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AR023089A1 - A PROCESS TO DEVELOP ALDEHIDO INTERMEDIATES - Google Patents

A PROCESS TO DEVELOP ALDEHIDO INTERMEDIATES

Info

Publication number
AR023089A1
AR023089A1 ARP000100957A AR023089A1 AR 023089 A1 AR023089 A1 AR 023089A1 AR P000100957 A ARP000100957 A AR P000100957A AR 023089 A1 AR023089 A1 AR 023089A1
Authority
AR
Argentina
Prior art keywords
treating
alcohol protecting
compound
derivatives
preparing
Prior art date
Application number
Other languages
Spanish (es)
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of AR023089A1 publication Critical patent/AR023089A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Un proceso para elaborar un nuevo intermedio de aldehído util para elaborar derivados de 13, 14-dihidroprostaglandinas A, D, E, y F y un método parapreparar un derivado de prostaglandina. El método para preparar el nuevo intermedio de aldehído util para elaborar derivados de 13, 14-dihidroprostaglandinastiene la estructura de la formula (1) en donde R es alquilo inferior, anillo alifático carbocíclico, anillo alifático heterocíclico, anillo aromático, o anilloheteroaromático; y Q1 y Q2 son grupos protectores de alcohol no electrofilos; en donde Q1 y Q2 son el mismo o diferente grupo protector de alcohol noelectrofilo, que comprende los pasos de: a) proveer un compuesto que tiene la estructura de la formula (2) en donde R y Q1 son como se definen anteriormente;b) tratar el compuesto proporcionado en el paso a antes mencionado con un agente de reduccion de hidruro; c) tratar el producto del paso b antes mencionado conun grupo protector de alcohol no electrofílico; y d) tratar el productodel paso c antes mencionado con un reactivo de particion de olefina y un reoxidante; ydicho compuesto. Los derivados son utiles para el tratamiento de muchos trastornos médicos incluyendo, por ejemplo, trastornos oculares, hipertension, controlde lafertilidad, y osteoporosis.A process for developing a new aldehyde intermediate useful for making derivatives of 13, 14-dihydroprostaglandins A, D, E, and F and a method for preparing a prostaglandin derivative. The method for preparing the new aldehyde intermediate useful for making derivatives of 13, 14-dihydroprostaglandin has the structure of the formula (1) wherein R is lower alkyl, carbocyclic aliphatic ring, heterocyclic aliphatic ring, aromatic ring, or heteroaromatic ring; and Q1 and Q2 are non-electrophilic alcohol protecting groups; wherein Q1 and Q2 are the same or different non-electrophilic alcohol protecting group, which comprises the steps of: a) providing a compound having the structure of formula (2) where R and Q1 are as defined above; b) treating the compound provided in the aforementioned step a with a hydride reducing agent; c) treating the product of step b mentioned above with a non-electrophilic alcohol protecting group; and d) treating the product of step c mentioned above with an olefin partition reagent and a reoxidant; and said compound. Derivatives are useful for the treatment of many medical disorders including, for example, eye disorders, hypertension, fertility control, and osteoporosis.

ARP000100957 1999-03-05 2000-03-03 A PROCESS TO DEVELOP ALDEHIDO INTERMEDIATES AR023089A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12301099P 1999-03-05 1999-03-05

Publications (1)

Publication Number Publication Date
AR023089A1 true AR023089A1 (en) 2002-09-04

Family

ID=22406203

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP000100957 AR023089A1 (en) 1999-03-05 2000-03-03 A PROCESS TO DEVELOP ALDEHIDO INTERMEDIATES

Country Status (3)

Country Link
AR (1) AR023089A1 (en)
AU (1) AU3861700A (en)
WO (1) WO2000051977A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030055084A1 (en) * 2001-07-30 2003-03-20 Millennium Pharmaceutical, Inc. Pharmaceutical compounds and methods of use thereof
ATE496903T1 (en) * 2007-02-01 2011-02-15 Allergan Inc THIOPHENE DERIVATIVES AS MEDICATIONS FOR THE TREATMENT OF OCCULAR HYPERTENSION
US7964595B2 (en) * 2008-01-18 2011-06-21 Allergan, Inc. Thiophenyl prostaglandin derivatives for treating glaucoma and ocular hypertension

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1507211A (en) * 1975-02-14 1978-04-12 Ono Pharmaceutical Co Prostaglandin analogues
DE2517771A1 (en) * 1975-04-18 1976-10-28 Schering Ag NEW PROSTAGLANDIN ACETYLENE ANALOGS AND METHOD FOR THEIR PRODUCTION

Also Published As

Publication number Publication date
AU3861700A (en) 2000-09-21
WO2000051977A1 (en) 2000-09-08

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