AR022090A1 - PARTICLES FOR THE ADMINISTRATION OF AN ACTIVE AGENT TO THE HUMAN PATIENT ALVELS, A METHOD FOR THEIR PREPARATION, AND THE USE OF THE SAME FOR THE PREPARATION OF AN INHALATION MEDICATION - Google Patents
PARTICLES FOR THE ADMINISTRATION OF AN ACTIVE AGENT TO THE HUMAN PATIENT ALVELS, A METHOD FOR THEIR PREPARATION, AND THE USE OF THE SAME FOR THE PREPARATION OF AN INHALATION MEDICATIONInfo
- Publication number
- AR022090A1 AR022090A1 ARP990104587A ARP990104587A AR022090A1 AR 022090 A1 AR022090 A1 AR 022090A1 AR P990104587 A ARP990104587 A AR P990104587A AR P990104587 A ARP990104587 A AR P990104587A AR 022090 A1 AR022090 A1 AR 022090A1
- Authority
- AR
- Argentina
- Prior art keywords
- preparation
- particles
- active agent
- administration
- human patient
- Prior art date
Links
- 239000002245 particle Substances 0.000 title abstract 5
- 239000013543 active substance Substances 0.000 title abstract 3
- 229940079593 drug Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000003966 growth inhibitor Substances 0.000 abstract 2
- 210000004072 lung Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Otolaryngology (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Abstract
Partículas para la administracion de un agente activo a los alvéolos de un paciente humano, partículas que contienen el agente activo y un inhibidor delcrecimiento higroscopico, donde el inhibidor del crecimiento higroscopico está incorporado al interior de las partículas donde las partículas exhiben una caídade la dosis emitida, en condiciones pulmonares simuladas, de no más de aproximadamente 25%.Particles for the administration of an active agent to the alveoli of a human patient, particles containing the active agent and a hygroscopic growth inhibitor, where the hygroscopic growth inhibitor is incorporated into the particles where the particles exhibit a fall in the emitted dose , in simulated lung conditions, of no more than approximately 25%.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10016398P | 1998-09-14 | 1998-09-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR022090A1 true AR022090A1 (en) | 2002-09-04 |
Family
ID=22278404
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990104587A AR022090A1 (en) | 1998-09-14 | 1999-09-13 | PARTICLES FOR THE ADMINISTRATION OF AN ACTIVE AGENT TO THE HUMAN PATIENT ALVELS, A METHOD FOR THEIR PREPARATION, AND THE USE OF THE SAME FOR THE PREPARATION OF AN INHALATION MEDICATION |
Country Status (44)
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6956021B1 (en) | 1998-08-25 | 2005-10-18 | Advanced Inhalation Research, Inc. | Stable spray-dried protein formulations |
| JP4874483B2 (en) | 1999-06-09 | 2012-02-15 | ロバート イー． シーバース | Supercritical fluid assisted nebulization and bubble drying |
| US6475468B2 (en) * | 2001-02-15 | 2002-11-05 | Aeropharm Technology Incorporated | Modulated release particles for aerosol delivery |
| US6737042B2 (en) * | 2001-05-24 | 2004-05-18 | Alexza Molecular Delivery Corporation | Delivery of drug esters through an inhalation route |
| EG24184A (en) * | 2001-06-15 | 2008-10-08 | Otsuka Pharma Co Ltd | Dry powder inhalation system for transpulmonary |
| CA2465675C (en) | 2001-11-20 | 2008-06-10 | Advanced Inhalation Research, Inc. | Improved particulate compositions for pulmonary delivery |
| BR0307935A (en) | 2002-02-25 | 2005-03-29 | Diffusion Pharmaceuticals Llc | Bipolar Trans Carotenoid Salts And Their Uses |
| US7759506B2 (en) | 2002-02-25 | 2010-07-20 | Diffusion Pharmaceuticals Llc | Bipolar trans carotenoid salts and their uses |
| CA2491129A1 (en) * | 2002-07-03 | 2004-01-15 | Brigham And Women's Hospital, Inc. | Central airway administration for systemic delivery of therapeutics |
