AR035876A1 - COMPOUNDS DERIVED FROM IMIDAZO-TRIAZINA AS LIGANDOS FOR GABA RECEPTORS, PHARMACEUTICAL COMPOSITIONS AND USE OF COMPOUNDS IN THE MANUFACTURE OF MEDICINES - Google Patents
COMPOUNDS DERIVED FROM IMIDAZO-TRIAZINA AS LIGANDOS FOR GABA RECEPTORS, PHARMACEUTICAL COMPOSITIONS AND USE OF COMPOUNDS IN THE MANUFACTURE OF MEDICINESInfo
- Publication number
- AR035876A1 AR035876A1 ARP020101634A AR035876A1 AR 035876 A1 AR035876 A1 AR 035876A1 AR P020101634 A ARP020101634 A AR P020101634A AR 035876 A1 AR035876 A1 AR 035876A1
- Authority
- AR
- Argentina
- Prior art keywords
- compounds
- imidazo
- pharmaceutical compositions
- triazina
- ligandos
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- 239000003814 drug Substances 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 102000005915 GABA Receptors Human genes 0.000 title 1
- 108010005551 GABA Receptors Proteins 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- -1 7- (4-fluorophenyl) imidazo [1,2-b] [1,2,4] triazine Chemical compound 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 229910052731 fluorine Inorganic materials 0.000 abstract 2
- 239000011737 fluorine Substances 0.000 abstract 2
- 125000004076 pyridyl group Chemical group 0.000 abstract 2
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 206010010904 Convulsion Diseases 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- 102000027484 GABAA receptors Human genes 0.000 abstract 1
- 108091008681 GABAA receptors Proteins 0.000 abstract 1
- 230000002411 adverse Effects 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 125000005816 fluoropropyl group Chemical group [H]C([H])(F)C([H])([H])C([H])([H])* 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Compuestos derivados de 7-(4-fluorofenil)imidazo[1,2-b][1,2,4]triazina, sustituidos en la posición meta del anillo fenilo con un anillo fenilo o piridinilo opcionalmente sustituido con flúor o ciano, son ligandos selectivos para receptores GABAA, en particular tienen buena afinidad para la subunidad alfa2 y/o alfa3 de los mismos, y son en consecuencia de beneficio en el tratamiento y/o prevención de condiciones adversas del sistema nervioso central, incluyendo ansiedad y convulsiones. Se describen también composiciones farmacéuticas y el uso de los compuestos en la preparación de medicamentos. Dichos compuestos son de fórmula (1), en donde: Z representa un anillo fenilo o piridinilo, opcionalmente sustituido con uno o dos sustituyentes seleccionados entre flúor y ciano; y R1 representa hidroxipropilo, fluoropropilo o trifluorometilo.Compounds derived from 7- (4-fluorophenyl) imidazo [1,2-b] [1,2,4] triazine, substituted at the meta position of the phenyl ring with a phenyl or pyridinyl ring optionally substituted with fluorine or cyano, are ligands selective for GABAA receptors, in particular they have good affinity for the alpha2 and / or alpha3 subunit thereof, and are consequently of benefit in the treatment and / or prevention of adverse central nervous system conditions, including anxiety and seizures. Pharmaceutical compositions and the use of the compounds in the preparation of medicaments are also described. Said compounds are of formula (1), wherein: Z represents a phenyl or pyridinyl ring, optionally substituted with one or two substituents selected from fluorine and cyano; and R1 represents hydroxypropyl, fluoropropyl or trifluoromethyl.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ARP020101634 AR035876A1 (en) | 2002-05-03 | 2002-05-03 | COMPOUNDS DERIVED FROM IMIDAZO-TRIAZINA AS LIGANDOS FOR GABA RECEPTORS, PHARMACEUTICAL COMPOSITIONS AND USE OF COMPOUNDS IN THE MANUFACTURE OF MEDICINES |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ARP020101634 AR035876A1 (en) | 2002-05-03 | 2002-05-03 | COMPOUNDS DERIVED FROM IMIDAZO-TRIAZINA AS LIGANDOS FOR GABA RECEPTORS, PHARMACEUTICAL COMPOSITIONS AND USE OF COMPOUNDS IN THE MANUFACTURE OF MEDICINES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR035876A1 true AR035876A1 (en) | 2004-07-21 |
Family
ID=42632480
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP020101634 AR035876A1 (en) | 2002-05-03 | 2002-05-03 | COMPOUNDS DERIVED FROM IMIDAZO-TRIAZINA AS LIGANDOS FOR GABA RECEPTORS, PHARMACEUTICAL COMPOSITIONS AND USE OF COMPOUNDS IN THE MANUFACTURE OF MEDICINES |
Country Status (1)
| Country | Link |
|---|---|
| AR (1) | AR035876A1 (en) |
-
2002
- 2002-05-03 AR ARP020101634 patent/AR035876A1/en active IP Right Grant
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR064561A1 (en) | DERIVATIVES OF 2-AZA-BICYCLE [3.1.0] HEXANE AND ITS USE IN THE PREPARATION OF A MEDICINAL PRODUCT FOR THE TREATMENT OF DISEASES RELATED TO GENERAL DYSFUNCTIONS OF THE OREXINE SYSTEM. | |
| UY30183A1 (en) | QUINOLINE DERIVATIVES | |
| AR011174A1 (en) | PIRAZINE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, THEIR USE IN THE PEPARATION OF MEDICINES AND THE PROCESS TO PREPARE THEM | |
| NZ590784A (en) | Pyrazolopyridine kinase inhibitors | |
| GB0117277D0 (en) | Therapeutic agents | |
| AR023681A1 (en) | DERIVATIVES OF TETRAHYDROBENZAZEPINAS, PHARMACEUTICAL COMPOSITIONS AND THE USE OF THE SAME FOR THE MANUFACTURE OF A MEDICINAL PRODUCT. | |
| CA2455181A1 (en) | Benzimidazo[4,5-f]isoquinolinone derivatives | |
| ATE555786T1 (en) | 1-ALKOXY 1H-IMIDAZO RING SYSTEMS AND METHODS | |
| WO2001038326A3 (en) | Imidazo-pyridine derivatives as ligands for gaba receptors | |
| JP2012522763A5 (en) | ||
| WO2005048933A3 (en) | Oxime substituted imidazo ring compounds | |
| AR033046A1 (en) | DERIVATIVES OF 4,5-DIHIDRO-1H-PIRAZOL HAVING CB1 ANTAGONIST ACTIVITY, PHARMACEUTICAL COMPOSITION AND PREPARATION METHODS | |
| JP2018526416A5 (en) | ||
| UY26048A1 (en) | DERIVATIVES OF PIRIDOPIRANOACEPINAS, ITS PREPARATION AND ITS THERAPEUTIC APPLICATION | |
| JP2018526419A5 (en) | ||
| AR049372A1 (en) | BICYCLE COMPOUNDS OF AMINA AND PHARMACEUTICAL COMPOSITIONS THAT UNDERSTAND THEM | |
| AR053082A1 (en) | DERIVATIVES 8-PERFLUOROALQUIL-6,7,8,9-TETRAHYDROPIRIMIDO [1,2-A] PYRIMIDIN-4-ONA SUBSTITUTED NHKIDERS OF GSK3BETA AND ITS EMPLOYMENT IN THE MANUFACTURE OF MEDICINES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES. | |
| AR056888A1 (en) | HIDEROCICLIL IMIDAZOL DERIVATIVES | |
| AR057770A1 (en) | INHIBITORS OF P38-MAP-QUINASA AND PHARMACEUTICAL COMPOSITION | |
| JP2009502953A5 (en) | ||
| CA2461218A1 (en) | Muscarinic agonists | |
| AR054524A1 (en) | METHODS AND DOSAGE FORMS TO REDUCE THE SIDE EFFECTS OF CARBAMATE COMPOUNDS | |
| DE602006011725D1 (en) | 3-TRIAZOLYL THIOALKYL-3-AZABICYCLO Ä3.1.0ÜHEXANE AND THEIR USE AS LIGANDS OF DOPAMINE D3 RECEPTOR | |
| ATE447575T1 (en) | SELECTIVE SPIROCYCLIC GLUCOCORTICOID RECEPTOR MODULATORS | |
| DE602004012400D1 (en) | N-Ä (PIPERAZINYL) HETARYLÜARYLSULFONAMIDE DERIVATIVES WITH AFFINITY TO DOPAMINE D3 RECEPTOR |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant; registration |