AR036905A1 - Derivados del 3-azabiciclo[3.1.0]hexano, composiciones farmaceuticas que los contienen, su uso en un metodo para tratar un trastorno o afeccion en un mamifero, e intermediarios utiles para su sintesis - Google Patents
Derivados del 3-azabiciclo[3.1.0]hexano, composiciones farmaceuticas que los contienen, su uso en un metodo para tratar un trastorno o afeccion en un mamifero, e intermediarios utiles para su sintesisInfo
- Publication number
- AR036905A1 AR036905A1 ARP020103960A ARP020103960A AR036905A1 AR 036905 A1 AR036905 A1 AR 036905A1 AR P020103960 A ARP020103960 A AR P020103960A AR P020103960 A ARP020103960 A AR P020103960A AR 036905 A1 AR036905 A1 AR 036905A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- optionally
- cycloalkyl
- heterocycloalkyl
- halogen
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 41
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 6
- 229910052736 halogen Inorganic materials 0.000 abstract 5
- 125000001072 heteroaryl group Chemical group 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 229910052799 carbon Inorganic materials 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 4
- 150000002367 halogens Chemical class 0.000 abstract 4
- 229910052760 oxygen Inorganic materials 0.000 abstract 4
- 229910052717 sulfur Inorganic materials 0.000 abstract 4
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 2
- 125000006568 (C4-C7) heterocycloalkyl group Chemical group 0.000 abstract 2
- 125000006708 (C5-C14) heteroaryl group Chemical group 0.000 abstract 2
- 125000005915 C6-C14 aryl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 150000001721 carbon Chemical group 0.000 abstract 2
- MCTWTZJPVLRJOU-UHFFFAOYSA-N 1-methyl-1H-imidazole Chemical compound CN1C=CN=C1 MCTWTZJPVLRJOU-UHFFFAOYSA-N 0.000 abstract 1
- HGWUUOXXAIISDB-UHFFFAOYSA-N 3-azabicyclo[3.1.0]hexane Chemical compound C1NCC2CC21 HGWUUOXXAIISDB-UHFFFAOYSA-N 0.000 abstract 1
- 101100240521 Caenorhabditis elegans nhr-16 gene Proteins 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 208000030814 Eating disease Diseases 0.000 abstract 1
- 208000019454 Feeding and Eating disease Diseases 0.000 abstract 1
- 229940123257 Opioid receptor antagonist Drugs 0.000 abstract 1
- SYGWYBOJXOGMRU-UHFFFAOYSA-N chembl233051 Chemical compound C1=CC=C2C3=CC(C(N(CCN(C)C)C4=O)=O)=C5C4=CC=CC5=C3SC2=C1 SYGWYBOJXOGMRU-UHFFFAOYSA-N 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 235000014632 disordered eating Nutrition 0.000 abstract 1
- 206010013663 drug dependence Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 208000002551 irritable bowel syndrome Diseases 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 208000011117 substance-related disease Diseases 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/04—Compounds containing oxirane rings containing only hydrogen and carbon atoms in addition to the ring oxygen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Obesity (AREA)
- Otolaryngology (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Gynecology & Obstetrics (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Un compuesto derivado del 3-azabiciclo [3.1.0] hexano de fórmula (1), donde X es H, halógeno, -OH, -CN, -alquilo C1-4 sustituido con 1 a 3 átomos de halógeno ó -O(alquil C1-4), estando el alquilo C1-4 de -O(alquil C1-4) opcionalmente sustituido con 1 a 3 átomos de halógeno; Q es halógeno, -OH, -O-(alquil C1-4) -NH2, -NH(alquil C1-4), -N(alquil C1-4) (alquil C1-4), -C(=O)NH2, -C(=O)NH(alquil C1-4), -C(=O)N(alquil C1-4) (alquil C1-4), -NHS(=O)2H, ó -NHS(=O)2R11; ó Q puede formar un anillo cicloalquilo ó heterocicloalquilo de 5 ó 6 miembros con cualquier átomo de carbono adyacente al átomo de carbono al que está unido, formando así un sistema de anillo bicíclico condensado con el fenilo al que está unido, comprendiendo dicho heterocicloalquilo de 1 a 3 heterorestos seleccionados entre O, S, -C(=O) y N, y conteniendo opcionalmente dicho cicloalquilo o heterocicloalquilo 1 o 2 dobles enlaces; R1 y R2 están conectados, con el carbono al que están unidos, para formar un cicloalquilo C3-7 ó un heterocicloalquilo de 4-7 miembros que comprende de 1 a 3 heterorestos seleccionados entre O, S, -C(=O) y N; y en el que dicho cicloalquilo ó heterocicloalquilo contiene opcionalmente 1 ó 2 dobles enlaces; y estando dicho cicloalquilo ó heterocicloalquilo opcionalmente condensado con un grupo arilo C6-14 ó un heteroarilo de 5-14 miembros; en el que dicho cicloalquilo C3-7 ó el heterocicloalquilo de 4-7 miembros formado por R1 y R2 pueden cada uno opcionalmente estar sustituido con 1 a 3 grupos R12, y cada uno de dichos arilo o heteroarilo opcionalmente condensado pueden estar sustituidos opcional e independientemente con 1 a 6 grupos R12, seleccionándose los grupos R12 entre R13, R16, -alquilo C1-4 que contiene 1 ó 2 enlaces insaturados, halógeno, -OR13, -NO2-CN, -cicloalquilo C3-6, -NR13R14, -NR13C(=O)R14, -C(=O)NR13R14, -OC(=O)R13, -C(=O)OR13, -C(=O)R13, -NR13, -NR13C(=O)R14, -NR13C(=O)ONR14R15, -NR13S(=O)2R14 y -S(=O)2R13; R3 es alquilo C1-4, conteniendo opcionalmente dicho alquilo C1-4 uno o dos enlaces insaturados; R4 es -alquilo C1-4 que puede opcionalmente contener 1 ó 2 enlaces insaturados, -OH, -CN, NO2, -OR16, -NH2, NHR16, NHR16R17 ó -NHC(=O)R16; R5 y R6 son cada uno independientemente H ó metilo; R6, R7, R9 y R10 son H; R11 se selecciona entre alquilo C1-4, -(alquilen C1-4)-O-(alquil C1-4), 4-(1-metilimidazol), -(alquilen C1-4)-NH2, -(alquilen C1-4)-NH(alquil C1-4), -(alquilen C1-4)-N(alquil C1-4) (alquil C1-4); cada R13, R14 y R15 se selecciona independientemente entre H, R16, alquilo C1-4, halógeno, -OH, -SH, -NH2, -NH(alquil C1-4),-N(alquil C1-4) (alquil C1-4), -O(alquil C1-4), -S(alquil C1-4), -CN, -NO2, -C(=O) (alquil C1-4), -C(=O)OH, -C(=O)O(alquil C1-4), -NHC(=O) (alquil C1-4), -C(=O)NH2, y -C(=O)N(alquil C1-4) (alquil C1-4), ó R13 y R14 cuando en -NR13R14, pueden estar opcionalmente conectados para formar un grupo heterocicloalquilo o heteroarilo de 4 a 6 miembros, cuyo grupo heteroarilo opcionalmente comprende de 1 a 3 heterorestos adicionales seleccionados entre N, S, O y C(=O); cada R16 y R17 se selecciona independientemente entre arilo C6-14 y heteroarilo de 5-14 miembros, en el que dicho heteroarilo comprende de 1 a 3 heterorestos seleccionados entre O, S, -C(=O) y N, y estando dicho arilo y heteroarilo opcionalmente sustituidos con 1 a 3 sustituyentes seleccionados entre alquilo C1-4 que opcionalmente contiene 1 ó 2 enlaces insaturados, halógeno, -OH -SH, -NH2, -NH(alquil C1-4), -N(alquil C1-4) (alquil C1-4), -O(alquil C1-4), -S(alquil C1-4), -CN, -NO2, -C(=O) (alquil C1-4), -NHC(=O) (alquil C1-4), -C(=O)NH2, y -C(=O)N(alquil C1-4) (alquil C1-4); y n es un número entero seleccionado entre 1, 2, 3, 4 y 5; ó una sal farmacéuticamente aceptable de éste. Los compuestos de fórmula (1) tienen actividad como antagonistas del receptor de opioides. Además se describen composiciones farmacéuticas, procedimientos terapéuticos que comprenden los compuestos de fórmula (1) y compuestos intermediarios útiles para su síntesis. Estos compuestos son de aplicación para tratar trastornos y estados como colon irritable, dependencia ó adicción a drogas y depuración y también ciertos trastornos de la alimentación.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33851101P | 2001-10-22 | 2001-10-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR036905A1 true AR036905A1 (es) | 2004-10-13 |
Family
ID=23325099
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP020103960A AR036905A1 (es) | 2001-10-22 | 2002-10-21 | Derivados del 3-azabiciclo[3.1.0]hexano, composiciones farmaceuticas que los contienen, su uso en un metodo para tratar un trastorno o afeccion en un mamifero, e intermediarios utiles para su sintesis |
Country Status (41)
| Country | Link |
|---|---|
| US (3) | US7049335B2 (es) |
| EP (1) | EP1440059B1 (es) |
| JP (2) | JP4155522B2 (es) |
| KR (1) | KR100621292B1 (es) |
| CN (1) | CN100368398C (es) |
| AP (1) | AP1816A (es) |
| AR (1) | AR036905A1 (es) |
| AT (1) | ATE392415T1 (es) |
| AU (1) | AU2002329557B2 (es) |
| BR (1) | BR0213464A (es) |
| CA (1) | CA2463264C (es) |
| CR (1) | CR7317A (es) |
| DE (1) | DE60226161T2 (es) |
| DK (1) | DK1440059T3 (es) |
| EA (1) | EA006708B1 (es) |
| EC (1) | ECSP045077A (es) |
| ES (1) | ES2302839T3 (es) |
| GE (1) | GEP20084300B (es) |
| GT (1) | GT200200216A (es) |
| HN (1) | HN2002000299A (es) |
| HR (1) | HRP20040288A2 (es) |
| HU (1) | HUP0401884A2 (es) |
| IL (2) | IL161157A0 (es) |
| IS (1) | IS7187A (es) |
| MA (1) | MA27141A1 (es) |
| MX (1) | MXPA04003730A (es) |
| MY (1) | MY136580A (es) |
| NO (1) | NO329092B1 (es) |
| NZ (1) | NZ531807A (es) |
| OA (1) | OA12711A (es) |
| PA (1) | PA8556701A1 (es) |
| PE (1) | PE20030610A1 (es) |
| PL (1) | PL368919A1 (es) |
| PT (1) | PT1440059E (es) |
| RS (1) | RS25104A (es) |
| SI (1) | SI1440059T1 (es) |
| SV (1) | SV2004001363A (es) |
| TN (1) | TNSN04071A1 (es) |
| UA (1) | UA75714C2 (es) |
| WO (1) | WO2003035622A1 (es) |
| ZA (1) | ZA200402172B (es) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1598339T3 (da) | 2001-04-18 | 2009-09-28 | Euro Celtique Sa | 1-(4-amino-cyclohexyl)-1,3-dihydro-2H-benzimidazol-2-on derivater og beslægtede forbindelser som nociceptin analoger og ORL1-ligander til behandling af smerte |
| SI1440059T1 (sl) * | 2001-10-22 | 2008-08-31 | Pfizer Prod Inc | Derivati 3-azabiciklo(3.1.0)heksana kot antagonisti opioidnega receptorja |
| CA2522323C (en) * | 2003-04-14 | 2009-09-15 | Pfizer Products Inc. | 3-azabicyclo[3.2.1]octane derivatives as opioid receptor ligands |
| US20050043327A1 (en) * | 2003-08-21 | 2005-02-24 | Pfizer Inc | Pharmaceutical composition for the prevention and treatment of addiction in a mammal |
| US7153976B2 (en) * | 2003-10-06 | 2006-12-26 | Pfizer Inc. | Purification process for an azabicyclo[3.1.0]hexane compound |
| US7473787B2 (en) * | 2003-10-14 | 2009-01-06 | Pfizer Inc | Bicyclic [3.1.0] derivatives as glycine transporter inhibitors |
| MXPA06004278A (es) * | 2003-10-16 | 2006-06-28 | Pfizer Prod Inc | Preparacion de derivados de 3-azabiciclo [3.1.0]hexano. |
| BRPI0507945A (pt) | 2004-02-23 | 2007-07-24 | Glaxo Group Ltd | derivados de azabiciclo (3.1.0) hexano utilizáveis como moduladores de receptores d3 de dopamina |
| CA2558274A1 (en) * | 2004-03-05 | 2005-09-15 | Banyu Pharmaceutical Co., Ltd. | Cycloalkanopyridine derivative |
| US20080227803A1 (en) * | 2004-12-14 | 2008-09-18 | Shioonogi & Co., Ltd., A Legal Entity Of Japan | Indolomorphinan Derivative Having Carboxy in 6'-Position |
| GB0512099D0 (en) * | 2005-06-14 | 2005-07-20 | Glaxo Group Ltd | Compounds |
| GB0517191D0 (en) | 2005-08-22 | 2005-09-28 | Glaxo Group Ltd | Compounds |
| US7592461B2 (en) * | 2005-12-21 | 2009-09-22 | Bristol-Myers Squibb Company | Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof |
| MY145633A (en) | 2006-03-01 | 2012-03-15 | Theravance Inc | 8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists |
| WO2008075162A2 (en) * | 2006-12-15 | 2008-06-26 | Pfizer Limited | Selective mu opioid receptor antagonists for the treatment of female sexual dysfunction |
| TWI409067B (zh) | 2007-02-28 | 2013-09-21 | Theravance Inc | ８-氮雜雙環〔３．２．１〕辛烷化合物之結晶型 |
| ES2390195T3 (es) * | 2007-08-27 | 2012-11-07 | Theravance, Inc. | Compuestos de amidoalquil-8-azabiciclo(3,2,1)octano, como antagonistas del receptor opioide mu |
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| NZ242117A (en) | 1991-03-29 | 1994-11-25 | Lilly Co Eli | 4-phenylpiperidine derivatives and medicaments containing them |
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