AR020138A1 - COMPUESTOS DERIVADOS DE N-{3-[1-(1H-IMIDAZOL-4-IL)-ALQUIL C1-4]-fenil}-ALCAN-SULFONAMIDA, COMPOSICION FARMACEUTICA QUE LOS CONTIENE Y METODO PARA ACTIVARADRENO RECEPTORES a1 EN UN MAMIFERO. - Google Patents
COMPUESTOS DERIVADOS DE N-{3-[1-(1H-IMIDAZOL-4-IL)-ALQUIL C1-4]-fenil}-ALCAN-SULFONAMIDA, COMPOSICION FARMACEUTICA QUE LOS CONTIENE Y METODO PARA ACTIVARADRENO RECEPTORES a1 EN UN MAMIFERO.Info
- Publication number
- AR020138A1 AR020138A1 ARP990103957A ARP990103957A AR020138A1 AR 020138 A1 AR020138 A1 AR 020138A1 AR P990103957 A ARP990103957 A AR P990103957A AR P990103957 A ARP990103957 A AR P990103957A AR 020138 A1 AR020138 A1 AR 020138A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- group
- alkoxy
- arylalkyl
- cycloalkyl
- Prior art date
Links
- 125000000217 alkyl group Chemical group 0.000 title abstract 6
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 229940124530 sulfonamide Drugs 0.000 title 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 7
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 6
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 abstract 4
- 125000000304 alkynyl group Chemical group 0.000 abstract 4
- 125000001475 halogen functional group Chemical group 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 4
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 4
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 2
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 2
- KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Chemical compound C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 abstract 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- 125000003302 alkenyloxy group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 2
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 2
- 125000001188 haloalkyl group Chemical group 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical compound C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 abstract 1
- PCNDJXKNXGMECE-UHFFFAOYSA-N Phenazine Natural products C1=CC=CC2=NC3=CC=CC=C3N=C21 PCNDJXKNXGMECE-UHFFFAOYSA-N 0.000 abstract 1
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 abstract 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 abstract 1
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 abstract 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 125000002837 carbocyclic group Chemical group 0.000 abstract 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000002140 imidazol-4-yl group Chemical group [H]N1C([H])=NC([*])=C1[H] 0.000 abstract 1
- 125000000336 imidazol-5-yl group Chemical group [H]N1C([H])=NC([H])=C1[*] 0.000 abstract 1
- ZLTPDFXIESTBQG-UHFFFAOYSA-N isothiazole Chemical compound C=1C=NSC=1 ZLTPDFXIESTBQG-UHFFFAOYSA-N 0.000 abstract 1
- CTAPFRYPJLPFDF-UHFFFAOYSA-N isoxazole Chemical compound C=1C=NOC=1 CTAPFRYPJLPFDF-UHFFFAOYSA-N 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
- VLLMWSRANPNYQX-UHFFFAOYSA-N thiadiazole Chemical compound C1=CSN=N1.C1=CSN=N1 VLLMWSRANPNYQX-UHFFFAOYSA-N 0.000 abstract 1
- 150000003852 triazoles Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/84—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Compuesto que tiene la formula 1: amida éster o prodroga aceptable para uso farmacéutico, donde R1 se selecciona del grupo formado por -S(O)2R9 y -C(O)R10;R9 se selecciona del grupo que consiste de alquenilo C2-10, alquilo C1-10, alquinilo C2-10, arilo, arilalquenilo C2-5, arilalquilo C2-5, cicloalquilo C3-8,cicloalquil C3-7 alquilo C1-4, haloalquilo C1-5, heterociclo mono y bi-ciclo, y -NZ1Z2 donde Z1 y Z2 se seleccionan independientemente del grupo formado porhidrogeno, alquilo C1-10, alquil C1-4 carbonilo, arilo, arilalquilo C2-5, y formilo; R10 se selecciona del grupo formado por alquenilo C2-10, alcoxi C1-6,alquilo C1-10, alquinilo C2-10, arilo, arilalquilo C2-5, cicloalquilo C3-8, cicloalquil C3-7 alquilo C1-5, halo C1-5, y -NZ1Z2 definido precedentemente; R2 seselecciona del grupo formado por hidrogeno, alquenilo C2-10, alcoxi C1-6, alquilo C1-10, halo, halo C1-5 alquilo C1-5, e hidroxi; R3 se selecciona del grupoformado por alqueniloxi C2-5, alquilo C1-10, alcoxi C1-6, alcoxi C1-4 alquilo C1-4, alquinil C1-4 oxi, arilalquilo C2-5, cicloalquil C3-7 alquilo C1-4, haloC1-5 alquilo C1-5, e hidroxi; con la condicion de que cuando R3 es seleccionado del grupo que consiste de alqueniloxi, alquilo, alcoxi, alcoxi-alquilo-alquinil-oxi, aril-alquilo, ciclaoalquil-alquilo, halo-alquilo e hidroxi, con los alcances indicados precedentemente, entonces R4 es seleccionado del grupo queconsiste de hidrogeno, alquilo C1-10, alcoxi C1-6, halo C1-5, e hidroxi; o R3 y R4 junto con los átomos de carbono a los cuales se encuentran unidos forman unanillo carbocíclico de 5, 6 o 7 miembros; o R3 y R4 junto con los átomos de carbono a los cuales se encuentran unidos forman un anillo de 5 o 6 miembros quecontiene 1 heteroátomo seleccionadodel grupo formado por O, NR11, y S(O)n; R11 se selecciona del grupo formado por hidrogneo, alquenilo C2-10, alcoxi C1-4,carbonilo, alquilo C1-10, alquil C1-4, carbonilo, alquinilo C2-10, arilalquilo C2-5, formilo, -C(O)NZ1Z2, y -SO2NZ1Z2; n es 0-2: R5 se selecciona del grupoformado por imidazol-4-ilo, imidazol-5-ilo, pirazol, oxazol, isoxazol, tiazol, isotiazol, oxidiazol, triazol, tiadiazol, piridina, pirimidina, pirazina y
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13079998A | 1998-08-07 | 1998-08-07 | |
| US09/364,901 US6503935B1 (en) | 1998-08-07 | 1999-07-29 | Imidazoles and related compounds as α1A agonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR020138A1 true AR020138A1 (es) | 2002-04-10 |
Family
ID=22446384
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990103957A AR020138A1 (es) | 1998-08-07 | 1999-08-06 | COMPUESTOS DERIVADOS DE N-{3-[1-(1H-IMIDAZOL-4-IL)-ALQUIL C1-4]-fenil}-ALCAN-SULFONAMIDA, COMPOSICION FARMACEUTICA QUE LOS CONTIENE Y METODO PARA ACTIVARADRENO RECEPTORES a1 EN UN MAMIFERO. |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6503935B1 (es) |
| EP (1) | EP1102754A1 (es) |
| JP (1) | JP2002522423A (es) |
| AR (1) | AR020138A1 (es) |
| AU (1) | AU5338699A (es) |
| CA (1) | CA2338594A1 (es) |
| TW (1) | TW517050B (es) |
| WO (1) | WO2000007997A1 (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6503935B1 (en) | 1998-08-07 | 2003-01-07 | Abbott Laboratories | Imidazoles and related compounds as α1A agonists |
| US20030073850A1 (en) * | 1998-08-07 | 2003-04-17 | Altenbach Robert J. | 4-Imidazole derivatives of benzyl and restricted benzyl sulfonamides, sulfamides, ureas, carbamates, and amides and their use |
| FI20000073A0 (fi) * | 2000-01-14 | 2000-01-14 | Orion Yhtymae Oy | Uusia imidatsolijohdannaisia |
| US6388090B2 (en) | 2000-01-14 | 2002-05-14 | Orion Corporation | Imidazole derivatives |
| US20020183357A1 (en) * | 2000-02-17 | 2002-12-05 | Brioni Jorge D. | Use of alpha- 1- alpha adrenoceptor agonists with alpha-1-Beta antagonism for the treatment of stress urinary incontinence |
| US6323231B1 (en) | 2000-02-17 | 2001-11-27 | Abbott Laboratories | Use of α1A adrenoceptor agonists with α1B and α1D antagonism for the treatment of stress urinary incontinence |
| US7071220B2 (en) * | 2000-09-18 | 2006-07-04 | Toa Eiyo Ltd. | N-substituted benzothiophenesulfonamide derivatives |
| US7541381B2 (en) * | 2002-02-19 | 2009-06-02 | Northwestern University | Non-covalent inhibitors of AmpC β-lactamase |
| AR040241A1 (es) | 2002-06-10 | 2005-03-23 | Merck & Co Inc | Inhibidores de la 11-beta-hidroxiesteroide deshidrogrenasa 1 para el tratamiento de la diabetes obesidad y dislipidemia |
| US7875642B2 (en) | 2004-01-26 | 2011-01-25 | Merck Sharp & Dohme Corp. | Crystalline forms of an inhibitor of 11-β-hydroxysteroid dehydrogenase type 1 |
| EP1884512A4 (en) | 2005-05-23 | 2011-09-28 | Sagami Chem Res | PYRAZOLE-1-CARBOXYL ESTER DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND PROCESS FOR PRODUCING PYRAZOLE DERIVATIVE |
