AR033807A1 - Uso de (r)-(-)-2-[5-(4-fluorofenil)-3-piridilmetilaminometil]-cromano y de sus sales aceptables para uso fisiologico, y las composiciones farmaceuticas que contiene estos compuestos - Google Patents
Uso de (r)-(-)-2-[5-(4-fluorofenil)-3-piridilmetilaminometil]-cromano y de sus sales aceptables para uso fisiologico, y las composiciones farmaceuticas que contiene estos compuestosInfo
- Publication number
- AR033807A1 AR033807A1 ARP010101105A ARP010101105A AR033807A1 AR 033807 A1 AR033807 A1 AR 033807A1 AR P010101105 A ARP010101105 A AR P010101105A AR P010101105 A ARP010101105 A AR P010101105A AR 033807 A1 AR033807 A1 AR 033807A1
- Authority
- AR
- Argentina
- Prior art keywords
- fluorophenyl
- pyridylmethylaminomethyl
- chroman
- pharmaceutical compositions
- acceptable salts
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- -1 4-FLUOROPHENYL Chemical class 0.000 title 1
- 239000003814 drug Substances 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- HKFMQJUJWSFOLY-OAQYLSRUSA-N sarizotan Chemical compound C1=CC(F)=CC=C1C1=CN=CC(CNC[C@@H]2OC3=CC=CC=C3CC2)=C1 HKFMQJUJWSFOLY-OAQYLSRUSA-N 0.000 abstract 3
- 101150097070 Drd3 gene Proteins 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 102100022738 5-hydroxytryptamine receptor 1A Human genes 0.000 abstract 1
- 101710138638 5-hydroxytryptamine receptor 1A Proteins 0.000 abstract 1
- 229940123603 Dopamine D2 receptor antagonist Drugs 0.000 abstract 1
- QDLVYMYXOLGZOD-ZMBIFBSDSA-N [(2r)-3,4-dihydro-2h-chromen-2-yl]methyl-[[5-(4-fluorophenyl)pyridin-3-yl]methyl]azanium;chloride Chemical group Cl.C1=CC(F)=CC=C1C1=CN=CC(CNC[C@@H]2OC3=CC=CC=C3CC2)=C1 QDLVYMYXOLGZOD-ZMBIFBSDSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000002411 adverse Effects 0.000 abstract 1
- 230000009286 beneficial effect Effects 0.000 abstract 1
- 239000000442 dopamine 2 receptor blocking agent Substances 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000018 receptor agonist Substances 0.000 abstract 1
- 229940044601 receptor agonist Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A61P25/10—Antiepileptics; Anticonvulsants for petit-mal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Uso del (R)-(-)-2-[5-(4-fluorofenil)-3-piridilmetilaminometil]-cromano y de sus sales fisiológicamente aceptables para la fabricación de un medicamento destinado al tratamiento de las afecciones extrapiramidales en el movimiento y/o de los efectos adversos en las afecciones extrapiramidales en el movimiento. Una sal preferida es el clorhidrato de (R)-(-)-2-[5-(4-fluorofenil)-3-piridilmetilaminometil]-cromano. El compuesto mencionado es un antagonista combinado selectivo del receptor D2 de dopamina y un agonista del receptor 5-HT1A. Además presenta una alta afinidad por el receptor D3 de dopamina, por lo que la interacción del (R)-(-)-2-[5-(4-fluorofenil)-3-piridilmetilaminometil]-cromano con dicho receptor D3 de dopamina conduce a los efectos beneficiosos sobre el sistema extrapiramidal sin presentar el riesgo de los efectos colaterales de otras drogas conocidas. Composiciones farmacéuticas que en calidad de principios activos contienen i) (R)-(-)-2-[5-(4-fluorofenil)-3-piridilmetilaminometil]-cromano o una de sus sales aceptables para uso fisiológico, y ii) al menos una droga contra el Parkinson.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00104531 | 2000-03-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR033807A1 true AR033807A1 (es) | 2004-01-07 |
Family
ID=8168017
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP010101105A AR033807A1 (es) | 2000-03-10 | 2001-03-09 | Uso de (r)-(-)-2-[5-(4-fluorofenil)-3-piridilmetilaminometil]-cromano y de sus sales aceptables para uso fisiologico, y las composiciones farmaceuticas que contiene estos compuestos |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US7928128B2 (es) |
| EP (2) | EP1645273A3 (es) |
| JP (1) | JP4901046B2 (es) |
| KR (1) | KR100830139B1 (es) |
| CN (1) | CN1188123C (es) |
| AR (1) | AR033807A1 (es) |
| AT (1) | ATE307578T1 (es) |
| AU (2) | AU3022201A (es) |
| BR (1) | BR0109119A (es) |
| CA (1) | CA2402402C (es) |
| CO (1) | CO5271686A1 (es) |
| CZ (1) | CZ301807B6 (es) |
| DE (1) | DE60114419T2 (es) |
| DK (1) | DK1299099T3 (es) |
| ES (1) | ES2251460T3 (es) |
| HK (1) | HK1054198B (es) |
| HU (1) | HU229309B1 (es) |
| ME (1) | MEP5608A (es) |
| MX (1) | MXPA02008800A (es) |
| MY (1) | MY136976A (es) |
| NO (1) | NO329583B1 (es) |
| PL (1) | PL200781B1 (es) |
| RS (1) | RS51316B (es) |
| RU (1) | RU2278663C2 (es) |
| SI (1) | SI1299099T1 (es) |
| SK (1) | SK286933B6 (es) |
| UA (1) | UA73981C2 (es) |
| WO (1) | WO2001068063A2 (es) |
| ZA (1) | ZA200208133B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA73981C2 (en) | 2000-03-10 | 2005-10-17 | Merck Patent Gmbh | (r)-(-)-2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane for treatment of extrapyramidal movement disorders (variants), pharmaceutical composition and kit |
| CN1292749C (zh) * | 2001-07-26 | 2007-01-03 | 默克专利股份有限公司 | 2－[5－(4－氟苯基)－3－吡啶基甲氨基甲基]苯并二氢吡喃及其生理学上可接受的盐的新用途 |
| US7618988B2 (en) * | 2001-09-19 | 2009-11-17 | Merck Patentgesellschaft | Use of substituted aminomethyl chromans |
| AU2006261314B2 (en) * | 2005-06-21 | 2012-03-22 | Merck Patent Gmbh | Solid pharmaceutical preparation containing (R)-(-)-2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]chroman |
| US9066903B2 (en) | 2006-02-28 | 2015-06-30 | The United States Of America As Represented By The Department Of Veterans Affairs | Pharmacological treatment of Parkinson's disease |
| US9248111B2 (en) | 2011-03-01 | 2016-02-02 | Pharnext | Therapeutic approaches for treating parkinson's disease |
| US10010515B2 (en) | 2011-03-01 | 2018-07-03 | Pharnext | Therapeutic approaches for treating Parkinson's disease |
| CN108937972A (zh) * | 2018-06-08 | 2018-12-07 | 青岛大学附属医院 | 一种多特征融合的就诊用户情绪监控方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2364685C3 (de) | 1973-12-27 | 1978-06-15 | Beiersdorf Ag, 2000 Hamburg | Phenoxyäthylamine |
| US4438119A (en) * | 1982-12-23 | 1984-03-20 | Mead Johnson & Company | Method for alleviation of extrapyramidal motor disorders |
| CA1337429C (en) | 1983-12-05 | 1995-10-24 | Guy Rosalia Eugene Van Lommen | Derivatives of 2,2'-iminobisethanol |
| SE460947B (sv) * | 1986-08-26 | 1989-12-11 | Lejus Medical Ab | En multiple-unit-dos komposition av l-dopa |
| DE3901814A1 (de) | 1988-07-28 | 1990-02-01 | Bayer Ag | Substituierte aminomethylzetraline sowie ihre heterocyclischen analoga |
| ATE145208T1 (de) | 1990-07-06 | 1996-11-15 | Yoshitomi Pharmaceutical | Kondensierte thiophenverbindungen und deren verwendung |
| DE4135474A1 (de) | 1991-10-28 | 1993-04-29 | Bayer Ag | 2-aminomethyl-chromane |
| US5314888A (en) | 1992-02-21 | 1994-05-24 | Trustees Of Tufts College | Veterinary method for treating inappropriate elimination of urine in household pets |
| SI9300097B (en) | 1992-02-27 | 2001-12-31 | Janssen Pharmaceutica Nv | (benzodioxan, benzofuran or benzopyran) alkylamino) alkyl substituted guanidines |
| EP0630238A4 (en) | 1992-03-11 | 1995-05-24 | Interneuron Pharma | REDUCTION OF FLUCTUATIONS AFTER MEALS OF PLASMIC CONCENTRATIONS OF LARGE NEUTRAL ACIDS. |
| DE4226527A1 (de) | 1992-08-11 | 1994-02-17 | Merck Patent Gmbh | 1,4-Benzodioxanderivate |
| JPH08503448A (ja) * | 1992-12-07 | 1996-04-16 | メレルダウファーマス−ティカルズ インコーポレイテッド | ５ｈｔ▲下１▼▲ａ▼受容体アゴニストによる不随意運動の処置 |
| GB9302622D0 (en) | 1993-02-10 | 1993-03-24 | Wellcome Found | Heteroaromatic compounds |
| CA2177046A1 (en) * | 1993-11-19 | 1995-05-26 | Mark Froimowitz | Octahydrobenzo[f]quinoline-based receptor agonists and antagonists |
| ATE183184T1 (de) * | 1994-01-31 | 1999-08-15 | Pfizer | Neuroprotektive chroman verbindungen |
| ZA954688B (en) | 1994-06-08 | 1996-01-29 | Lundbeck & Co As H | Serotonin 5-HT1A and dopamin D2 receptor ligands |
| FR2723091B1 (fr) * | 1994-07-29 | 1996-11-08 | Esteve Labor Dr | Tetrahydropyridine-(6,4-hydroxypiperidine) alkylazoles |
| SI0707007T1 (en) * | 1994-10-14 | 2002-04-30 | Merck Patent Gmbh | (R)-(-)-2-(5-(4-fluorophenyl)-3-pyridylmethylaminomethyl)chromane as CNS active agent |
| US5502080A (en) * | 1994-11-01 | 1996-03-26 | Hitzig; Pietr | Combined use of dopamine and serotonin agonists in the treatment of allergic disorders |
| US5554383A (en) | 1995-04-06 | 1996-09-10 | Trustees Of Tufts College | Veterinary method for clinically modifying the behavior of dogs exhibiting canine affective aggression |
| US5541199A (en) * | 1995-06-02 | 1996-07-30 | American Home Products Corporation | Chroman-2-ylmethylamino derivatives |
| GB9514380D0 (en) | 1995-07-13 | 1995-09-13 | Knoll Ag | Therapeutic agents |
| EP0839144B1 (en) | 1995-07-13 | 2001-09-19 | Knoll GmbH | Piperazine derivatives as therapeutic agents |
| US5670667A (en) | 1995-07-25 | 1997-09-23 | American Home Products Corporation | Chroman-2-ylmethylamino derivatives |
| US5756521A (en) | 1996-04-03 | 1998-05-26 | American Home Products Corporation | Chroman-2-ylmethylamino derivatives |
| DE19648384A1 (de) * | 1996-11-22 | 1998-05-28 | Merck Patent Gmbh | Fluorene, Dibenzofurane und Dibenzothiophene |
| ATE253058T1 (de) | 1997-09-02 | 2003-11-15 | Duphar Int Res | Piperidin- und piperazin derivate als 5-ht1- rezeptor-agonisten |
| EP0900792B1 (en) | 1997-09-02 | 2003-10-29 | Duphar International Research B.V | Piperazine and piperidine derivatives as 5-HT1A and dopamine D2-receptor (ant)agonists |
| DE19751949A1 (de) | 1997-11-24 | 1999-05-27 | Bayer Ag | Verwendung von substituierten Aminomethyl-Chromanen zur Verhinderung der neuronalen Degeneration und zur Förderung der neuronalen Regeneration |
| WO1999045906A1 (en) | 1998-03-09 | 1999-09-16 | Trustees Of Tufts College | Treatment of compulsive behaviours in man and animals |
| JP3665567B2 (ja) * | 1998-03-17 | 2005-06-29 | ファイザー・プロダクツ・インク | ビシクロ［２．２．１］ヘプタンおよび関連化合物 |
| FR2781671A1 (fr) * | 1998-07-28 | 2000-02-04 | Synthelabo | Compositions pharmaceutiques contenant un inhibiteur de la recapture de la serotonine et leur application en therapeutique |
| UA71590C2 (en) | 1998-11-13 | 2004-12-15 | Duphar Int Res | Piperazine and piperidine derivatives |
| UA73981C2 (en) | 2000-03-10 | 2005-10-17 | Merck Patent Gmbh | (r)-(-)-2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane for treatment of extrapyramidal movement disorders (variants), pharmaceutical composition and kit |
-
2001
- 2001-01-02 UA UA2002108054A patent/UA73981C2/uk unknown
- 2001-02-01 PL PL356428A patent/PL200781B1/pl not_active IP Right Cessation
- 2001-02-01 DK DK01902375T patent/DK1299099T3/da active
- 2001-02-01 HU HU0300079A patent/HU229309B1/hu not_active IP Right Cessation
- 2001-02-01 HK HK03106499.0A patent/HK1054198B/zh not_active IP Right Cessation
- 2001-02-01 EP EP05022178A patent/EP1645273A3/en not_active Withdrawn
- 2001-02-01 AU AU3022201A patent/AU3022201A/xx active Pending
- 2001-02-01 US US10/221,031 patent/US7928128B2/en not_active Expired - Fee Related
- 2001-02-01 KR KR1020027011793A patent/KR100830139B1/ko not_active Expired - Fee Related
- 2001-02-01 WO PCT/EP2001/001038 patent/WO2001068063A2/en not_active Ceased
- 2001-02-01 BR BR0109119-0A patent/BR0109119A/pt not_active Application Discontinuation
- 2001-02-01 SK SK1264-2002A patent/SK286933B6/sk not_active IP Right Cessation
- 2001-02-01 AT AT01902375T patent/ATE307578T1/de active
- 2001-02-01 AU AU2001230222A patent/AU2001230222C1/en not_active Ceased
- 2001-02-01 CN CNB018062725A patent/CN1188123C/zh not_active Expired - Fee Related
- 2001-02-01 EP EP01902375A patent/EP1299099B1/en not_active Expired - Lifetime
- 2001-02-01 JP JP2001566627A patent/JP4901046B2/ja not_active Expired - Fee Related
- 2001-02-01 ES ES01902375T patent/ES2251460T3/es not_active Expired - Lifetime
- 2001-02-01 RU RU2002127006/15A patent/RU2278663C2/ru not_active IP Right Cessation
- 2001-02-01 DE DE60114419T patent/DE60114419T2/de not_active Expired - Lifetime
- 2001-02-01 MX MXPA02008800A patent/MXPA02008800A/es active IP Right Grant
- 2001-02-01 CA CA2402402A patent/CA2402402C/en not_active Expired - Fee Related
- 2001-02-01 ME MEP-56/08A patent/MEP5608A/xx unknown
- 2001-02-01 RS YUP-674/02A patent/RS51316B/sr unknown
- 2001-02-01 CZ CZ20022951A patent/CZ301807B6/cs not_active IP Right Cessation
- 2001-02-01 SI SI200130475T patent/SI1299099T1/sl unknown
- 2001-03-07 MY MYPI20011030A patent/MY136976A/en unknown
- 2001-03-09 AR ARP010101105A patent/AR033807A1/es unknown
- 2001-03-12 CO CO01019802A patent/CO5271686A1/es not_active Application Discontinuation
-
2002
- 2002-09-09 NO NO20024291A patent/NO329583B1/no not_active IP Right Cessation
- 2002-10-09 ZA ZA200208133A patent/ZA200208133B/en unknown
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