AR038662A1 - Compuestos de isocromano - Google Patents
Compuestos de isocromanoInfo
- Publication number
- AR038662A1 AR038662A1 ARP020104961A ARP020104961A AR038662A1 AR 038662 A1 AR038662 A1 AR 038662A1 AR P020104961 A ARP020104961 A AR P020104961A AR P020104961 A ARP020104961 A AR P020104961A AR 038662 A1 AR038662 A1 AR 038662A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- hydrogen
- halo
- formulas
- alkoxy
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 14
- 229910052739 hydrogen Inorganic materials 0.000 abstract 9
- 239000001257 hydrogen Substances 0.000 abstract 9
- 150000002431 hydrogen Chemical class 0.000 abstract 5
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 4
- 125000001475 halogen functional group Chemical group 0.000 abstract 4
- -1 morpholino, pyrrolidino Chemical group 0.000 abstract 4
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 150000002825 nitriles Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000003386 piperidinyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/76—Benzo[c]pyrans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Compuestos de fórmula (1), su preparación y uso como compuestos farmacéuticos. Reivindicación 1: Un compuesto de fórmula general (1) en la que: R1 es uno cualquiera de -CN, -CONR13R14, -SO2NR13R14, -(CH2)t-R21o un resto del grupo de fórmulas (2); -R21 es un resto seleccionado del grupo de fórmulas (3) en las que cada uno de R13, R14, R22 y R23 es hidrógeno o alquilo C1-6, o R13 y R14 tomados junto con el átomo de nitrógeno al que están unidos forman un anillo morfolino, pirrolidino o piperidinilo opcionalmente sustituido con uno o dos grupos alquilo C1-6. Cada uno de R13' y R24 se selecciona independientemente entre hidrógeno, alquilo C1-6, alcoxi C1-6, carboxi, hidroxi, ciano, halo, trifluorometilo, nitro, amino, acil(C1-6)-amino, alquil(C1-6)-tio, fenilo o fenoxi; A es O ó S; t es 0, 1, ó 2; r es 0, 1, 2 ó 3; v es 0, 1 ó 2; R2 es hidrógeno, alquilo C1-6, alcoxi C1-6 o halo; cada uno de R3, R4, R5, R6, R7 y R8 es hidrógeno o alquilo C1-6; cada uno de R9, R10, R11, y R12 es hidrógeno, alquilo C1-6 o -(CH2)q-OR20, siendo R20 alquilo C1-6; n es 1 ó 2; p es 0, 1 ó 2; q es 1 ó 2; -W-V< es -CH2-C(R25)<, -O-C(R25)<, -S-C(R25)<, -CH=C<, -CH2-N< o -C(O)-N<, R25 es hidrógeno o alquilo C1-6; -X-Y- es -NZ-CH2-, -CZQ-CH2-, -ZC=CH-; en los que Z es un elemento del grupo de fórmulas (4), en los que -T- es -CH2-, -O-, -S-, -C(O)- o -CH=CH-, cada uno de m y s es 0 ó 1; cada uno de R15, R16 y R19 es hidrógeno, halo, alquilo C1-6 o alcoxi C1-6, carboxi-alquilo(C1-6), ciano, halógeno, trifluorometilo, trifluorometoxi, nitro, amino, acil(C1-6)-amino o alquil(C1-6)-tio y cada uno de R17 y R18 es hidrógeno o alquilo C1-6; Q es hidrógeno, halo, nitrilo, carboxi-alquilo(C1-6), hidroxi, alquilo C1-6 o alcoxi C1-6; y sales farmacéuticamente aceptables de los mismos; con la condición de que: a) cuando -T- es -CH2-, -O-, -S- o -C(O)-, entonces (m + s) sea 1 ó 2, y b) cuando Z es (i)a, (ii)a, (iii)a, (iv), (v)a, (vi), (vii), (viii)a, (x)a, (xi)a, (xii)a, (x)b, (xi)b o (xiii) del grupo de fórmulas (4), entonces R1 sea -(CH2)t-R21.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0130339.5A GB0130339D0 (en) | 2001-12-19 | 2001-12-19 | Isochroman compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR038662A1 true AR038662A1 (es) | 2005-01-26 |
Family
ID=9927920
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP020104961A AR038662A1 (es) | 2001-12-19 | 2002-12-18 | Compuestos de isocromano |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP1458703B1 (es) |
| JP (1) | JP2005516952A (es) |
| CN (1) | CN1312148C (es) |
| AR (1) | AR038662A1 (es) |
| AT (1) | ATE355283T1 (es) |
| AU (1) | AU2002359378B8 (es) |
| BR (1) | BR0214859A (es) |
| CA (1) | CA2469278A1 (es) |
| CY (1) | CY1106552T1 (es) |
| DE (1) | DE60218529T2 (es) |
| DK (1) | DK1458703T3 (es) |
| ES (1) | ES2280606T3 (es) |
| GB (1) | GB0130339D0 (es) |
| MX (1) | MXPA04006085A (es) |
| PE (1) | PE20030728A1 (es) |
| PT (1) | PT1458703E (es) |
| SI (1) | SI1458703T1 (es) |
| SV (1) | SV2004001441A (es) |
| TW (1) | TW200301116A (es) |
| WO (1) | WO2003053948A1 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7534796B2 (en) | 2005-02-18 | 2009-05-19 | Wyeth | Imidazo[4,5-b]pyridine antagonists of gonadotropin releasing hormone receptor |
| US7538113B2 (en) | 2005-02-18 | 2009-05-26 | Wyeth | 4-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor |
| US7582634B2 (en) | 2005-02-18 | 2009-09-01 | Wyeth | 7-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor |
| US7531542B2 (en) | 2005-05-18 | 2009-05-12 | Wyeth | Benzooxazole and benzothiazole antagonists of gonadotropin releasing hormone receptor |
| US7582636B2 (en) | 2005-05-26 | 2009-09-01 | Wyeth | Piperazinylimidazopyridine and piperazinyltriazolopyridine antagonists of Gonadotropin Releasing Hormone receptor |
| NL2000351C2 (nl) | 2005-12-22 | 2007-09-11 | Pfizer Prod Inc | Estrogeen-modulatoren. |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4247553A (en) * | 1977-10-31 | 1981-01-27 | The Upjohn Company | Methods of treating psychosis |
| ES2133714T3 (es) * | 1993-12-28 | 1999-09-16 | Upjohn Co | Compuestos heterociclicos para el tratamiento de trastornos del snc y cardiovasculares. |
| AU6252296A (en) * | 1995-06-30 | 1997-02-05 | Pharmacia & Upjohn Company | 1,6-disubstituted isochromans for treatment of migraine headaches |
| GB2370270A (en) * | 2000-12-20 | 2002-06-26 | Lilly Co Eli | Pharmaceutical compounds |
-
2001
- 2001-12-19 GB GBGB0130339.5A patent/GB0130339D0/en not_active Ceased
-
2002
- 2002-11-18 TW TW091133608A patent/TW200301116A/zh unknown
- 2002-12-06 MX MXPA04006085A patent/MXPA04006085A/es active IP Right Grant
- 2002-12-06 JP JP2003554664A patent/JP2005516952A/ja not_active Ceased
- 2002-12-06 CA CA002469278A patent/CA2469278A1/en not_active Abandoned
- 2002-12-06 WO PCT/US2002/036148 patent/WO2003053948A1/en not_active Ceased
- 2002-12-06 DK DK02793911T patent/DK1458703T3/da active
- 2002-12-06 ES ES02793911T patent/ES2280606T3/es not_active Expired - Lifetime
- 2002-12-06 EP EP02793911A patent/EP1458703B1/en not_active Expired - Lifetime
- 2002-12-06 SI SI200230528T patent/SI1458703T1/sl unknown
- 2002-12-06 AT AT02793911T patent/ATE355283T1/de not_active IP Right Cessation
- 2002-12-06 AU AU2002359378A patent/AU2002359378B8/en not_active Ceased
- 2002-12-06 CN CNB028281209A patent/CN1312148C/zh not_active Expired - Fee Related
- 2002-12-06 BR BR0214859-5A patent/BR0214859A/pt not_active IP Right Cessation
- 2002-12-06 PT PT02793911T patent/PT1458703E/pt unknown
- 2002-12-06 DE DE60218529T patent/DE60218529T2/de not_active Expired - Lifetime
- 2002-12-13 PE PE2002001229A patent/PE20030728A1/es not_active Application Discontinuation
- 2002-12-18 AR ARP020104961A patent/AR038662A1/es unknown
- 2002-12-19 SV SV2002001441A patent/SV2004001441A/es not_active Application Discontinuation
-
2007
- 2007-04-26 CY CY20071100573T patent/CY1106552T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GB0130339D0 (en) | 2002-02-06 |
| CN1620447A (zh) | 2005-05-25 |
| MXPA04006085A (es) | 2004-09-27 |
| PE20030728A1 (es) | 2003-08-29 |
| AU2002359378B2 (en) | 2008-08-21 |
| PT1458703E (pt) | 2007-05-31 |
| JP2005516952A (ja) | 2005-06-09 |
| ES2280606T3 (es) | 2007-09-16 |
| SI1458703T1 (sl) | 2007-08-31 |
| CY1106552T1 (el) | 2012-01-25 |
| EP1458703B1 (en) | 2007-02-28 |
| AU2002359378A1 (en) | 2003-07-09 |
| CA2469278A1 (en) | 2003-07-03 |
| BR0214859A (pt) | 2004-11-03 |
| AU2002359378B8 (en) | 2008-09-11 |
| ATE355283T1 (de) | 2006-03-15 |
| WO2003053948A1 (en) | 2003-07-03 |
| TW200301116A (en) | 2003-07-01 |
| DE60218529D1 (de) | 2007-04-12 |
| DE60218529T2 (de) | 2007-11-22 |
| CN1312148C (zh) | 2007-04-25 |
| EP1458703A1 (en) | 2004-09-22 |
| SV2004001441A (es) | 2004-05-07 |
| DK1458703T3 (da) | 2007-06-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |