AR029091A1 - Uso de compuestos de 1-amino-5-fenilpentano-3-ol y/o 1-amino-6-fenilhexano-3-ol para la preparacion de un medicamento con efecto antagonista de n-metil-d-aspartato-(nmda) - Google Patents
Uso de compuestos de 1-amino-5-fenilpentano-3-ol y/o 1-amino-6-fenilhexano-3-ol para la preparacion de un medicamento con efecto antagonista de n-metil-d-aspartato-(nmda)Info
- Publication number
- AR029091A1 AR029091A1 ARP010102344A ARP010102344A AR029091A1 AR 029091 A1 AR029091 A1 AR 029091A1 AR P010102344 A ARP010102344 A AR P010102344A AR P010102344 A ARP010102344 A AR P010102344A AR 029091 A1 AR029091 A1 AR 029091A1
- Authority
- AR
- Argentina
- Prior art keywords
- amino
- phenylpentane
- nmda
- aspartate
- methyl
- Prior art date
Links
- MQRVXBDFCCKLST-UHFFFAOYSA-N 1-amino-5-phenylpentan-3-ol Chemical compound NCCC(O)CCC1=CC=CC=C1 MQRVXBDFCCKLST-UHFFFAOYSA-N 0.000 title abstract 2
- LKVTZBZZXGPMIC-UHFFFAOYSA-N 1-amino-6-phenylhexan-3-ol Chemical compound NCCC(O)CCCC1=CC=CC=C1 LKVTZBZZXGPMIC-UHFFFAOYSA-N 0.000 title abstract 2
- HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 239000005557 antagonist Substances 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 230000003042 antagnostic effect Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/402—1-aryl substituted, e.g. piretanide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Emergency Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Se refiere al uso de al menos un compuesto de 1-amino-5-fenilpentano-3-ol y/o 1-amino-6-fenilhexano-3-ol y/o de sus enantiomeros y/o uno de sus diastereomeros y/o una de sus sales fisiologicamente tolerables para la preparacion de un medicamento con efecto antagonista de N-metil-D-aspartato- (NMDA).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10025238A DE10025238A1 (de) | 2000-05-22 | 2000-05-22 | Verwendung substituierter 1-Amino-5-phenylpentan-3-ol- und/oder 1-Amino-6-phenylhexan-3-ol- Verbindungen als Arzneimittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR029091A1 true AR029091A1 (es) | 2003-06-04 |
Family
ID=7643080
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP010102344A AR029091A1 (es) | 2000-05-22 | 2001-05-17 | Uso de compuestos de 1-amino-5-fenilpentano-3-ol y/o 1-amino-6-fenilhexano-3-ol para la preparacion de un medicamento con efecto antagonista de n-metil-d-aspartato-(nmda) |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6784175B2 (es) |
| EP (1) | EP1289514B1 (es) |
| JP (1) | JP2004509842A (es) |
| AR (1) | AR029091A1 (es) |
| AT (1) | ATE281158T1 (es) |
| AU (2) | AU7402201A (es) |
| CA (1) | CA2406198A1 (es) |
| DE (2) | DE10025238A1 (es) |
| ES (1) | ES2231502T3 (es) |
| HU (1) | HUP0301884A2 (es) |
| MX (1) | MXPA02011410A (es) |
| NZ (1) | NZ521439A (es) |
| PE (1) | PE20011261A1 (es) |
| PT (1) | PT1289514E (es) |
| UY (1) | UY26718A1 (es) |
| WO (1) | WO2001089505A1 (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6856700B1 (en) * | 2000-05-24 | 2005-02-15 | Microsoft Corporation | Palettized image compression |
| US20060063802A1 (en) | 2004-03-29 | 2006-03-23 | Matthieu Guitton | Methods for the treatment of tinnitus induced by cochlear excitotoxicity |
| US8268866B2 (en) | 2004-03-29 | 2012-09-18 | Matthieu Guitton | Methods for the treatment of tinnitus induced by cochlear excitotoxicity |
| US9072662B2 (en) | 2004-03-29 | 2015-07-07 | Auris Medical Ag | Methods for the treatment of tinnitus induced by cochlear excitotoxicity |
| EP2792347A1 (en) * | 2005-09-28 | 2014-10-22 | Auris Medical AG | Pharmaceutical compositions for the treatment of inner ear disorders |
| WO2012009258A2 (en) * | 2010-07-13 | 2012-01-19 | Edward Roberts | Peptidomimetic galanin receptor modulators |
| US20150044200A1 (en) | 2011-12-12 | 2015-02-12 | Otolanum Ag | Treatment of tinnitus through modulation of chloride co-transporter nkcc1 in the auditory system |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4017637A (en) | 1973-03-26 | 1977-04-12 | American Home Products Corporation | Benzylamine analgesics |
| US4155935A (en) * | 1973-03-26 | 1979-05-22 | American Home Products Corporation | Benzylamine analgesics |
| US4366172A (en) * | 1977-09-29 | 1982-12-28 | The Upjohn Company | 4-Amino-cyclohexanols, their pharmaceutical compositions and methods of use |
| IE913279A1 (en) * | 1990-09-26 | 1992-04-08 | Astra Ab | (2-Thienyl)alkylamine Derivatives Having Neuroprotective¹Properties |
| DE19915601A1 (de) * | 1999-04-07 | 2000-10-19 | Gruenenthal Gmbh | 3-Amino-3-arylpropan-1-ol-Derivate, deren Herstellung und Verwendung |
-
2000
- 2000-05-22 DE DE10025238A patent/DE10025238A1/de not_active Withdrawn
-
2001
- 2001-05-10 ES ES01940450T patent/ES2231502T3/es not_active Expired - Lifetime
- 2001-05-10 JP JP2001585750A patent/JP2004509842A/ja active Pending
- 2001-05-10 PT PT01940450T patent/PT1289514E/pt unknown
- 2001-05-10 EP EP01940450A patent/EP1289514B1/de not_active Expired - Lifetime
- 2001-05-10 DE DE50104405T patent/DE50104405D1/de not_active Expired - Fee Related
- 2001-05-10 AU AU7402201A patent/AU7402201A/xx active Pending
- 2001-05-10 AT AT01940450T patent/ATE281158T1/de not_active IP Right Cessation
- 2001-05-10 MX MXPA02011410A patent/MXPA02011410A/es active IP Right Grant
- 2001-05-10 WO PCT/EP2001/005349 patent/WO2001089505A1/de not_active Ceased
- 2001-05-10 CA CA002406198A patent/CA2406198A1/en not_active Abandoned
- 2001-05-10 AU AU2001274022A patent/AU2001274022B2/en not_active Ceased
- 2001-05-10 NZ NZ521439A patent/NZ521439A/en unknown
- 2001-05-10 US US10/276,617 patent/US6784175B2/en not_active Expired - Fee Related
- 2001-05-10 HU HU0301884A patent/HUP0301884A2/hu unknown
- 2001-05-17 AR ARP010102344A patent/AR029091A1/es not_active Application Discontinuation
- 2001-05-18 UY UY26718A patent/UY26718A1/es not_active Application Discontinuation
- 2001-05-21 PE PE2001000456A patent/PE20011261A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU7402201A (en) | 2001-12-03 |
| JP2004509842A (ja) | 2004-04-02 |
| US6784175B2 (en) | 2004-08-31 |
| NZ521439A (en) | 2005-06-24 |
| EP1289514A1 (de) | 2003-03-12 |
| AU2001274022B2 (en) | 2004-10-14 |
| ATE281158T1 (de) | 2004-11-15 |
| HUP0301884A2 (hu) | 2003-09-29 |
| EP1289514B1 (de) | 2004-11-03 |
| CA2406198A1 (en) | 2002-10-16 |
| WO2001089505A1 (de) | 2001-11-29 |
| DE10025238A1 (de) | 2001-11-29 |
| PE20011261A1 (es) | 2002-01-26 |
| MXPA02011410A (es) | 2003-06-06 |
| DE50104405D1 (de) | 2004-12-09 |
| UY26718A1 (es) | 2001-06-29 |
| ES2231502T3 (es) | 2005-05-16 |
| PT1289514E (pt) | 2005-02-28 |
| US20030181450A1 (en) | 2003-09-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |