AR021971A1 - PROTEASE INHIBITORS - Google Patents
PROTEASE INHIBITORSInfo
- Publication number
- AR021971A1 AR021971A1 ARP990106648A AR021971A1 AR 021971 A1 AR021971 A1 AR 021971A1 AR P990106648 A ARP990106648 A AR P990106648A AR 021971 A1 AR021971 A1 AR 021971A1
- Authority
- AR
- Argentina
- Prior art keywords
- disease
- cartilage
- matrix
- compounds
- excessive
- Prior art date
Links
- 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 title 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 206010065687 Bone loss Diseases 0.000 abstract 2
- 102000035195 Peptidases Human genes 0.000 abstract 2
- 108091005804 Peptidases Proteins 0.000 abstract 2
- 239000004365 Protease Substances 0.000 abstract 2
- 210000000845 cartilage Anatomy 0.000 abstract 2
- 230000015556 catabolic process Effects 0.000 abstract 2
- 238000006731 degradation reaction Methods 0.000 abstract 2
- 239000011159 matrix material Substances 0.000 abstract 2
- QTLLOLTVQMFWDZ-UHFFFAOYSA-N 4-aminoazepan-3-one Chemical compound NC1CCCNCC1=O QTLLOLTVQMFWDZ-UHFFFAOYSA-N 0.000 abstract 1
- 102000004171 Cathepsin K Human genes 0.000 abstract 1
- 108090000625 Cathepsin K Proteins 0.000 abstract 1
- 208000037147 Hypercalcaemia Diseases 0.000 abstract 1
- 208000010191 Osteitis Deformans Diseases 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 208000027868 Paget disease Diseases 0.000 abstract 1
- 206010003246 arthritis Diseases 0.000 abstract 1
- 210000000988 bone and bone Anatomy 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000016097 disease of metabolism Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000024693 gingival disease Diseases 0.000 abstract 1
- 208000007565 gingivitis Diseases 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 230000000148 hypercalcaemia Effects 0.000 abstract 1
- 208000030915 hypercalcemia disease Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 208000027202 mammary Paget disease Diseases 0.000 abstract 1
- 208000030159 metabolic disease Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 201000008482 osteoarthritis Diseases 0.000 abstract 1
- 201000001245 periodontitis Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente proporciona inhibidores de proteasas de 4-amino-azepan-3-ona y sus sales, hidratos y solvatos farmacéuticamente aceptables que inhibenproteasas, con inclusion de catepsina K, composiciones farmacéuticas de dichos compuestos, nuevos compuestos intermediarios de los compuestos de este tipo, ymétodos para tratar enfermedades de pérdida osea excesiva o degradacion excesiva de cartílago o matriz, con inclusion de osteoporosis; enfermedad gingival coninclusion de gingivitis y periodontitis; artritis, más específicamente, osteoartritis y artritis reumatoide; enfermedad de Paget; hipercalcemia de caráctermaligno; y enfermedad metabolica osea, que comprende inhibir dicha pérdida osea o degradacion excesiva de cartílago o matriz por administracion de un compuestode la presente a un paciente que se encuentra en necesidad de ello.It provides inhibitors of 4-amino-azepan-3-one proteases and their pharmaceutically acceptable salts, hydrates and solvates that inhibit proteases, including cathepsin K, pharmaceutical compositions of said compounds, novel intermediates of compounds of this type, and methods for treating diseases of excessive bone loss or excessive degradation of cartilage or matrix, including osteoporosis; gingival disease including gingivitis and periodontitis; arthritis, more specifically, osteoarthritis and rheumatoid arthritis; Paget's disease; hypercalcemia of a natural character; and bone metabolic disease, which comprises inhibiting said bone loss or excessive degradation of cartilage or matrix by administering a compound thereof to a patient in need thereof.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11363698P | 1998-12-23 | 1998-12-23 | |
| US16458199A | 1999-11-10 | 1999-11-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR021971A1 true AR021971A1 (en) | 2002-09-04 |
Family
ID=45570254
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990106648 AR021971A1 (en) | 1998-12-23 | 1999-12-21 | PROTEASE INHIBITORS |
Country Status (1)
| Country | Link |
|---|---|
| AR (1) | AR021971A1 (en) |
-
1999
- 1999-12-21 AR ARP990106648 patent/AR021971A1/en not_active Application Discontinuation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |