AR029154A1 - Una tableta de liberacion controlada que comprende betahistina y un proceso para la preparacion de dicha tableta - Google Patents
Una tableta de liberacion controlada que comprende betahistina y un proceso para la preparacion de dicha tabletaInfo
- Publication number
- AR029154A1 AR029154A1 ARP000100974A ARP000100974A AR029154A1 AR 029154 A1 AR029154 A1 AR 029154A1 AR P000100974 A ARP000100974 A AR P000100974A AR P000100974 A ARP000100974 A AR P000100974A AR 029154 A1 AR029154 A1 AR 029154A1
- Authority
- AR
- Argentina
- Prior art keywords
- preparation
- betahistine
- active ingredient
- controlled
- betahistina
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Otolaryngology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Una tableta de liberacion controlada comprende un ingrediente activo que comprende betahistina o una sal de la misma aceptable para uso farmacéutico, incorporada en al menos un compuesto graso; al menos un polímero hidrofílico capaz de absorber agua; y excipientes adecuados. Betahistina es un vasodilatador activo usado para administracion oral en la terapia de vértigo. La preparacion de una forma farmacéutica con un perfil de liberacion adecuado de betahistina reduciría la cantidad de administraciones diarias a solamente una, mientras que se mantendría constante la concentracion del ingrediente activo dentro del rango de dosis terapéuticas. Un proceso para la preparacion de las tabletas de liberacion controlada comprende los pasos de: a) incorporar dicho ingrediente activo de la misma, en al menos un compuesto graso mediante granulacion por fusion; b) mezclar el granulado del paso a) con al menos un compuesto hidrofílico y excipientes adecuados; c) someter a compresion la mezcla del paso b).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1999MI000454A IT1309591B1 (it) | 1999-03-05 | 1999-03-05 | Composizioni a rilascio controllato di betaistina. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR029154A1 true AR029154A1 (es) | 2003-06-18 |
Family
ID=11382165
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP000100974A AR029154A1 (es) | 1999-03-05 | 2000-03-03 | Una tableta de liberacion controlada que comprende betahistina y un proceso para la preparacion de dicha tableta |
Country Status (37)
| Country | Link |
|---|---|
| EP (1) | EP1158963B1 (es) |
| JP (1) | JP2002538197A (es) |
| KR (1) | KR20010102498A (es) |
| CN (1) | CN1165295C (es) |
| AR (1) | AR029154A1 (es) |
| AT (1) | ATE231392T1 (es) |
| AU (1) | AU762532B2 (es) |
| BG (1) | BG105807A (es) |
| BR (1) | BR0008739A (es) |
| CA (1) | CA2364226A1 (es) |
| CO (1) | CO5170438A1 (es) |
| CZ (1) | CZ299510B6 (es) |
| DE (1) | DE60001266T2 (es) |
| DK (1) | DK1158963T3 (es) |
| EE (1) | EE200100453A (es) |
| ES (1) | ES2189739T3 (es) |
| GE (1) | GEP20033078B (es) |
| HK (1) | HK1042246B (es) |
| HR (1) | HRP20010650A2 (es) |
| HU (1) | HUP0200243A2 (es) |
| ID (1) | ID30127A (es) |
| IL (1) | IL145263A0 (es) |
| IT (1) | IT1309591B1 (es) |
| MX (1) | MXPA01008893A (es) |
| NO (1) | NO319135B1 (es) |
| NZ (1) | NZ513949A (es) |
| PE (1) | PE20001547A1 (es) |
| PL (1) | PL196290B1 (es) |
| PT (1) | PT1158963E (es) |
| RU (1) | RU2248791C2 (es) |
| SI (1) | SI1158963T1 (es) |
| SK (1) | SK284584B6 (es) |
| TR (1) | TR200102566T2 (es) |
| UA (1) | UA65652C2 (es) |
| WO (1) | WO2000053162A1 (es) |
| YU (1) | YU64001A (es) |
| ZA (1) | ZA200107318B (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100500130C (zh) * | 2003-01-23 | 2009-06-17 | 株式会社太平洋 | 缓释制剂及其制备方法 |
| SI1493435T1 (sl) * | 2003-07-04 | 2008-10-31 | Formenti Farmaceutici Spa | Betahistinski sestavki s kontroliranim sproĺ äśanjem |
| US7728015B2 (en) | 2004-04-22 | 2010-06-01 | Mor Research Applications Ltd. | Compositions for weight management |
| CA2553309A1 (en) | 2004-04-22 | 2005-11-03 | Mor Research Applications Ltd. | Method of food intake management |
| JP2008507508A (ja) * | 2004-07-22 | 2008-03-13 | 株式會社アモーレパシフィック | トピラメート徐放性製剤及びその製造方法 |
| JP2006176461A (ja) * | 2004-12-24 | 2006-07-06 | Dai Ichi Seiyaku Co Ltd | 粒状物 |
| EA022565B1 (ru) | 2008-05-27 | 2016-01-29 | Дзе Юниверсити Оф Мельбурн | Способы лечения млекопитающих с дисфункциями евстахиевой трубы |
| EP2314296A1 (en) * | 2009-10-22 | 2011-04-27 | Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi | Orally Disintegrating Tablets of Betahistine |
| EP2491930A1 (en) * | 2011-02-25 | 2012-08-29 | Deva Holding Anonim Sirketi | Pharmaceutical combination of betahistine and trimetazidine |
| DE102012105528A1 (de) | 2012-06-25 | 2014-01-02 | Hennig Arzneimittel Gmbh & Co. Kg | Arzneiform zur Freisetzung von Wirkstoffen |
| WO2015053620A1 (en) * | 2013-10-07 | 2015-04-16 | Disphar International B.V. | Betahistine composition |
| ES2862209T3 (es) * | 2017-07-20 | 2021-10-07 | Intas Pharmaceuticals Ltd | Composiciones orales sólidas de liberación prolongada no pulsátil que contienen betahistina |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2397840B1 (es) * | 1977-07-22 | 1981-03-20 | Cherqui Jean | |
| FR2432313A1 (fr) * | 1978-08-01 | 1980-02-29 | Foulhoux Pierre | Nouvelle forme galenique de la betahistine et son procede d'obtention |
| GB2280604B (en) * | 1993-07-02 | 1997-04-30 | Resource Medical Limited | Processing of active agents |
| US6190591B1 (en) * | 1996-10-28 | 2001-02-20 | General Mills, Inc. | Embedding and encapsulation of controlled release particles |
-
1999
- 1999-03-05 IT IT1999MI000454A patent/IT1309591B1/it active
-
2000
- 2000-02-28 TR TR2001/02566T patent/TR200102566T2/xx unknown
- 2000-02-28 AT AT00910723T patent/ATE231392T1/de not_active IP Right Cessation
- 2000-02-28 BR BR0008739-4A patent/BR0008739A/pt not_active Application Discontinuation
- 2000-02-28 HR HR20010650A patent/HRP20010650A2/hr not_active Application Discontinuation
- 2000-02-28 PL PL350232A patent/PL196290B1/pl unknown
- 2000-02-28 IL IL14526300A patent/IL145263A0/xx unknown
- 2000-02-28 PT PT00910723T patent/PT1158963E/pt unknown
- 2000-02-28 JP JP2000603651A patent/JP2002538197A/ja active Pending
- 2000-02-28 EE EEP200100453A patent/EE200100453A/xx unknown
- 2000-02-28 DK DK00910723T patent/DK1158963T3/da active
- 2000-02-28 CA CA002364226A patent/CA2364226A1/en not_active Abandoned
- 2000-02-28 CN CNB008046190A patent/CN1165295C/zh not_active Expired - Fee Related
- 2000-02-28 WO PCT/EP2000/001642 patent/WO2000053162A1/en not_active Ceased
- 2000-02-28 SI SI200030050T patent/SI1158963T1/xx unknown
- 2000-02-28 GE GEAP20006082A patent/GEP20033078B/en unknown
- 2000-02-28 HU HU0200243A patent/HUP0200243A2/hu unknown
- 2000-02-28 ID IDW00200101790A patent/ID30127A/id unknown
- 2000-02-28 MX MXPA01008893A patent/MXPA01008893A/es unknown
- 2000-02-28 KR KR1020017011271A patent/KR20010102498A/ko not_active Ceased
- 2000-02-28 YU YU64001A patent/YU64001A/sh unknown
- 2000-02-28 NZ NZ513949A patent/NZ513949A/en unknown
- 2000-02-28 AU AU32831/00A patent/AU762532B2/en not_active Ceased
- 2000-02-28 SK SK1249-2001A patent/SK284584B6/sk unknown
- 2000-02-28 UA UA2001085807A patent/UA65652C2/uk unknown
- 2000-02-28 EP EP00910723A patent/EP1158963B1/en not_active Expired - Lifetime
- 2000-02-28 RU RU2001124607/15A patent/RU2248791C2/ru not_active IP Right Cessation
- 2000-02-28 ES ES00910723T patent/ES2189739T3/es not_active Expired - Lifetime
- 2000-02-28 HK HK02104045.5A patent/HK1042246B/zh not_active IP Right Cessation
- 2000-02-28 DE DE60001266T patent/DE60001266T2/de not_active Expired - Fee Related
- 2000-02-28 CZ CZ20013186A patent/CZ299510B6/cs not_active IP Right Cessation
- 2000-03-02 CO CO00015153A patent/CO5170438A1/es not_active Application Discontinuation
- 2000-03-03 PE PE2000000181A patent/PE20001547A1/es not_active Application Discontinuation
- 2000-03-03 AR ARP000100974A patent/AR029154A1/es active IP Right Grant
-
2001
- 2001-08-09 BG BG105807A patent/BG105807A/bg unknown
- 2001-09-04 ZA ZA200107318A patent/ZA200107318B/en unknown
- 2001-09-04 NO NO20014301A patent/NO319135B1/no unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |