AR020306A1 - Composicion terapeutica y su uso como inhibidora de la ciclooxigenasa-2 en la prevencion de alteraciones cardiovasculares. - Google Patents
Composicion terapeutica y su uso como inhibidora de la ciclooxigenasa-2 en la prevencion de alteraciones cardiovasculares.Info
- Publication number
- AR020306A1 AR020306A1 ARP980101789A AR020306A1 AR 020306 A1 AR020306 A1 AR 020306A1 AR P980101789 A ARP980101789 A AR P980101789A AR 020306 A1 AR020306 A1 AR 020306A1
- Authority
- AR
- Argentina
- Prior art keywords
- heterocyclyl
- alkyl
- arylamino
- inhibitor
- unsaturated
- Prior art date
Links
- 230000001225 therapeutic effect Effects 0.000 title abstract 2
- 230000004075 alteration Effects 0.000 title 1
- 230000002526 effect on cardiovascular system Effects 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 230000002265 prevention Effects 0.000 title 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 6
- -1 1,3BIS (cyclohexylmethyl) - 1,2,3,6-tetrahydro-2,6-dioxo-9H-purin-8-yl Chemical group 0.000 abstract 5
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 3
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
- 125000003282 alkyl amino group Chemical group 0.000 abstract 2
- 125000004644 alkyl sulfinyl group Chemical group 0.000 abstract 2
- 125000004414 alkyl thio group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000001475 halogen functional group Chemical group 0.000 abstract 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 229940093444 Cyclooxygenase 2 inhibitor Drugs 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- ZRVUJXDFFKFLMG-UHFFFAOYSA-N Meloxicam Chemical group OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=NC=C(C)S1 ZRVUJXDFFKFLMG-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000005078 alkoxycarbonylalkyl group Chemical group 0.000 abstract 1
- 125000000278 alkyl amino alkyl group Chemical group 0.000 abstract 1
- 125000004689 alkyl amino carbonyl alkyl group Chemical group 0.000 abstract 1
- 125000004457 alkyl amino carbonyl group Chemical group 0.000 abstract 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000006350 alkyl thio alkyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000004103 aminoalkyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000004659 aryl alkyl thio group Chemical group 0.000 abstract 1
- 125000001769 aryl amino group Chemical group 0.000 abstract 1
- 125000005129 aryl carbonyl group Chemical group 0.000 abstract 1
- 125000005160 aryl oxy alkyl group Chemical group 0.000 abstract 1
- 125000005110 aryl thio group Chemical group 0.000 abstract 1
- 125000005164 aryl thioalkyl group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 125000002837 carbocyclic group Chemical group 0.000 abstract 1
- 125000004181 carboxyalkyl group Chemical group 0.000 abstract 1
- 125000004966 cyanoalkyl group Chemical group 0.000 abstract 1
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
- 239000003255 cyclooxygenase 2 inhibitor Substances 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 125000005844 heterocyclyloxy group Chemical group 0.000 abstract 1
- 150000004678 hydrides Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 229960001929 meloxicam Drugs 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- CXJONBHNIJFARE-UHFFFAOYSA-N n-[6-(2,4-difluorophenoxy)-1-oxo-2,3-dihydroinden-5-yl]methanesulfonamide Chemical compound CS(=O)(=O)NC1=CC=2CCC(=O)C=2C=C1OC1=CC=C(F)C=C1F CXJONBHNIJFARE-UHFFFAOYSA-N 0.000 abstract 1
- HYWYRSMBCFDLJT-UHFFFAOYSA-N nimesulide Chemical compound CS(=O)(=O)NC1=CC=C([N+]([O-])=O)C=C1OC1=CC=CC=C1 HYWYRSMBCFDLJT-UHFFFAOYSA-N 0.000 abstract 1
- 229960000965 nimesulide Drugs 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000004043 oxo group Chemical group O=* 0.000 abstract 1
- RZJQGNCSTQAWON-UHFFFAOYSA-N rofecoxib Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C1=C(C=2C=CC=CC=2)C(=O)OC1 RZJQGNCSTQAWON-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La composicion terapéutica consiste en un inhibidor de ciclo-oxigenasa-2 o una sal farmacéuticamente aceptable o derivado del mismo y su uso para prevenirla afeccion cardiovascular relacionada con la inflamacion en un individuo que necesita taltrata miento, composicion que es seleccionada entre meloxicam,nimesulida, MK-966, L-783003, T-614, D-1367, L-748731, , CT3, CGP-28238, BF-389, GR-253035, ácido (E)-4-(1,3BIS(ciclohexilmetil)-1,2,3,6-tetrahidro-2,6-dioxo-9H-purin-8-il)cinámico, L-745337 y c ompuestos de formula 1: donde A es un sustituyente seleccionado a partir de anillos heterocíclicos parcialmente insaturadoso insaturados y carbocíclicos parcialmente insaturados o insaturados; donde R1 es como mínimo un sustituyenteseleccionado a pa rtir de heterociclo,cicloalquilo, cicloalquenilo y arilo, donde R1 es opcionalmente sustituido en una posicion sustituible con uno o más radicales seleccionados entre alquilohaloalquilo, ciano, carboxilo, alcoxicarbonilo,hidroxilo, hidroxialquilo, h aloalcoxi, amino, alquilamino, arilamino, nitro, alcoxialquilo, alquilsulfinilo,halo, alcoxi y alquiltio, donde R2 es metilo o amino; y donde R3 es un radical seleccionado a partir de hidruro, halo, alquilo, alquenilo,alquinilo, oxo,ciano, carboxilo , cianoalquilo, heterocicliloxi, alquiloxi, alquiltio, alquilcarbonilo, cicloalquilo, arilo, haloalquilo, heterociclilo cicloalquenilo,aralquilo, heterociclilalquilo, acilo, alquiltioalquilo, hidroxialquilo,alcoxicarbonilo, arilcarbonilo, aralquilca rbonilo, aralquenilo, alcoxialquilo,ariltioalquilo, ariloxialquilo, aralquiltioalquilo, aralcoxialquilo, aralcoxialquilo, alcoxiaralcoxialquilo, alcoxicarbonilalquilo, aminocarbonilo,aminocarbonilalquilo,alquilaminocarbonilo, N-arilaminocarbonilo, N -alquil-N-arilaminocarbonilo, alquilaminocarbonilalquilo, carboxialquilo, alquilamino,N-arilamino, N-aralquilamino, N-alquil-N-aralquilamino, Nalquil-N-arilamino, aminoalquilo, alquilaminoalquilo, N-arilaminoalquilo, N-aralquilaminoalquilo,N-alquil-N -aralquilaminoalquilo, N-alquil-N-arilaminoalquilo, ariloxi, aralcoxi, ariltio, aralquiltio, alquilsulfinilo, alquilsulfonilo, aminosulfonilo,
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4662697P | 1997-05-16 | 1997-05-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR020306A1 true AR020306A1 (es) | 2002-05-08 |
Family
ID=45571889
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980101789 AR020306A1 (es) | 1997-05-16 | 1998-04-17 | Composicion terapeutica y su uso como inhibidora de la ciclooxigenasa-2 en la prevencion de alteraciones cardiovasculares. |
Country Status (1)
| Country | Link |
|---|---|
| AR (1) | AR020306A1 (es) |
-
1998
- 1998-04-17 AR ARP980101789 patent/AR020306A1/es unknown
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| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |