[go: up one dir, main page]

AR039880A1 - Proceso para formar un dispositivo para la entrega de drogas - Google Patents

Proceso para formar un dispositivo para la entrega de drogas

Info

Publication number
AR039880A1
AR039880A1 ARP030101589A ARP030101589A AR039880A1 AR 039880 A1 AR039880 A1 AR 039880A1 AR P030101589 A ARP030101589 A AR P030101589A AR P030101589 A ARP030101589 A AR P030101589A AR 039880 A1 AR039880 A1 AR 039880A1
Authority
AR
Argentina
Prior art keywords
drug
permeable
core
devices
outer tube
Prior art date
Application number
ARP030101589A
Other languages
English (en)
Original Assignee
Control Delivery Sys Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Control Delivery Sys Inc filed Critical Control Delivery Sys Inc
Publication of AR039880A1 publication Critical patent/AR039880A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts, ocular implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0092—Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A61K9/204—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/2853—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Molecular Biology (AREA)
  • Nanotechnology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)

Abstract

Un dispositivo para la entrega de drogas, en su totalidad o en parte, co-extruyendo un núcleo de droga y un tubo exterior. El tubo exterior puede ser permeable, semi-permeable o impermeable, a la droga. El núcleo de droga puede incluir una matriz polimérica que no afecte de manera significativa la velocidad de la liberación de la droga. El tubo exterior, la matriz polimérica del núcleo de droga o ambos, pueden ser bioerosionables. El producto co-extruído puede ser segmentado en dispositivos para la entrega de drogas. Los dispositivos pueden ser dejados sin recubrir de manera tal que sus respectivos extremos estén abiertos, o los dispositivos pueden estar recubiertos con por ejemplo una capa que es permeable a la droga, semi-permeable a la droga, o bioerosionable. Reivindicación 7: El método de acuerdo con la reivindicación 1, en el cual el núcleo interior de la droga comprende un esteroide. Reivindicación 8: El método de acuerdo con la reivindicación 7, en el cual el esteroide incluye por lo menos: FA (acetonida de flucinola), etabonato de loteprednol, o TA (acetonida de triamcinolona). Reivindicación 9: El método de acuerdo con la reivindicación 1, en el cual por lo menos el núcleo interior de la droga o la por lo menos una piel polimérica comprende un anti-metabolito. Reivindicación 10: El método de acuerdo con la reivindicación 9, en el cual el anti-metabolito comprende 5-FA (5-fluoruracilo). Reivindicación 12: El método de acuerdo con la reivindicación 1, en el cual la piel polimérica exterior comprende por lo menos uno de los siguientes: PCL (policaprolactona), un copolímero EVA (etileno/acetato de vinilo), cianoacralato de polialquilo, poliuretano, un nylon, un PLGA (poli(di-láctido-co-glicólido)).
ARP030101589A 2002-05-07 2003-05-06 Proceso para formar un dispositivo para la entrega de drogas AR039880A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37797402P 2002-05-07 2002-05-07
US45234803P 2003-03-06 2003-03-06

Publications (1)

Publication Number Publication Date
AR039880A1 true AR039880A1 (es) 2005-03-09

Family

ID=45443180

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP030101589A AR039880A1 (es) 2002-05-07 2003-05-06 Proceso para formar un dispositivo para la entrega de drogas

Country Status (12)

Country Link
US (2) US20040009222A1 (es)
EP (1) EP1503731A1 (es)
JP (1) JP2005532313A (es)
KR (1) KR20100120243A (es)
CN (1) CN1658836A (es)
AR (1) AR039880A1 (es)
AU (1) AU2003234439A1 (es)
BR (1) BR0309844A (es)
CA (1) CA2484632C (es)
MX (1) MXPA04011004A (es)
TW (1) TWI305723B (es)
WO (1) WO2003094888A1 (es)

Families Citing this family (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040121014A1 (en) * 1999-03-22 2004-06-24 Control Delivery Systems, Inc. Method for treating and/or preventing retinal diseases with sustained release corticosteroids
US6217895B1 (en) * 1999-03-22 2001-04-17 Control Delivery Systems Method for treating and/or preventing retinal diseases with sustained release corticosteroids
US6375972B1 (en) * 2000-04-26 2002-04-23 Control Delivery Systems, Inc. Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof
US20040175410A1 (en) * 2000-04-26 2004-09-09 Control Delivery Systems, Inc. Sustained release device and method for ocular delivery of carbonic anhydrase inhibitors
US20040115268A1 (en) * 2000-04-26 2004-06-17 Control Delivery Systems, Inc. Systemic delivery of antiviral agents
US20040208910A1 (en) * 2000-04-26 2004-10-21 Control Delivery Systems, Inc. Sustained release device and method for ocular delivery of adrenergic agents
US6726918B1 (en) 2000-07-05 2004-04-27 Oculex Pharmaceuticals, Inc. Methods for treating inflammation-mediated conditions of the eye
AU3649502A (en) 2000-11-29 2002-06-11 Oculex Pharm Inc Methods for reducing or preventing transplant rejection in the eye and intraocular implants for use therefor
GB0203296D0 (en) 2002-02-12 2002-03-27 Glaxo Group Ltd Novel composition
US8871241B2 (en) * 2002-05-07 2014-10-28 Psivida Us, Inc. Injectable sustained release delivery devices
DK2561860T3 (en) * 2002-05-31 2018-04-30 Titan Pharmaceuticals Inc Implantable polymer device for prolonged release of buprenorphine
US8637512B2 (en) 2002-07-29 2014-01-28 Glaxo Group Limited Formulations and method of treatment
US20050048099A1 (en) 2003-01-09 2005-03-03 Allergan, Inc. Ocular implant made by a double extrusion process
KR101152183B1 (ko) * 2003-03-31 2012-06-15 타이탄 파머슈티컬즈 인코퍼레이티드 도파민 아고니스트의 지속 방출을 위한 이식가능한 폴리머디바이스
CA2530120A1 (en) * 2003-06-26 2005-01-06 Mediolanum Pharmaceuticals Ltd. Subcutaneous implants having limited initial release of the active principle and subsequent linearly varying extended release thereof
TWI357815B (en) * 2003-06-27 2012-02-11 Euro Celtique Sa Multiparticulates
US8025899B2 (en) 2003-08-28 2011-09-27 Abbott Laboratories Solid pharmaceutical dosage form
US8377952B2 (en) * 2003-08-28 2013-02-19 Abbott Laboratories Solid pharmaceutical dosage formulation
EP1718274A2 (en) * 2004-01-26 2006-11-08 Control Delivery Systems, Inc. Controlled and sustained delivery of nucleic acid-based therapeutic agents
US8685435B2 (en) * 2004-04-30 2014-04-01 Allergan, Inc. Extended release biodegradable ocular implants
US20050244469A1 (en) 2004-04-30 2005-11-03 Allergan, Inc. Extended therapeutic effect ocular implant treatments
US20060024350A1 (en) * 2004-06-24 2006-02-02 Varner Signe E Biodegradable ocular devices, methods and systems
US20060110428A1 (en) * 2004-07-02 2006-05-25 Eugene Dejuan Methods and devices for the treatment of ocular conditions
EP2377569A1 (en) 2004-07-02 2011-10-19 QLT Plug Delivery, Inc. Treatment medium delivery device and methods for delivery of such treatment mediums to the eye using such a delivery device
BRPI0514834B8 (pt) * 2004-09-02 2021-06-22 Sanofi Aventis Deutschland processo de montagem de dispositivos de envio de fármaco e dispositivo de envio de fármaco
