AR031121A1 - Proceso para preparar 2-(piridin-4-ilamino)-pirido[2,3-d]pirimidin-7-ona - Google Patents
Proceso para preparar 2-(piridin-4-ilamino)-pirido[2,3-d]pirimidin-7-onaInfo
- Publication number
- AR031121A1 AR031121A1 ARP010103715A ARP010103715A AR031121A1 AR 031121 A1 AR031121 A1 AR 031121A1 AR P010103715 A ARP010103715 A AR P010103715A AR P010103715 A ARP010103715 A AR P010103715A AR 031121 A1 AR031121 A1 AR 031121A1
- Authority
- AR
- Argentina
- Prior art keywords
- phenyl
- alkyl
- heteroaromatic
- cycloalkyl
- formula
- Prior art date
Links
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 9
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 3
- 125000001072 heteroaryl group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 3
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 2
- 238000003786 synthesis reaction Methods 0.000 abstract 2
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 229910000102 alkali metal hydride Inorganic materials 0.000 abstract 1
- 150000008046 alkali metal hydrides Chemical class 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Chemical group 0.000 abstract 1
- 159000000018 pyrido[2,3-d]pyrimidines Chemical class 0.000 abstract 1
- OYRRZWATULMEPF-UHFFFAOYSA-N pyrimidin-4-amine Chemical compound NC1=CC=NC=N1 OYRRZWATULMEPF-UHFFFAOYSA-N 0.000 abstract 1
- 229910052717 sulfur Chemical group 0.000 abstract 1
- 239000011593 sulfur Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
Proceso de síntesis para preparar pirido[2,3-d]pirimidinas con un grupo piridilamino en posicion 2, de formula (2), que comprende reaccionar 4-aminopirimidina de formula (3) con hidruro o amida de metal alcalino y 2-alquilsulfanil-pirido[2,3-d]pirimidina de formula (1), en donde R' y R'' son hidrogeno, alquilo C1-6, halogeno, o fenilo; R2 es hidrogeno(CH2)nPh, donde Ph es fenilo o fenilo sustituido, y n es 0, 1, 2, o 3; heteroaromático, cicloalquilo, alquilo C1-6 y alquenilo C2-6, donde los grupos alquilo y alquenilo pueden ser sustituidos por NR5R6, fenilo, fenilo sustituido, alcoxi, halogeno, cicloalquilo, y donde R5 y R6 son independientemente hidrogeno, alquilo C1-6, alquenilo C2-6, (CH2)nPh, donde Ph es fenilo o fenilo sustituido, y n es 0, 1, 2, o 3; cicloalquilo, heteroaromático y R5 y R6 junto con el nitrogeno al que están unidos pueden completar un anillo de 3 a 7 átomos de carbono y de manera opcional con 1, 2, o 3 heteroátomos seleccionados del nitrogeno, oxígeno, y azufre; y Ar es fenilo, fenilo sustituido, o heteroaromático. Son comercialmente viables como agentes anticáncer, cuya síntesis exige alta pureza y rendimiento.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22286600P | 2000-08-04 | 2000-08-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR031121A1 true AR031121A1 (es) | 2003-09-10 |
Family
ID=22834051
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP010103715A AR031121A1 (es) | 2000-08-04 | 2001-08-03 | Proceso para preparar 2-(piridin-4-ilamino)-pirido[2,3-d]pirimidin-7-ona |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US6900316B2 (es) |
| EP (1) | EP1417207B1 (es) |
| JP (1) | JP2005507392A (es) |
| AP (1) | AP1334A (es) |
| AR (1) | AR031121A1 (es) |
| AT (1) | ATE303385T1 (es) |
| AU (1) | AU2001298008A1 (es) |
| BR (1) | BR0113037A (es) |
| CA (1) | CA2424057A1 (es) |
| DE (1) | DE60113161T2 (es) |
| DK (1) | DK1417207T3 (es) |
| DO (1) | DOP2001000226A (es) |
| ES (1) | ES2248233T3 (es) |
| GT (1) | GT200100157A (es) |
| HN (1) | HN2001000172A (es) |
| MX (1) | MXPA03000865A (es) |
| PA (1) | PA8524001A1 (es) |
| PE (1) | PE20020260A1 (es) |
| PT (1) | PT1417207E (es) |
| SV (1) | SV2002000573A (es) |
| TN (1) | TNSN01117A1 (es) |
| UY (1) | UY26866A1 (es) |
| WO (1) | WO2003027110A2 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2417942C (en) * | 2000-08-04 | 2010-06-29 | Warner-Lambert Company | 2-(4-pyridyl)amino-6-dialkoxyphenyl-pyrido[2,3-d]pyrimidin-7-ones |
| CA2417937A1 (en) * | 2000-08-04 | 2002-02-14 | Warner-Lambert Company | Process for preparing 2-(4-pyridyl)amino-6-dialkyloxyphenyl-pyrido[2,3-d]pyrimidin-7-ones |
| US6518276B2 (en) * | 2000-08-31 | 2003-02-11 | Syntex (U.S.A.) Llc | 7-oxo-pyridopyrimidines (II) |
| PA8577501A1 (es) * | 2002-07-25 | 2004-02-07 | Warner Lambert Co | Inhibidores de quinasas |
| BRPI0507852A (pt) * | 2004-02-18 | 2007-07-10 | Warner Lambert Co | 2-(piridin-3-ilamino)-pirido[2,3-d]pirimidin-7-onas |
| DE102004054215A1 (de) * | 2004-11-10 | 2006-05-11 | Merck Patent Gmbh | Pyridopyrimidinonderivate |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL117923A (en) | 1995-05-03 | 2000-06-01 | Warner Lambert Co | Anti-cancer pharmaceutical compositions containing polysubstituted pyrido¬2,3-d¾pyrimidine derivatives and certain such novel compounds |
| US5620981A (en) * | 1995-05-03 | 1997-04-15 | Warner-Lambert Company | Pyrido [2,3-D]pyrimidines for inhibiting protein tyrosine kinase mediated cellular proliferation |
| US5945422A (en) | 1997-02-05 | 1999-08-31 | Warner-Lambert Company | N-oxides of amino containing pyrido 2,3-D! pyrimidines |
| IL150059A0 (en) | 1999-12-17 | 2002-12-01 | Ariad Pharma Inc | Novel heterocycles |
| CA2417942C (en) * | 2000-08-04 | 2010-06-29 | Warner-Lambert Company | 2-(4-pyridyl)amino-6-dialkoxyphenyl-pyrido[2,3-d]pyrimidin-7-ones |
| CA2417937A1 (en) * | 2000-08-04 | 2002-02-14 | Warner-Lambert Company | Process for preparing 2-(4-pyridyl)amino-6-dialkyloxyphenyl-pyrido[2,3-d]pyrimidin-7-ones |
| GEP20063909B (en) * | 2002-01-22 | 2006-08-25 | Warner Lambert Co | 2-(PYRIDIN-2-YLAMINO)-PYRIDO[2,3d] PYRIMIDIN-7-ONES |
-
2001
- 2001-07-12 DE DE60113161T patent/DE60113161T2/de not_active Expired - Fee Related
- 2001-07-12 CA CA002424057A patent/CA2424057A1/en not_active Abandoned
- 2001-07-12 BR BR0113037-4A patent/BR0113037A/pt not_active IP Right Cessation
- 2001-07-12 US US10/343,803 patent/US6900316B2/en not_active Expired - Fee Related
- 2001-07-12 AT AT01274395T patent/ATE303385T1/de not_active IP Right Cessation
- 2001-07-12 EP EP01274395A patent/EP1417207B1/en not_active Expired - Lifetime
- 2001-07-12 ES ES01274395T patent/ES2248233T3/es not_active Expired - Lifetime
- 2001-07-12 AU AU2001298008A patent/AU2001298008A1/en not_active Abandoned
- 2001-07-12 WO PCT/US2001/051422 patent/WO2003027110A2/en not_active Ceased
- 2001-07-12 PT PT01274395T patent/PT1417207E/pt unknown
- 2001-07-12 DK DK01274395T patent/DK1417207T3/da active
- 2001-07-12 MX MXPA03000865A patent/MXPA03000865A/es active IP Right Grant
- 2001-07-12 JP JP2003530698A patent/JP2005507392A/ja active Pending
- 2001-07-20 AP APAP/P/2001/002231A patent/AP1334A/en active
- 2001-07-27 SV SV2001000573A patent/SV2002000573A/es not_active Application Discontinuation
- 2001-08-01 TN TNTNSN01117A patent/TNSN01117A1/en unknown
- 2001-08-03 PE PE2001000775A patent/PE20020260A1/es not_active Application Discontinuation
- 2001-08-03 GT GT200100157A patent/GT200100157A/es unknown
- 2001-08-03 HN HN2001000172A patent/HN2001000172A/es unknown
- 2001-08-03 AR ARP010103715A patent/AR031121A1/es not_active Application Discontinuation
- 2001-08-03 DO DO2001000226A patent/DOP2001000226A/es unknown
- 2001-08-03 UY UY26866A patent/UY26866A1/es not_active Application Discontinuation
- 2001-08-03 PA PA20018524001A patent/PA8524001A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE60113161T2 (de) | 2006-06-14 |
| PE20020260A1 (es) | 2002-04-19 |
| SV2002000573A (es) | 2002-01-16 |
| MXPA03000865A (es) | 2003-06-18 |
| EP1417207B1 (en) | 2005-08-31 |
| ES2248233T3 (es) | 2006-03-16 |
| US6900316B2 (en) | 2005-05-31 |
| CA2424057A1 (en) | 2003-04-03 |
| JP2005507392A (ja) | 2005-03-17 |
| AP1334A (en) | 2004-11-29 |
| DK1417207T3 (da) | 2005-12-27 |
| HN2001000172A (es) | 2005-03-04 |
| PT1417207E (pt) | 2005-11-30 |
| AP2001002231A0 (en) | 2001-09-30 |
| DE60113161D1 (de) | 2005-10-06 |
| WO2003027110A3 (en) | 2004-02-26 |
| ATE303385T1 (de) | 2005-09-15 |
| WO2003027110A2 (en) | 2003-04-03 |
| AU2001298008A1 (en) | 2003-04-07 |
| BR0113037A (pt) | 2004-01-20 |
| EP1417207A2 (en) | 2004-05-12 |
| UY26866A1 (es) | 2001-09-28 |
| PA8524001A1 (es) | 2002-07-30 |
| US20030176700A1 (en) | 2003-09-18 |
| DOP2001000226A (es) | 2002-06-15 |
| TNSN01117A1 (en) | 2005-11-10 |
| GT200100157A (es) | 2002-07-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |