AR044258A1 - Intermedios utiles en la sintesis de los inhibidores de las proteasas de vih y procedimientos para preparar los mismos - Google Patents
Intermedios utiles en la sintesis de los inhibidores de las proteasas de vih y procedimientos para preparar los mismosInfo
- Publication number
- AR044258A1 AR044258A1 ARP040101550A ARP040101550A AR044258A1 AR 044258 A1 AR044258 A1 AR 044258A1 AR P040101550 A ARP040101550 A AR P040101550A AR P040101550 A ARP040101550 A AR P040101550A AR 044258 A1 AR044258 A1 AR 044258A1
- Authority
- AR
- Argentina
- Prior art keywords
- synthesis
- inhibitors
- procedures
- prepare
- same
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
- C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/25—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
- C07C323/43—Y being a hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/36—Compounds containing oxirane rings with hydrocarbon radicals, substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Indole Compounds (AREA)
- Pyrrole Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Se describen los compuestos intermedios 3-aminobuteno y 1,2 dihidroxi-3-aminobutano óptimamente activos, útiles en la síntesis de los inhibidores de la proteasas de VIH y los procedimientos de preparación de estos compuestos intermedios. Reivindicación 1: Un compuesto de fórmula (1), en la que R1 es un grupo protector de nitrógeno adecuado, R2 es H o R1 junto con R2 forman un grupo protector de nitrógeno adecuado, y R3 es tioalquilo o tioarilo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46923503P | 2003-05-08 | 2003-05-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR044258A1 true AR044258A1 (es) | 2005-09-07 |
Family
ID=33435224
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP040101550A AR044258A1 (es) | 2003-05-08 | 2004-05-06 | Intermedios utiles en la sintesis de los inhibidores de las proteasas de vih y procedimientos para preparar los mismos |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US7173059B2 (es) |
| EP (1) | EP1633704A2 (es) |
| JP (1) | JP2006525307A (es) |
| KR (1) | KR100695861B1 (es) |
| CN (1) | CN1819993A (es) |
| AR (1) | AR044258A1 (es) |
| AU (1) | AU2004236038A1 (es) |
| BR (1) | BRPI0410125A (es) |
| CA (1) | CA2524927A1 (es) |
| CL (1) | CL2004000960A1 (es) |
| CO (1) | CO5700812A2 (es) |
| MX (1) | MXPA05012036A (es) |
| NO (1) | NO20055836L (es) |
| NZ (1) | NZ543236A (es) |
| RU (1) | RU2321580C2 (es) |
| SG (4) | SG145571A1 (es) |
| TW (1) | TW200505413A (es) |
| WO (1) | WO2004099129A2 (es) |
| ZA (1) | ZA200508711B (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ543236A (en) * | 2003-05-08 | 2008-06-30 | Pfizer | Intermediates useful in the synthesis of nelfinavir and methods for preparing the same |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5260461A (en) * | 1988-01-11 | 1993-11-09 | Massachusetts Institute Of Technology | Ligands for ADH: cinchona alkaloids and moderately sized organic substituents linked through a planar aromatic spacer group |
| US5484926A (en) * | 1993-10-07 | 1996-01-16 | Agouron Pharmaceuticals, Inc. | HIV protease inhibitors |
| WO1997011937A1 (en) | 1995-09-26 | 1997-04-03 | Japan Tobacco Inc. | Process for producing amide derivatives and intermediates |
| ATE416158T1 (de) * | 1995-09-26 | 2008-12-15 | Japan Tobacco Inc | Verfahren zur herstellung von amidderivaten und ihren zwischenverbindungen |
| US5587481A (en) * | 1996-02-20 | 1996-12-24 | The Monsanto Company | Preparation of (S)-decahydroisoquinoline-3-carboxylic acid t-butylamide |
| US5705647A (en) * | 1996-09-05 | 1998-01-06 | Agouron Pharmaceuticals, Inc. | Intermediates for making HIV-protease inhibitors |
| CN100439331C (zh) * | 2002-07-19 | 2008-12-03 | 中国科学院上海有机化学研究所 | 抗爱滋病药物那非那维的中间体、合成方法以及用途 |
| NZ543236A (en) * | 2003-05-08 | 2008-06-30 | Pfizer | Intermediates useful in the synthesis of nelfinavir and methods for preparing the same |
-
2004
- 2004-04-28 NZ NZ543236A patent/NZ543236A/en unknown
- 2004-04-28 BR BRPI0410125-1A patent/BRPI0410125A/pt not_active IP Right Cessation
- 2004-04-28 SG SG200700324-7A patent/SG145571A1/en unknown
- 2004-04-28 AU AU2004236038A patent/AU2004236038A1/en not_active Abandoned
- 2004-04-28 KR KR1020057021130A patent/KR100695861B1/ko not_active Expired - Fee Related
- 2004-04-28 SG SG200700327-0A patent/SG145573A1/en unknown
- 2004-04-28 MX MXPA05012036A patent/MXPA05012036A/es active IP Right Grant
- 2004-04-28 CN CNA2004800196045A patent/CN1819993A/zh active Pending
- 2004-04-28 EP EP04729941A patent/EP1633704A2/en not_active Withdrawn
- 2004-04-28 RU RU2005135043/04A patent/RU2321580C2/ru active
- 2004-04-28 WO PCT/IB2004/001380 patent/WO2004099129A2/en not_active Ceased
- 2004-04-28 SG SG200700328-8A patent/SG145574A1/en unknown
- 2004-04-28 CA CA002524927A patent/CA2524927A1/en not_active Abandoned
- 2004-04-28 SG SG200700326-2A patent/SG145572A1/en unknown
- 2004-04-28 JP JP2006506570A patent/JP2006525307A/ja not_active Abandoned
- 2004-05-04 US US10/839,111 patent/US7173059B2/en not_active Expired - Fee Related
- 2004-05-05 CL CL200400960A patent/CL2004000960A1/es unknown
- 2004-05-06 AR ARP040101550A patent/AR044258A1/es not_active Application Discontinuation
- 2004-05-07 TW TW093112961A patent/TW200505413A/zh unknown
-
2005
- 2005-10-26 ZA ZA2005/08711A patent/ZA200508711B/en unknown
- 2005-11-01 CO CO05111045A patent/CO5700812A2/es not_active Application Discontinuation
- 2005-12-08 NO NO20055836A patent/NO20055836L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| KR100695861B1 (ko) | 2007-03-19 |
| AU2004236038A1 (en) | 2004-11-18 |
| TW200505413A (en) | 2005-02-16 |
| SG145571A1 (en) | 2008-09-29 |
| CO5700812A2 (es) | 2006-11-30 |
| MXPA05012036A (es) | 2006-02-03 |
| US20050250949A1 (en) | 2005-11-10 |
| WO2004099129A3 (en) | 2005-01-13 |
| SG145573A1 (en) | 2008-09-29 |
| NO20055836L (no) | 2006-02-06 |
| NZ543236A (en) | 2008-06-30 |
| US7173059B2 (en) | 2007-02-06 |
| JP2006525307A (ja) | 2006-11-09 |
| BRPI0410125A (pt) | 2006-05-09 |
| RU2005135043A (ru) | 2006-06-10 |
| WO2004099129A2 (en) | 2004-11-18 |
| RU2321580C2 (ru) | 2008-04-10 |
| EP1633704A2 (en) | 2006-03-15 |
| NO20055836D0 (no) | 2005-12-08 |
| KR20060009001A (ko) | 2006-01-27 |
| SG145574A1 (en) | 2008-09-29 |
| CN1819993A (zh) | 2006-08-16 |
| ZA200508711B (en) | 2006-12-27 |
| CA2524927A1 (en) | 2004-11-18 |
| CL2004000960A1 (es) | 2005-03-18 |
| SG145572A1 (en) | 2008-09-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |