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AR037098A1 - Proceso para preparar un compuesto intermediario derivado de halo alquil sulfona y compuestos intermediarios que se usan en dicho proceso - Google Patents

Proceso para preparar un compuesto intermediario derivado de halo alquil sulfona y compuestos intermediarios que se usan en dicho proceso

Info

Publication number
AR037098A1
AR037098A1 ARP020103762A ARP020103762A AR037098A1 AR 037098 A1 AR037098 A1 AR 037098A1 AR P020103762 A ARP020103762 A AR P020103762A AR P020103762 A ARP020103762 A AR P020103762A AR 037098 A1 AR037098 A1 AR 037098A1
Authority
AR
Argentina
Prior art keywords
halo
sulfona
rental
prepare
compounds used
Prior art date
Application number
ARP020103762A
Other languages
English (en)
Inventor
Kenneth Warren
Anne Margaret Kane
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of AR037098A1 publication Critical patent/AR037098A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/02—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
    • C07C303/28—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reaction of hydroxy compounds with sulfonic acids or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C323/11—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/12—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/30—Isothioureas
    • C07C335/32—Isothioureas having sulfur atoms of isothiourea groups bound to acyclic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Un proceso para preparar un compuesto intermediario, derivado de halo alquil sulfona de fórmula (1) donde n es un entero entre 3 y 14; R1 es haloC1-10alquilo, C1-10alquilo, C2-10alquenilo, C2-10cicloalquilo, carboxiC1-10alquilo, C1-10alcoxicarbonilC1-10alquilo, arilo (tal como fenilo), aril(C1-10)alquilo (tal como fenil(C1-10)alquilo) o di(C1-6alquil)amino; y R2 es un grupo halo; proceso que comprende la halogenación de un compuesto de fórmula(2) donde n y R1 son como se los definió previamente. También se describen y reivindican compuestos intermediarios de fórmula (3) donde n es un entero entre 3 y 14 y compuesto de fórmula (4) donde R6 es haloC1-10alquilo. Mediante este proceso se obtienen compuestos intermediarios que pueden ser usados en la síntesis de fulvestrant.
ARP020103762A 2001-10-05 2002-10-04 Proceso para preparar un compuesto intermediario derivado de halo alquil sulfona y compuestos intermediarios que se usan en dicho proceso AR037098A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0123961.5A GB0123961D0 (en) 2001-10-05 2001-10-05 Process and intermediates

Publications (1)

Publication Number Publication Date
AR037098A1 true AR037098A1 (es) 2004-10-20

Family

ID=9923306

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP020103762A AR037098A1 (es) 2001-10-05 2002-10-04 Proceso para preparar un compuesto intermediario derivado de halo alquil sulfona y compuestos intermediarios que se usan en dicho proceso

Country Status (20)

