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AR044070A1 - Derivados de 2 -acilamino -4- feniltiazol, su preparacion y su aplicacion en terapeutica - Google Patents

Derivados de 2 -acilamino -4- feniltiazol, su preparacion y su aplicacion en terapeutica

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Publication number
AR044070A1
AR044070A1 ARP040101382A ARP040101382A AR044070A1 AR 044070 A1 AR044070 A1 AR 044070A1 AR P040101382 A ARP040101382 A AR P040101382A AR P040101382 A ARP040101382 A AR P040101382A AR 044070 A1 AR044070 A1 AR 044070A1
Authority
AR
Argentina
Prior art keywords
alk
group
alkyl
conr4
formula
Prior art date
Application number
ARP040101382A
Other languages
English (en)
Inventor
Daniel Floutard
Pierre Fraisse
Samir Jegham
Bernard Labeeuw
Pierre Carayon
Pierre Casellas
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of AR044070A1 publication Critical patent/AR044070A1/es

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
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Abstract

Procedimiento de preparación intermediarios, composiciones farmacéuticas y usos del presente. Reivindicación 1: Compuestos que responden a la fórmula (1), en la cual: R1 representa un átomo de hidrógeno o de halógeno, un grupo alquilo (C1-4), trifluoroetilo, hidroxilo, alcoxi (C1-4), trifluorometoxi, trifluoroetoxi, cicloalquiloxi (C3-8), aliloxi, ciclopropilmetoxi, alquiltio (C1-4); R2 representa un átomo de hidrógeno o de halógeno, un grupo alquilo (C1-8), trifluoroetilo, perfluoroalquilo (C1-4), cicloalquilo (C3-10), fenilo, alcoxi (C1-8), trifluorometoxi, trifluoroetoxi, aliloxi, cicloalquilmetoxi (C3-8), cicloalquiloxi (C3-8), cicloalquilmetilo (C3-8); R3 representa un grupo elegido entre: a) -O-alk(C2-4)-A; -O- alk(C1-4)-B; -O-E; b) -alk(C1-4)-A; c) -B; d) -alk(C1-4)-NR4-alk(C2-3)-A; -alk(C1-4)-NR4-alk(C1-3)-B; e) -CONR4-alk(C2-4)-A; -CONR4-alk(C1-4)-B; -CONR4-E; f) -CO-D-alk(C1-2)-A; -CO-G-A; o un resto seleccionado del grupo de fórmulas (2); R4 representa un átomo de hidrógeno o un grupo alquilo (C1-4); A representa un grupo NR5R6; B representa un grupo de fórmula (3); D representa un grupo de fórmula (4); E representa un grupo de fórmula (5); G representa un grupo de fórmula (6); R5 y R6 representan cada uno, independientemente entre sí, un átomo de hidrógeno, un grupo alquilo (C1-6), alilo, alk (C2-4), -O-alquilo (C1-4), alk(2-4)-OH, alk(C1-3)-CON(R4)2, alk(C2-3)-NHCO-alquilo (C1-4), cicloalquilo (C3-7), cicloalquilmetilo (C3-7), - CO-alquilo (C1-4), pirrolidinilo eventualmente sustituido por un grupo -CO-alquilo (C1-4), bencilo, tetrahidropiranilo, tetrahidropiranilmetilo, dimetiltetrahidropiranilo, tetrahidrofurilo, tetrahidrofurilmetilo; o R5 y R6 junto con el átomo de nitrógeno al cual están unidos constituyen un radical heterocíclico elegido entre: aziridinilo, azetidinilo, pirrolidinilo, piperidinilo, perhidroazepinilo, morfolinilo, piperazinilo, tropanilo, quinuclidinilo, 2-azabiciclo[2,2,1]heptanilo, 2- azabiciclo[2,2,2]octanilo, dichos radicales heterocíclicos están no sustituidos o sustituidos por un grupo fenilo, halogenofenilo, trifluorometilfenilo, trifluorometilo, hidroxi, metoxi, hidroximetilo, metoximetilo, formamido, trifluoroacetilamino, un grupo -NR4R7, tetrahidropiran-4-ilamino, -CON(R4)2, -CONR4R'4, -CH2CON(R4)2, alquilo(C1-4)-CONR4-, cicloalquilo(C3-8)-CONR4-, alquilo(C1-4)-OCONR4-, cicloalquilo(C3-8)-OCONR4-, (alquilo(C1-4)-OCO-)2N-, alquilo(C1-4)-COO-; o sustituidos por uno o varios grupos metilo; R'4 representa un grupo (CH2)s unido al átomo de carbono portador de -CONR4R'4; R7 representa un átomo de hidrógeno, un alquilo (C1-4), un grupo -SO2CH3 o R4 y R7 junto con el átomo de nitrógeno al cual están unidos constituyen un radical pirrolidinilo o piperidinilo; p representa 1, 2, 3, 4 ó 5; q representa 0, 1 ó 2; r representa 1 ó 2; s representa 2 ó 3; p + q es inferior o igual a 5; p + r es inferior o igual a 5; alk representa un alquileno; a condición de que R1 y R2 no sean simultáneamente un átomo de hidrógeno, en estado de base o de sal de adición con un ácido, así como también en estado de hidrato o de solvato.
ARP040101382A 2003-04-25 2004-04-23 Derivados de 2 -acilamino -4- feniltiazol, su preparacion y su aplicacion en terapeutica AR044070A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0305213A FR2854158B1 (fr) 2003-04-25 2003-04-25 Derives de 2-acylamino-4-phenylethiazole, leur preparation et leur application en therapeutique

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AR044070A1 true AR044070A1 (es) 2005-08-24

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US (2) US7504511B2 (es)
EP (1) EP1656373B1 (es)
JP (2) JP4839208B2 (es)
KR (1) KR20060006935A (es)
CN (1) CN1826339A (es)
AR (1) AR044070A1 (es)
AT (1) ATE541843T1 (es)
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Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO2676B1 (en) * 2004-04-06 2012-06-17 جانسين فارماسوتيكا ان. في Derivatives of second-aza-spiro- (5,4) -dikan and their use as antihistamines
JO2527B1 (en) * 2004-04-06 2010-03-17 شركة جانسين فارماسوتيكا ان. في Derivatives of second-aza-Spiro- (5,5) -andecan and their use as antihistamines
FR2872813B1 (fr) 2004-07-09 2007-01-19 Sanofi Synthelabo Derives de 2-carbamide-4-phenylthiazole, leur preparation et leur application en therapeutique
GB0421908D0 (en) * 2004-10-01 2004-11-03 Angeletti P Ist Richerche Bio New uses
FR2876692B1 (fr) * 2004-10-19 2007-02-23 Sanofi Aventis Sa Derives de 2-amido-4-phenylthiazole, leur preparation et leur application en therapeutique
EP1833807A1 (en) * 2005-01-05 2007-09-19 Rigel Pharmaceuticals, Inc. Ubiquitin ligase inhibitors
ES2350647T3 (es) 2005-03-08 2011-01-25 Janssen Pharmaceutica Nv Derivados de diaza-espiro-[4.4]-nonano como antagonistas de neuroquininas (nk1).
UA92746C2 (en) * 2005-05-09 2010-12-10 Акилайон Фармасьютикалз, Инк. Thiazole compounds and methods of use
WO2007053498A1 (en) * 2005-11-01 2007-05-10 Millennium Pharmaceuticals, Inc. Compounds useful as antagonists of ccr2
WO2007053495A2 (en) * 2005-11-01 2007-05-10 Millennium Pharmaceuticals, Inc. Compounds useful as antagonists of ccr2
WO2007053499A2 (en) 2005-11-01 2007-05-10 Millennium Pharmaceuticals, Inc. Compounds useful as antagonists of ccr2
FR2895989B1 (fr) * 2006-01-06 2010-04-30 Sanofi Aventis Derives de 2-carbamide-4-phenylthiazole, leur preparation et leur application en therapeutique
EP2059515A2 (en) * 2006-04-12 2009-05-20 Pfizer Limited Pyrrolidine derivatives as modulators of chemokine ccr5 receptors
RU2303597C1 (ru) * 2006-05-12 2007-07-27 Иващенко Андрей Александрович Фармацевтическая композиция, способы ее получения и применения
CN101096363B (zh) * 2006-06-27 2011-05-11 中国人民解放军军事医学科学院毒物药物研究所 2,4,5-三取代噻唑类化合物、其制备方法、药物组合物及其制药用途
US20080076120A1 (en) * 2006-09-14 2008-03-27 Millennium Pharmaceuticals, Inc. Methods for the identification, evaluation and treatment of patients having CC-Chemokine receptor 2 (CCR-2) mediated disorders
EP2099454A4 (en) * 2006-11-17 2010-11-10 Abbott Lab AMINOPYRROLIDINES AS CHEMOKINE RECEPTOR ANTAGONISTS
PL2366703T3 (pl) * 2007-02-13 2015-02-27 Ab Science Postać polimorficzna pochodnej 2-amino-(nitroarylo)-tiazolu
WO2008124000A2 (en) * 2007-04-02 2008-10-16 Ligand Pharmaceuticals Incorporated Thiazole derivatives as androgen receptor modulator compounds
JP5603770B2 (ja) 2007-05-31 2014-10-08 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｃｒ２受容体拮抗薬およびその使用
SI2184279T1 (sl) * 2007-07-31 2015-04-30 Shionogi & Co., Ltd. Farmacevtski sestavek, ki vsebuje optično aktivno spojino z aktivnostjo agonista receptorja trombopoetina in njene vmesne spojine
EA020548B1 (ru) 2008-12-19 2014-12-30 Бёрингер Ингельхайм Интернациональ Гмбх Циклические пиримидин-4-карбоксамиды в качестве антагонистов рецептора ccr2, предназначенные для лечения воспаления, астмы и хозл
PE20121614A1 (es) 2009-12-17 2012-12-21 Boehringer Ingelheim Int Derivados de 6-amino,4-carbonil-pirimidina sustituida como antagonistas del receptor ccr2
CA2793311C (en) * 2010-03-17 2019-01-15 Taivex Therapeutics Inc. Modulators of hec1 activity and methods therefor
JP5646736B2 (ja) 2010-05-12 2014-12-24 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規ｃｃｒ２受容体アンタゴニスト、これらの製造方法、及び薬物としてのこれらの使用
EP2569298B1 (en) 2010-05-12 2015-11-25 Boehringer Ingelheim International GmbH Novel ccr2 receptor antagonists, method for producing the same, and use thereof as medicaments
WO2011144501A1 (en) * 2010-05-17 2011-11-24 Boehringer Ingelheim International Gmbh Ccr2 antagonists and uses thereof
WO2011147772A1 (en) 2010-05-25 2011-12-01 Boehringer Ingelheim International Gmbh Ccr2 receptor antagonists
EP2576538B1 (en) 2010-06-01 2015-10-28 Boehringer Ingelheim International GmbH New CCR2 antagonists
JP5786258B2 (ja) 2011-07-15 2015-09-30 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規かつ選択的なｃｃｒ２拮抗薬
CN103086859B (zh) * 2011-11-08 2015-11-11 清华大学 2,4-二羟基-5,6-取代-1-卤代苯衍生物、其合成方法及其应用
US11071736B2 (en) 2011-11-21 2021-07-27 Taivex Therapeutics Corporation Modulators of HEC1 activity and methods therefor
CA2990460C (en) 2015-07-02 2023-10-17 Centrexion Therapeutics Corporation (4-((3r,4r)-3-methoxytetrahydro-pyran-4-ylamino)piperidin-1-yl)(5-methyl-6-(((2r,6s)-6-(p-tolyl)tetrahydro-2h-pyran-2-yl)methylamino)pyrimidin-4-yl)methanone citrate
US11028061B2 (en) * 2015-07-27 2021-06-08 Sanford Burnham Prebys Medical Discovery Institute Modulators of myocyte lipid accumulation and insulin resistance and methods of use thereof
WO2019222393A1 (en) 2018-05-15 2019-11-21 The Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Neuroprotective compositions and methods of using the same
US20210380546A1 (en) * 2018-10-22 2021-12-09 The Regents Of The University Of California Vaccine adjuvant
CN112004798A (zh) * 2019-01-07 2020-11-27 江苏凯迪恩医药科技有限公司 一种苯甲酰胺类化合物、中间体、制备方法及应用
US12479816B2 (en) 2019-02-08 2025-11-25 University of Pittsburgh—of the Commonwealth System of Higher Education 20-HETE formation inhibitors

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD55034A (es) *
DE55034C (de) * H. KRÜGER in Berlin N., Artilleriestrafse 23 Zapfenverschlufs für chirurgische Instrumente
US3458526A (en) * 1966-09-26 1969-07-29 Upjohn Co Certain 2-amino-4,5-bis(p-methoxyphenyl)thiazoles
FR2296497A1 (fr) * 1974-12-31 1976-07-30 Asselin Robert Perfectionnement apporte aux fixations de verres optiques sur supports en vue de leur usinage
DE2706269C3 (de) * 1977-02-15 1979-08-02 Th. Goldschmidt Ag, 4300 Essen Verwendung von Aminderivaten zur Beeinflussung der Theologischen Eigenschaften von Bitumen und bituminösen Massen
FR2406634A1 (fr) * 1977-10-19 1979-05-18 Fabre Sa Pierre Immunostimulants derives d'amino thiazoles
JPH0717589B2 (ja) * 1990-01-22 1995-03-01 ファイザー製薬株式会社 新規１，３―ジカルボニル化合物およびその組成物
FR2677356B1 (fr) * 1991-06-05 1995-03-17 Sanofi Sa Derives heterocycliques d'acylamino-2 thiazoles-5 substitues, leur preparation et compositions pharmaceutiques en contenant.
EP0519449A1 (en) 1991-06-21 1992-12-23 Boehringer Mannheim Italia S.P.A. 2-Amino-4-aryl thiazoles with antiasthmatic and antiinflammatory activities on the respiratory tract
GB9816837D0 (en) * 1998-08-04 1998-09-30 Zeneca Ltd Amide derivatives
AU674207B2 (en) * 1993-04-07 1996-12-12 Otsuka Pharmaceutical Co., Ltd. N-acylated 4-amino piperidine derivatives
DE4326344A1 (de) * 1993-08-05 1995-02-09 Thomae Gmbh Dr K Carbonamide, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
AU2056800A (en) * 1998-12-18 2000-07-03 Du Pont Pharmaceuticals Company Heterocyclic piperidines as modulators of chemokine receptor activity
AU2001280187A1 (en) * 2000-08-28 2002-03-13 Toray Industries, Inc. Cyclic amine derivatives
JP4083422B2 (ja) * 2000-12-22 2008-04-30 石原産業株式会社 アニリン誘導体またはその塩ならびにそれらを含有するサイトカイン産生抑制剤
KR20030064852A (ko) * 2000-12-22 2003-08-02 이시하라 산교 가부시끼가이샤 아닐린 유도체 또는 그의 염 및 이들을 함유하는사이토카인 생산 억제제
GB0104050D0 (en) * 2001-02-19 2001-04-04 Astrazeneca Ab Chemical compounds
GB0108876D0 (en) * 2001-04-09 2001-05-30 Novartis Ag Organic Compounds
US20030055263A1 (en) * 2001-07-11 2003-03-20 Boehringer Ingelheim Pharma Kg Carboxylic acid derivatives, medicaments comprising these compounds, their use and processes for their production
US7265134B2 (en) 2001-08-17 2007-09-04 Merck & Co., Inc. Tyrosine kinase inhibitors
TW200403058A (en) 2002-04-19 2004-03-01 Bristol Myers Squibb Co Heterocyclo inhibitors of potassium channel function
JP2004256429A (ja) * 2003-02-26 2004-09-16 Sankyo Co Ltd イソキノリン誘導体
FR2872813B1 (fr) * 2004-07-09 2007-01-19 Sanofi Synthelabo Derives de 2-carbamide-4-phenylthiazole, leur preparation et leur application en therapeutique
FR2876692B1 (fr) * 2004-10-19 2007-02-23 Sanofi Aventis Sa Derives de 2-amido-4-phenylthiazole, leur preparation et leur application en therapeutique
FR2895989B1 (fr) 2006-01-06 2010-04-30 Sanofi Aventis Derives de 2-carbamide-4-phenylthiazole, leur preparation et leur application en therapeutique

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US7777041B2 (en) 2010-08-17
RU2005136663A (ru) 2006-03-20
US7504511B2 (en) 2009-03-17
ZA200508608B (en) 2007-01-31
CO5640106A2 (es) 2006-05-31
FR2854158B1 (fr) 2006-11-17
JP2011126891A (ja) 2011-06-30
TW200510325A (en) 2005-03-16
AU2004234101A1 (en) 2004-11-11
WO2004096798A3 (fr) 2006-01-26
OA13049A (fr) 2006-11-10
CN1826339A (zh) 2006-08-30
US20060135575A1 (en) 2006-06-22
JP2006524669A (ja) 2006-11-02
JP4839208B2 (ja) 2011-12-21
ECSP056111A (es) 2006-03-01
BRPI0409716A (pt) 2006-05-02
CA2521158A1 (fr) 2004-11-11
TNSN05254A1 (en) 2007-07-10
RS20050769A (sr) 2007-11-15
US20090156574A1 (en) 2009-06-18
EP1656373B1 (fr) 2012-01-18
FR2854158A1 (fr) 2004-10-29
CR8037A (es) 2008-07-29
EP1656373A2 (fr) 2006-05-17
NO20054905L (no) 2006-01-25
WO2004096798A2 (fr) 2004-11-11
MXPA05011522A (es) 2006-01-23
MA27769A1 (fr) 2006-02-01
NO20054905D0 (no) 2005-10-24
ATE541843T1 (de) 2012-02-15
RU2348630C2 (ru) 2009-03-10

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