| AU2003298010A1 (en) * | 2002-12-19 | 2004-07-29 | Pharmacia Corporation | Non-hygroscopic formulation comprising a hydroscopic drug |
| DE10338403A1 (en) * | 2003-08-18 | 2005-03-17 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Powder formulation containing the CGRP antagonist 1- [N 2 - [3,5-dibromo-N - [[4- (3,4-dihydro-2 (1 H) -oxoquinazolin-3-yl] -1-piperidinyl] carbonyl] -D-tyrosyl] -L-lysyl] -4- (4-pyrindinyl) piperazine, process for its preparation and its use as inhalant |
| GB0327723D0 (en) * | 2003-09-15 | 2003-12-31 | Vectura Ltd | Pharmaceutical compositions |
| US20070020299A1 (en) | 2003-12-31 | 2007-01-25 | Pipkin James D | Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid |
| KR101725225B1 (en) | 2004-04-23 | 2017-04-12 | 사이덱스 파마슈티칼스, 인크. | DPI formulation containing sulfoalkyl ether cyclodextrin |
| US8030350B2 (en) * | 2005-02-24 | 2011-10-04 | Diffusion Pharmaceuticals Llc | Trans carotenoids, their synthesis, formulation and uses |
| RU2007137121A (en) * | 2005-03-09 | 2009-04-20 | Оно Фармасьютикал Ко., Лтд. (Jp) | PARTICLE AND PREPARATION CONTAINING THE SPECIFIED PARTICLE |
| PT2952197T (en) | 2005-10-26 | 2017-07-28 | Cydex Pharmaceuticals Inc | COMPOSITIONS OF CYLODEXTRIN SULFOHYLKYL ETHER AND METHODS FOR THEIR PREPARATION |
| US7629331B2 (en) | 2005-10-26 | 2009-12-08 | Cydex Pharmaceuticals, Inc. | Sulfoalkyl ether cyclodextrin compositions and methods of preparation thereof |
| US20080035143A1 (en) * | 2006-08-14 | 2008-02-14 | Sievers Robert E | Human-powered dry powder inhaler and dry powder inhaler compositions |
| WO2008050847A1 (en) * | 2006-10-25 | 2008-05-02 | Dainippon Sumitomo Pharma Co., Ltd. | Granular preparation prevented from caking |
| EP1925295A1 (en) * | 2006-11-22 | 2008-05-28 | Boehringer Ingelheim Pharma GmbH & Co. KG | Stable powder formulation containing a new antichinolinergic agent |
| EP2146948A4 (en) | 2007-04-13 | 2010-08-04 | Diffusion Pharmaceuticals Llc | Use of bipolar trans carotenoids as a pretreatment and in the treatment of peripheral vascular disease |
| US12370352B2 (en) | 2007-06-28 | 2025-07-29 | Cydex Pharmaceuticals, Inc. | Nasal and ophthalmic delivery of aqueous corticosteroid solutions |
| WO2009058399A1 (en) | 2007-10-31 | 2009-05-07 | Diffusion Pharmaceuticals Llc | A new class of therapeutics that enhance small molecule diffusion |
| EP2432502B1 (en) * | 2009-05-20 | 2018-01-03 | Aeras | Stable, spray dried, immunogenic, viral compositions |
| EP3539542B1 (en) | 2009-06-22 | 2023-04-19 | Diffusion Pharmaceuticals LLC | Diffusion enhancing compounds and their use with a thrombolytic |
| CN103124498A (en) | 2010-06-02 | 2013-05-29 | 扩散药品有限公司 | Oral formulations of bipolar trans carotenoids |
| CN104394846B (en) | 2012-05-03 | 2018-10-19 | 爱尔兰詹森科学公司 | Polyinosinic acid-polycytidylic acid (poly(I:C)) formulations for the treatment of upper respiratory infections |
| BR112015010601B1 (en) * | 2012-11-09 | 2022-07-19 | Civitas Therapeutics, Inc. | PHARMACEUTICAL COMPOSITION AND USE OF THE COMPOSITION |
| US20180043585A9 (en) * | 2013-09-20 | 2018-02-15 | Virginia Commonwealth University | Delivery of particles using hygroscopic excipients |
| US10806770B2 (en) | 2014-10-31 | 2020-10-20 | Monash University | Powder formulation |
| JP7032320B2 (en) | 2016-03-24 | 2022-03-08 | ディフュージョン・ファーマシューティカルズ・エルエルシー | Use of bipolar transcarotenoids with chemotherapy and radiation therapy to treat cancer |
| US20220378727A1 (en) * | 2021-05-14 | 2022-12-01 | The University Of Hong Kong | Dry powder formulations of tamibarotene for pulmonary and intranasal delivery |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3155573A (en) * | 1958-05-06 | 1964-11-03 | Benger Lab Ltd | Inhalant composition and method of making same |
| AU659328B2 (en) * | 1992-06-12 | 1995-05-11 | Teijin Limited | Ultrafine powder for inhalation and production thereof |
| US6524557B1 (en) * | 1994-12-22 | 2003-02-25 | Astrazeneca Ab | Aerosol formulations of peptides and proteins |
| US5874064A (en) | 1996-05-24 | 1999-02-23 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
| CA2277801C (en) * | 1997-01-16 | 2002-10-15 | Massachusetts Institute Of Technology | Preparation of particles for inhalation |
| US6086376A (en) * | 1998-01-30 | 2000-07-11 | Rtp Pharma Inc. | Dry aerosol suspension of phospholipid-stabilized drug microparticles in a hydrofluoroalkane propellant |
-
1999
- 1999-09-09 MA MA25762A patent/MA25590A1/en unknown
- 1999-09-13 ZA ZA200101995A patent/ZA200101995B/en unknown
- 1999-09-13 JP JP2000569846A patent/JP2002524535A/en not_active Withdrawn
- 1999-09-13 BR BR9913722-4A patent/BR9913722A/en not_active IP Right Cessation
- 1999-09-13 GE GEAP19995857A patent/GEP20043257B/en unknown
- 1999-09-13 KR KR1020017003208A patent/KR20010075063A/en not_active Ceased
- 1999-09-13 AP APAP/P/2001/002093A patent/AP1374A/en active
- 1999-09-13 WO PCT/US1999/021109 patent/WO2000015262A1/en not_active Ceased
- 1999-09-13 HN HN1999000159A patent/HN1999000159A/en unknown
- 1999-09-13 PE PE1999000925A patent/PE20001061A1/en not_active Application Discontinuation
- 1999-09-13 TW TW088115876A patent/TWI226248B/en not_active IP Right Cessation
- 1999-09-13 SK SK344-2001A patent/SK3442001A3/en unknown
- 1999-09-13 PL PL99346768A patent/PL195574B1/en not_active IP Right Cessation
- 1999-09-13 EA EA200100300A patent/EA003476B1/en active IP Right Revival
- 1999-09-13 ID IDW20010582A patent/ID28845A/en unknown
- 1999-09-13 YU YU24201A patent/YU24201A/en unknown
- 1999-09-13 IL IL14156299A patent/IL141562A0/en not_active IP Right Cessation
- 1999-09-13 CN CN99810871A patent/CN1317977A/en active Pending
- 1999-09-13 HK HK02101738.3A patent/HK1042231A1/en unknown
- 1999-09-13 TR TR2001/01182T patent/TR200101182T2/en unknown
- 1999-09-13 MY MYPI99003947A patent/MY129282A/en unknown
- 1999-09-13 EP EP99969035A patent/EP1117442A1/en not_active Withdrawn
- 1999-09-13 UA UA2001031707A patent/UA76085C2/en unknown
- 1999-09-13 NZ NZ510168A patent/NZ510168A/en unknown
- 1999-09-13 HR HR20010189A patent/HRP20010189A2/en not_active Application Discontinuation
- 1999-09-13 AU AU60397/99A patent/AU753014B2/en not_active Ceased
- 1999-09-13 HU HU0103837A patent/HUP0103837A3/en unknown
- 1999-09-13 EE EEP200100151A patent/EE200100151A/en unknown
- 1999-09-13 CA CA002343920A patent/CA2343920A1/en not_active Abandoned
- 1999-09-13 OA OA1200100063A patent/OA11781A/en unknown
- 1999-09-13 AR ARP990104587A patent/AR022090A1/en unknown
- 1999-09-13 DZ DZ990192A patent/DZ2892A1/en active
- 1999-09-13 CZ CZ2001829A patent/CZ2001829A3/en unknown
- 1999-09-14 UY UY25711A patent/UY25711A1/en not_active Application Discontinuation
- 1999-09-14 CO CO99058265A patent/CO5130023A1/en unknown
- 1999-09-14 TN TNTNSN99173A patent/TNSN99173A1/en unknown
- 1999-09-14 PA PA19998481901A patent/PA8481901A1/en unknown
- 1999-09-14 GT GT199900156A patent/GT199900156A/en unknown
- 1999-10-31 SA SA99200718A patent/SA99200718B1/en unknown
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2001
- 2001-02-21 IL IL141562A patent/IL141562A/en unknown
- 2001-03-05 IS IS5878A patent/IS5878A/en unknown
- 2001-03-13 NO NO20011251A patent/NO20011251L/en not_active Application Discontinuation
- 2001-03-14 LT LT2001021A patent/LT4897B/en not_active IP Right Cessation
- 2001-03-14 LV LV010041A patent/LV12658B/en unknown
- 2001-04-10 BG BG105430A patent/BG105430A/en unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |