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AR035401A1 - El uso de compuestos derivados de feniletenilo y feniletinilo; compuestos derivados de feniletinilo; compuestos derivados de feniletenilo; un procedimiento para la elaboracion de los mismos; y medicamentos que los contienen - Google Patents

El uso de compuestos derivados de feniletenilo y feniletinilo; compuestos derivados de feniletinilo; compuestos derivados de feniletenilo; un procedimiento para la elaboracion de los mismos; y medicamentos que los contienen

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Publication number
AR035401A1
AR035401A1 ARP010105602A ARP010105602A AR035401A1 AR 035401 A1 AR035401 A1 AR 035401A1 AR P010105602 A ARP010105602 A AR P010105602A AR P010105602 A ARP010105602 A AR P010105602A AR 035401 A1 AR035401 A1 AR 035401A1
Authority
AR
Argentina
Prior art keywords
lower alkyl
hydrogen
halogen
compounds derived
phenylethynyl
Prior art date
Application number
ARP010105602A
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English (en)
Inventor
Vincent Mutel
Juergen Wichmann
Jens-Uwe Peters
Original Assignee
Hoffmann La Roche
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Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR035401A1 publication Critical patent/AR035401A1/es

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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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Abstract

El uso de compuestos derivados de feniletenilo y feniletinilo de fórmula general (1) donde: R1, R2, R3, R4 y R5 significan, independientemente entre sí, hidrógeno, alquilo inferior, -(CH2)n-halógeno, alcoxi inferior, -(CH2)n-NRR', -(CH2)n-N(R)-C(O)-alquilo inferior, arilo o heteroarilo que está insustituido o sustituido por uno o más residuos de alquilo inferior; R, R' y R'' significan, independientemente entre sí, hidrógeno o alquilo inferior; A significa -CH=CH-o -C:::C; y B significa (B1), (B2), (B3), (B4), (B5) o (B6), donde R6 significa hidrógeno, alquilo inferior, -(CH2)n-C(O)OR o halógeno; R7 significa hidrógeno, alquilo inferior, -(CH2)n-C(O)OR', halógeno, nitro o heteroarilo que está insustituido o sustituido por cicloalquilo o alquilo inferior; R8 significa hidrógeno, alquilo inferior, -(CH2)n-OH, -(CH2)n-C(O)OR'' o arilo; R9 significa alquilo inferior; R10 significa hidrógeno, halógeno o alquilo inferior; R11 significa hidrógeno o alquilo; R12 significa -(CH2)n-N(R)-C(O)-alquilo inferior; R13 significa hidrógeno o alquilo inferior; R14, R15, R16 y R17 significan, independientemente entre sí, hidrógeno, alquilo inferior, -(CH2)n-halógeno o alcoxi inferior; R18, R19 y R20 significan, independientemente entre sí, hidrógeno, alquilo inferior, -(CH2)n-halógeno o alcoxi Inferior; R21 significa hidrógeno o alquilo inferior; R22 significa hidrógeno, alquilo inferior o alquilo inferior que lleva uno o más sustituyentes seleccionados entre hidroxi o halógeno; R23 significa hidrógeno, alquilo inferior, alcanoílo inferior o nitro; R24, R25 y R26 significan, independientemente entre sí, hidrógeno o alquilo inferior; n es 0, 1, 2, 3, 4, 5 o 6; X es -CH2-, -O- o -S-; e Y es -CH= o -N=; y sus sales farmacéuticamente aceptables para la elaboración de medicamentos para el tratamiento o para la prevención de trastornos mediados por receptor de mGluR5. Compuestos derivados de feniletinilo de fórmula (2) donde: R1, R2, R3, R4, R5 y B tienen los significados dados anteriormente; y sus sales farmacéuticamente aceptables; con excepción de: 1-metil-2-feniletinil-1H-imidazol, 1-metil-2-(4-metoxi-feniletinil)-1H-imidazol, 1-metil-5-feniletinil-1H-imidazol, y 1-metil-4-feniletinil-1H-imidazol. Compuestos derivados de feniletenilo de fórmula (3) en la cual: R1, R2, R3, R4, R5, R6, R7 y R8 tienen los significados dados anteriormente; y sus sales farmacéuticamente aceptables. Compuestos derivados de feniletenilo de fórmula (4) en la cual: R1, R2, R3, R4, R5, R9 y R11 tienen los significados dados anteriormente; R10 significa halógeno y sus sales farmacéuticamente aceptables. Un procedimiento para la elaboración de los compuestos de fórmulas (2), (3) y (4), así como también, de sus sales farmacéuticamente aceptables, y medicamentos que los contienen.
ARP010105602A 2000-12-04 2001-12-03 El uso de compuestos derivados de feniletenilo y feniletinilo; compuestos derivados de feniletinilo; compuestos derivados de feniletenilo; un procedimiento para la elaboracion de los mismos; y medicamentos que los contienen AR035401A1 (es)

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AR035401A1 true AR035401A1 (es) 2004-05-26

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ARP010105602A AR035401A1 (es) 2000-12-04 2001-12-03 El uso de compuestos derivados de feniletenilo y feniletinilo; compuestos derivados de feniletinilo; compuestos derivados de feniletenilo; un procedimiento para la elaboracion de los mismos; y medicamentos que los contienen

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GB0128996D0 (en) 2001-12-04 2002-01-23 Novartis Ag Organic compounds
JP4637578B2 (ja) 2002-08-09 2011-02-23 アストラゼネカ アクチボラグ 代謝調節型グルタミン酸受容体−５の調節因子としての１，２，４−オキサジアゾール類
JP2006502134A (ja) 2002-08-09 2006-01-19 アストラゼネカ アクチボラグ 代謝調節型グルタミン酸受容体において活性を有する化合物
JP2006506340A (ja) * 2002-08-09 2006-02-23 アストラゼネカ アクチボラグ 代謝調節型グルタミン酸受容体５のモジュレーターとしてのオキサジアゾール
ITMI20030151A1 (it) * 2003-01-30 2004-07-31 Recordati Ind Chimica E Farma Ceutica S P A Uso di antagonisti selettivi del recettore mglu5 per il trattamento di disfunzioni neuromuscolari del tratto urinario inferiore.
CA2517083A1 (en) 2003-03-04 2004-09-16 Addex Pharmaceuticals Sa Novel aminopyridine derivatives as mglur5 antagonists
AU2004218115A1 (en) 2003-03-07 2004-09-16 Astellas Pharma Inc. Nitrogenous heterocyclic derivative having 2,6-disubstituted styryl
TWI292318B (en) 2003-03-10 2008-01-11 Hoffmann La Roche Imidazol-4-yl-ethynyl-pyridine derivatives
AU2004226450A1 (en) * 2003-03-26 2004-10-14 Merck & Co. Inc. Benzamide modulators of metabotropic glutamate receptors
UA80888C2 (en) 2003-06-05 2007-11-12 Hoffmann La Roche Imidazole derivatives as glutmate receptor antagonists
US7531529B2 (en) 2003-06-05 2009-05-12 Roche Palo Alto Llc Imidazole derivatives
KR100717914B1 (ko) * 2003-06-12 2007-05-11 에프. 호프만-라 로슈 아게 글루타메이트 수용체 길항제로서 헤테로아릴-치환된이미다졸 유도체
EP1729771B1 (en) 2004-03-22 2009-10-14 Eli Lilly & Company Pyridyl derivatives and their use as mglu5 receptor antagonists
MY149038A (en) * 2004-05-26 2013-07-15 Eisai R&D Man Co Ltd Cinnamide compound
EP1756086B1 (en) * 2004-06-01 2008-06-04 F.Hoffmann-La Roche Ag Pyridin-4-yl-ethynyl-imidazoles and pyrazoles as mglu5 receptor antagonists
HRP20080363T3 (hr) * 2004-06-01 2008-09-30 F. Hoffmann - La Roche Ag Piridin-4-il-etinil-imidazoli i pirazoli kao antagonisti mglu5 receptora
GB0413605D0 (en) 2004-06-17 2004-07-21 Addex Pharmaceuticals Sa Novel compounds
DE102004044884A1 (de) * 2004-09-14 2006-05-24 Grünenthal GmbH Substituierte bizyklische Imidazo-3-yl-amin-Verbindungen
AU2005297966B2 (en) 2004-10-26 2010-12-23 Eisai R & D Management Co., Ltd. Amorphous object of cinnamide compound
BRPI0517423A (pt) * 2004-12-27 2008-10-07 Astrazeneca Ab composto, composição farmacêutica, método para o tratamento ou prevenção de distúrbios neurológicos e psiquiátricos associados com disfunção do glutamato em um animal, e, uso em um composto
RU2401258C2 (ru) * 2005-03-16 2010-10-10 Авентис Фармасьютикалз Инк. Дипиразолы в качестве средств для центральной нервной системы
BRPI0609719B8 (pt) 2005-03-23 2021-05-25 Hoffmann La Roche derivados de acetilenil-pirazol-pirimidina como antagonistas de mgbur2
GB0508319D0 (en) 2005-04-25 2005-06-01 Novartis Ag Organic compounds
CN101309916A (zh) * 2005-11-18 2008-11-19 卫材R&D管理有限公司 制备肉桂酰胺衍生物的方法
US20090048448A1 (en) * 2005-11-18 2009-02-19 Ikuo Kushida Salts of cynnamide compound or solvates thereof
EP1953154A4 (en) * 2005-11-24 2013-11-20 Eisai R&D Man Co Ltd CINNAMIDE COMPOUNDS OF MORPHOLINE TYPE
TWI370130B (en) 2005-11-24 2012-08-11 Eisai R&D Man Co Ltd Two cyclic cinnamide compound
WO2007071967A2 (en) * 2005-12-19 2007-06-28 The University Of Liverpool Substituted phenol derivatives as analgesics
DE102005062985A1 (de) * 2005-12-28 2007-07-05 Grünenthal GmbH Substituierte bis(hetero)aromatische N-Ethylpropiolamide und ihre Verwendung zur Herstellung von Arzneimitteln
TWI378091B (en) 2006-03-09 2012-12-01 Eisai R&D Man Co Ltd Multi-cyclic cinnamide derivatives
KR101464651B1 (ko) * 2006-03-09 2014-11-24 에자이 알앤드디 매니지먼트 가부시키가이샤 다환식 신나미드 유도체
DE102006011574A1 (de) 2006-03-10 2007-10-31 Grünenthal GmbH Substituierte Imidazo[2,1-b]thiazol-Verbindungen und ihre Verwendung zur Herstellung von Arzneimitteln
AR062095A1 (es) * 2006-07-28 2008-10-15 Eisai R&D Man Co Ltd Profarmaco de compuesto cinamida
MY148217A (en) 2006-12-21 2013-03-29 Hoffmann La Roche Polymorphs of a mglur5 receptor antagonist
US20080207900A1 (en) 2007-02-28 2008-08-28 Teiji Kimura Two cyclic oxomorphorin derivatives
KR20100016580A (ko) * 2007-05-16 2010-02-12 에자이 알앤드디 매니지먼트 가부시키가이샤 신나미드 유도체의 원폿 제조 방법
US7935815B2 (en) * 2007-08-31 2011-05-03 Eisai R&D Management Co., Ltd. Imidazoyl pyridine compounds and salts thereof
WO2009028588A1 (ja) * 2007-08-31 2009-03-05 Eisai R & D Management Co., Ltd. 多環式化合物
EP2239265A1 (en) * 2008-01-28 2010-10-13 Eisai R&D Management Co., Ltd. Crystalline cinnamide compounds or salts thereof
US8323805B2 (en) 2009-06-04 2012-12-04 Nitto Denko Corporation Emissive aryl-heteroaryl acetylenes
US8334287B2 (en) 2009-07-17 2012-12-18 Hoffmann-La Roche Inc. Imidazoles
US8642626B2 (en) 2010-07-29 2014-02-04 Taisho Pharmaceutical Co., Ltd. Ethinyl-pyrazole derivative
EP2636668B1 (en) * 2010-11-05 2018-08-01 OAT Agrio Co., Ltd. Ethynylphenylamidine compound or salt thereof, method for producing same, and fungicide for agricultural and horticultural use
WO2012172093A1 (en) * 2011-06-17 2012-12-20 Merz Pharma Gmbh & Co. Kgaa Dihydroindolizine derivate as metabotropic glutamate receptor modulators
KR101291037B1 (ko) * 2011-10-12 2013-08-01 사회복지법인 삼성생명공익재단 레스베라트롤 유도체와 스티릴-오각형 방향족 화합물 및 이들의 베타-아밀로이드 플라그에 대한 결합제 및 진단영상제의 용도
US10941132B2 (en) 2016-01-05 2021-03-09 Hua Medicine (Shanghai) Ltd. Pyrazole derivatives
US10669255B2 (en) 2016-04-06 2020-06-02 Hua Medicine (Shanghai) Ltd. Pyrrole derivatives
JP7098630B2 (ja) 2017-01-10 2022-07-11 バイエル・アクチエンゲゼルシヤフト 有害生物防除剤としてのヘテロサイクレン誘導体
KR20250048143A (ko) 2017-07-31 2025-04-07 노파르티스 아게 코카인 사용 감소 또는 코카인 사용 재발 예방에 있어서 마보글루란트의 용도
US12479816B2 (en) 2019-02-08 2025-11-25 University of Pittsburgh—of the Commonwealth System of Higher Education 20-HETE formation inhibitors
CN114746408B (zh) * 2019-12-02 2025-02-14 豪夫迈·罗氏有限公司 炔基-(杂芳基)-甲酰胺hcn1抑制剂

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3303199A (en) 1963-07-15 1967-02-07 Geigy Chem Corp Certain imidazolone derivatives and process for making same
US3341548A (en) 1964-04-29 1967-09-12 Hoffmann La Roche Nitroimidazoles and their preparation
DE2035905A1 (de) * 1970-07-20 1972-02-03 Chemische Fabrik Stockhausen & Cie.,4150Krefeld Imidazolverbindungen und deren Herstellungsverfahren
CA1174673A (en) 1981-02-27 1984-09-18 Walter Hunkeler Imidazodiazepines
US4711962A (en) 1984-10-18 1987-12-08 Stauffer Chemical Company Process for selective preparation of ratios of isomers formed on N-substitution of asymmetric imidazoles
WO1991000277A1 (en) 1989-06-30 1991-01-10 E.I. Du Pont De Nemours And Company Substituted imidazoles
US5821937A (en) * 1996-02-23 1998-10-13 Netsuite Development, L.P. Computer method for updating a network design
TW544448B (en) * 1997-07-11 2003-08-01 Novartis Ag Pyridine derivatives
ID28529A (id) * 1997-08-14 2001-05-31 Hoffmann La Roche Vinileter heterosiklik untuk gangguan neurologi
US6377987B1 (en) * 1999-04-30 2002-04-23 Cisco Technology, Inc. Mechanism for determining actual physical topology of network based on gathered configuration information representing true neighboring devices
EP1214303A1 (en) * 1999-08-31 2002-06-19 Merck & Co., Inc. Heterocyclic compounds and methods of use thereof

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