AR039021A1 - Gen humano de la proteasa desubiquitinante del cromosoma 7 y su ortologo murino - Google Patents
Gen humano de la proteasa desubiquitinante del cromosoma 7 y su ortologo murinoInfo
- Publication number
- AR039021A1 AR039021A1 ARP030100962A ARP030100962A AR039021A1 AR 039021 A1 AR039021 A1 AR 039021A1 AR P030100962 A ARP030100962 A AR P030100962A AR P030100962 A ARP030100962 A AR P030100962A AR 039021 A1 AR039021 A1 AR 039021A1
- Authority
- AR
- Argentina
- Prior art keywords
- mdub7
- hdub7
- chromosome
- murine
- human
- Prior art date
Links
- 108090000623 proteins and genes Proteins 0.000 title abstract 3
- 241001529936 Murinae Species 0.000 title abstract 2
- 210000000349 chromosome Anatomy 0.000 title abstract 2
- 101710083939 Deubiquitinase SseL Proteins 0.000 title 1
- 101710111400 Protease ElaD Proteins 0.000 title 1
- 108091005804 Peptidases Proteins 0.000 abstract 2
- 239000004365 Protease Substances 0.000 abstract 2
- 210000004027 cell Anatomy 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000002773 nucleotide Substances 0.000 abstract 2
- 125000003729 nucleotide group Chemical group 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 230000026683 transduction Effects 0.000 abstract 2
- 238000010361 transduction Methods 0.000 abstract 2
- 102000004127 Cytokines Human genes 0.000 abstract 1
- 108090000695 Cytokines Proteins 0.000 abstract 1
- 102000001477 Deubiquitinating Enzymes Human genes 0.000 abstract 1
- 108010093668 Deubiquitinating Enzymes Proteins 0.000 abstract 1
- 102000035195 Peptidases Human genes 0.000 abstract 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 1
- 230000000692 anti-sense effect Effects 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 230000003394 haemopoietic effect Effects 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6472—Cysteine endopeptidases (3.4.22)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Se identifican análogos humanos y murinos de DUBs, proteasas desubiquitinantes inducibles por citoquinas y hematopoyético-específicas, agrupadas sobre el cromosoma 7, y sus respectivas regiones regulatorias. El nucleótido o las proteínas codificadas por el mismo pueden utilizarse en ensayos para identificar inhibidores de hDUB7 o mDUB7. La presente también incluye a péptidos de transducción que comprenden un NLS o una secuencia de hDUB7 o mDUB7 unidos a una molécula de carga, y métodos para administrar una proteína biológicamente activa, un compuesto terapéuticamente efectivo, un nucleótido antisentido o un compuesto de prueba a una célula, en el cual se agrega a una célula un péptido de transducción de manera exógena. Reivindicación 1: Un polinucleótido aislado que codifica una proteasa desubiquinitante humana, seleccionado del grupo integrado por hDUB7 y mDUB7.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36660102P | 2002-03-22 | 2002-03-22 | |
| GBGB0218518.9A GB0218518D0 (en) | 2002-03-22 | 2002-08-09 | Human deubiquitinating protease gene on chromosome 7 and its murine ortholog |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR039021A1 true AR039021A1 (es) | 2005-02-02 |
Family
ID=23443690
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP030100962A AR039021A1 (es) | 2002-03-22 | 2003-03-19 | Gen humano de la proteasa desubiquitinante del cromosoma 7 y su ortologo murino |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US7179631B2 (es) |
| AR (1) | AR039021A1 (es) |
| GB (1) | GB0218518D0 (es) |
| TW (1) | TWI348914B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105764503A (zh) | 2013-10-15 | 2016-07-13 | 西雅图基因公司 | 用于改善配体-药物偶联物药代动力学的peg化的药物-接头 |
| KR20180090290A (ko) | 2015-12-04 | 2018-08-10 | 시애틀 지네틱스, 인크. | 사차화 튜불리신 화합물들의 컨쥬게이트들 |
| US11793880B2 (en) | 2015-12-04 | 2023-10-24 | Seagen Inc. | Conjugates of quaternized tubulysin compounds |
| EP3433278A4 (en) | 2016-03-25 | 2019-11-06 | Seattle Genetics, Inc. | METHOD FOR THE PRODUCTION OF PEGYLATED ACTIVE LINKERS AND INTERMEDIATE PRODUCTS THEREOF |
| US11730822B2 (en) | 2017-03-24 | 2023-08-22 | Seagen Inc. | Process for the preparation of glucuronide drug-linkers and intermediates thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01128680A (ja) | 1987-11-12 | 1989-05-22 | Ricoh Co Ltd | 静止画像再生用トラッキング制御装置 |
| CA2229204C (en) | 1995-08-09 | 2012-10-09 | Alan D. D'andrea | Deubiquitinating enzymes that regulate cell growth |
| CA2332573A1 (en) | 1998-07-06 | 2000-01-13 | Elizabeth Esther Mary Bates | Mammalian genes; dendritic cell prostaglandin-like transponder (dc-pgt), hdtea84, hsljd37r and rankl, hcc5 chemokine, deubiquitinating 11 and 12 (dub11, dub12), md-1, md2 and cyclin e2, related reagents and methods |
| EP1203016A2 (en) | 1999-08-09 | 2002-05-08 | Incyte Genomics, Inc. | Proteases and protease inhibitors |
| US6451994B1 (en) | 1999-09-27 | 2002-09-17 | Millennium Pharmaceuticals, Inc. | 23413, a novel human ubiquitin protease |
| WO2001023589A2 (en) | 1999-09-29 | 2001-04-05 | Millennium Pharmaceuticals, Inc. | 23431, a novel human ubiquitin protease |
-
2002
- 2002-08-09 GB GBGB0218518.9A patent/GB0218518D0/en not_active Ceased
-
2003
- 2003-03-05 US US10/379,981 patent/US7179631B2/en not_active Expired - Lifetime
- 2003-03-19 AR ARP030100962A patent/AR039021A1/es unknown
- 2003-03-21 TW TW092106238A patent/TWI348914B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| US7179631B2 (en) | 2007-02-20 |
| TWI348914B (en) | 2011-09-21 |
| US20040001820A1 (en) | 2004-01-01 |
| TW200408404A (en) | 2004-06-01 |
| GB0218518D0 (en) | 2002-09-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |