRONADEL ASSEMBLIES AND APPLICATION METHOD
WO2007084247A2 (en) * 2005-12-28 2007-07-26 Alza Corporation Stable therapeutic formulations
US20070202186A1 (en) 2006-02-22 2007-08-30 Iscience Interventional Corporation Apparatus and formulations for suprachoroidal drug delivery
JP2009530307A (ja) * 2006-03-15 2009-08-27 アルザ コーポレイション 骨減少症を予防し、または治療するための副甲状腺ホルモン薬の経皮送達のための装置、並びに方法
US20070224252A1 (en) * 2006-03-27 2007-09-27 Trautman Joseph C Microprojections with capillary control features and method
US8197435B2 (en) 2006-05-02 2012-06-12 Emory University Methods and devices for drug delivery to ocular tissue using microneedle
WO2007131050A2 (en) * 2006-05-02 2007-11-15 Georgia Tech Research Corporation Method for drug delivery to ocular tissue using microneedle
JP5297595B2 (ja) * 2007-03-20 2013-09-25 凸版印刷株式会社 針状体および針状体製造方法
JP5090032B2 (ja) * 2007-03-20 2012-12-05 凸版印刷株式会社 針状体および針状体製造方法
AU2014200648B2 (en) * 2007-04-16 2015-09-24 Corium Pharma Solutions, Inc. Solvent-cast microneedle arrays containing active
AU2008241470B2 (en) * 2007-04-16 2013-11-07 Corium Pharma Solutions, Inc. Solvent-cast microneedle arrays containing active
US8911749B2 (en) 2007-04-16 2014-12-16 Corium International, Inc. Vaccine delivery via microneedle arrays
JP2008284318A (ja) * 2007-05-15 2008-11-27 Kosumedei Seiyaku Kk 生体由来物質からなる投薬用微細針
US8288142B2 (en) * 2007-06-19 2012-10-16 Uvarkina Tamara P Hyaluronidase and method of use thereof
EP2011629A1 (de) * 2007-07-03 2009-01-07 F. Hoffman-la Roche AG Verfahren zur Herstellung eines mikrofluiden Systems auf einer Polymeroberfläche
KR101522747B1 (ko) 2007-08-06 2015-05-26 알레간 인코포레이티드 데스모프레신 약물 전달을 위한 방법 및 장치
JP5504632B2 (ja) * 2008-03-05 2014-05-28 セイコーエプソン株式会社 電気泳動装置、電気泳動装置の駆動方法、電子機器
US20100286045A1 (en) 2008-05-21 2010-11-11 Bjarke Mirner Klein Methods comprising desmopressin
US11963995B2 (en) 2008-05-21 2024-04-23 Ferring B.V. Methods comprising desmopressin
HUE041370T2 (hu) 2008-05-21 2019-05-28 Ferring Bv Orodiszperzibilis dezmopresszin az alvás noktúria által meg nem zavart kezdeti szakaszának megnövelésére
CN102039000B (zh) * 2009-10-20 2015-08-26 苏州纳通生物纳米技术有限公司 一种透皮给药试剂盒
AU2011248108B2 (en) 2010-05-04 2016-05-26 Corium Pharma Solutions, Inc. Method and device for transdermal delivery of parathyroid hormone using a microprojection array
CN104758118B (zh) 2010-10-15 2018-04-06 科尼尔赛德生物医学公司 用于进入眼睛的装置
EP2683358B1 (en) * 2011-03-07 2015-06-03 3M Innovative Properties Company Microneedle devices and methods
JP2014532482A (ja) * 2011-10-28 2014-12-08 クウォン， スン−ユン 片頭痛を処置するための可溶性固溶体穿孔器パッチ
CA2857501C (en) * 2011-11-30 2020-06-23 3M Innovative Properties Company Microneedle device having a peptide therapeutic agent and an amino acid, methods of making and using the same
JP5472771B1 (ja) 2012-09-28 2014-04-16 コスメディ製薬株式会社 段差に薬物を保持したマイクロニードル
EP4566672A3 (en) 2012-11-08 2025-08-13 Clearside Biomedical Inc. Methods for the treatment of ocular disease in human subjects
CA2896188C (en) 2012-12-21 2021-02-23 Corium International, Inc. Microarray for delivery of therapeutic agent and methods of use
ES2921481T3 (es) 2013-03-12 2022-08-26 Corium Inc Aplicadores para microproyecciones
WO2014144973A1 (en) 2013-03-15 2014-09-18 Corium International, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
US10195409B2 (en) 2013-03-15 2019-02-05 Corium International, Inc. Multiple impact microprojection applicators and methods of use
CA2903763C (en) 2013-03-15 2021-11-16 Corium International, Inc. Microarray with polymer-free microstructures, methods of making, and methods of use
US10384046B2 (en) 2013-03-15 2019-08-20 Corium, Inc. Microarray for delivery of therapeutic agent and methods of use
US9539139B2 (en) 2013-05-03 2017-01-10 Clearside Biomedical, Inc. Apparatus and methods for ocular injection
WO2014197317A1 (en) 2013-06-03 2014-12-11 Clearside Biomedical, Inc. Apparatus and methods for drug delivery using multiple reservoirs
CN105517621B (zh) * 2013-09-06 2019-01-01 久光制药株式会社 微型针片材
CN103611214A (zh) * 2013-12-03 2014-03-05 上海交通大学 针药微系统及其制备方法
JP6325082B2 (ja) * 2014-02-27 2018-05-16 久光製薬株式会社 マイクロニードル・シート
CA2943611A1 (en) 2014-03-28 2015-10-01 Duke University Method of treating cancer using selective estrogen receptor modulators
JP2017524419A (ja) 2014-06-20 2017-08-31 クリアサイド バイオメディカル，インコーポレイテッド 薬剤送達のための挿入深さを制御するための可変径カニューレ及び方法
EP3188714A1 (en) 2014-09-04 2017-07-12 Corium International, Inc. Microstructure array, methods of making, and methods of use
USD750223S1 (en) 2014-10-14 2016-02-23 Clearside Biomedical, Inc. Medical injector for ocular injection
WO2016088886A1 (ja) 2014-12-05 2016-06-09 久光製薬株式会社 マイクロニードルデバイスシステム
CA2984357A1 (en) 2015-04-29 2016-11-03 Radius Pharmaceuticals, Inc. Methods for treating cancer
US10857093B2 (en) 2015-06-29 2020-12-08 Corium, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
EP3413851B1 (en) 2016-02-10 2023-09-27 Clearside Biomedical, Inc. Packaging
JP2019514581A (ja) 2016-05-02 2019-06-06 クリアサイド バイオメディカル，インコーポレイテッド 眼の薬物送達のためのシステムおよび方法
WO2017204418A1 (ko) * 2016-05-23 2017-11-30 주식회사유한양행 사마귀 치료를 위한 블레오마이신을 함유하는 마이크로니들 패치 및 이의 제작방법
CN116726371A (zh) * 2016-08-03 2023-09-12 沃达瑞公司 微阵列和方法
WO2018031913A1 (en) 2016-08-12 2018-02-15 Clearside Biomedical, Inc. Devices and methods for adjusting the insertion depth of a needle for medicament delivery
WO2018124290A1 (ja) 2016-12-28 2018-07-05 コスメディ製薬株式会社 薬剤を塗布したマイクロニードルアレイ
KR101947624B1 (ko) * 2016-12-29 2019-02-14 랩앤피플주식회사 멀티형 마이크로 니들
EP3498330B1 (en) * 2016-12-29 2025-03-12 Labnpeople Co.,Ltd. Microneedle array
JP7481115B2 (ja) 2017-01-05 2024-05-10 ラジウス ファーマシューティカルズ，インコーポレイテッド Ｒａｄ１９０１－２ｈｃｌの多形性形態
US12090294B2 (en) 2017-05-02 2024-09-17 Georgia Tech Research Corporation Targeted drug delivery methods using a microneedle
EP3722070A4 (en) * 2017-12-05 2021-09-08 Furukawa Electric Co., Ltd. FUNCTIONAL ELEMENT AND METHOD OF MANUFACTURING THEREOF
KR102022968B1 (ko) * 2018-01-12 2019-09-19 주식회사 에스엔비아 마이크로 니들 시트 구조 및 그 제조방법
IL279853B2 (en) 2018-07-04 2025-01-01 Radius Pharmaceuticals Inc Polymorphic forms of RAD 1901-2HCL
CN119390714A (zh) 2019-02-12 2025-02-07 雷迪厄斯制药公司 方法和化合物
WO2021206294A1 (ko) 2020-04-06 2021-10-14 (주)일론 화장품 흡수 유도용 미세바늘이 장착된 화장품 주입기 및 이의 제작방법
US20250128035A1 (en) 2021-09-15 2025-04-24 Cosmed Pharmaceutical Co., Ltd. Microneedle array coated with drug

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3136314A (en) * 1960-08-01 1964-06-09 Kravitz Harvey Vaccinating devices
US3351059A (en) * 1964-06-02 1967-11-07 Norman Lettvin Single stable dose vaccinator
US3964482A (en) * 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
BE795384A (fr) * 1972-02-14 1973-08-13 Ici Ltd Pansements
OA05448A (fr) * 1975-10-16 1981-03-31 Manufrance Manufacture Francai Dispositif vaccinateur multipénétrant.
FR2474856A1 (fr) * 1980-01-31 1981-08-07 Merieux Inst Dispositif scarificateur
EP0429842B1 (en) * 1989-10-27 1996-08-28 Korea Research Institute Of Chemical Technology Device for the transdermal administration of protein or peptide drug
US5279544A (en) * 1990-12-13 1994-01-18 Sil Medics Ltd. Transdermal or interdermal drug delivery devices
US5487726A (en) * 1994-06-16 1996-01-30 Ryder International Corporation Vaccine applicator system
WO1996037155A1 (en) * 1995-05-22 1996-11-28 Silicon Microdevices, Inc. Micromechanical device and method for enhancing delivery of compounds through the skin
ZA984649B (en) * 1997-06-13 1999-12-17 Cryopreservation Tech Cc "Drug delivery devices and methods for treatment of viral and microbial infections and wasting syndromes".
KR100572539B1 (ko) * 1997-12-11 2006-04-24 알자 코포레이션 경피성 작용제 유동률을 증진시키기 위한 장치
WO1999029365A1 (en) * 1997-12-11 1999-06-17 Alza Corporation Device for enhancing transdermal agent flux
JPH11249287A (ja) * 1998-03-05 1999-09-17 Matsushita Electric Works Ltd 印刷版用材、印刷版、製版方法および印刷装置
US6091975A (en) * 1998-04-01 2000-07-18 Alza Corporation Minimally invasive detecting device
JP2002517300A (ja) * 1998-06-10 2002-06-18 ジョージア テック リサーチ コーポレイション 微小針デバイスおよび製造方法ならびにそれらの使用
JP2000034677A (ja) * 1998-07-15 2000-02-02 Dainippon Printing Co Ltd 部分親水性シート
WO2002094368A1 (en) * 2000-10-26 2002-11-28 Alza Corporation Transdermal drug delivery devices having coated microprotrusions
US6663820B2 (en) * 2001-03-14 2003-12-16 The Procter & Gamble Company Method of manufacturing microneedle structures using soft lithography and photolithography
ATE444773T1 (de) * 2001-04-20 2009-10-15 Alza Corp Mikroprojektionsanordnung mit einem überzug, der ein vorteilhaftes mittel enthält
CA2530531A1 (en) * 2003-06-30 2005-01-20 Alza Corporation Formulations for coated microprojections containing non-volatile counterions

Also Published As

Publication number Publication date
EP1638468A1 (en) 2006-03-29
CN100586385C (zh) 2010-02-03
BRPI0412021A (pt) 2006-08-15
CA2530520A1 (en) 2005-01-20
ATE369802T1 (de) 2007-09-15
TW200514591A (en) 2005-05-01
AU2004255228A1 (en) 2005-01-20
DE602004008278D1 (de) 2007-09-27
EP1638468B1 (en) 2007-08-15
JP2007521090A (ja) 2007-08-02
CN1842300A (zh) 2006-10-04
DE602004008278T2 (de) 2008-02-14
WO2005004729A1 (en) 2005-01-20
PT1638468E (pt) 2007-10-10
ES2290738T3 (es) 2008-02-16
KR20060029162A (ko) 2006-04-04
US20040265365A1 (en) 2004-12-30
MXPA06000283A (es) 2006-07-03
PL1638468T3 (pl) 2008-01-31
DK1638468T3 (da) 2007-12-17
JP5174347B2 (ja) 2013-04-03

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