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AR038179A1 - Fenilsulfonamidas para uso terapeutico - Google Patents

Fenilsulfonamidas para uso terapeutico

Info

Publication number
AR038179A1
AR038179A1 ARP030100126A ARP030100126A AR038179A1 AR 038179 A1 AR038179 A1 AR 038179A1 AR P030100126 A ARP030100126 A AR P030100126A AR P030100126 A ARP030100126 A AR P030100126A AR 038179 A1 AR038179 A1 AR 038179A1
Authority
AR
Argentina
Prior art keywords
group
6alkyl
halogen
alkyl
optionally substituted
Prior art date
Application number
ARP030100126A
Other languages
English (en)
Inventor
Andrew Baxter
Timothy B Johnson
Nicholas Kindon
Bryan Roberts
Michael Stocks
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE0200119A external-priority patent/SE0200119D0/xx
Priority claimed from SE0201857A external-priority patent/SE0201857D0/xx
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of AR038179A1 publication Critical patent/AR038179A1/es

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    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • A—HUMAN NECESSITIES
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    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/20—Nitrogen atoms
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
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    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring

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  • Animal Behavior & Ethology (AREA)
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  • Tropical Medicine & Parasitology (AREA)

Abstract

Reivindicación 1: Un compuesto caracterizado porque responde a la fórmula (1) o una sal aceptable para uso farmacéutico o solvato del mismo en donde: R1, R2 y R3 son en forma independiente H, halógeno, ciano, CF3, OCF3, OC1-6alquilo o C1-6alquilo; R4 es halógeno, CO2R12, C1-6 alcoxi donde el grupo alquilo puede formar un anillo saturado de 3 a 6 miembros o puede sustituirse con 1-3 átomos de F o un grupo ciano; C3-6 alqueniloxi o C3-6 alquiniloxi donde cualquiera puede ser opcionalmente sustituido con hidroxi o NR14R15; OC1-6 alquil-X-C1-6 alquilo donde los grupos alquilo pueden formar un anillo saturado de 3-6 miembros; OC1-6alquilR11, o OC2-alquil-X-R11 donde el grupo alquilo puede formar un anillo saturado de 3 a 6 miembros y es opcionalmente sustituido con 1-3 grupos seleccionados entre hidroxi, halógeno, NR14R15, SR13, S(O)2R13, S(O)R13 o COR13, OC1-6 alquilR16, R5 y R6 son en forma independiente H, ciano, halógeno, CO2R12, CONR14R15, C1-6alquilo opcionalmente sustituido por hidroxi, NR14R15, o 1-3 átomos de F; C1-6 alquilR11 o XCH(R11)C1-6alquilo o XCH(R16)C1-6alquilo donde el grupo alquilo puede ser opcionalmente sustituido con 1-3 grupos seleccionados entre hidroxi, y NR14R15, NR14R15, N(R11)R11, X-(CH2)qNR14R15, (CH2)nNR14R15, NHC(O)C1-6alquilo opcionalmente sustituido por uno o más grupos hidroxilo, C3-6 alquinilo o C3-6 alquenilo opcionalmente ramificado y opcionalmente sustituido con 1-3 grupos seleccionados entre hidroxi, ciano, halógeno y =O; R11, X-R11, X-R12, X-C1-6alquilR16, X-R16, X-(CH2)nCOR12, X-(CH2)nCONR14R15, X-(CH2)nR11, X-(CH2)nCN; X-(CH2)qOR12, (CH2)nOR12, (CH2)n-X-R11, X-(CH2)qNHC(O)NHR12, X-(CH2)qNHC(O)R12, X-(CH2)qNHS(O)2R12, X-(CH2)qNHS(O)2R11, X-C3-6alquenilo; X-C3-6alquinilo; n es 1, 2, 3, 4 ó 5; q es 2, 3, 4, 5 ó 6; X es NR13, O, S, S(O), S(O)2; R11 es un grupo arilo o un anilo heteroaromático de 5-7 miembros que contiene 1-4 heteroátomos seleccionados entre N, O ó S cada uno de los cuales puede ser opcionalmente sustituido por 1-3 grupos seleccionados entre halógeno, C(O)NR14R11, C(O)OR12, hidroxi, =O, =S, CN, NO2, COR13, NR14R15, X(CH2)qNR14R15, (CH2)nNR14R15, (CH2)nOH, SR13, S(O)R13, S(O)2R15C1-6alquil-X-C1-6alquilo, C1-6alquilo o C1-6alcoxi donde el grupo alquilo puede formar un anillo de 3-6 miembros o es opcionalmente sustituido con 1-3 grupos seleccionados entre hidroxi, halógeno, NR14R11, SR13, S(O)R13, S(O)2R13; R12 y R13 son en forma independiente H o C1-6 alquilo donde el grupo alquilo o puede sustituirse con 1-3 átomos de F o puede formar un anillo saturado de 3-6 miembros; o R14 y R15 junto con el átomo de N al cual están unidos forman un anillo saturado de 4-8 miembros que contiene 1-3 heteroátomos seleccionados entre N, O, y S y opcionalmente sustituido por C1-6 alquilo, C1-6 alquil-OH, o hidroxi; y R16 es un anillo saturado de 4-8 miembros que contiene 1-3 heteroátomos seleccionados entre N, O, o S y opcionalmente sustituido con 1-3 grupos seleccionados entre hidroxi, ciano, halógeno y =O, con la condición de que: cuando R4 es halógeno o C1-4alcoxi y R5 es H, halógeno, C1-4alquilo, C1-2alcoxi, C1-2alquiltio, trifluorometilo o etinilo y cuando uno de R1, R2 o R3 es C1-6alquilo o C1-6alcoxi y se encuentra en posición meta con respecto al grupo sulfonamida, entonces el grupo orto tanto respecto del grupo sulfonamida y del grupo C1-6alquilo o C1-6alcoxi no es H; cuando R4 es halógeno o C1-4alcoxi y R5 es H, halógeno, C1-4alquilo, C1-2alcoxi, C1-2alquiltio, trifluorometilo o etinilo y cuando uno de R1, R2 o R3 es C1-6 alquilo o C1-6alcoxi y se encuentra en posición orto respecto del grupo sulfonamida, entonces el grupo orto respecto del C1-6alquilo o C1-6alcoxi y también meta respecto del grupo sulfonamida no es H; cuando dos de R1, R2, R3 son H y el otro es un grupo metilo en posición para respecto de la sulfonamida y R4 es metoxi, entonces R5 no es H o Br, y cuando R5 es metilo y R6 es metoxi y uno de R1, R2 o R3 es Br o I y los otros dos son ambos H, entonces el grupo Br o I no se encuentra en posición orto respecto del grupo sulfonamida.
ARP030100126A 2002-01-16 2003-01-16 Fenilsulfonamidas para uso terapeutico AR038179A1 (es)

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MXPA04006806A (es) 2004-12-06
TW200303308A (en) 2003-09-01
CA2472204A1 (en) 2003-07-24
PL371432A1 (en) 2005-06-13
CO5640137A2 (es) 2006-05-31
NZ533750A (en) 2006-03-31
AU2003201802A1 (en) 2003-07-30
US20100081670A1 (en) 2010-04-01
IL162678A0 (en) 2005-11-20
ATE534635T1 (de) 2011-12-15
WO2003059893A1 (en) 2003-07-24
IS7348A (is) 2004-07-08
RU2312105C2 (ru) 2007-12-10
KR20040073566A (ko) 2004-08-19
EP1467976A1 (en) 2004-10-20
RU2004119966A (ru) 2005-06-10
TWI328007B (en) 2010-08-01
ES2375107T3 (es) 2012-02-24
US7662825B2 (en) 2010-02-16
BR0306922A (pt) 2004-11-09
CN100357275C (zh) 2007-12-26
RU2312105C9 (ru) 2008-06-10
CN1639132A (zh) 2005-07-13
JP2005521650A (ja) 2005-07-21
JP4504021B2 (ja) 2010-07-14

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