AR029322A1 - Un polinucleotido de estreptococo aislado que codifica un polipeptido capaz de generar anticuerpos que tienen especificidad de union para un segundo polipeptido de secuencias reveladas, los polipeptidos mencionados y un proceso para su fabricacion, un polipeptido quimerico, compuesto por dichos segu - Google Patents
Un polinucleotido de estreptococo aislado que codifica un polipeptido capaz de generar anticuerpos que tienen especificidad de union para un segundo polipeptido de secuencias reveladas, los polipeptidos mencionados y un proceso para su fabricacion, un polipeptido quimerico, compuesto por dichos seguInfo
- Publication number
- AR029322A1 AR029322A1 ARP990106746A ARP990106746A AR029322A1 AR 029322 A1 AR029322 A1 AR 029322A1 AR P990106746 A ARP990106746 A AR P990106746A AR P990106746 A ARP990106746 A AR P990106746A AR 029322 A1 AR029322 A1 AR 029322A1
- Authority
- AR
- Argentina
- Prior art keywords
- polypeptide
- generating antibodies
- isolated
- streptococo
- polinucleotide
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title abstract 13
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 13
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 13
- 238000000034 method Methods 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title 1
- 102000040430 polynucleotide Human genes 0.000 abstract 4
- 108091033319 polynucleotide Proteins 0.000 abstract 4
- 239000002157 polynucleotide Substances 0.000 abstract 4
- 229960005486 vaccine Drugs 0.000 abstract 2
- 208000031729 Bacteremia Diseases 0.000 abstract 1
- 208000035143 Bacterial infection Diseases 0.000 abstract 1
- 201000009906 Meningitis Diseases 0.000 abstract 1
- 206010033078 Otitis media Diseases 0.000 abstract 1
- 241000194017 Streptococcus Species 0.000 abstract 1
- 102000004357 Transferases Human genes 0.000 abstract 1
- 108090000992 Transferases Proteins 0.000 abstract 1
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
- C07K14/3156—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci from Streptococcus pneumoniae (Pneumococcus)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Communicable Diseases (AREA)
- Neurosurgery (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Neurology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Se refiere a un polinucleotido de estreptococo aislado que codifica un polipéptido capaz de generar anticuerpos que tienen especificidad de union para un segundo polipéptido. Provee 1) el polinucleotido que codifica el polipéptido, 2) el polipéptido capaz de generar dichos anticuerpos y 3) el segundo polipéptido cuyas secuencias características se revelan. También son objeto de la invencion un vector que comprende dicho polinucleotido, una célula hospedadora transferasa con dicho vector, y un proceso para producir dicho polipéptido capáz de generar anticuerpos que tienen especificidad de union para el segundo polipéptido. Finalmente se proveen polipéptidos quiméricos que comprenden dos o más de dichos segundos polipéptidos. Los polinucleotidos y polipéptidos pueden utilizarse para la preparacion de vacunas para el tratamiento terapéutico o profiláctico de la meningitis, la otitis media, bacteriemia, infeccion neumonica o la infeccion bacteriana estreptococica. Comprende también las vacunas y su método de preparacion.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11380098P | 1998-12-23 | 1998-12-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR029322A1 true AR029322A1 (es) | 2003-06-25 |
Family
ID=22351610
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990106746A AR029322A1 (es) | 1998-12-23 | 1999-12-23 | Un polinucleotido de estreptococo aislado que codifica un polipeptido capaz de generar anticuerpos que tienen especificidad de union para un segundo polipeptido de secuencias reveladas, los polipeptidos mencionados y un proceso para su fabricacion, un polipeptido quimerico, compuesto por dichos segu |
Country Status (29)
| Country | Link |
|---|---|
| EP (2) | EP2261358B1 (es) |
| JP (2) | JP4761623B2 (es) |
| KR (4) | KR101078919B1 (es) |
| CN (3) | CN101134775A (es) |
| AP (1) | AP2001002199A0 (es) |
| AR (1) | AR029322A1 (es) |
| AT (1) | ATE394489T1 (es) |
| AU (1) | AU1764900A (es) |
| BR (1) | BR9916477A (es) |
| CA (1) | CA2356836C (es) |
| CL (1) | CL2009002037A1 (es) |
| CY (3) | CY1108223T1 (es) |
| CZ (2) | CZ302790B6 (es) |
| DE (1) | DE69938670D1 (es) |
| DK (3) | DK1950302T3 (es) |
| EA (1) | EA007409B1 (es) |
| ES (3) | ES2400280T3 (es) |
| HU (1) | HU229664B1 (es) |
| IL (3) | IL143905A0 (es) |
| MX (1) | MXPA01006427A (es) |
| NO (1) | NO330800B1 (es) |
| NZ (1) | NZ512574A (es) |
| OA (1) | OA11736A (es) |
| PL (3) | PL206576B1 (es) |
| PT (3) | PT2261358E (es) |
| TR (2) | TR200200633T2 (es) |
| UY (1) | UY25877A1 (es) |
| WO (1) | WO2000039299A2 (es) |
| ZA (1) | ZA200105114B (es) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE347600T1 (de) | 1998-02-20 | 2006-12-15 | Id Biomedical Corp | Gruppe b-streptococcus antigene |
| US20030134407A1 (en) | 1998-07-27 | 2003-07-17 | Le Page Richard William Falla | Nucleic acids and proteins from Streptococcus pneumoniae |
| EP1801218A3 (en) * | 1998-07-27 | 2007-10-10 | Sanofi Pasteur Limited | Nucleic acids and proteins from streptococcus pneumoniae |
| EP1140157B1 (en) | 1998-12-21 | 2009-02-18 | MedImmune, Inc. | Streptococcus pneumoniae proteins and immunogenic fragments for vaccines |
| AU1764900A (en) * | 1998-12-23 | 2000-07-31 | Id Biomedical Corporation | Novel streptococcus antigens |
| US7128918B1 (en) | 1998-12-23 | 2006-10-31 | Id Biomedical Corporation | Streptococcus antigens |
| US6866855B2 (en) | 2000-06-12 | 2005-03-15 | University Of Saskatchewan | Immunization of dairy cattle with GapC protein against Streptococcus infection |
| US6833134B2 (en) | 2000-06-12 | 2004-12-21 | University Of Saskacthewan | Immunization of dairy cattle with GapC protein against Streptococcus infection |
| WO2001096379A2 (en) | 2000-06-12 | 2001-12-20 | University Of Saskatchewan | Immunization of dairy cattle with chimeric gapc protein against streptococcus infection |
| NZ553554A (en) | 2000-06-20 | 2008-11-28 | Id Biomedical Corp | Streptococcus antigens |
| US7074415B2 (en) | 2000-06-20 | 2006-07-11 | Id Biomedical Corporation | Streptococcus antigens |
| WO2002079475A2 (en) * | 2001-03-30 | 2002-10-10 | Shire Biochem Inc. | Streptococcus pyogenes antigens and corresponding dna fragments |
| AU2002317107B2 (en) | 2001-07-06 | 2008-06-12 | Id Biomedical Corporation | Group B streptococcus antigens and corresponding DNA fragments |
| GB0130228D0 (en) * | 2001-12-18 | 2002-02-06 | Hansa Medica Ab | Protein |
| EP1456231A2 (en) * | 2001-12-20 | 2004-09-15 | Shire Biochem Inc. | Streptococcus antigens |
| SI1601770T1 (sl) * | 2003-03-04 | 2010-01-29 | Intercell Ag | Streptococcus pyogenes antigeni |
| EP1615950A2 (en) * | 2003-04-15 | 2006-01-18 | Intercell AG | S. pneumoniae antigens |
| EP3020411A1 (en) | 2005-12-22 | 2016-05-18 | GlaxoSmithKline Biologicals s.a. | Vaccine |
| GB0607088D0 (en) | 2006-04-07 | 2006-05-17 | Glaxosmithkline Biolog Sa | Vaccine |
| MX2009013949A (es) | 2007-06-26 | 2010-05-24 | Glaxosmithkline Biolog Sa | Vacuna que comprende conjugados de polisacárido capsular de streptococcus pneumoniae. |
| CA2694466A1 (en) * | 2007-07-23 | 2009-01-29 | Sanofi Pasteur Limited | Immunogenic polypeptides and monoclonal antibodies |
| MX2010011412A (es) * | 2008-04-16 | 2010-11-12 | Glaxosmithkline Biolog Sa | Vacuna. |
| JP5722782B2 (ja) | 2008-09-26 | 2015-05-27 | ナノバイオ コーポレーション | ナノエマルジョン治療用組成物及びその使用方法 |
| CN102413838A (zh) | 2009-04-30 | 2012-04-11 | 科勒制药集团有限公司 | 肺炎球菌疫苗及其用途 |
| WO2010132833A1 (en) | 2009-05-14 | 2010-11-18 | The Regents Of The University Of Michigan | Streptococcus vaccine compositions and methods of using the same |
| AU2010290931B2 (en) | 2009-09-03 | 2014-02-06 | Pfizer Vaccines Llc | PCSK9 vaccine |
| GB201003920D0 (en) | 2010-03-09 | 2010-04-21 | Glaxosmithkline Biolog Sa | Method of treatment |
| AU2011336366B2 (en) | 2010-12-03 | 2016-05-12 | Sanofi Pasteur Limited | Composition for immunization against Streptococcus pneumoniae |
| AU2012207088A1 (en) | 2011-01-20 | 2013-05-02 | Children's Medical Center Corporation | Vaccines and compositions against Streptococcus pneumoniae |
| WO2012131504A1 (en) | 2011-03-02 | 2012-10-04 | Pfizer Inc. | Pcsk9 vaccine |
| KR20140033127A (ko) | 2011-05-17 | 2014-03-17 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 스트렙토코쿠스 뉴모니애에 대한 백신 |
| AU2013207191B2 (en) * | 2012-01-05 | 2017-10-26 | Deutsches Krebsforschungszentrum Stiftung Des Offentlichen Rechts | Means and methods for treating or diagnosing IDH1 R132H mutant-positive cancers |
| KR20150093838A (ko) * | 2012-12-14 | 2015-08-18 | 사노피 파스퇴르 리미티드 | 면역원성을 평가하기 위한 방법 |
| ES2883343T3 (es) | 2014-01-21 | 2021-12-07 | Pfizer | Polisacáridos capsulares de Streptococcus pneumoniae y conjugados de los mismos |
| DK3096786T3 (da) | 2014-01-21 | 2021-08-02 | Pfizer | Streptococcus pneumoniae-kapselpolysaccharider og konjugater deraf |
| US11160855B2 (en) | 2014-01-21 | 2021-11-02 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| SG11201604728XA (en) | 2014-01-21 | 2016-08-30 | Pfizer | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| US10668164B2 (en) | 2014-02-14 | 2020-06-02 | Pfizer Inc. | Immunogenic glycoprotein conjugates |
| MX395525B (es) | 2015-01-15 | 2025-03-25 | Pfizer | Composiciones inmunogenicas para usar en vacunas neumococicas. |
| BR112018000087A2 (pt) | 2015-07-21 | 2018-09-04 | Pfizer Inc. | composições imunogênicas que compreendem antígenos de sacarídeos capsulares conjugados, kits que compreendem as mesmas e usos das mesmas |
| GB201518684D0 (en) | 2015-10-21 | 2015-12-02 | Glaxosmithkline Biolog Sa | Vaccine |
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| BR112019014833A2 (pt) | 2017-01-20 | 2020-04-14 | Pfizer | composições imunogênicas para uso em vacinas pneumococais |
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| CA3120922A1 (en) | 2018-12-12 | 2020-06-18 | Pfizer Inc. | Immunogenic multiple hetero-antigen polysaccharide-protein conjugates and uses thereof |
| JP7239509B6 (ja) | 2019-02-22 | 2023-03-28 | ファイザー・インク | 細菌多糖類を精製するための方法 |
| US20220184199A1 (en) | 2019-04-10 | 2022-06-16 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens, kits comprising the same and uses thereof |
| CN114728050A (zh) | 2019-07-31 | 2022-07-08 | 圣诺菲·帕斯图尔公司 | 多价肺炎球菌多糖-蛋白质缀合物组合物及其使用方法 |
| CN114667343A (zh) | 2019-11-01 | 2022-06-24 | 辉瑞大药厂 | 大肠杆菌组合物及其方法 |
| WO2021165847A1 (en) | 2020-02-21 | 2021-08-26 | Pfizer Inc. | Purification of saccharides |
| CN115605498A (zh) | 2020-02-23 | 2023-01-13 | 辉瑞公司(Us) | 大肠杆菌组合物及其方法 |
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| MX2023004912A (es) | 2020-10-27 | 2023-05-16 | Pfizer | Composiciones de escherichia coli y metodos de las mismas. |
| US12138302B2 (en) | 2020-10-27 | 2024-11-12 | Pfizer Inc. | Escherichia coli compositions and methods thereof |
| MX2023005221A (es) | 2020-11-04 | 2023-05-16 | Pfizer | Composiciones inmunogenicas para uso en vacunas neumococicas. |
| US12357681B2 (en) | 2020-12-23 | 2025-07-15 | Pfizer Inc. | E. coli FimH mutants and uses thereof |
| CA3218544A1 (en) | 2021-05-03 | 2022-11-10 | Pfizer Inc. | Vaccination against bacterial and betacoronavirus infections |
| WO2022234416A1 (en) | 2021-05-03 | 2022-11-10 | Pfizer Inc. | Vaccination against pneumoccocal and covid-19 infections |
| EP4346892A2 (en) | 2021-05-28 | 2024-04-10 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| WO2022249107A2 (en) | 2021-05-28 | 2022-12-01 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| KR20240128715A (ko) | 2022-01-13 | 2024-08-26 | 화이자 인코포레이티드 | 접합된 피막 사카라이드 항원을 포함하는 면역원성 조성물 및 그의 용도 |
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| WO2024084397A1 (en) | 2022-10-19 | 2024-04-25 | Pfizer Inc. | Vaccination against pneumoccocal and covid-19 infections |
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| IL321069A (en) | 2022-12-01 | 2025-07-01 | Pfizer | Pneumococcal conjugate vaccine preparations |
| EP4661911A1 (en) | 2023-02-10 | 2025-12-17 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| AU2024246082A1 (en) | 2023-03-30 | 2025-10-16 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| AU2024255922A1 (en) | 2023-04-14 | 2025-10-30 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| WO2024224266A1 (en) | 2023-04-24 | 2024-10-31 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| CN121263203A (zh) | 2023-05-19 | 2026-01-02 | 葛兰素史克生物有限公司 | 诱导对呼吸道合胞病毒和肺炎链球菌感染的免疫反应的方法 |
| WO2025057078A1 (en) | 2023-09-14 | 2025-03-20 | Pfizer Inc. | Adjuvanted immunogenic compositions comprising conjugated pneumococcal capsular saccharide antigens and uses thereof |
| WO2025133971A1 (en) | 2023-12-23 | 2025-06-26 | Pfizer Inc. | Improved methods for producing bacterial capsular saccharide glycoconjugates |
| WO2025186705A2 (en) | 2024-03-06 | 2025-09-12 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| WO2025191415A1 (en) | 2024-03-11 | 2025-09-18 | Pfizer Inc. | Immunogenic compositions comprising conjugated escherichia coli saccharides and uses thereof |
| WO2025219908A2 (en) | 2024-04-19 | 2025-10-23 | Pfizer Inc. | Media and fermentation methods for polysaccharide production in bacterial cell culture |
| WO2025219904A1 (en) | 2024-04-19 | 2025-10-23 | Pfizer Inc. | Improved methods for producing glycoconjugates by reductive amination in aprotic solvent |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US4425437A (en) | 1979-11-05 | 1984-01-10 | Genentech, Inc. | Microbial polypeptide expression vehicle |
| US4431739A (en) | 1979-11-05 | 1984-02-14 | Genentech, Inc. | Transformant bacterial culture capable of expressing heterologous protein |
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| US5882896A (en) * | 1996-09-24 | 1999-03-16 | Smithkline Beecham Corporation | M protein |
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-
1999
- 1999-12-20 AU AU17649/00A patent/AU1764900A/en not_active Abandoned
- 1999-12-20 AT AT99960748T patent/ATE394489T1/de active
- 1999-12-20 BR BR9916477-9A patent/BR9916477A/pt active Search and Examination
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