AR030715A1 - FLAVORING SYSTEMS FOR PHARMACEUTICAL COMPOSITIONS AND METHODS TO MAKE SUCH COMPOSITIONS - Google Patents
FLAVORING SYSTEMS FOR PHARMACEUTICAL COMPOSITIONS AND METHODS TO MAKE SUCH COMPOSITIONSInfo
- Publication number
- AR030715A1 AR030715A1 ARP010104207A ARP010104207A AR030715A1 AR 030715 A1 AR030715 A1 AR 030715A1 AR P010104207 A ARP010104207 A AR P010104207A AR P010104207 A ARP010104207 A AR P010104207A AR 030715 A1 AR030715 A1 AR 030715A1
- Authority
- AR
- Argentina
- Prior art keywords
- flavored
- mixtures
- pharmaceutical compositions
- flavoring
- flavoring systems
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 5
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 5
- 239000004615 ingredient Substances 0.000 abstract 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 abstract 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 abstract 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 2
- 235000003599 food sweetener Nutrition 0.000 abstract 2
- 239000007788 liquid Substances 0.000 abstract 2
- 239000003765 sweetening agent Substances 0.000 abstract 2
- WBZFUFAFFUEMEI-UHFFFAOYSA-M Acesulfame k Chemical compound [K+].CC1=CC(=O)[N-]S(=O)(=O)O1 WBZFUFAFFUEMEI-UHFFFAOYSA-M 0.000 abstract 1
- KJHKTHWMRKYKJE-SUGCFTRWSA-N Kaletra Chemical compound N1([C@@H](C(C)C)C(=O)N[C@H](C[C@H](O)[C@H](CC=2C=CC=CC=2)NC(=O)COC=2C(=CC=CC=2C)C)CC=2C=CC=CC=2)CCCNC1=O KJHKTHWMRKYKJE-SUGCFTRWSA-N 0.000 abstract 1
- ILRKKHJEINIICQ-OOFFSTKBSA-N Monoammonium glycyrrhizinate Chemical compound N.O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O ILRKKHJEINIICQ-OOFFSTKBSA-N 0.000 abstract 1
- NCDNCNXCDXHOMX-UHFFFAOYSA-N Ritonavir Natural products C=1C=CC=CC=1CC(NC(=O)OCC=1SC=NC=1)C(O)CC(CC=1C=CC=CC=1)NC(=O)C(C(C)C)NC(=O)N(C)CC1=CSC(C(C)C)=N1 NCDNCNXCDXHOMX-UHFFFAOYSA-N 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 239000000796 flavoring agent Substances 0.000 abstract 1
- 235000019634 flavors Nutrition 0.000 abstract 1
- 235000011187 glycerol Nutrition 0.000 abstract 1
- 235000019534 high fructose corn syrup Nutrition 0.000 abstract 1
- 229960004525 lopinavir Drugs 0.000 abstract 1
- 239000003607 modifier Substances 0.000 abstract 1
- NCDNCNXCDXHOMX-XGKFQTDJSA-N ritonavir Chemical compound N([C@@H](C(C)C)C(=O)N[C@H](C[C@H](O)[C@H](CC=1C=CC=CC=1)NC(=O)OCC=1SC=NC=1)CC=1C=CC=CC=1)C(=O)N(C)CC1=CSC(C(C)C)=N1 NCDNCNXCDXHOMX-XGKFQTDJSA-N 0.000 abstract 1
- 229960000311 ritonavir Drugs 0.000 abstract 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 abstract 1
- 239000011780 sodium chloride Substances 0.000 abstract 1
- 239000001509 sodium citrate Substances 0.000 abstract 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Fats And Perfumes (AREA)
Abstract
Sistemas saborizantes para una composicion farmacéutica líquida y composiciones farmacéuticas que contienen dichos sistemas saborizantes. Los sistemas saborizantes de la invencion incluyen por lo menos un agente edulcorante, por lo menos dos ingredientes con sabor, y por lo menos un modificador del sabor que se selecciona entre el grupo que consiste en ácido cítrico, citrato de sodio, cloruro de sodio y mezclas de los mismos. Por lo menos dos de los ingredientes saborizados se seleccionan entre el grupo que consiste en un ingrediente con sabor a vainilla, un ingrediente con sabor a menta, un ingrediente con sabor a mentol, un ingrediente con sabor a algodon de azucar, y mezclas de los mismos. El (los) agente(s) edulcorante(s) comprende(n) glicerina, glicirricinato de monoamonio, sacarina sodica, acesulfame potásico, jarabe de maíz de alta fructosa, y/o mezclas de los mismos. Las composiciones farmacéuticas de la invencion incluyen un sistema saborizante de la invencion, un sistema solvente, y por lo menos un agente farmacéuticamente activo, como por ejemplo lopinavir o derivados del mismo, ritonavir o derivados del mismo, o mezclas de los mismos. También se describen métodos para hacer dichas composiciones farmacéuticas líquidas.Flavoring systems for a liquid pharmaceutical composition and pharmaceutical compositions containing said flavoring systems. The flavoring systems of the invention include at least one sweetening agent, at least two flavored ingredients, and at least one flavor modifier that is selected from the group consisting of citric acid, sodium citrate, sodium chloride and mixtures thereof. At least two of the flavored ingredients are selected from the group consisting of a vanilla-flavored ingredient, a mint-flavored ingredient, a menthol-flavored ingredient, a sugar-flavored cotton-flavored ingredient, and mixtures of same. The sweetening agent (s) comprises glycerin, monoammonium glycyrrhizinate, sodium saccharin, potassium acesulfame, high fructose corn syrup, and / or mixtures thereof. The pharmaceutical compositions of the invention include a flavoring system of the invention, a solvent system, and at least one pharmaceutically active agent, such as lopinavir or derivatives thereof, ritonavir or derivatives thereof, or mixtures thereof. Methods for making such liquid pharmaceutical compositions are also described.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65519200A | 2000-09-05 | 2000-09-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR030715A1 true AR030715A1 (en) | 2003-09-03 |
Family
ID=24627898
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP010104207A AR030715A1 (en) | 2000-09-05 | 2001-09-04 | FLAVORING SYSTEMS FOR PHARMACEUTICAL COMPOSITIONS AND METHODS TO MAKE SUCH COMPOSITIONS |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP1315487A2 (en) |
| JP (1) | JP2004522698A (en) |
| AR (1) | AR030715A1 (en) |
| AU (1) | AU2001288695A1 (en) |
| BR (1) | BR0108433A (en) |
| CA (1) | CA2417258A1 (en) |
| MX (1) | MXPA03001952A (en) |
| PE (1) | PE20020373A1 (en) |
| UY (1) | UY26925A1 (en) |
| WO (1) | WO2002020057A2 (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60028754T2 (en) | 1999-11-12 | 2007-05-31 | Abbott Laboratories, Abbott Park | SOLID DISPERSION WITH RITONAVIR, FENOFIBRATE OR GRISEOFULVIN |
| US7364752B1 (en) | 1999-11-12 | 2008-04-29 | Abbott Laboratories | Solid dispersion pharamaceutical formulations |
| KR20050061604A (en) * | 2002-11-22 | 2005-06-22 | 피르메니히 에스아 | Oral compositions which mask the salty taste of salts |
| US8025899B2 (en) | 2003-08-28 | 2011-09-27 | Abbott Laboratories | Solid pharmaceutical dosage form |
| GB2423711B (en) * | 2005-10-24 | 2007-02-14 | Fortune Apex Dev Ltd | Method for preparing a pharmaceutical composition with enhanced mucoadhesion |
| TW201340998A (en) * | 2012-02-29 | 2013-10-16 | Takeda Pharmaceutical | Oral preparation |
| US8771651B2 (en) * | 2012-09-10 | 2014-07-08 | Johnson & Johnson Consumer Companies, Inc. | Mouth rinses and tooth sensitivity treatment compositions |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL111991A (en) * | 1994-01-28 | 2000-07-26 | Abbott Lab | Liquid pharmaceutical composition of HIV protease inhibitors in organic solvent |
| WO1997046222A1 (en) * | 1996-06-03 | 1997-12-11 | Merck & Co., Inc. | Pediatric formulation for hiv protease inhibitors |
-
2001
- 2001-09-04 PE PE2001000889A patent/PE20020373A1/en not_active Application Discontinuation
- 2001-09-04 WO PCT/US2001/027415 patent/WO2002020057A2/en not_active Ceased
- 2001-09-04 BR BRPI0108433-0A patent/BR0108433A/en not_active IP Right Cessation
- 2001-09-04 EP EP01968449A patent/EP1315487A2/en not_active Withdrawn
- 2001-09-04 AR ARP010104207A patent/AR030715A1/en unknown
- 2001-09-04 AU AU2001288695A patent/AU2001288695A1/en not_active Abandoned
- 2001-09-04 JP JP2002524540A patent/JP2004522698A/en not_active Withdrawn
- 2001-09-04 MX MXPA03001952A patent/MXPA03001952A/en unknown
- 2001-09-04 UY UY26925A patent/UY26925A1/en not_active Application Discontinuation
- 2001-09-04 CA CA002417258A patent/CA2417258A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2001288695A1 (en) | 2002-03-22 |
| MXPA03001952A (en) | 2003-09-10 |
| UY26925A1 (en) | 2002-04-26 |
| CA2417258A1 (en) | 2002-03-14 |
| WO2002020057A3 (en) | 2002-05-10 |
| PE20020373A1 (en) | 2002-05-13 |
| BR0108433A (en) | 2006-06-06 |
| WO2002020057A2 (en) | 2002-03-14 |
| EP1315487A2 (en) | 2003-06-04 |
| JP2004522698A (en) | 2004-07-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |