AR033685A1 - DERIVATIVES OF THE TETRAMIC ACID, CONIOSETIN AND DERIVATIVES OF THE SAME, PROCEDURE FOR THE PREPARATION, DRUGS, PROCEDURE FOR THE PREPARATION OF DRUGS, EMPLOYMENT OF SUCH DERIVATIVES FOR THE PREPARATION OF MEDICINES - Google Patents
DERIVATIVES OF THE TETRAMIC ACID, CONIOSETIN AND DERIVATIVES OF THE SAME, PROCEDURE FOR THE PREPARATION, DRUGS, PROCEDURE FOR THE PREPARATION OF DRUGS, EMPLOYMENT OF SUCH DERIVATIVES FOR THE PREPARATION OF MEDICINESInfo
- Publication number
- AR033685A1 AR033685A1 ARP010105666A ARP010105666A AR033685A1 AR 033685 A1 AR033685 A1 AR 033685A1 AR P010105666 A ARP010105666 A AR P010105666A AR P010105666 A ARP010105666 A AR P010105666A AR 033685 A1 AR033685 A1 AR 033685A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkenyl
- alkyl
- preparation
- straight
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pyrrole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Derivados del ácido tetrámico que comprenden un compuesto de la fórmula general 1 en la cual significan: R1, R2 y R3 independientemente entre sí: 1) halógeno, o 2 alquilo-C1-6, alquenilo-C2-6 o alquinilo-C2-6, donde el alquilo, el alquenilo y el alquinilo son de cadena recta o ramificados y están eventualmente sustituidos una o dos veces por 2.1) -OH 2.2) =O, 2.3 -O-alquilo-C1-6, donde el alquilo es de cadena recta o ramificado, 2.4) -O-alquenilo-C2-6, donde el alquenilo es de cadena recta o ramificado, 2.5 -arilo, 2.6) -NH-alquilo-C1-6, donde el alquilo es de cadena recta o ramificado, 2.7) -NH-alquenilo-C2-6, don de alquenilo es de cadena recta o ramificado, 2.8) -NH2 o 2.9) halógeno, en donde los sustituyentes 2.1 a 2.9 pueden estar adicionalmente sustituidos por funciones -CN, -amida u -oxima, R4 alquilo-C1-6 en el cual el alquilo puede ser de cadena recta o ramificado y está eventualmente sustituido una o dos veces como se describe en 2.1 a 2.9, o alquenilo-C2-6, donde el alquenilo puede ser de cadena recta o ramificado, R5 H o metilo, y, X, X2, X3 y X4, independientemente entre sí O, NH, H-alquilo-C1-6, N-alquenilo-C2-6, N-alquinilo-C2-6, en las cuales el alquilo, el alquenilo o el alquinilo son de cadena recta o ramificados, N-acilo, N-arilo, N-O-R o S; y/o una forma estereoisomérica del compuesto de la fórmula 1 y/o mezclas de esta forma en toda proporción, y/o una sal fisiológicamente compatible del compuesto de la fórmula 1; que son formados por el microorganismo Coniochaeta ellipsoidea Udagawa (DSM 13856) en el curso de fermentación, a derivados químicos de la coniosetina, a un procedimiento para su preparación, medicamentos, procedimiento para la preparación de medicamentos y el empleo de los mismos para la preparación de medicamentos para el tratamiento de enfermedades infecciosas bacterianas, y de micosis.Tetramic acid derivatives comprising a compound of the general formula 1 in which they mean: R1, R2 and R3 independently of each other: 1) halogen, or 2-C1-6 alkyl, C2-6 alkenyl or C2-6 alkynyl , where the alkyl, alkenyl and alkynyl are straight or branched chain and are eventually substituted once or twice by 2.1) -OH 2.2) = O, 2.3 -O-C1-6 alkyl, where the alkyl is chain straight or branched, 2.4) -O-C2-6 alkenyl, where the alkenyl is straight or branched chain, 2.5-aryl, 2.6) -NH-C1-6 alkyl, where the alkyl is straight or branched chain, 2.7) -NH-C2-6 alkenyl, where alkenyl is straight or branched chain, 2.8) -NH2 or 2.9) halogen, where substituents 2.1 to 2.9 may be additionally substituted by -CN, -amide or - oxime, R4-C1-6 alkyl in which the alkyl can be straight or branched chain and is optionally substituted once or twice as described in 2.1 to 2.9, or C2-6 alkenyl, where the alkenyl can be straight or branched chain, R5 H or methyl, and, X, X2, X3 and X4, independently of each other O, NH, H-C1-6 alkyl, N-C2-6 alkenyl, N-alkynyl -C2-6, in which the alkyl, alkenyl or alkynyl are straight or branched chain, N-acyl, N-aryl, NOR or S; and / or a stereoisomeric form of the compound of the formula 1 and / or mixtures of this form in every proportion, and / or a physiologically compatible salt of the compound of the formula 1; which are formed by the microorganism Coniochaeta ellipsoidea Udagawa (DSM 13856) in the course of fermentation, to chemical derivatives of coniosetine, to a procedure for its preparation, medicines, procedure for the preparation of medicines and the use thereof for the preparation of medicines for the treatment of bacterial infectious diseases, and of mycosis.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10060810A DE10060810A1 (en) | 2000-12-07 | 2000-12-07 | Coniosetin and derivatives thereof, processes for making and using the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR033685A1 true AR033685A1 (en) | 2004-01-07 |
Family
ID=7666132
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP010105666A AR033685A1 (en) | 2000-12-07 | 2001-12-05 | DERIVATIVES OF THE TETRAMIC ACID, CONIOSETIN AND DERIVATIVES OF THE SAME, PROCEDURE FOR THE PREPARATION, DRUGS, PROCEDURE FOR THE PREPARATION OF DRUGS, EMPLOYMENT OF SUCH DERIVATIVES FOR THE PREPARATION OF MEDICINES |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6599930B2 (en) |
| EP (1) | EP1341758B1 (en) |
| JP (1) | JP4057910B2 (en) |
| AR (1) | AR033685A1 (en) |
| AT (1) | ATE331706T1 (en) |
| AU (2) | AU2796602A (en) |
| CA (1) | CA2430827C (en) |
| CY (1) | CY1105292T1 (en) |
| DE (2) | DE10060810A1 (en) |
| DK (1) | DK1341758T3 (en) |
| ES (1) | ES2266298T3 (en) |
| IL (2) | IL156162A0 (en) |
| MX (1) | MXPA03004849A (en) |
| PT (1) | PT1341758E (en) |
| WO (1) | WO2002046152A2 (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10146737A1 (en) | 2001-09-22 | 2003-04-10 | Aventis Pharma Gmbh | Coniosulfides and their derivatives, process for their preparation and use as medicines |
| US6962943B2 (en) | 2001-11-21 | 2005-11-08 | Aventis Pharma Deutschland Gmbh | Gabusectin derivatives, processes for preparing them and their use |
| DE10156906A1 (en) * | 2001-11-21 | 2003-05-28 | Aventis Pharma Gmbh | New 3-(octahydronaphth-1-yl-methylene)-pyrrolidine derivatives, prepared by culturing a microorganism, shows strong antibacterial activity |
| US7541344B2 (en) * | 2003-06-03 | 2009-06-02 | Eli Lilly And Company | Modulation of survivin expression |
| US8552208B2 (en) * | 2007-09-11 | 2013-10-08 | University of Tennesseee Research Foundation | Analogs of tetramic acid |
| CN113755347B (en) * | 2021-10-20 | 2023-07-28 | 王晓艳 | Endophytic fungus AM1 for promoting nitrogen absorption of camellia oleifera |
| CN118813419B (en) * | 2024-07-11 | 2025-07-11 | 哈尔滨师范大学 | Cannabis endophytic fungus HSDM capable of simultaneously producing 3 flavone components and application thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3959468A (en) * | 1974-05-06 | 1976-05-25 | The United States Of America As Represented By The Secretary Of Agriculture | Antibiotic equisetin and method of production |
| GB2306476A (en) * | 1995-10-27 | 1997-05-07 | Merck & Co Inc | Hiv integrase inhibitors |
| US5759842A (en) * | 1996-10-24 | 1998-06-02 | Merck & Co., Inc. | In vitro HIV integrase inhibitors |
| WO2000028064A1 (en) | 1998-11-09 | 2000-05-18 | Aventis Pharma Deutschland Gmbh | Vancoresmycin, a process for its production and its use as a pharmaceutical |
-
2000
- 2000-12-07 DE DE10060810A patent/DE10060810A1/en not_active Withdrawn
-
2001
- 2001-11-30 AT AT01989546T patent/ATE331706T1/en active
- 2001-11-30 AU AU2796602A patent/AU2796602A/en active Pending
- 2001-11-30 DK DK01989546T patent/DK1341758T3/en active
- 2001-11-30 MX MXPA03004849A patent/MXPA03004849A/en active IP Right Grant
- 2001-11-30 DE DE50110363T patent/DE50110363D1/en not_active Expired - Lifetime
- 2001-11-30 WO PCT/EP2001/014013 patent/WO2002046152A2/en not_active Ceased
- 2001-11-30 IL IL15616201A patent/IL156162A0/en active IP Right Grant
- 2001-11-30 CA CA2430827A patent/CA2430827C/en not_active Expired - Fee Related
- 2001-11-30 EP EP01989546A patent/EP1341758B1/en not_active Expired - Lifetime
- 2001-11-30 AU AU2002227966A patent/AU2002227966B2/en not_active Ceased
- 2001-11-30 ES ES01989546T patent/ES2266298T3/en not_active Expired - Lifetime
- 2001-11-30 JP JP2002547891A patent/JP4057910B2/en not_active Expired - Fee Related
- 2001-11-30 PT PT01989546T patent/PT1341758E/en unknown
- 2001-12-05 AR ARP010105666A patent/AR033685A1/en not_active Application Discontinuation
- 2001-12-06 US US10/003,413 patent/US6599930B2/en not_active Expired - Lifetime
-
2003
- 2003-05-27 IL IL156162A patent/IL156162A/en not_active IP Right Cessation
-
2006
- 2006-09-07 CY CY20061101279T patent/CY1105292T1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL156162A (en) | 2008-08-07 |
| EP1341758B1 (en) | 2006-06-28 |
| ES2266298T3 (en) | 2007-03-01 |
| ATE331706T1 (en) | 2006-07-15 |
| DE50110363D1 (en) | 2006-08-10 |
| WO2002046152A3 (en) | 2002-11-21 |
| CA2430827A1 (en) | 2002-06-13 |
| CA2430827C (en) | 2010-02-09 |
| AU2796602A (en) | 2002-06-18 |
| WO2002046152A2 (en) | 2002-06-13 |
| US6599930B2 (en) | 2003-07-29 |
| IL156162A0 (en) | 2003-12-23 |
| AU2002227966B2 (en) | 2006-08-03 |
| DK1341758T3 (en) | 2006-10-30 |
| PT1341758E (en) | 2006-09-29 |
| EP1341758A2 (en) | 2003-09-10 |
| CY1105292T1 (en) | 2010-03-03 |
| JP2004515490A (en) | 2004-05-27 |
| US20020137788A1 (en) | 2002-09-26 |
| DE10060810A1 (en) | 2002-06-20 |
| MXPA03004849A (en) | 2003-08-19 |
| JP4057910B2 (en) | 2008-03-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed, e.g., due to non-payment of fee |