| CN118684628B (zh) * | 2024-05-20 | 2025-06-17 | 中国人民解放军军事科学院军事医学研究院 | 取代二氢茚基咪唑类化合物及其制备方法和用途 |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU518569B2 (en) | 1979-08-07 | 1981-10-08 | Farmos-Yhtyma Oy | 4-benzyl- and 4-benzoyl imidazole derivatives |
| DE3064042D1 (en) | 1979-08-27 | 1983-08-11 | Bayer Ag | Light collector system and use of coumarin derivatives as energy converters in such systems |
| GB2071655B (en) | 1980-03-04 | 1983-06-22 | Erba Farmitalia | N-amidazolyl derivatives of1-chroman and process for their preparation |
| US4320148A (en) | 1980-11-24 | 1982-03-16 | Smithkline Corporation | 2-Aminotetralin compounds, pharmaceutical compositions and method of producing central alpha1 agonist activity |
| PT77219B (fr) | 1982-08-24 | 1986-02-04 | May & Baker Ltd | Procede de preparation des derives de la benzamide |
| US4634705A (en) | 1984-06-06 | 1987-01-06 | Abbott Laboratories | Adrenergic amidines |
| US4813998A (en) | 1986-02-27 | 1989-03-21 | Janssen Pharmaceutica N.V. | Herbicidal 1H-imidazole-5-carboxylic acid derivatives |
| IT1216256B (it) | 1986-08-13 | 1990-02-22 | Menarini Sas | (benzofuran-2-il) imidazoli, con attivita' farmacologica,loro sali e procedimenti di fabbricazione relativi. |
| US5043447A (en) | 1987-04-24 | 1991-08-27 | Syntex Pharmaceuticals, Ltd. | Substituted imidazolyl-alkyl-piperazine and -diazepine derivatives |
| IL91542A0 (en) | 1988-10-06 | 1990-04-29 | Erba Carlo Spa | N-imidazolyl-and n-imidazolyl-methyl derivatives of substituted bicyclic compounds,their preparation and pharmaceutical compositions containing them |
| US5073566A (en) | 1989-11-30 | 1991-12-17 | Eli Lilly And Company | Angiotensin ii antagonist 1,3-imidazoles and use thereas |
| JP3393891B2 (ja) | 1992-08-18 | 2003-04-07 | 塩野義製薬株式会社 | イミダゾール類の製造方法 |
| US5296609A (en) | 1993-04-09 | 1994-03-22 | Syntex Pharmaceuticals, Ltd. | Process for the preparation of 1,2,4-substituted imidazoles and related aminoalkylimidazole derivatives |
| SE9302333D0 (sv) | 1993-07-06 | 1993-07-06 | Ab Astra | New compounds |
| HUT74386A (en) | 1993-11-15 | 1996-12-30 | Schering Corp | Phenyl-alkyl imidazoles as h3-receptor antagonists and pharmaceutical compositions containing them |
| US5616601A (en) | 1994-07-28 | 1997-04-01 | Gd Searle & Co | 1,2-aryl and heteroaryl substituted imidazolyl compounds for the treatment of inflammation |
| GB9425211D0 (en) | 1994-12-14 | 1995-02-15 | Ucb Sa | Substituted 1H-imidazoles |
| DE19514579A1 (de) | 1995-04-20 | 1996-10-24 | Boehringer Ingelheim Kg | Verwendung von alpha¶1¶¶L¶-Agonisten zur Behandlung der Harninkontinenz |
| CA2222573A1 (en) | 1995-06-02 | 1996-12-05 | Carlos C. Forray | The use of alpha-1c-selective adrenoceptor agonists for the treatment of urinary incontinence |
| US5610174A (en) | 1995-06-02 | 1997-03-11 | Synaptic Pharmaceutical Corporation | Use of α1A -selective adrenoceptor agonists for the treatment of urinary incontinence |
| US5756528A (en) | 1995-06-06 | 1998-05-26 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| RU2182904C2 (ru) | 1996-02-09 | 2002-05-27 | Джеймс Блэк Фаундейшн Лимитед | Сульфонамиды и способы их получения |
| JP2000507955A (ja) | 1996-04-03 | 2000-06-27 | メルク エンド カンパニー インコーポレーテッド | ファルネシル―タンパク質転移酵素の阻害剤 |
| WO1997040017A2 (en) | 1996-04-19 | 1997-10-30 | Novo Nordisk A/S | Modulators of molecules with phosphotyrosine recognition units |
| GB9702194D0 (en) | 1997-02-04 | 1997-03-26 | Lilly Co Eli | Sulphonide derivatives |
| US5866579A (en) | 1997-04-11 | 1999-02-02 | Synaptic Pharmaceutical Corporation | Imidazole and imidazoline derivatives and uses thereof |
| SG72827A1 (en) | 1997-06-23 | 2000-05-23 | Hoffmann La Roche | Phenyl-and aminophenyl-alkylsulfonamide and urea derivatives |
| US6407132B1 (en) | 1997-07-25 | 2002-06-18 | James Black Foundation Limited | Substituted imidazole derivatives and their use as histamine H3 receptor ligands |
| FR2768055A1 (fr) | 1997-09-11 | 1999-03-12 | Synthelabo | Utilisation de derives de sulfonanilide pour obtenir un medicament destine au traitement de l'ejaculation retrograde ou de l'aspermie |
| FR2768054A1 (fr) | 1997-09-11 | 1999-03-12 | Synthelabo | Utilisation de derives de benzene sulfonamide pour obtenir un medicament destine au traitement de l'ejaculation retrograde ou de l'aspermie |
| US6503935B1 (en) | 1998-08-07 | 2003-01-07 | Abbott Laboratories | Imidazoles and related compounds as α1A agonists |
-
1999
- 1999-07-29 US US09/364,901 patent/US6503935B1/en not_active Expired - Fee Related
- 1999-08-06 AR ARP990103957A patent/AR020138A1/es not_active Application Discontinuation
- 1999-08-06 JP JP2000563631A patent/JP2002522423A/ja not_active Withdrawn
- 1999-08-06 CA CA002338594A patent/CA2338594A1/en not_active Abandoned
- 1999-08-06 EP EP99939019A patent/EP1102754A1/en not_active Withdrawn
- 1999-08-06 WO PCT/US1999/017739 patent/WO2000007997A1/en not_active Ceased
- 1999-08-06 AU AU53386/99A patent/AU5338699A/en not_active Abandoned
- 1999-09-14 TW TW088113524A patent/TW517050B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| TW517050B (en) | 2003-01-11 |
| AU5338699A (en) | 2000-02-28 |
| JP2002522423A (ja) | 2002-07-23 |
| WO2000007997A8 (en) | 2000-05-04 |
| EP1102754A1 (en) | 2001-05-30 |
| CA2338594A1 (en) | 2000-02-17 |
| WO2000007997A1 (en) | 2000-02-17 |
| US6503935B1 (en) | 2003-01-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR020138A1 (es) | COMPUESTOS DERIVADOS DE N-{3-[1-(1H-IMIDAZOL-4-IL)-ALQUIL C1-4]-fenil}-ALCAN-SULFONAMIDA, COMPOSICION FARMACEUTICA QUE LOS CONTIENE Y METODO PARA ACTIVARADRENO RECEPTORES a1 EN UN MAMIFERO. | |
| YU48390B (sh) | Novi derivati 2-anilinopirimidina, postupak za njihovo dobijanje i sredstva za uništavanje štetočina, koja sadrže ove derivate | |
| PE20020131A1 (es) | Derivados de pirazol | |
| ES2054309T3 (es) | Compuestos de urea sustituida y su preparacion y uso. | |
| DE69231445D1 (de) | Triazole enthaltende antifungizide mittel | |
| HU9501585D0 (en) | Azoxycyanobenzene-derivatives, process for their preparation, fungicidal compositions containing them | |
| ES394919A1 (es) | Procedimiento para la preparacion de nuevos 1-fenoxi-2-hi- droxi - 3 - alcohilaminopropanos racemicos u opticamente ac-tivos. | |
| GB869776A (en) | Isobutyrophenone compounds and the production thereof | |
| GB830832A (en) | New quinolones and therapeutic compositions containing them | |
| ES518527A0 (es) | Esteres fenolicos. | |
| NZ195740A (en) | N-substituted 2-methylnaphthylamide derivatives and fungicidal compositions | |
| WO1998045254A3 (en) | Oxime compounds, their use, and intermediates for their production | |
| US2507337A (en) | 1, 5-dialkyl tetrazoles and preparation thereof | |
| ES2604313T3 (es) | Métodos para preparar compuestos bicíclicos basados en imidazol | |
| ES8607954A1 (es) | Un procedimiento de preparar un derivado de 1-aril-1h-tetrazol | |
| ES475004A1 (es) | Un procedimiento para la preparacion de sales de eteres del acido clavulanico | |
| GB1178930A (en) | Pharmaceutical Compositions | |
| FI941635A0 (fi) | Androst-4-eno(4,5-b)pyrrolijohdannaiset ja menetelmä niiden valmistamiseksi | |
| GB1071124A (en) | Derivatives of pyrazolo-[4',5'-b]-11-oxo-18ª‡- and 18ª‰-olean-12-en-30-oic acid | |
| GB1502343A (en) | Derivatives of desglucohellebrin and a process for their preparation | |
| GB999097A (en) | 2-isoxazolin-5-ones and fungicidal compositions containing them | |
| GB863060A (en) | Sulphanilamido-pyrazoles | |
| IE50437B1 (en) | Process for the manufacture of acylhydrazones of formylacetic acid esters | |
| GB1039375A (en) | Dibenzocycloheptene compounds | |
| FI933205L (fi) | Tiatsolietanolijohdannaisia, menetelmä niiden valmistamiseksi ja niiden välituotteet |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |