AR023130A1 - Composiciones para promover el crecimiento - Google Patents
Composiciones para promover el crecimientoInfo
- Publication number
- AR023130A1 AR023130A1 ARP000101281A ARP000101281A AR023130A1 AR 023130 A1 AR023130 A1 AR 023130A1 AR P000101281 A ARP000101281 A AR P000101281A AR P000101281 A ARP000101281 A AR P000101281A AR 023130 A1 AR023130 A1 AR 023130A1
- Authority
- AR
- Argentina
- Prior art keywords
- compositions
- promote growth
- inhibitors
- growth
- promote
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title 1
- 229940124213 Dipeptidyl peptidase 4 (DPP IV) inhibitor Drugs 0.000 abstract 1
- 206010056438 Growth hormone deficiency Diseases 0.000 abstract 1
- 208000020221 Short stature Diseases 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 239000003603 dipeptidyl peptidase IV inhibitor Substances 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Pyrrole Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Abstract
Inhibidores de dipeptidil peptidasa IV y composiciones farmacéuticas que comprenden estos inhibidores son utiles en el tratamiento de corta estatura debidoa la deficiencia de la Hormona de Crecimiento y para promover el crecimiento de tejido GH-depen diente o recrecimiento.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9906715.9A GB9906715D0 (en) | 1999-03-23 | 1999-03-23 | Compositions for promoting growth |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR023130A1 true AR023130A1 (es) | 2002-09-04 |
Family
ID=10850230
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP000101281A AR023130A1 (es) | 1999-03-23 | 2000-03-22 | Composiciones para promover el crecimiento |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US6521644B1 (es) |
| EP (1) | EP1171121B1 (es) |
| JP (1) | JP2002539244A (es) |
| KR (1) | KR100704348B1 (es) |
| CN (1) | CN1359293A (es) |
| AR (1) | AR023130A1 (es) |
| AT (1) | ATE297728T1 (es) |
| AU (1) | AU772421B2 (es) |
| CA (1) | CA2366926A1 (es) |
| CZ (1) | CZ20013411A3 (es) |
| DE (1) | DE60020825T2 (es) |
| GB (1) | GB9906715D0 (es) |
| HK (1) | HK1048589A1 (es) |
| HU (1) | HUP0200391A3 (es) |
| IL (2) | IL145568A0 (es) |
| MX (1) | MXPA01009610A (es) |
| MY (1) | MY124214A (es) |
| NO (1) | NO20014608L (es) |
| NZ (1) | NZ514450A (es) |
| PL (1) | PL195529B1 (es) |
| RU (1) | RU2242228C2 (es) |
| TR (1) | TR200102648T2 (es) |
| TW (1) | TWI239246B (es) |
| UA (1) | UA73115C2 (es) |
| WO (1) | WO2000056297A2 (es) |
| ZA (1) | ZA200108082B (es) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040152745A1 (en) * | 1999-11-12 | 2004-08-05 | Guilford Pharmaceuticals, Inc. | Dipeptidyl peptidase IV inhibitors and methods of making and using dipeptidyl peptidase IV inhibitors |
| GB9928330D0 (en) * | 1999-11-30 | 2000-01-26 | Ferring Bv | Novel antidiabetic agents |
| US6395767B2 (en) | 2000-03-10 | 2002-05-28 | Bristol-Myers Squibb Company | Cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV and method |
| AU2002316437A1 (en) * | 2001-06-27 | 2003-03-03 | Smithkline Beecham Corporation | Pyrrolidines as dipeptidyl peptidase inhibitors |
| UA74912C2 (en) | 2001-07-06 | 2006-02-15 | Merck & Co Inc | Beta-aminotetrahydroimidazo-(1,2-a)-pyrazines and tetratriazolo-(4,3-a)-pyrazines as inhibitors of dipeptylpeptidase for the treatment or prevention of diabetes |
| US7309714B2 (en) * | 2002-12-04 | 2007-12-18 | Merck & Co., Inc. | Phenylalanine derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes |
| KR20050122220A (ko) | 2003-03-25 | 2005-12-28 | 다케다 샌디에고, 인코포레이티드 | 디펩티딜 펩티다제 억제제 |
| WO2004103993A1 (en) | 2003-05-14 | 2004-12-02 | Syrrx, Inc. | Dipeptidyl peptidase inhibitors |
| BRPI0413452A (pt) * | 2003-08-13 | 2006-10-17 | Takeda Pharmaceutical | composto, composição farmacêutica, kit, artigo de fabricação, e, métodos de inibir dpp-iv, terapêutico e de tratar um estado de doença, cáncer, distúrbios autoimunes, uma condição einfecção por hiv |
| US7678909B1 (en) | 2003-08-13 | 2010-03-16 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| US7169926B1 (en) | 2003-08-13 | 2007-01-30 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| WO2005030751A2 (en) * | 2003-09-08 | 2005-04-07 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| WO2005026148A1 (en) * | 2003-09-08 | 2005-03-24 | Takeda San Diego, Inc. | Dipeptidyl peptidase inhibitors |
| US7732446B1 (en) | 2004-03-11 | 2010-06-08 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| CN102079743B (zh) * | 2004-03-15 | 2020-08-25 | 武田药品工业株式会社 | 二肽基肽酶抑制剂 |
| JP2008501714A (ja) * | 2004-06-04 | 2008-01-24 | 武田薬品工業株式会社 | ジペプチジルペプチダーゼインヒビター |
| WO2006019965A2 (en) | 2004-07-16 | 2006-02-23 | Takeda San Diego, Inc. | Dipeptidyl peptidase inhibitors |
| WO2006068978A2 (en) * | 2004-12-21 | 2006-06-29 | Takeda Pharmaceutial Company Limited | Dipeptidyl peptidase inhibitors |
| DOP2006000008A (es) | 2005-01-10 | 2006-08-31 | Arena Pharm Inc | Terapia combinada para el tratamiento de la diabetes y afecciones relacionadas y para el tratamiento de afecciones que mejoran mediante un incremento de la concentración sanguínea de glp-1 |
| AP2007004234A0 (en) * | 2005-04-22 | 2007-12-31 | Alantos Pharm Holding | Dipeptidyl peptidase-IV inhibitors |
| GEP20135838B (en) * | 2005-09-14 | 2013-06-10 | Takeda Pharmaceutical | Dipeptidyl peptidase inhibitors usage at diabetes treatment |
| PE20070622A1 (es) * | 2005-09-14 | 2007-08-22 | Takeda Pharmaceutical | Administracion de inhibidores de dipeptidil peptidasa |
| EP1931350B2 (en) * | 2005-09-14 | 2021-08-04 | Takeda Pharmaceutical Company Limited | Administration of dipeptidyl peptidase inhibitors |
| TW200745080A (en) * | 2005-09-16 | 2007-12-16 | Takeda Pharmaceuticals Co | Polymorphs of tartrate salt of 2-[2-(3-(R)-amino-piperidin-1-yl)-5-fluoro-6-oxo-6H-pyrimidin-1-ylmethyl]-benzonitrile and methods of use therefor |
| CA2622642C (en) | 2005-09-16 | 2013-12-31 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| TW200745079A (en) * | 2005-09-16 | 2007-12-16 | Takeda Pharmaceuticals Co | Polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile and methods of use therefor |
| WO2007112347A1 (en) | 2006-03-28 | 2007-10-04 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| WO2007112368A1 (en) * | 2006-03-28 | 2007-10-04 | Takeda Pharmaceutical Company Limited | Preparation of (r)-3-aminopiperidine dihydrochloride |
| PE20071221A1 (es) | 2006-04-11 | 2007-12-14 | Arena Pharm Inc | Agonistas del receptor gpr119 en metodos para aumentar la masa osea y para tratar la osteoporosis y otras afecciones caracterizadas por masa osea baja, y la terapia combinada relacionada a estos agonistas |
| US8324383B2 (en) | 2006-09-13 | 2012-12-04 | Takeda Pharmaceutical Company Limited | Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile |
| KR102062824B1 (ko) * | 2006-09-13 | 2020-01-07 | 다케다 야쿠힌 고교 가부시키가이샤 | 2-[6-(3-아미노-피페리딘-1-일)-3-메틸-2,4-디옥소-3,4-디하이드로-2h-피리미딘-1-일메틸]-4-플루오로-벤조니트릴의 용도 |
| TW200838536A (en) * | 2006-11-29 | 2008-10-01 | Takeda Pharmaceutical | Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor |
| US8093236B2 (en) | 2007-03-13 | 2012-01-10 | Takeda Pharmaceuticals Company Limited | Weekly administration of dipeptidyl peptidase inhibitors |
| EP2146210A1 (en) | 2008-04-07 | 2010-01-20 | Arena Pharmaceuticals, Inc. | Methods of using A G protein-coupled receptor to identify peptide YY (PYY) secretagogues and compounds useful in the treatment of conditions modulated by PYY |
| JO2870B1 (en) | 2008-11-13 | 2015-03-15 | ميرك شارب اند دوهم كورب | Amino Tetra Hydro Pirans as Inhibitors of Peptide Dipeptide IV for the Treatment or Prevention of Diabetes |
| AR077642A1 (es) | 2009-07-09 | 2011-09-14 | Arena Pharm Inc | Moduladores del metabolismo y el tratamiento de trastornos relacionados con el mismo |
| US8455533B2 (en) | 2009-09-02 | 2013-06-04 | Merck Sharp & Dohme Corp. | Aminotetrahydropyrans as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes |
| CA2784799C (en) | 2009-12-30 | 2014-06-10 | Shanghai Fochon Pharmaceutical Co Ltd | Certain dipeptidyl peptidase inhibtors |
| WO2011103256A1 (en) | 2010-02-22 | 2011-08-25 | Merck Sharp & Dohme Corp. | Substituted aminotetrahydrothiopyrans and derivatives thereof as dipeptidyl peptidase-iv inhibitors for the treatment of diabetes |
| WO2011127051A1 (en) | 2010-04-06 | 2011-10-13 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
| EP2571876B1 (en) | 2010-05-21 | 2016-09-07 | Merck Sharp & Dohme Corp. | Substituted seven-membered heterocyclic compounds as dipeptidyl peptidase-iv inhibitors for the treatment of diabetes |
| CN103221410B (zh) | 2010-09-22 | 2017-09-15 | 艾尼纳制药公司 | Gpr119受体调节剂和对与其相关的障碍的治疗 |
| US20140018371A1 (en) | 2011-04-01 | 2014-01-16 | Arena Pharmaceuticals, Inc. | Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto |
| WO2012145361A1 (en) | 2011-04-19 | 2012-10-26 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
| WO2012145603A1 (en) | 2011-04-22 | 2012-10-26 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
| US20140051714A1 (en) | 2011-04-22 | 2014-02-20 | Arena Pharmaceuticals, Inc. | Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto |
| WO2012170702A1 (en) | 2011-06-08 | 2012-12-13 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
| WO2013055910A1 (en) | 2011-10-12 | 2013-04-18 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
| WO2013122920A1 (en) | 2012-02-17 | 2013-08-22 | Merck Sharp & Dohme Corp. | Dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes |
| WO2014018350A1 (en) | 2012-07-23 | 2014-01-30 | Merck Sharp & Dohme Corp. | Treating diabetes with dipeptidyl peptidase-iv inhibitors |
| WO2014074668A1 (en) | 2012-11-08 | 2014-05-15 | Arena Pharmaceuticals, Inc. | Modulators of gpr119 and the treatment of disorders related thereto |
| KR20180006881A (ko) | 2015-03-09 | 2018-01-19 | 인테크린 테라퓨틱스, 아이엔씨. | 비알코올성 지방간 질환 및/또는 지방이영양증의 치료 방법 |
| AU2018249822A1 (en) | 2017-04-03 | 2019-10-31 | Coherus Biosciences Inc. | PPArgamma agonist for treatment of progressive supranuclear palsy |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2063360T3 (es) * | 1989-06-16 | 1995-01-01 | Upjohn Co | Analogos potentes de grf, estabilizados. |
| CA2080474A1 (en) | 1990-04-14 | 1991-10-15 | William W. Bachovchin | Inhibitors of dipeptidyl-aminopeptidase type iv |
| HUT63857A (en) * | 1990-11-14 | 1993-10-28 | Upjohn Co | Process for producing grf-analogs |
| RU2114119C1 (ru) * | 1990-12-13 | 1998-06-27 | Дзе Апджон Компани | Слитой белок и способ выделения слитого белка |
| JPH0543453A (ja) * | 1991-08-20 | 1993-02-23 | Sumitomo Pharmaceut Co Ltd | 創傷治癒促進用局所用徐放性製剤 |
| HUT67319A (en) * | 1991-08-30 | 1995-03-28 | Life Medical Sciences Inc | Compositions for treating wounds |
| DE69233671T2 (de) * | 1991-10-22 | 2007-10-18 | New England Medical Center Hospitals, Inc., Boston | Inhibitoren der Dipeptidyl-Aminopeptidase vom Typ IV |
| IL111785A0 (en) | 1993-12-03 | 1995-01-24 | Ferring Bv | Dp-iv inhibitors and pharmaceutical compositions containing them |
| JPH09295946A (ja) * | 1995-05-16 | 1997-11-18 | Mitsui Pharmaceut Inc | 医薬組成物 |
| JPH09308259A (ja) * | 1996-05-17 | 1997-11-28 | Toshiba Lighting & Technol Corp | 電源装置、放電ランプ点灯装置及び照明装置 |
| TW492957B (en) | 1996-11-07 | 2002-07-01 | Novartis Ag | N-substituted 2-cyanopyrrolidnes |
| US5952301A (en) | 1996-12-10 | 1999-09-14 | 1149336 Ontario Inc. | Compositions and methods for enhancing intestinal function |
-
1999
- 1999-03-23 GB GBGB9906715.9A patent/GB9906715D0/en not_active Ceased
-
2000
- 2000-03-21 US US09/937,031 patent/US6521644B1/en not_active Expired - Fee Related
- 2000-03-21 MY MYPI20001117A patent/MY124214A/en unknown
- 2000-03-21 DE DE60020825T patent/DE60020825T2/de not_active Expired - Fee Related
- 2000-03-21 AU AU33186/00A patent/AU772421B2/en not_active Ceased
- 2000-03-21 KR KR1020017012145A patent/KR100704348B1/ko not_active Expired - Fee Related
- 2000-03-21 CZ CZ20013411A patent/CZ20013411A3/cs unknown
- 2000-03-21 JP JP2000606202A patent/JP2002539244A/ja active Pending
- 2000-03-21 RU RU2001128504/15A patent/RU2242228C2/ru not_active IP Right Cessation
- 2000-03-21 TR TR2001/02648T patent/TR200102648T2/xx unknown
- 2000-03-21 CN CN00805326A patent/CN1359293A/zh active Pending
- 2000-03-21 HK HK02108644.1A patent/HK1048589A1/zh unknown
- 2000-03-21 HU HU0200391A patent/HUP0200391A3/hu unknown
- 2000-03-21 IL IL14556800A patent/IL145568A0/xx active IP Right Grant
- 2000-03-21 AT AT00911195T patent/ATE297728T1/de not_active IP Right Cessation
- 2000-03-21 MX MXPA01009610A patent/MXPA01009610A/es active IP Right Grant
- 2000-03-21 EP EP00911195A patent/EP1171121B1/en not_active Expired - Lifetime
- 2000-03-21 NZ NZ514450A patent/NZ514450A/xx unknown
- 2000-03-21 PL PL00350796A patent/PL195529B1/pl unknown
- 2000-03-21 UA UA2001096487A patent/UA73115C2/uk unknown
- 2000-03-21 CA CA002366926A patent/CA2366926A1/en not_active Abandoned
- 2000-03-21 WO PCT/IB2000/000393 patent/WO2000056297A2/en not_active Ceased
- 2000-03-22 AR ARP000101281A patent/AR023130A1/es unknown
- 2000-03-23 TW TW089105321A patent/TWI239246B/zh not_active IP Right Cessation
-
2001
- 2001-09-21 NO NO20014608A patent/NO20014608L/no not_active Application Discontinuation
- 2001-09-23 IL IL145568A patent/IL145568A/en unknown
- 2001-10-02 ZA ZA200108082A patent/ZA200108082B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US6521644B1 (en) | 2003-02-18 |
| MXPA01009610A (es) | 2002-07-02 |
| NZ514450A (en) | 2002-11-26 |
| TR200102648T2 (tr) | 2001-12-21 |
| PL350796A1 (en) | 2003-02-10 |
| KR20010108389A (ko) | 2001-12-07 |
| IL145568A0 (en) | 2002-06-30 |
| TWI239246B (en) | 2005-09-11 |
| KR100704348B1 (ko) | 2007-04-05 |
| ATE297728T1 (de) | 2005-07-15 |
| HUP0200391A2 (en) | 2002-06-29 |
| WO2000056297A2 (en) | 2000-09-28 |
| MY124214A (en) | 2006-06-30 |
| NO20014608L (no) | 2001-10-31 |
| ZA200108082B (en) | 2002-12-24 |
| UA73115C2 (en) | 2005-06-15 |
| EP1171121A2 (en) | 2002-01-16 |
| HK1048589A1 (zh) | 2003-04-11 |
| JP2002539244A (ja) | 2002-11-19 |
| AU3318600A (en) | 2000-10-09 |
| DE60020825T2 (de) | 2006-05-04 |
| AU772421B2 (en) | 2004-04-29 |
| GB9906715D0 (en) | 1999-05-19 |
| IL145568A (en) | 2007-09-20 |
| HUP0200391A3 (en) | 2002-11-28 |
| EP1171121B1 (en) | 2005-06-15 |
| RU2242228C2 (ru) | 2004-12-20 |
| CZ20013411A3 (cs) | 2002-04-17 |
| DE60020825D1 (de) | 2005-07-21 |
| PL195529B1 (pl) | 2007-09-28 |
| WO2000056297A3 (en) | 2001-01-25 |
| NO20014608D0 (no) | 2001-09-21 |
| CN1359293A (zh) | 2002-07-17 |
| CA2366926A1 (en) | 2000-09-28 |
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