AR036086A1 - Compuestos de {[ 2- morfonil-4-il]-2-oxoetil}-(2-oxopirrolidinil 3-il)naftalen-2-sulfonamida, composiciones farmaceuticas formuladas con dichos compuestos; uso de dichos compuestos en la manufactura de medicamentos para el tratamiento de condiciones susceptibles de mejoramiento mediante la inhibicio - Google Patents
Compuestos de {[ 2- morfonil-4-il]-2-oxoetil}-(2-oxopirrolidinil 3-il)naftalen-2-sulfonamida, composiciones farmaceuticas formuladas con dichos compuestos; uso de dichos compuestos en la manufactura de medicamentos para el tratamiento de condiciones susceptibles de mejoramiento mediante la inhibicioInfo
- Publication number
- AR036086A1 AR036086A1 ARP020102128A ARP020102128A AR036086A1 AR 036086 A1 AR036086 A1 AR 036086A1 AR P020102128 A ARP020102128 A AR P020102128A AR P020102128 A ARP020102128 A AR P020102128A AR 036086 A1 AR036086 A1 AR 036086A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- compounds
- group
- 3alkyl
- phenyl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 239000003814 drug Substances 0.000 title 1
- 230000005764 inhibitory process Effects 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 229940124530 sulfonamide Drugs 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 125000001424 substituent group Chemical group 0.000 abstract 7
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 6
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 6
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 5
- 125000006615 aromatic heterocyclic group Chemical group 0.000 abstract 5
- 229910052736 halogen Inorganic materials 0.000 abstract 5
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 4
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 4
- 150000002367 halogens Chemical class 0.000 abstract 4
- 125000005842 heteroatom Chemical group 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 229910052757 nitrogen Inorganic materials 0.000 abstract 4
- 229910052760 oxygen Inorganic materials 0.000 abstract 4
- 229910052717 sulfur Inorganic materials 0.000 abstract 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
- 125000002947 alkylene group Chemical group 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000006274 (C1-C3)alkoxy group Chemical group 0.000 abstract 1
- 108010074860 Factor Xa Proteins 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004450 alkenylene group Chemical group 0.000 abstract 1
- MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000002619 bicyclic group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Se describen y reivindican compuestos que posee propiedades inhibitorias del factor Xa de fórmula (1) donde R1 representa hidrógeno, -alquilo C1-6, alquenilo C3-6, -(alquil C2-3)NRbRc, -(alquil C2-3)NHCORb, fenilo o un grupo heterocíclico aromático de 5 o 6 miembros, estando el fenilo o el grupo heterocíclico aromático de 5 o 6 miembros opcionalmente sustituidos con halógeno, o R1 representa un grupo X-W, en el que X representa alquileno C1-3 y W representa -CN, -CO2H, -CONRbRc, -COalquilo C1-6, -CO2alquilo C1-6, fenilo o un grupo heterocíclico aromático o no aromático de 5 o 6 miembros que contiene al menos un heteroátomo seleccionado entre O, N o S, estando el fenilo o el grupo heterocíclico aromático opcionalmente sustituido con uno o más sustituyentes seleccionados entre: alquilo C1-3, -alcoxi C1-3, (alquil C1-3)OH, halógeno, -CN, -CF3, NH2, -CO2H y -OH; R2 y R3 representan independientemente hidrógeno, -alquilo C1-3 o -CF3 con la condición de que uno de R2 y R3 es alquilo- C1-3 o CF3 y el otro es hidrógeno; Rb y Rc representan independientemente hidrógeno o -alquilo C1-3; A representa un grupo seleccionado entre: el grupo de fórmulas (2); Z representa uno o dos sustituyentes opcionales seleccionados independientemente entre halógeno y OH, W representa un sustituyente opcional -alquilo C1-3, Alq representa alquileno C2-3 o alquenileno C2-3, T representa un heteroátomo seleccionado entre O, N o S; B representa uno o más sustituyentes opcionales sobre los átomos de carbono del anillo seleccionados entre (1) uno o más sustituyentes seleccionados entre -CF3, -F, -CO2H, -alquilo C1-6, -(alquil C1-6)OH, -(alquil C1-3)NRbRc y -(alquil C0-3)CONRbRc y -(alquil C0-3) CO2alquiloC1-3, -CONH(alquil C2-3)OH, -CH2NH(alquil C2-3)OH, -CH2Oalquilo C1-3 y -CH2SO2alquilo C1-3; (2) un grupo -Y -Re, Y representa -alquileno C1-3-, -CO-, -(alquil C1-3)NH-, -(alquil C1-3)NHCO-, -(alquil C1-3)NHSO2-, -CH2NHSO2CH2- o un enlace directo, Re representa fenilo, un cicloalquilo de 5 a 6i miembros o un heterociclo de 5 o 6 miembros que contiene al menos un heteroátomo seleccionado entre O, N o S, cada uno de los cuales está opcionalmente sustituido con uno o más sustituyentes seleccionados entre: -alquilo C1-3, -alcoxi C1-3, -(alquil C1-3)OH, halógeno, -CN, CF3, -NH2, -CO2H y -OH, o (3) un segundo anillo R1 que está condensado con el anillo heterocíclico en el que R1 representa fenilo, un grupo cicloalquilo de 5 o 6 miembros o un grupo heterocíclico aromático de 5 o 6 miembros que contiene al menos un heteroátomo seleccionado entre O, N o S, y el grupo bicíclico condensado está opcionalmente sustituido con uno o más sustituyentes seleccionados entre: -alquilo C1-3, -alcoxi C1-3, -(alquil C1-3)OH, halógeno, -CN, -CF3, -NH2, -CO2H y -OH, y sus derivados farmacéuticamente aceptables. Se describen y reivindican los objetos restantes mencionados en el título.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0114005.2A GB0114005D0 (en) | 2001-06-08 | 2001-06-08 | Chemical compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR036086A1 true AR036086A1 (es) | 2004-08-11 |
Family
ID=9916209
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP020102128A AR036086A1 (es) | 2001-06-08 | 2002-06-06 | Compuestos de {[ 2- morfonil-4-il]-2-oxoetil}-(2-oxopirrolidinil 3-il)naftalen-2-sulfonamida, composiciones farmaceuticas formuladas con dichos compuestos; uso de dichos compuestos en la manufactura de medicamentos para el tratamiento de condiciones susceptibles de mejoramiento mediante la inhibicio |
Country Status (28)
| Country | Link |
|---|---|
| US (4) | US7186717B2 (es) |
| EP (1) | EP1395553B1 (es) |
| JP (1) | JP4242274B2 (es) |
| KR (1) | KR100877245B1 (es) |
| CN (1) | CN1256324C (es) |
| AR (1) | AR036086A1 (es) |
| AT (1) | ATE289294T1 (es) |
| AU (1) | AU2002311451B2 (es) |
| BR (1) | BR0210207A (es) |
| CA (1) | CA2449629A1 (es) |
| CO (1) | CO5540285A2 (es) |
| CZ (1) | CZ20033325A3 (es) |
| DE (1) | DE60203006T2 (es) |
| DK (1) | DK1395553T3 (es) |
| ES (1) | ES2235050T3 (es) |
| GB (1) | GB0114005D0 (es) |
| HU (1) | HUP0400156A3 (es) |
| IL (1) | IL159195A0 (es) |
| MX (1) | MXPA03011384A (es) |
| MY (1) | MY136859A (es) |
| NO (1) | NO326689B1 (es) |
| NZ (1) | NZ530004A (es) |
| PL (1) | PL368082A1 (es) |
| PT (1) | PT1395553E (es) |
| SI (1) | SI1395553T1 (es) |
| TW (1) | TWI298719B (es) |
| WO (1) | WO2002100830A1 (es) |
| ZA (1) | ZA200309367B (es) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0114005D0 (en) * | 2001-06-08 | 2001-08-01 | Glaxo Group Ltd | Chemical compounds |
| GB0130705D0 (en) * | 2001-12-21 | 2002-02-06 | Glaxo Group Ltd | Chemical compounds |
| GB0228533D0 (en) * | 2002-12-06 | 2003-01-15 | Glaxo Group Ltd | Crystalline form |
| GB0228552D0 (en) * | 2002-12-06 | 2003-01-15 | Glaxo Group Ltd | Chemical compounds |
| US20050119266A1 (en) * | 2003-10-01 | 2005-06-02 | Yan Shi | Pyrrolidine and piperidine derivatives as factor Xa inhibitors |
| PL1637141T3 (pl) * | 2004-09-21 | 2012-04-30 | Trobio Ab | Stabilizowana kompozycja proteazy zawierająca proteazę serynową, pochodne morfoliny i odwracalne inhibitory tej proteazy serynowej |
| AU2005299693B2 (en) * | 2004-10-26 | 2012-07-05 | Janssen Pharmaceutica, N.V. | Factor Xa compounds |
| WO2006110726A2 (en) * | 2005-04-11 | 2006-10-19 | Glaxo Group Limited | Dosage formulations and methods of treatment and prevention |
| CN102380100A (zh) * | 2005-09-22 | 2012-03-21 | 特罗比奥股份公司 | 稳定的蛋白酶组合物 |
| JP5080476B2 (ja) * | 2005-09-22 | 2012-11-21 | トルービオ・アーベー | 安定化プロテアーゼ組成物 |
| DE102007028406A1 (de) | 2007-06-20 | 2008-12-24 | Bayer Healthcare Ag | Substituierte Oxazolidinone und ihre Verwendung |
| DE102007028319A1 (de) | 2007-06-20 | 2008-12-24 | Bayer Healthcare Ag | Substituierte Oxazolidinone und ihre Verwendung |
| DE102007028407A1 (de) | 2007-06-20 | 2008-12-24 | Bayer Healthcare Ag | Substituierte Oxazolidinone und ihre Verwendung |
| TWI615390B (zh) * | 2013-04-26 | 2018-02-21 | 賽諾菲公司 | ５－氯－噻吩－２－羧酸［（ｓ）－２－［甲基－３－（２－側氧基－吡咯啶－１－基）－苯磺醯基胺基］－３－（４－甲基－哌嗪－１－基）－３－側氧基－丙基］－醯胺之酒石酸鹽 |
| DE102014108210A1 (de) | 2014-06-11 | 2015-12-17 | Dietrich Gulba | Rodentizid |
| EP3078378B1 (en) | 2015-04-08 | 2020-06-24 | Vaiomer | Use of factor xa inhibitors for regulating glycemia |
| EP4070658A1 (de) | 2021-04-06 | 2022-10-12 | BIORoxx GmbH | Verwendung von blutgerinnungshemmenden verbindungen als rodentizide |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL92011A0 (en) | 1988-10-19 | 1990-07-12 | Abbott Lab | Heterocyclic peptide renin inhibitors |
| DE4035961A1 (de) * | 1990-11-02 | 1992-05-07 | Thomae Gmbh Dr K | Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| DE4121947A1 (de) * | 1991-07-03 | 1993-01-07 | Basf Ag | 2-(3-(4-amidino-phenyl))-propionsaeurederivate, ihre herstellung und verwendung |
| US5703208A (en) * | 1994-06-17 | 1997-12-30 | Corvas International, Inc. | 3-amino-2-oxo-1-piperidineacetic derivatives as enzyme inhibitors |
| WO1998016523A2 (en) | 1996-10-11 | 1998-04-23 | Cor Therapeutics, Inc. | Selective factor xa inhibitors |
| BR9713921A (pt) | 1996-12-13 | 2000-03-21 | Rhone Poulenc Rorer Pharma | Composto, composição farmacêutica, processo para tógico capaz de ser modulado através da inibição do fator xa |
| US6281227B1 (en) | 1996-12-13 | 2001-08-28 | Aventis Pharma Deutschland Gmbh | Sulfonic acid sulfonylamino n-(heteroaralkyl)-azaheterocyclylamide compounds |
| US6602864B1 (en) | 1996-12-13 | 2003-08-05 | Aventis Pharma Deutschland Gmbh | Sulfonic acid or sulfonylamino N-(heteroaralkyl)-azaheterocyclylamide compounds |
| US6187797B1 (en) * | 1996-12-23 | 2001-02-13 | Dupont Pharmaceuticals Company | Phenyl-isoxazoles as factor XA Inhibitors |
| IL123986A (en) | 1997-04-24 | 2011-10-31 | Organon Nv | Medicinal compounds |
| ID23991A (id) * | 1997-09-30 | 2000-06-14 | Daiichi Seiyaku Co | Turunan-turunan sulfonil |
| BR9907300A (pt) | 1998-01-27 | 2000-10-24 | Aventis Pharm Prod Inc | Inibidores do fator xa oxoaza-heterociclila substituìdos |
| CN1298430A (zh) | 1998-04-22 | 2001-06-06 | 昭和电工株式会社 | 表面被均匀氟化的粒状金属氧化物及其制造方法和用途 |
| AU1926700A (en) | 1998-12-31 | 2000-07-24 | Aventis Pharmaceuticals Inc. | 3-(thio-substituted amido)-lactams useful as inhibitors of matrix metalloproteinase |
| EP1175405A4 (en) | 1999-02-09 | 2002-05-15 | Bristol Myers Squibb Co | LACTAM INHIBITORS OF FACTOR Xa AND ASSOCIATED METHOD |
| KR20020004971A (ko) * | 1999-03-16 | 2002-01-16 | 이경하 | 치환 프로린 유도체 및 이들을 함유하고 있는 의약 조성물 |
| WO2000069465A1 (en) | 1999-05-12 | 2000-11-23 | Ono Pharmaceutical Co., Ltd. | Anticancer agents containing ep1 antagonists as the active ingredient |
| SK1182002A3 (en) | 1999-07-28 | 2002-11-06 | Aventis Pharm Prod Inc | Substituted oxoazaheterocyclyl compounds |
| EP1358178A2 (en) | 2001-01-30 | 2003-11-05 | Bristol-Myers Squibb Company | Sulfonamide lactam inhibitors of factor xa |
| GB0114005D0 (en) * | 2001-06-08 | 2001-08-01 | Glaxo Group Ltd | Chemical compounds |
| GB0114004D0 (en) * | 2001-06-08 | 2001-08-01 | Glaxo Group Ltd | Chemical compounds |
| GB0228552D0 (en) * | 2002-12-06 | 2003-01-15 | Glaxo Group Ltd | Chemical compounds |
| GB0228533D0 (en) * | 2002-12-06 | 2003-01-15 | Glaxo Group Ltd | Crystalline form |
-
2001
- 2001-06-08 GB GBGB0114005.2A patent/GB0114005D0/en not_active Ceased
-
2002
- 2002-06-06 BR BR0210207-2A patent/BR0210207A/pt not_active Application Discontinuation
- 2002-06-06 IL IL15919502A patent/IL159195A0/xx unknown
- 2002-06-06 TW TW091112153A patent/TWI298719B/zh active
- 2002-06-06 HU HU0400156A patent/HUP0400156A3/hu unknown
- 2002-06-06 AR ARP020102128A patent/AR036086A1/es unknown
- 2002-06-06 SI SI200230101T patent/SI1395553T1/xx unknown
- 2002-06-06 CN CNB028154002A patent/CN1256324C/zh not_active Expired - Fee Related
- 2002-06-06 DK DK02738368T patent/DK1395553T3/da active
- 2002-06-06 EP EP02738368A patent/EP1395553B1/en not_active Expired - Lifetime
- 2002-06-06 CA CA002449629A patent/CA2449629A1/en not_active Abandoned
- 2002-06-06 PT PT02738368T patent/PT1395553E/pt unknown
- 2002-06-06 MY MYPI20022097A patent/MY136859A/en unknown
- 2002-06-06 CZ CZ20033325A patent/CZ20033325A3/cs unknown
- 2002-06-06 US US10/479,545 patent/US7186717B2/en not_active Expired - Fee Related
- 2002-06-06 AU AU2002311451A patent/AU2002311451B2/en not_active Ceased
- 2002-06-06 JP JP2003503599A patent/JP4242274B2/ja not_active Expired - Fee Related
- 2002-06-06 WO PCT/GB2002/002721 patent/WO2002100830A1/en not_active Ceased
- 2002-06-06 PL PL02368082A patent/PL368082A1/xx unknown
- 2002-06-06 DE DE60203006T patent/DE60203006T2/de not_active Expired - Lifetime
- 2002-06-06 AT AT02738368T patent/ATE289294T1/de not_active IP Right Cessation
- 2002-06-06 NZ NZ530004A patent/NZ530004A/en unknown
- 2002-06-06 MX MXPA03011384A patent/MXPA03011384A/es active IP Right Grant
- 2002-06-06 KR KR1020037016070A patent/KR100877245B1/ko not_active Expired - Fee Related
- 2002-06-06 ES ES02738368T patent/ES2235050T3/es not_active Expired - Lifetime
-
2003
- 2003-12-02 ZA ZA200309367A patent/ZA200309367B/en unknown
- 2003-12-05 NO NO20035440A patent/NO326689B1/no not_active IP Right Cessation
- 2003-12-05 CO CO03107408A patent/CO5540285A2/es not_active Application Discontinuation
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2006
- 2006-10-11 US US11/548,395 patent/US7429587B2/en not_active Expired - Fee Related
- 2006-10-11 US US11/548,404 patent/US7326785B2/en not_active Expired - Fee Related
- 2006-10-11 US US11/548,402 patent/US7517879B2/en not_active Expired - Fee Related
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