AR034909A1 - DERIVATIVES OF AMINOALQUIMIDAZOL, ITS PREPARATIONS AND ITS APPLICATIONS IN THERAPEUTICS - Google Patents
DERIVATIVES OF AMINOALQUIMIDAZOL, ITS PREPARATIONS AND ITS APPLICATIONS IN THERAPEUTICSInfo
- Publication number
- AR034909A1 AR034909A1 ARP020102827A ARP020102827A AR034909A1 AR 034909 A1 AR034909 A1 AR 034909A1 AR P020102827 A ARP020102827 A AR P020102827A AR P020102827 A ARP020102827 A AR P020102827A AR 034909 A1 AR034909 A1 AR 034909A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- therapeutics
- phenyl
- aminoalquimidazol
- preparations
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title 1
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000006596 (C1-C3) alkylcarbonyloxy group Chemical group 0.000 abstract 1
- 125000006274 (C1-C3)alkoxy group Chemical group 0.000 abstract 1
- 229940115480 Histamine H3 receptor antagonist Drugs 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 125000001231 benzoyloxy group Chemical group C(C1=CC=CC=C1)(=O)O* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 239000003395 histamine H3 receptor antagonist Substances 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Child & Adolescent Psychology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Compuesto que responde a la fórmula (1) en la cual: A representa un grupo alquilo C0-6, el grupo alquilo puede estar substituido por un átomo de halógeno, un hidroxi o un fenilo; y R1, R2, R3 y R4 representan independientemente entre sí, un átomo de hidrógeno, de halógeno, un hidroxi, un grupo nitro, ciano, trifluorometilo, alquilo C1-3, fenilo, alcoxi C1-3, fenoxi, alquilcarboniloxi C1-3, benzoiloxi, -C(O)OH, alquilo-C(O)O-C1-3, fenilo-C(O)O-, -CONH2, alquilo-C(O)NH-C1-3 ó -C(O)N(alquilo C1-3)2; así como sus sales, N-óxidos e hidratos. Aplicación en terapéutica como antagonista del receptor de la histamina de tipo H3.Compound that responds to formula (1) in which: A represents a C0-6 alkyl group, the alkyl group may be substituted by a halogen atom, a hydroxy or a phenyl; and R1, R2, R3 and R4 independently represent each other, a hydrogen atom, a halogen, a hydroxy, a nitro, cyano, trifluoromethyl group, C1-3 alkyl, phenyl, C1-3 alkoxy, phenoxy, C1-3 alkylcarbonyloxy , benzoyloxy, -C (O) OH, alkyl-C (O) O-C1-3, phenyl-C (O) O-, -CONH2, alkyl-C (O) NH-C1-3 or -C (O ) N (C1-3 alkyl) 2; as well as its salts, N-oxides and hydrates. Application in therapeutics as a histamine H3 receptor antagonist.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0110080A FR2827863A1 (en) | 2001-07-27 | 2001-07-27 | New dihydropyrrolyl alkyl imidazole derivatives having histamine receptor antagonist activity for treatment of obesity, diabetes, and central nervous system disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR034909A1 true AR034909A1 (en) | 2004-03-24 |
Family
ID=8866000
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP020102827A AR034909A1 (en) | 2001-07-27 | 2002-07-26 | DERIVATIVES OF AMINOALQUIMIDAZOL, ITS PREPARATIONS AND ITS APPLICATIONS IN THERAPEUTICS |
Country Status (3)
| Country | Link |
|---|---|
| AR (1) | AR034909A1 (en) |
| FR (1) | FR2827863A1 (en) |
| WO (1) | WO2003011856A1 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022175384A1 (en) * | 2021-02-17 | 2022-08-25 | Fundación Universidad Católica De Valencia San Vicente Mártir | Small-molecule agents with antiviral activity against rna viruses |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69205287T2 (en) * | 1991-12-18 | 1996-03-14 | Schering Corp., Kenilworth, N.J. | IMIDAZOLYLALKYL PIPERAZINE AND DIAZEPINE DERIVATIVES AS HISTAMINE H3 AGONISTS / ANTAGONISTS. |
| SG44510A1 (en) * | 1991-12-18 | 1997-12-19 | Schering Corp | Imidazolyl or imidazoylalkyl substituted with a four or five membered nitrogen containing heterocyclic ring |
| AU7823894A (en) * | 1993-08-27 | 1995-03-21 | Vrije Universiteit | New imidazole derivatives having agonistic or antagonistic activity on the histamine h3 receptor |
| PT841922E (en) * | 1995-05-30 | 2002-07-31 | Gliatech Inc | IH-IMIDAZOLE DERIVATIVES 4 (5) -SUBSTITUTES |
| WO1999024421A1 (en) * | 1997-11-07 | 1999-05-20 | Schering Corporation | Imidazoylalkyl substituted with a five, six or seven membered heterocyclic ring containing one nitrogen atom |
| US6133291A (en) * | 1998-10-16 | 2000-10-17 | Schering Corporation | N-(imidazolylalkyl)substituted cyclic amines as histamine-H3 agonists or antagonists |
-
2001
- 2001-07-27 FR FR0110080A patent/FR2827863A1/en active Pending
-
2002
- 2002-07-26 WO PCT/FR2002/002677 patent/WO2003011856A1/en not_active Ceased
- 2002-07-26 AR ARP020102827A patent/AR034909A1/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003011856A1 (en) | 2003-02-13 |
| FR2827863A1 (en) | 2003-01-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |