AR036408A1 - Tieno[2,3-d]pirimidinas sustituidas con glicina con actividad agonista combinada de lh y fsh - Google Patents
Tieno[2,3-d]pirimidinas sustituidas con glicina con actividad agonista combinada de lh y fshInfo
- Publication number
- AR036408A1 AR036408A1 ARP020103310A ARP020103310A AR036408A1 AR 036408 A1 AR036408 A1 AR 036408A1 AR P020103310 A ARP020103310 A AR P020103310A AR P020103310 A ARP020103310 A AR P020103310A AR 036408 A1 AR036408 A1 AR 036408A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- hydroxy
- fsh
- glycine
- alkoxy
- Prior art date
Links
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical group NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 title abstract 3
- 239000004471 Glycine Substances 0.000 title abstract 2
- 239000000556 agonist Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 10
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 5
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- 108010011942 LH Receptors Proteins 0.000 abstract 1
- 230000003213 activating effect Effects 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- -1 cyano, amino Chemical group 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 230000035558 fertility Effects 0.000 abstract 1
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 102000014650 luteinizing hormone receptor activity proteins Human genes 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 150000003230 pyrimidines Chemical class 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
- A61P5/08—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH for decreasing, blocking or antagonising the activity of the anterior pituitary hormones
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Diabetes (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Derivados de tieno [2,3-d]pirimidinas sustituidas con glicina, de acuerdo con la fórmula general (1) o una sal farmacéuticamente aceptable de los mismos, donde X es O o H, H; A es S, NH, N(R6), O o un enlace; R1 es (1-4C)alquilo, (2-4C)alquenilo, fenilo o (2-5C)heteroarilo, estando el anillo de fenilo o heteroarilo opcionalmente sustituido con uno o más del grupo de sustituyentes: hidroxilo, halógeno, nitro, trifluorometilo, ciano, amino o (1-4C)(dialquilamino; R2 es H, (1-4C)alquilo, (1-4C)alcoxi(2-4)alquilo o hidroxi (2-4C)alquilo, (1-4C)alcoxi(2-4C)alquilo o hidroxi(2-4C)alquilo, (C1-4)alcoxi(C2-4)alquilo o hidroxi (C2-4)alquilo; R3 y R4 pueden seleccionarse independientemente entre H e hidroxi (1-4C)alquilo; R5 es H o (1-4)alquilo; y R6 puede seleccionarse entre los mismos grupos descritos para R1. Los compuestos tienen actividad activadora del receptor de LH y también de FSH, y pueden usarse en terapias reguladoras de la fertilidad.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01203328 | 2001-09-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR036408A1 true AR036408A1 (es) | 2004-09-08 |
Family
ID=8180877
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP020103310A AR036408A1 (es) | 2001-09-04 | 2002-09-02 | Tieno[2,3-d]pirimidinas sustituidas con glicina con actividad agonista combinada de lh y fsh |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US7375109B2 (es) |
| EP (1) | EP1427734B1 (es) |
| JP (1) | JP4263094B2 (es) |
| KR (1) | KR100891630B1 (es) |
| CN (1) | CN1261437C (es) |
| AR (1) | AR036408A1 (es) |
| AT (1) | ATE309251T1 (es) |
| AU (1) | AU2002333750B2 (es) |
| BR (1) | BR0212173A (es) |
| CA (1) | CA2457212C (es) |
| CY (1) | CY1106052T1 (es) |
| DE (1) | DE60207280T2 (es) |
| DK (1) | DK1427734T3 (es) |
| EC (1) | ECSP044990A (es) |
| ES (1) | ES2252540T3 (es) |
| HR (1) | HRP20040194A2 (es) |
| HU (1) | HUP0401443A3 (es) |
| IL (2) | IL160194A0 (es) |
| IS (1) | IS2419B (es) |
| MX (1) | MXPA04002046A (es) |
| NO (1) | NO328792B1 (es) |
| NZ (1) | NZ531375A (es) |
| PE (1) | PE20030467A1 (es) |
| PL (1) | PL368388A1 (es) |
| RU (1) | RU2294331C2 (es) |
| WO (1) | WO2003020727A1 (es) |
| ZA (1) | ZA200401459B (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6890923B2 (en) * | 2002-12-16 | 2005-05-10 | Astrazeneca Ab | Compounds |
| KR100666484B1 (ko) * | 2005-02-04 | 2007-01-09 | 삼성전자주식회사 | 반도체 메모리 장치의 입출력 회로 및 입출력 방법 |
| WO2010047674A1 (en) | 2008-10-20 | 2010-04-29 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Low molecular weight thyroid stimulating hormone receptor (tshr) agonists |
| CN101762915B (zh) * | 2008-12-24 | 2013-04-17 | 北京京东方光电科技有限公司 | Tft-lcd阵列基板及其驱动方法 |
| CA2789818A1 (en) | 2010-04-08 | 2011-10-13 | The United States Of America, As Represented By The Secretary, Departmen T Of Health And Human Services | Inverse agonists and neutral antagonists for the tsh receptor |
| EP3415517B1 (en) | 2012-09-28 | 2022-04-20 | Takeda Pharmaceutical Company Limited | Crystalline form of 1-(4-1-(2,6-difluorobenzyl)-5-dimethylaminomethyl-3-(6-methoxypyridazin-3-yl)-2,4-dioxo-1,2,3,4-tetrahydrothieno(2,3-d)-pyrimidin-6yl)phenyl)-3-methoxyurea |
| JP2022551316A (ja) | 2019-10-10 | 2022-12-08 | ミオバント サイエンシズ ゲーエムベーハー | Ｎ－（４－（１－（２，６－ジフルオロベンジル）－５－（（ジメチルアミノ）メチル）－３－（６－メトキシ－３－ピリダジニル）－２，４－ジオキソ－１，２，３，４－テトラヒドロチエノ［２，３－ｄ］ピリミジン－６－イル）フェニル）－Ｎ’－メトキシ尿素の結晶形 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2054784T3 (es) | 1987-08-08 | 1994-08-16 | Akzo Nv | Un metodo para la fabricacion de un implante. |
| DE19632423A1 (de) * | 1996-08-12 | 1998-02-19 | Merck Patent Gmbh | Thienopyrimidine |
| TW564247B (en) * | 1999-04-08 | 2003-12-01 | Akzo Nobel Nv | Bicyclic heteraromatic compound |
-
2002
- 2002-08-29 HR HR20040194A patent/HRP20040194A2/hr not_active Application Discontinuation
- 2002-08-29 PL PL02368388A patent/PL368388A1/xx not_active Application Discontinuation
- 2002-08-29 CA CA2457212A patent/CA2457212C/en not_active Expired - Fee Related
- 2002-08-29 HU HU0401443A patent/HUP0401443A3/hu unknown
- 2002-08-29 DK DK02797646T patent/DK1427734T3/da active
- 2002-08-29 KR KR1020047003096A patent/KR100891630B1/ko not_active Expired - Fee Related
- 2002-08-29 DE DE60207280T patent/DE60207280T2/de not_active Expired - Lifetime
- 2002-08-29 AU AU2002333750A patent/AU2002333750B2/en not_active Ceased
- 2002-08-29 ES ES02797646T patent/ES2252540T3/es not_active Expired - Lifetime
- 2002-08-29 WO PCT/EP2002/009648 patent/WO2003020727A1/en not_active Ceased
- 2002-08-29 BR BR0212173-5A patent/BR0212173A/pt not_active IP Right Cessation
- 2002-08-29 MX MXPA04002046A patent/MXPA04002046A/es active IP Right Grant
- 2002-08-29 NZ NZ531375A patent/NZ531375A/en not_active IP Right Cessation
- 2002-08-29 AT AT02797646T patent/ATE309251T1/de not_active IP Right Cessation
- 2002-08-29 JP JP2003524997A patent/JP4263094B2/ja not_active Expired - Fee Related
- 2002-08-29 EP EP02797646A patent/EP1427734B1/en not_active Expired - Lifetime
- 2002-08-29 IL IL16019402A patent/IL160194A0/xx unknown
- 2002-08-29 RU RU2004110036/04A patent/RU2294331C2/ru not_active IP Right Cessation
- 2002-08-29 US US10/488,483 patent/US7375109B2/en not_active Expired - Lifetime
- 2002-08-29 CN CNB02817240XA patent/CN1261437C/zh not_active Expired - Fee Related
- 2002-09-02 AR ARP020103310A patent/AR036408A1/es unknown
- 2002-09-03 PE PE2002000839A patent/PE20030467A1/es not_active Application Discontinuation
-
2004
- 2004-02-03 IL IL160194A patent/IL160194A/en not_active IP Right Cessation
- 2004-02-13 IS IS7152A patent/IS2419B/is unknown
- 2004-02-23 ZA ZA200401459A patent/ZA200401459B/en unknown
- 2004-02-26 EC EC2004004990A patent/ECSP044990A/es unknown
- 2004-03-03 NO NO20040922A patent/NO328792B1/no not_active IP Right Cessation
-
2005
- 2005-12-22 CY CY20051101587T patent/CY1106052T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |