AR036192A1 - Peptidos antibioticos con actividad antimicrobiana de amplio espectro y composiciones que los contienen - Google Patents
Peptidos antibioticos con actividad antimicrobiana de amplio espectro y composiciones que los contienenInfo
- Publication number
- AR036192A1 AR036192A1 ARP020102793A ARP020102793A AR036192A1 AR 036192 A1 AR036192 A1 AR 036192A1 AR P020102793 A ARP020102793 A AR P020102793A AR P020102793 A ARP020102793 A AR P020102793A AR 036192 A1 AR036192 A1 AR 036192A1
- Authority
- AR
- Argentina
- Prior art keywords
- amino acid
- hydrophilic
- xaa5
- xaa1
- xaa4
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 5
- 239000000203 mixture Substances 0.000 title abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
- 230000000845 anti-microbial effect Effects 0.000 title abstract 2
- 230000003115 biocidal effect Effects 0.000 title abstract 2
- 238000001228 spectrum Methods 0.000 title 1
- 150000001413 amino acids Chemical group 0.000 abstract 12
- 230000002209 hydrophobic effect Effects 0.000 abstract 4
- 230000007935 neutral effect Effects 0.000 abstract 4
- 102000044503 Antimicrobial Peptides Human genes 0.000 abstract 1
- 108700042778 Antimicrobial Peptides Proteins 0.000 abstract 1
- QEYJFBMTSMLPKZ-ZKWXMUAHSA-N Asn-Ala-Val Chemical compound [H]N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(O)=O QEYJFBMTSMLPKZ-ZKWXMUAHSA-N 0.000 abstract 1
- XINDHUAGVGCNSF-QSFUFRPTSA-N His-Ala-Ile Chemical compound [H]N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(O)=O XINDHUAGVGCNSF-QSFUFRPTSA-N 0.000 abstract 1
- OMHLATXVNQSALM-FQUUOJAGSA-N Leu-Ile-Pro Chemical compound CC[C@H](C)[C@@H](C(=O)N1CCC[C@@H]1C(=O)O)NC(=O)[C@H](CC(C)C)N OMHLATXVNQSALM-FQUUOJAGSA-N 0.000 abstract 1
- YCCUXNNKXDGMAM-KKUMJFAQSA-N Phe-Leu-Ser Chemical compound [H]N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(O)=O YCCUXNNKXDGMAM-KKUMJFAQSA-N 0.000 abstract 1
- 244000052769 pathogen Species 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43595—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from coelenteratae, e.g. medusae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
La presente se refiere a péptidos antimicrobianos que tienen una misma secuencia de aminoácidos o una secuencia funcionalmente equivalente y por lo menos la misma actividad antimicrobiana que el péptido definido por la fórmula: Phe Leu Ser Leu Ile Pro His Ala Ile Asn Ala Val Ser Xaa1 Xaa2 Xaa3 Xaa4 His Xaa5, en donde Xaa1, Xaa2, Xaa3, Xaa4 y Xaa5 representan cada uno, independientemente, un aminoácido hidrofóbico, un aminoácido básico hidrofílico o un aminoácido hidrofílico neutro, con la condición de que (i) cuando Xaa1, Xaa2 y Xaa3 son aminoácidos hidrofóbicos, Xaa4 es un aminoácido básico hidrofílico y Xaa5 es un aminoácido neutro hidrofílico; (ii) cuando Xaa2, Xaa3 y Xaa5 son aminoácidos hidrofóbicos, Xaa1 es un aminoácido hidrofóbico o un aminoácido neutro hidrofílico y Xaa4 es un aminoácido básico hidrofílico o un aminoácido neutro hidrofílico. Estos péptidos pueden ser usados en composiciones para retardar fitopatógenos y para proteger las plantas de patógenos, comprendiendo por lo menos un péptido antibiótico y un vehículo agronómicamente aceptable. Otra materialización de la presente provee composiciones terapéuticas, que incluyen uno o más péptidos revelados en la presente y un vehículo farmacológico adecuado.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BRPI0104510A BRPI0104510B8 (pt) | 2001-07-27 | 2001-07-27 | peptídeos antibióticos da família das phylloseptinas isolados da secreção da pele de phylloseptina hypocondrialis e composição antimicrobiana relacionada |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR036192A1 true AR036192A1 (es) | 2004-08-18 |
Family
ID=38080824
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP020102793A AR036192A1 (es) | 2001-07-27 | 2002-07-24 | Peptidos antibioticos con actividad antimicrobiana de amplio espectro y composiciones que los contienen |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7371720B2 (es) |
| EP (1) | EP1412380B1 (es) |
| JP (2) | JP4349903B2 (es) |
| AR (1) | AR036192A1 (es) |
| AU (1) | AU2002317638B2 (es) |
| BR (1) | BRPI0104510B8 (es) |
| CA (1) | CA2453112C (es) |
| MX (1) | MXPA04000806A (es) |
| WO (1) | WO2003010191A1 (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5590770B2 (ja) * | 2004-09-30 | 2014-09-17 | コーニンクレッカ フィリップス エヌ ヴェ | 異なる抽出レベルにより臨床ガイドラインをナビゲートする臨床ガイドライン用の意思決定支援システム |
| JP2008521825A (ja) | 2004-11-29 | 2008-06-26 | バーテックス ファーマシューティカルズ インコーポレイテッド | ムスカリン受容体のモジュレーター |
| WO2007041052A2 (en) | 2005-09-29 | 2007-04-12 | Merck & Co., Inc. | Acylated spiropiperidine derivatives as melanocortin-4 receptor modulators |
| WO2008039327A2 (en) | 2006-09-22 | 2008-04-03 | Merck & Co., Inc. | Method of treatment using fatty acid synthesis inhibitors |
| JP5319518B2 (ja) | 2007-04-02 | 2013-10-16 | Ｍｓｄ株式会社 | インドールジオン誘導体 |
| CA2741644C (en) | 2008-10-30 | 2013-05-07 | Merck Sharp & Dohme Corp. | Isonicotinamide orexin receptor antagonists |
| GB0821687D0 (en) | 2008-11-28 | 2008-12-31 | Secr Defence | Peptides |
| FR2954136B1 (fr) * | 2009-12-17 | 2012-04-20 | Oreal | Composition deodorante a base de peptides antimicrobiens et procede de traitement des odeurs corporelles |
| FR2954137B1 (fr) * | 2009-12-17 | 2012-04-20 | Oreal | Utilisation de peptides comme agents antipelliculaires |
| CN102250216B (zh) * | 2011-06-27 | 2013-03-06 | 昆明理工大学 | 黑斑蛙抗微生物肽及其基因和应用 |
| AR088352A1 (es) | 2011-10-19 | 2014-05-28 | Merck Sharp & Dohme | Antagonistas del receptor de 2-piridiloxi-4-nitrilo orexina |
| CN106397568B (zh) * | 2016-12-02 | 2019-10-01 | 河南牧翔动物药业有限公司 | 一种抗菌肽Dermaseptin-M及其应用 |
| US11174288B2 (en) | 2016-12-06 | 2021-11-16 | Northeastern University | Heparin-binding cationic peptide self-assembling peptide amphiphiles useful against drug-resistant bacteria |
| CN109601437B (zh) * | 2019-01-25 | 2021-06-15 | 淮海工学院 | 泥鳅粘液胁迫分泌并收集的方法 |
| US12331018B2 (en) | 2019-02-13 | 2025-06-17 | Merck Sharp & Dohme Llc | Pyrrolidine orexin receptor agonists |
| WO2020167706A1 (en) | 2019-02-13 | 2020-08-20 | Merck Sharp & Dohme Corp. | 5-alkyl pyrrolidine orexin receptor agonists |
| WO2021026047A1 (en) | 2019-08-08 | 2021-02-11 | Merck Sharp & Dohme Corp. | Heteroaryl pyrrolidine and piperidine orexin receptor agonists |
| CN110606869B (zh) * | 2019-10-12 | 2022-06-07 | 广州市乾相生物科技有限公司 | 一种促皮肤愈合肽oa-gp11及其制备方法与应用 |
| CA3189908A1 (en) | 2020-08-18 | 2022-02-24 | Stephane L. Bogen | Bicycloheptane pyrrolidine orexin receptor agonists |
| CN115974980B (zh) * | 2023-01-19 | 2025-08-12 | 陕西师范大学 | 一种多功能小鲵皮肤肽tsin4及其应用 |
-
2001
- 2001-07-27 BR BRPI0104510A patent/BRPI0104510B8/pt not_active IP Right Cessation
-
2002
- 2002-07-24 AR ARP020102793A patent/AR036192A1/es not_active Application Discontinuation
- 2002-07-26 AU AU2002317638A patent/AU2002317638B2/en not_active Expired
- 2002-07-26 JP JP2003515550A patent/JP4349903B2/ja not_active Expired - Lifetime
- 2002-07-26 MX MXPA04000806A patent/MXPA04000806A/es active IP Right Grant
- 2002-07-26 WO PCT/BR2002/000104 patent/WO2003010191A1/en not_active Ceased
- 2002-07-26 CA CA2453112A patent/CA2453112C/en not_active Expired - Lifetime
- 2002-07-26 EP EP02747113A patent/EP1412380B1/en not_active Expired - Lifetime
- 2002-07-26 US US10/484,837 patent/US7371720B2/en not_active Expired - Lifetime
-
2009
- 2009-03-30 JP JP2009082410A patent/JP2009185039A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US7371720B2 (en) | 2008-05-13 |
| JP2009185039A (ja) | 2009-08-20 |
| JP2005508878A (ja) | 2005-04-07 |
| MXPA04000806A (es) | 2005-06-06 |
| WO2003010191A1 (en) | 2003-02-06 |
| AU2002317638B2 (en) | 2008-05-22 |
| US20040242488A1 (en) | 2004-12-02 |
| CA2453112C (en) | 2010-09-07 |
| CA2453112A1 (en) | 2003-02-06 |
| JP4349903B2 (ja) | 2009-10-21 |
| BRPI0104510B1 (pt) | 2017-03-07 |
| BR0104510A (pt) | 2004-02-17 |
| EP1412380B1 (en) | 2007-07-04 |
| EP1412380A1 (en) | 2004-04-28 |
| BRPI0104510B8 (pt) | 2021-05-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR036192A1 (es) | Peptidos antibioticos con actividad antimicrobiana de amplio espectro y composiciones que los contienen | |
| ES2155518T3 (es) | Compuestos antimicrobianos de amplio espectro y metodo de uso. | |
| ATE332922T1 (de) | Antimikrobiell wirkendes peptid | |
| ES2163444T3 (es) | Composiciones y metodos para la administracion oral de farmacos. | |
| WO1992001462A1 (en) | Amphiphilic peptide compositions and analogues thereof | |
| BRPI0514420A (pt) | peptìdeo, variante do mesmo, ou um sal farmaceuticamente aceitável do mesmo, composição, uso de um peptìdeo ou de uma variante de peptìdeo, substrato, e, métodos de tratamento ou prevenção de um infecção microbiana, e de tratamento de uma ferida em um indivìduo | |
| AU4837300A (en) | Antimicrobial theta defensins and methods of using same | |
| AR030278A1 (es) | Peptido modulador del receptor de trombopoyetina | |
| US5235038A (en) | Deletion and substitution analogues of melittin peptide | |
| Potera | From bacteria: a new weapon against fungal infection | |
| JP6124139B2 (ja) | 低赤血球溶解性の抗微生物ペプチド、医薬組成物およびその使用 | |
| TWI403330B (zh) | 低血球溶解性之抗微生物胜肽、醫藥組成物及其用途 | |
| MY147920A (en) | Antibacterial and antiviral peptides from actinomadura namibiensis | |
| WO1997002287A1 (en) | Parevins and tachytegrins | |
| ES2002915A6 (es) | Un procedimiento para la preparacion de un peptido de veneno de serpiente que detiene el crecimiento. | |
| CA2217679A1 (en) | Peptides and therapeutic agent for autoimmune diseases containing the same | |
| WO2008079314A3 (en) | Novel anti-microbial peptidomimetic compounds and methods to calculate anti-microbial activity | |
| ES2199098T1 (es) | Metodo para la extraccion y uso de peptidos que son activos como antibioticos para tratar enfermedades infecciosas. | |
| EP0455719A4 (en) | Composition and treatment with peptide combinations | |
| AU714294C (en) | Parevins and tachytegrins | |
| IE32565L (en) | Cyclopeptides | |
| AU2002255562A1 (en) | Virus derived antimicrobial peptides | |
| WO2022136442A3 (en) | Compositions comprising cyclotides and other insecticidal peptides and uses thereof | |
| Güell Costa et al. | Design, synthesis and biological evaluation of cyclic peptidotriazoles derived from BPC194 as novel agents for plant protection | |
| AR045992A1 (es) | Compuestos lipopeptidicos |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure | ||
| FC | Refusal |