Country Link
US (1) US7323602B2 (es)
EP (1) EP1436256B1 (es)
JP (1) JP4346440B2 (es)
KR (1) KR100937916B1 (es)
CN (1) CN100522938C (es)
AR (1) AR037098A1 (es)
AT (1) ATE519736T1 (es)
AU (1) AU2002329452B2 (es)
BR (2) BRPI0212982B1 (es)
CA (1) CA2462237C (es)
ES (1) ES2368903T3 (es)
GB (1) GB0123961D0 (es)
IL (2) IL161084A0 (es)
MX (1) MXPA04003020A (es)
MY (1) MY139404A (es)
NO (1) NO331195B1 (es)
NZ (1) NZ531943A (es)
SA (1) SA02230410B1 (es)
WO (1) WO2003031399A1 (es)
ZA (1) ZA200402470B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0025221D0 (en) 2000-10-14 2000-11-29 Astrazeneca Ab New process
ATE482966T1 (de) * 2004-07-27 2010-10-15 Sicor Inc Verfahren zur herstellung von 7-alpha-alkylierte 19-norsteroide
US8324277B2 (en) 2007-08-01 2012-12-04 University of Pittsburgh—of the Commonwealth System of Higher Education Nitrated-fatty acids modulation of type II diabetes
ES2692291T3 (es) 2008-05-01 2018-12-03 Complexa Inc. Ácidos grasos vinil sustituidos
EP2299997A4 (en) 2008-06-19 2012-01-11 Univ Utah Res Found USE OF NITRATED LIPIDS FOR THE TREATMENT OF SIDE EFFECTS OF TOXIC MEDICAL THERAPIES
US20140024713A1 (en) 2008-06-19 2014-01-23 University Of Utah Research Foundation Use of nitrated lipids for treatment of side effects of toxic medical therapies
CN102227441A (zh) * 2008-10-15 2011-10-26 斯索恩有限公司 制备氟维司群的方法和中间体
JP2013500966A (ja) 2009-07-31 2013-01-10 ユニバーシティー オブ ピッツバーグ − オブ ザ コモンウェルス システム オブ ハイヤー エデュケーション 抗炎症剤としての脂肪酸
EP2483233A4 (en) * 2009-10-02 2013-08-14 Complexa Inc HETEROATOMA CONTAINING SUBSTITUTED FATTY ACIDS
EP2744491B1 (en) 2011-08-19 2020-07-29 The University of Utah Research Foundation Combination therapy with nitrated lipids and inhibitors of the renin-angiotensin-aldosterone system
ES2971969T3 (es) 2015-07-07 2024-06-10 H Lundbeck As Inhibidores de PDE9 con cadena principal de imidazopirazinona para el tratamiento de enfermedades periféricas
KR20180098222A (ko) 2015-10-02 2018-09-03 컴플렉사, 인코포레이티드 활성화된 지방산의 치료학적 유효량을 이용한 질환의 예방, 치료 및 역행
MA52792A (fr) 2018-05-25 2021-04-14 Imara Inc Formes cristallines et monohydrate de 6- [(3s,4s)-4-méthyl-1-(pyrimidin-2-ylméthyl) pyrrolidin-3-yl]-3-tétrahydropyran-4-yl-7h-imidazo [1,5-a] pyrazin-8-one
KR20250108770A (ko) 2018-08-31 2025-07-15 카듀리온 파마슈티칼스, 인크. 겸상 세포 질환의 치료를 위한 pde9 억제제
WO2025195993A1 (en) 2024-03-18 2025-09-25 Minakem Process for the preparation of fulvestrant

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8327256D0 (en) * 1983-10-12 1983-11-16 Ici Plc Steroid derivatives
SE8705150D0 (sv) * 1987-12-23 1987-12-23 Haessle Ab Novel antiarrhythmic agents
US5552391A (en) * 1990-01-16 1996-09-03 La Jolla Pharmaceutical Company Chemically-defined non-polymeric valency platform molecules and conjugates thereof
DE4132182A1 (de) * 1991-09-24 1993-03-25 Schering Ag 11(beta)-substituierte 14, 17-ethanoestratriene, verfahren zur herstellung dieser verbindungen, sowie ihre verwendung zur herstellung von arzneimitteln
EP1228062B1 (en) * 1999-11-12 2004-04-28 Basf Aktiengesellschaft Herbicidal 2-aryloxy-6-fluoroalkylthioalk(en)yloxy-pyridines
GB0025221D0 (en) 2000-10-14 2000-11-29 Astrazeneca Ab New process

Also Published As

Publication number Publication date
KR100937916B1 (ko) 2010-01-21
KR20050033507A (ko) 2005-04-12
CA2462237C (en) 2012-07-03
GB0123961D0 (en) 2001-11-28
US20050033085A1 (en) 2005-02-10
IL161084A (en) 2011-06-30
HK1066786A1 (en) 2005-04-01
CN100522938C (zh) 2009-08-05
US7323602B2 (en) 2008-01-29
JP2005504845A (ja) 2005-02-17
NO331195B1 (no) 2011-10-31
WO2003031399A1 (en) 2003-04-17
AU2002329452B2 (en) 2009-03-12
EP1436256A1 (en) 2004-07-14
ES2368903T3 (es) 2011-11-23
MY139404A (en) 2009-09-30
IL161084A0 (en) 2004-08-31
BRPI0212982B1 (pt) 2017-09-12
CA2462237A1 (en) 2003-04-17
BR0212982A (pt) 2004-10-13
ATE519736T1 (de) 2011-08-15
EP1436256B1 (en) 2011-08-10
JP4346440B2 (ja) 2009-10-21
NO20041387L (no) 2004-03-31
MXPA04003020A (es) 2004-07-05
NZ531943A (en) 2006-09-29
CN1564812A (zh) 2005-01-12
SA02230410B1 (ar) 2009-01-31
ZA200402470B (en) 2005-02-23

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