WO2006026844A1 (en) * 2004-09-09 2006-03-16 Biolab Sanus Farmacêutica Ltda. Hormone delayed release composition on the basis of polyorganosiloxanes or ethylene vinyl acetate resp. process for its manufacture
WO2006110487A1 (en) * 2005-04-08 2006-10-19 Surmodics, Inc. Sustained release implants for subretinal delivery
EP3838903B1 (en) 2005-12-13 2023-11-22 Incyte Holdings Corporation Pyrrolo[2,3-d]pyrimidine derivative as janus kinase inhibitor
CA2648421C (en) 2006-03-31 2016-01-12 Qlt Plug Delivery, Inc. Nasolacrimal drainage system implants for drug therapy
JP4827626B2 (ja) * 2006-06-14 2011-11-30 キヤノン株式会社 被制御機器、遠隔制御システムおよび遠隔制御システムの制御方法、プログラム
US9173773B2 (en) 2006-06-21 2015-11-03 Johnson & Johnson Vision Care, Inc. Punctal plugs for the delivery of active agents
CN101932582B (zh) 2007-06-13 2013-09-25 因塞特公司 詹纳斯激酶抑制剂(R)-3-(4-(7H-吡咯并[2,3-d]嘧啶-4-基)-1H-吡唑-1-基)-3-环戊基丙腈的盐
CA2698580C (en) 2007-09-07 2016-10-11 Qlt Plug Delivery, Inc. Lacrimal implant detection
UA101493C2 (ru) 2008-03-11 2013-04-10 Инсайт Корпорейшн Производные азетидина и циклобутана как ингибиторы jak
CL2009001884A1 (es) * 2008-10-02 2010-05-14 Incyte Holdings Corp Uso de 3-ciclopentil-3-[4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il)propanonitrilo, inhibidor de janus quinasa, y uso de una composición que lo comprende para el tratamiento del ojo seco.
EP2246063A1 (en) * 2009-04-29 2010-11-03 Ipsen Pharma S.A.S. Sustained release formulations comprising GnRH analogues
EP3785683B1 (en) * 2009-05-18 2023-11-01 Dose Medical Corporation Drug eluting ocular implant
RS59632B1 (sr) 2009-05-22 2020-01-31 Incyte Holdings Corp 3-[4-(7h-pirolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il]oktan- ili heptan-nitril kao jak inhibitori
US8716303B2 (en) * 2009-05-22 2014-05-06 Incyte Corporation N-(hetero)aryl-pyrrolidine derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines and pyrrol-3-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors
US8563760B2 (en) * 2009-08-31 2013-10-22 Mayo Foundation For Medical Education And Research Process for the synthesis of long-chain fatty acids
TW201113285A (en) * 2009-09-01 2011-04-16 Incyte Corp Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors
JP2013505113A (ja) * 2009-09-22 2013-02-14 エボニック デグサ コーポレイション 生物活性剤の放出プロファイルを調節するためのインプラントデバイス
EP2480200A2 (en) * 2009-09-22 2012-08-01 Evonik Degussa Corporation Implant devices having varying bioactive agent loading configurations
CA2785468A1 (en) * 2009-12-23 2011-06-30 Psivida Us, Inc. Sustained release delivery devices
ME02386B (me) 2010-03-10 2016-09-20 Incyte Holdings Corp Derivati piperidin-4-il azetidina kao inhibitori jak1
CA2795706A1 (en) * 2010-04-06 2011-10-13 Allergan, Inc. Sustained-release reservoir implants for intracameral drug delivery
NZ603686A (en) 2010-05-21 2014-11-28 Incyte Corp Topical formulation for a jak inhibitor
TW201249845A (en) 2010-11-19 2012-12-16 Incyte Corp Cyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as JAK inhibitors
JP5917544B2 (ja) 2010-11-19 2016-05-18 インサイト・ホールディングス・コーポレイションＩｎｃｙｔｅ Ｈｏｌｄｉｎｇｓ Ｃｏｒｐｏｒａｔｉｏｎ Ｊａｋ阻害剤としての複素環置換ピロロピリジンおよびピロロピリミジン
KR20140040819A (ko) 2011-06-20 2014-04-03 인사이트 코포레이션 Ｊａｋ 저해제로서의 아제티디닐 페닐, 피리딜 또는 피라지닐 카르복스아미드 유도체
TW201313721A (zh) 2011-08-18 2013-04-01 Incyte Corp 作為ｊａｋ抑制劑之環己基氮雜環丁烷衍生物
CA2846446A1 (en) 2011-08-30 2013-03-07 Universiteit Gent Multi-layered release formulation
UA111854C2 (uk) 2011-09-07 2016-06-24 Інсайт Холдінгс Корпорейшн Способи і проміжні сполуки для отримання інгібіторів jak
TW201406761A (zh) 2012-05-18 2014-02-16 Incyte Corp 做爲ｊａｋ抑制劑之哌啶基環丁基取代之吡咯并吡啶及吡咯并嘧啶衍生物
HK1211599A1 (en) 2012-11-08 2016-05-27 Eleven Biotherapeutics, Inc. Il-6 antagonists and uses thereof
US10166191B2 (en) 2012-11-15 2019-01-01 Incyte Corporation Sustained-release dosage forms of ruxolitinib
WO2014107737A2 (en) 2013-01-07 2014-07-10 Eleven Biotherapeutics, Inc. Local delivery of il-17 inhibitors for treating ocular disease
DK2964650T3 (en) 2013-03-06 2019-02-11 Incyte Holdings Corp PROCEDURES AND INTERMEDIATES FOR THE MANUFACTURE OF A JAK INHIBITOR
DK2968880T3 (da) * 2013-03-15 2025-05-19 Taris Biomedical Llc Lægemiddelafgivelsesindretninger med lægemiddelpermeabel komponent
SI3030227T1 (sl) 2013-08-07 2020-08-31 Incyte Corporation Dozirne oblike s podaljšanim sproščanjem za inhibitor JAK1
WO2015184407A1 (en) * 2014-05-30 2015-12-03 Textile-Based Delivery, Inc. Drug delivery systems and related methods of use
WO2015184305A1 (en) 2014-05-30 2015-12-03 Incyte Corporation TREATMENT OF CHRONIC NEUTROPHILIC LEUKEMIA (CNL) AND ATYPICAL CHRONIC MYELOID LEUKEMIA (aCML) BY INHIBITORS OF JAK1
CN104224546A (zh) * 2014-10-08 2014-12-24 慈溪市瑞天机械设备有限公司 一种插管式胶囊充填机
KR20170076756A (ko) 2014-10-30 2017-07-04 텍스타일-베이스드 딜리버리, 인코포레이티드 전달 시스템
SMT202500415T1 (it) 2014-11-07 2026-01-12 F Hoffmann La Roche Ltd Anticorpi per il-6 migliorati
WO2016073894A1 (en) 2014-11-07 2016-05-12 Eleven Biotherapeutics, Inc. Therapeutic agents with increased ocular retention
KR20180116359A (ko) 2016-02-23 2018-10-24 세센 바이오, 아이엔씨. 인터루킨-6의 길항제 제제 및 이의 용도
WO2017196697A1 (en) * 2016-05-12 2017-11-16 Merck Sharp & Dohme Corp. Drug delivery system for the delivery of antiviral agents
CN116987014A (zh) * 2016-11-09 2023-11-03 诺沃梅迪科斯有限公司 1,1-二甲双胍的亚硝酸盐、药物组合物和使用方法
BR112020001262A2 (pt) 2017-07-25 2020-07-21 PK Med SAS processo para preparar uma composição de entrega de fármaco
US11103460B2 (en) 2017-08-07 2021-08-31 Board Of Regents, The University Of Texas System Fabrication methods for nanodelivery systems for long term controlled delivery of active pharmaceutical ingredients
US10596161B2 (en) 2017-12-08 2020-03-24 Incyte Corporation Low dose combination therapy for treatment of myeloproliferative neoplasms
LT3746429T (lt) 2018-01-30 2022-05-10 Incyte Corporation (1-(3-fluor-2-(trifluormetil)izonikotinil)piperidin-4-ono) gamybos būdai
MY206999A (en) 2018-03-30 2025-01-23 Incyte Corp Treatment of hidradenitis suppurativa using jak inhibitors
WO2021222063A1 (en) * 2020-04-28 2021-11-04 Essentium, Inc. Three-dimensionally printable antiviral filament
US11833155B2 (en) 2020-06-03 2023-12-05 Incyte Corporation Combination therapy for treatment of myeloproliferative neoplasms
EP4444273A4 (en) * 2021-12-06 2025-11-26 Ocular Therapeutix Inc EXTRUDED OCULAR INSERTS OR IMPLANTS AND ASSOCIATED PROCESSES
CN117618322A (zh) * 2022-08-15 2024-03-01 深圳善康医药科技股份有限公司 一种长效缓控释植入剂的制备方法

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3630200A (en) * 1969-06-09 1971-12-28 Alza Corp Ocular insert
US3828777A (en) * 1971-11-08 1974-08-13 Alza Corp Microporous ocular device
US4177256A (en) * 1973-04-25 1979-12-04 Alza Corporation Osmotic bursting drug delivery device
US3914402A (en) * 1973-06-14 1975-10-21 Alza Corp Ophthalmic dosage form, for releasing medication over time
US4014335A (en) * 1975-04-21 1977-03-29 Alza Corporation Ocular drug delivery device
US4863735A (en) * 1985-02-19 1989-09-05 Massachusetts Institute Of Technology Biodegradable polymeric drug delivery system with adjuvant activity
US4764364A (en) * 1986-02-25 1988-08-16 S R I International Method of preparing bioerodible polymers having pH sensitivity in the acid range and resulting product
US4789513A (en) * 1987-06-05 1988-12-06 P.C.E. Corp. Coextrusion apparatus and process
ES2054784T3 (es) * 1987-08-08 1994-08-16 Akzo Nv Un metodo para la fabricacion de un implante.
GB9025372D0 (en) * 1990-11-22 1991-01-09 Nat Res Dev Pharmaceutical dosage forms
US5378475A (en) * 1991-02-21 1995-01-03 University Of Kentucky Research Foundation Sustained release drug delivery devices
DE9219148U1 (de) * 1991-08-23 1998-08-27 The Gillette Company, Boston, Mass. Matrizen mit verzögerter Freisetzung für Dentalzwecke
US5393536A (en) * 1993-04-05 1995-02-28 Crane Plastics Company Coextrusion apparatus
JPH0748246A (ja) * 1993-08-06 1995-02-21 Fujisawa Pharmaceut Co Ltd 徐放性注入剤
US5443505A (en) * 1993-11-15 1995-08-22 Oculex Pharmaceuticals, Inc. Biocompatible ocular implants
US6051576A (en) * 1994-01-28 2000-04-18 University Of Kentucky Research Foundation Means to achieve sustained release of synergistic drugs by conjugation
PT740650E (pt) * 1994-01-28 2004-10-29 Univ Kentucky Res Found Co-farmacos como um metodo de administracao controlada de farmacos
US5569429A (en) * 1995-05-05 1996-10-29 Randcastle Extrusion Systems, Inc. Dynamic seal and sealing method
US6283951B1 (en) * 1996-10-11 2001-09-04 Transvascular, Inc. Systems and methods for delivering drugs to selected locations within the body
DE19539361A1 (de) * 1995-10-23 1997-04-24 Basf Ag Verfahren zur Herstellung von mehrschichtigen, festen Arzneiformen zur oralen oder rektalen Verabreichung
US6441047B2 (en) * 1995-11-17 2002-08-27 Alcon Manufacturing Ltd.. Combination therapy for treating glaucoma
TW358031B (en) * 1997-04-11 1999-05-11 Akze Nobel N V Drug delivery system for 2 or more active substances
FR2766088B1 (fr) * 1997-07-17 2001-01-05 Dow Corning Sa Dispositifs a liberation controlee d'un agent pharmaceutique, leur fabrication par co-extrusion et article intermediaire
US5902598A (en) * 1997-08-28 1999-05-11 Control Delivery Systems, Inc. Sustained release drug delivery devices
JP3240593B2 (ja) * 1998-02-16 2001-12-17 株式会社高研 可溶性コラーゲンパウダーを担体とする医薬徐放剤
US6267154B1 (en) * 1998-06-05 2001-07-31 Abbott Laboratories System for storing mixing and administering a drug
US6368658B1 (en) * 1999-04-19 2002-04-09 Scimed Life Systems, Inc. Coating medical devices using air suspension
US20030105121A1 (en) * 1999-07-27 2003-06-05 Bernard Bihari Method of preventing lipodystrophy syndrome or reversing a pre-existing syndrome in HIV-infected patients being treated with antiretroviral agents
US6491683B1 (en) * 1999-09-07 2002-12-10 Alza Corporation Osmotic dosage form composed of an extruded polymer tube form
US6375972B1 (en) * 2000-04-26 2002-04-23 Control Delivery Systems, Inc. Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof
US6242058B1 (en) * 2000-05-12 2001-06-05 Dow Corning Corporation Method for forming coatings from radiation curable compositions containing alkenyl ether functional polyisobutylenes
AU2001289653A1 (en) * 2000-07-14 2002-01-30 Universiteit Gent Composite solid shaped articles for the controlled delivery of biologically active ingredients
EP1213014B1 (en) * 2000-12-07 2005-04-20 Warner-Lambert Company LLC Process and system for uniform release drug delivery
WO2002089767A1 (en) * 2001-05-03 2002-11-14 Massachusetts Eye And Ear Infirmary Implantable drug delivery device and use thereof

Also Published As

Publication number Publication date
CA2484632A1 (en) 2003-11-20
CN1658836A (zh) 2005-08-24
BR0309844A (pt) 2005-02-15
MXPA04011004A (es) 2005-01-25
TWI305723B (en) 2009-02-01
AU2003234439A1 (en) 2003-11-11
JP2005532313A (ja) 2005-10-27
KR20100120243A (ko) 2010-11-12
CA2484632C (en) 2012-12-11
US20040009222A1 (en) 2004-01-15
TW200400814A (en) 2004-01-16
WO2003094888A9 (en) 2004-05-13
WO2003094888A1 (en) 2003-11-20
US20190201324A1 (en) 2019-07-04
EP1503731A1 (en) 2005-02-09

Similar Documents

Publication Publication Date Title
AR039880A1 (es) Proceso para formar un dispositivo para la entrega de drogas
US7488339B2 (en) Multilayer medical device
CA2500928A1 (en) Device with an expandable portion for drug release
PT1631255E (pt) Sistema de administração de fármacos
GB2415908A (en) Vacuum wound dressings
WO2008139473A3 (en) Delivery device for delivering bioactive agents to internal tissue in a body
EP1323437B1 (en) Adhesive sheet for application on skin and process for production thereof
MXPA02009547A (es) Composicion de vitamina de liberacion sostenida.
DE69918310D1 (de) Tablette mit verzögerter freigabe enthaltend einen blutzuckersenkenden wirkstoff und einen antihyperglyzemischen wirkstoff
ECSP055788A (es) Sistema de suministro de fármacos
WO2005051172A3 (en) Method and device for cavity obliteration
JP5389806B2 (ja) 細長い中空体を含有する経皮治療システム
MX2023005315A (es) Pelicula delgada oral.
AU2017249048A1 (en) Double disk transdermal system
WO2001034062A3 (en) Dimensionally stable balloons
AR089765A1 (es) Un sistema para el suministro de un farmaco
PA8615501A1 (es) Formulaciones farmaceuticas transdermicas
EP0439202A3 (en) Apparatus and method for manufacturing balloons for medical devices
CL2004000884A1 (es) Composicion farmaceutica en forma de hidrogel que contiene un diester de acido carbonico, un alquilalcohol c2-c4, por lo menos una sustancia activa y una matriz de polimero; uso en el tratamiento de carencias esteroidales.
JP2019520890A5 (es)
JPH08231385A (ja) 経皮投与薬用支持体
MY135804A (en) Processes of forming a drug delivery device
CN117244159B (zh) 一种转移定量药物至药物球囊的方法及装置
US20250114577A1 (en) Profiled Drug-Coated Balloons Using Nanoparticles and Methods of Drug Delivery Therewith
MX2023008402A (es) Pelicula delgada oral multicapa.

Legal Events

Date Code Title Description
FA Abandonment or withdrawal