AR023058A1 - Derivados del tiazol, un procedimiento para su obtencion, composiciones farmaceuticas que los comprenden y el empleo de los mismos para la preparacion demedicamentos - Google Patents
Derivados del tiazol, un procedimiento para su obtencion, composiciones farmaceuticas que los comprenden y el empleo de los mismos para la preparacion demedicamentosInfo
- Publication number
- AR023058A1 AR023058A1 ARP990105306A ARP990105306A AR023058A1 AR 023058 A1 AR023058 A1 AR 023058A1 AR P990105306 A ARP990105306 A AR P990105306A AR P990105306 A ARP990105306 A AR P990105306A AR 023058 A1 AR023058 A1 AR 023058A1
- Authority
- AR
- Argentina
- Prior art keywords
- cell
- procedure
- obtaining
- preparation
- pharmaceutical compositions
- Prior art date
Links
- 229940079593 drug Drugs 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 241000894006 Bacteria Species 0.000 abstract 1
- 206010012689 Diabetic retinopathy Diseases 0.000 abstract 1
- 206010016654 Fibrosis Diseases 0.000 abstract 1
- 241000233866 Fungi Species 0.000 abstract 1
- 206010027476 Metastases Diseases 0.000 abstract 1
- 208000010191 Osteitis Deformans Diseases 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 208000027868 Paget disease Diseases 0.000 abstract 1
- 201000004681 Psoriasis Diseases 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- 239000000853 adhesive Substances 0.000 abstract 1
- 230000001070 adhesive effect Effects 0.000 abstract 1
- 206010003246 arthritis Diseases 0.000 abstract 1
- 230000008619 cell matrix interaction Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000007812 deficiency Effects 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 230000004761 fibrosis Effects 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000008611 intercellular interaction Effects 0.000 abstract 1
- 208000002780 macular degeneration Diseases 0.000 abstract 1
- 208000027202 mammary Paget disease Diseases 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 208000037803 restenosis Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000001356 surgical procedure Methods 0.000 abstract 1
- 150000007979 thiazole derivatives Chemical class 0.000 abstract 1
- 230000004614 tumor growth Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Oncology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Communicable Diseases (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Ophthalmology & Optometry (AREA)
- Vascular Medicine (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Derivados de tiazol que comprenden compuestos de formula (1), así como las sales y ésteres farmacéuticamente aceptables de los mismos, en donde R1, R2 y R3tienen el significado dado en la memoria. Inhiben la union de las proteínas adhesivas a la superficie de diferentes tipos de células y en consecuencia influyensobre las interacciones célula-célula y célula-matriz. También se describen composiciones farmacéuticas para el control o prevencion de neoplasmas, metástasisde tumores, crecimiento tumoral, osteoporosis, enfermedad de Paget, retinopatía diabética, degeneracion macular, restenosis después de una intervencionvascular, psoriasis, artitris, fibrosis, deficiencia renal, así como infecciones causadas por virus, bacterias u hongos, un procedimiento para su obtencion yel empleo de los mismos para la preparacion de medicamentos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98119985 | 1998-10-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR023058A1 true AR023058A1 (es) | 2002-09-04 |
Family
ID=8232838
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990105306A AR023058A1 (es) | 1998-10-22 | 1999-10-20 | Derivados del tiazol, un procedimiento para su obtencion, composiciones farmaceuticas que los comprenden y el empleo de los mismos para la preparacion demedicamentos |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US6297266B1 (es) |
| EP (1) | EP1123283B1 (es) |
| JP (1) | JP3530137B2 (es) |
| KR (1) | KR100469219B1 (es) |
| CN (1) | CN1211375C (es) |
| AR (1) | AR023058A1 (es) |
| AT (1) | ATE266012T1 (es) |
| AU (1) | AU760219B2 (es) |
| BR (1) | BR9914666A (es) |
| CA (1) | CA2347741C (es) |
| CO (1) | CO5150186A1 (es) |
| CZ (1) | CZ20011395A3 (es) |
| DE (1) | DE69917058T2 (es) |
| DK (1) | DK1123283T3 (es) |
| ES (1) | ES2221482T3 (es) |
| HK (1) | HK1047281A1 (es) |
| HR (1) | HRP20010275A2 (es) |
| HU (1) | HUP0104202A3 (es) |
| ID (1) | ID28356A (es) |
| IL (1) | IL142090A0 (es) |
| MA (1) | MA26756A1 (es) |
| NO (1) | NO20011908L (es) |
| NZ (1) | NZ510676A (es) |
| PE (1) | PE20001116A1 (es) |
| PL (1) | PL347427A1 (es) |
| PT (1) | PT1123283E (es) |
| RU (1) | RU2214404C2 (es) |
| TR (1) | TR200101115T2 (es) |
| WO (1) | WO2000024724A1 (es) |
| YU (1) | YU29201A (es) |
| ZA (1) | ZA200102653B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7125875B2 (en) | 1999-04-15 | 2006-10-24 | Bristol-Myers Squibb Company | Cyclic protein tyrosine kinase inhibitors |
| HUP0202708A3 (en) * | 1999-04-15 | 2004-12-28 | Bristol Myers Squibb Co | Cyclic protein tyrosine kinase inhibitors, pharmaceutical compositions containing them and their use |
| ES2287096T3 (es) * | 2000-01-19 | 2007-12-16 | Synvista Therapeutics, Inc. | Compuestos de tiazol, imidazol y oxazol y tratamientos de trastornos asociados con el envejecimiento de las proteinas. |
| CA2419820A1 (en) | 2000-08-17 | 2002-02-21 | Lumera Corporation | Design and synthesis of advanced nlo materials for electro-optic applications |
| HUP0303538A2 (hu) | 2000-12-21 | 2005-02-28 | Bristol-Myers Squibb Co. | Tirozin kinázok Tec családjának tiazolil-vegyület inhibitorai és ezeket tartalmazó gyógyszerkészítmények |
| CA2580725A1 (en) * | 2004-09-20 | 2006-03-30 | 4Sc Ag | Novel heterocyclic nf-kb inhibitors |
| UA103319C2 (en) | 2008-05-06 | 2013-10-10 | Глаксосмитклайн Ллк | Thiazole- and oxazole-benzene sulfonamide compounds |
| WO2010012793A1 (en) * | 2008-08-01 | 2010-02-04 | Bayer Cropscience Sa | Fungicide aminothiazole derivatives |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL95548A0 (en) * | 1989-09-15 | 1991-06-30 | Fujisawa Pharmaceutical Co | Thiazole derivatives,processes for the preparation thereof and pharmaceutical composition containing the same |
| US5273982A (en) | 1990-03-09 | 1993-12-28 | Hoffmann-La Roche Inc. | Acetic acid derivatives |
| CA2037153A1 (en) * | 1990-03-09 | 1991-09-10 | Leo Alig | Acetic acid derivatives |
| US6306840B1 (en) * | 1995-01-23 | 2001-10-23 | Biogen, Inc. | Cell adhesion inhibitors |
| JPH0987237A (ja) * | 1995-09-21 | 1997-03-31 | Kyowa Hakko Kogyo Co Ltd | 芳香族誘導体 |
| WO1997037655A1 (en) | 1996-04-10 | 1997-10-16 | Merck & Co., Inc. | αvβ3 ANTAGONISTS |
| PL330915A1 (en) | 1996-06-28 | 1999-06-07 | Merck Patent Gmbh | Phenylaniline derivatives as inhibitors of integrin |
| SI0928793T1 (en) * | 1998-01-02 | 2002-10-31 | F. Hoffmann-La Roche Ag | Thiazole derivatives |
| US6100282A (en) | 1998-01-02 | 2000-08-08 | Hoffman-La Roche Inc. | Thiazole derivatives |
| US6001855A (en) | 1998-01-02 | 1999-12-14 | Hoffman-La Roche Inc. | Thiazole derivatives |
| EP0928790B1 (en) * | 1998-01-02 | 2003-03-05 | F. Hoffmann-La Roche Ag | Thiazole derivatives |
-
1999
- 1999-10-15 JP JP2000578294A patent/JP3530137B2/ja not_active Expired - Fee Related
- 1999-10-15 KR KR10-2001-7004899A patent/KR100469219B1/ko not_active Expired - Fee Related
- 1999-10-15 CN CNB998124265A patent/CN1211375C/zh not_active Expired - Fee Related
- 1999-10-15 CA CA002347741A patent/CA2347741C/en not_active Expired - Fee Related
- 1999-10-15 ID IDW20010863A patent/ID28356A/id unknown
- 1999-10-15 HK HK02108922.4A patent/HK1047281A1/zh unknown
- 1999-10-15 EP EP99970988A patent/EP1123283B1/en not_active Expired - Lifetime
- 1999-10-15 AT AT99970988T patent/ATE266012T1/de not_active IP Right Cessation
- 1999-10-15 WO PCT/EP1999/007824 patent/WO2000024724A1/en not_active Ceased
- 1999-10-15 IL IL14209099A patent/IL142090A0/xx unknown
- 1999-10-15 PT PT99970988T patent/PT1123283E/pt unknown
- 1999-10-15 TR TR2001/01115T patent/TR200101115T2/xx unknown
- 1999-10-15 RU RU2001113285/04A patent/RU2214404C2/ru not_active IP Right Cessation
- 1999-10-15 YU YU29201A patent/YU29201A/sh unknown
- 1999-10-15 NZ NZ510676A patent/NZ510676A/xx unknown
- 1999-10-15 HR HR20010275A patent/HRP20010275A2/hr not_active Application Discontinuation
- 1999-10-15 HU HU0104202A patent/HUP0104202A3/hu unknown
- 1999-10-15 PL PL99347427A patent/PL347427A1/xx not_active Application Discontinuation
- 1999-10-15 CZ CZ20011395A patent/CZ20011395A3/cs unknown
- 1999-10-15 BR BR9914666-5A patent/BR9914666A/pt not_active IP Right Cessation
- 1999-10-15 DE DE69917058T patent/DE69917058T2/de not_active Expired - Fee Related
- 1999-10-15 DK DK99970988T patent/DK1123283T3/da active
- 1999-10-15 AU AU11519/00A patent/AU760219B2/en not_active Ceased
- 1999-10-15 ES ES99970988T patent/ES2221482T3/es not_active Expired - Lifetime
- 1999-10-18 PE PE1999001048A patent/PE20001116A1/es not_active Application Discontinuation
- 1999-10-19 US US09/420,387 patent/US6297266B1/en not_active Expired - Fee Related
- 1999-10-20 CO CO99066263A patent/CO5150186A1/es unknown
- 1999-10-20 AR ARP990105306A patent/AR023058A1/es not_active Application Discontinuation
-
2001
- 2001-03-30 ZA ZA200102653A patent/ZA200102653B/en unknown
- 2001-04-18 NO NO20011908A patent/NO20011908L/no not_active Application Discontinuation
- 2001-04-20 MA MA26171A patent/MA26756A1/fr unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |