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AR038887A1 - Amidas heterociclicas - Google Patents

Amidas heterociclicas

Info

Publication number
AR038887A1
AR038887A1 ARP030100767A ARP030100767A AR038887A1 AR 038887 A1 AR038887 A1 AR 038887A1 AR P030100767 A ARP030100767 A AR P030100767A AR P030100767 A ARP030100767 A AR P030100767A AR 038887 A1 AR038887 A1 AR 038887A1
Authority
AR
Argentina
Prior art keywords
alkyl
hydroxy
alkoxy
independently selected
optionally substituted
Prior art date
Application number
ARP030100767A
Other languages
English (en)
Inventor
Alan BIRCH
Andrew Morley
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of AR038887A1 publication Critical patent/AR038887A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

Amidas heterocíclicas que poseen actividad inhibidora de la actividad de glucógeno fosforilasa y por lo tanto tienen valor en el tratamiento de estados de enfermedad con un aumento en la actividad de la glucógeno fosforilasa. También se describen procesos para la fabricación de dichos derivados de amidas heterocíclicas y composiciones farmacéuticas que los contienen. Reivindicación 1: Un compuesto caracterizado porque responde a la fórmula (1) donde: la línea de puntos es una unión simple o doble; A es fenileno o heteroarileno; m es 0, 1 ó 2; n es 0, 1 ó 2; R1 se selecciona independientemente entre halo, nitro, ciano, hidroxi, carboxi, carbamoilo, N-alquilcarbamoilo C1-4, N,N-(alquil C1-4)2carbamoilo, sulfamoilo, N-alquilsulfamoilo C1-4, N,N-(alquil C1-4)2sulfamoilo, -S(O)balquilo C1-4 (donde b es 0, 1, ó 2), alquilo C1-4, alquenilo C2-4 alquinilo C2-4, alcoxi C1-4, alcanoilo C1-4, alcanoiloxi C1-4, hidroxi alquilo C1-4, fluorometilo, difluorometilo, trifluorometilo y trifluorometoxi; o, cuando n es 2, los dos grupos R1, junto con los átomos de carbono de A a los cuales están unidos, pueden formar un anillo de 4 a 7 miembros, que contiene opcionalmente 1 ó 2 heteroátomos seleccionados independientemente entre O, S y N, y estando opcionalmente sustituidos por 1 ó 2 grupos metilo; R4 se selecciona independientemente entre hidrógeno, halo, nitro, ciano, hidroxi, fluorometilo, difluorometilo, trifluorometilo, trifluorometoxi, carboxi, carbamoilo, alquilo C1-4, alquenilo C2-4, alquinilo C2-4, alcoxi C1-4 y alcanoilo C1-4; R2 es hidrógeno, hidroxi o carboxi; R3 se selecciona independientemente entre hidrógeno, hidroxi, alcoxi C1-4, alcanoilo C1-4, carbamoilo, cicloalquilo C3-7 (opcionalmente sustituido con 1 ó 2 grupos hidroxi), ciano alquilo C1-4, arilo, heterociclilo, alquilo C1-4 (opcionalmente sustituido por 1 ó 2 grupos R8), y grupos de las fórmulas (2) y (3) donde y es 0 ó 1, t es 0, 1, 2 ó 3 y a es 1 ó 2; con la salvedad de que el grupo hidroxi no es un sustituyente en el carbono del anillo adyacente al oxígeno del anillo; o R8 se selecciona independientemente entre hidroxi, alcoxi C1-4 alcoxi C1-4; hidroxi alcoxi C1-4; acetales cíclicos de 5 y 6 miembros y derivados mono- y di-metilo de los mismos, arilo, heterociclilo, cicloalquilo C3-7, alcanoilo C1-4, alcoxi C1-4, alquil C1-4 S(O)b- (donde b es 0, 1 ó 2), cicloalquil C3-6 S(O)b- (donde b es 0, 1 ó 2), aril S(O)b- (donde b es 0, 1 ó 2), heterociclil S(O)b- (donde b es 0, 1 ó 2), bencil S(O)b- (donde b es 0, 1 ó 2), -N(OH)CHO, -C(=N-OH)NH2, -C(=N-OH)NH alquilo C1-4, -C(=N-OH)N(alquil C1-4)2, -C(=N-OH)NH cicloalquilo C3-6, -C(=N-OH)N(cicloalquil C3-6)2, -COCOOR9, -C(O)N(R9)(R10), -NHC(O)R9, -C(O)NHSO2(alquilo C1-4), -NHSO2R9, (R9)(R10)NSO2-, -COCH2OR11, (R9)(R10)N- y -COOR9; R9 y R10 se seleccionan independientemente entre hidrógeno, hidroxi, alquilo C1-4 (opcionalmente sustituido por 1 ó 2 grupos R13), cicloalquilo C3-7 (opcionalmente sustituido por 1 ó 2 grupos hidroxi), ciano alquilo C1-4, trihalo alquilo C1-4, arilo, heterociclilo y heterociclil alquilo C1-4; o R9 y R10 junto con el nitrógeno; a los cuales están unidos forman un anillo de 4 a 6 miembros donde el anillo es opcionalmente sustituido en un carbono por 1 ó 2 sustituyentes independientemente seleccionados entre oxo, hidroxi, carboxi, halo, nitro, ciano, carbonilo, alcoxi C1-4 y heterociclilo; o el anillo puede ser opcionalmente sustituido en dos carbonos adyacentes por -O-CH2-O- para formar un acetal cíclico donde uno o ambos hidrógenos del grupo -O-CH2-O- pueden ser reemplazados por un metilo; R13 se selecciona entre halo, trihalometilo, y alcoxi C1-4; R11 se selecciona independientemente entre hidrógeno, alquilo C1-4 e hidroxi alquilo C1-4; o una sal aceptable para uso farmacéutico o prodroga del mismo.
ARP030100767A 2002-03-06 2003-03-06 Amidas heterociclicas AR038887A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0205162.1A GB0205162D0 (en) 2002-03-06 2002-03-06 Chemical compounds

Publications (1)

Publication Number Publication Date
AR038887A1 true AR038887A1 (es) 2005-02-02

Family

ID=9932326

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP030100767A AR038887A1 (es) 2002-03-06 2003-03-06 Amidas heterociclicas

Country Status (8)

Country Link
US (1) US7169927B2 (es)
EP (1) EP1485371A2 (es)
JP (1) JP2005525364A (es)
AR (1) AR038887A1 (es)
AU (1) AU2003216991A1 (es)
GB (1) GB0205162D0 (es)
TW (1) TW200403233A (es)
WO (1) WO2003074513A2 (es)

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Also Published As

Publication number Publication date
TW200403233A (en) 2004-03-01
US7169927B2 (en) 2007-01-30
GB0205162D0 (en) 2002-04-17
EP1485371A2 (en) 2004-12-15
JP2005525364A (ja) 2005-08-25
US20050131016A1 (en) 2005-06-16
AU2003216991A8 (en) 2003-09-16
AU2003216991A1 (en) 2003-09-16
WO2003074513A3 (en) 2003-12-31
WO2003074513A2 (en) 2003-09-12

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