AR028475A1 - DERIVATIVES OF AZAINDOL AND USE OF THE SAME FOR THE MANUFACTURE OF A MEDICINAL PRODUCT FOR THE TREATMENT OF DEPRESSION. - Google Patents
DERIVATIVES OF AZAINDOL AND USE OF THE SAME FOR THE MANUFACTURE OF A MEDICINAL PRODUCT FOR THE TREATMENT OF DEPRESSION.Info
- Publication number
- AR028475A1 AR028475A1 ARP000101879A ARP000101879A AR028475A1 AR 028475 A1 AR028475 A1 AR 028475A1 AR P000101879 A ARP000101879 A AR P000101879A AR P000101879 A ARP000101879 A AR P000101879A AR 028475 A1 AR028475 A1 AR 028475A1
- Authority
- AR
- Argentina
- Prior art keywords
- depression
- manufacture
- treatment
- azaindol
- derivatives
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 208000020401 Depressive disease Diseases 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 abstract 2
- BAXOFTOLAUCFNW-UHFFFAOYSA-N 1H-indazole Chemical compound C1=CC=C2C=NNC2=C1 BAXOFTOLAUCFNW-UHFFFAOYSA-N 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 125000002837 carbocyclic group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- -1 cyano, carbamoyl Chemical group 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000000926 neurological effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 229940076279 serotonin Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Compuestos derivados de azaindol y el uso de los mismos para la manufactura de un medicamento para el tratamiento de enfermedades afectadas por trastornos de los sistemas neurologicos afectados por la serotonina, como por ejemplo, la depresion y la ansiedad, que tienen la formula (1), donde: R1 y R2 forman un anillo carbocíclico de entre 5 y 7 átomos de carbono, donde dicho anillo puede estar saturado o no saturado y puede contener uno o más heteroátomos; y X es independientemente hidrogeno, ciano, carbamoílo, halogeno o alcoxi; o sus sales farmacéuticamente aceptables.Compounds derived from azaindole and their use for the manufacture of a medicine for the treatment of diseases affected by disorders of the neurological systems affected by serotonin, such as depression and anxiety, which have the formula (1) , where: R1 and R2 form a carbocyclic ring of between 5 and 7 carbon atoms, where said ring may be saturated or unsaturated and may contain one or more heteroatoms; and X is independently hydrogen, cyano, carbamoyl, halogen or alkoxy; or its pharmaceutically acceptable salts.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29673699A | 1999-04-22 | 1999-04-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR028475A1 true AR028475A1 (en) | 2003-05-14 |
Family
ID=23143341
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP000101879A AR028475A1 (en) | 1999-04-22 | 2000-04-19 | DERIVATIVES OF AZAINDOL AND USE OF THE SAME FOR THE MANUFACTURE OF A MEDICINAL PRODUCT FOR THE TREATMENT OF DEPRESSION. |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1171439A1 (en) |
| JP (1) | JP2002543079A (en) |
| CN (1) | CN1348451A (en) |
| AR (1) | AR028475A1 (en) |
| AU (1) | AU4364400A (en) |
| BR (1) | BR0010693A (en) |
| CA (1) | CA2367681A1 (en) |
| WO (1) | WO2000064898A1 (en) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005534619A (en) * | 2002-03-28 | 2005-11-17 | エーザイ株式会社 | Azaindole as C-JUNN-terminal kinase inhibitor |
| PL1696920T3 (en) | 2003-12-19 | 2015-03-31 | Plexxikon Inc | Compounds and methods for development of ret modulators |
| ATE443707T1 (en) | 2004-11-26 | 2009-10-15 | Janssen Pharmaceutica Nv | ISOXAZOLINE INDOLE DERIVATIVES WITH IMPROVED ANTIPSYCHOTIC AND ANXIOLYTIC ACTIVITY |
| WO2008063888A2 (en) | 2006-11-22 | 2008-05-29 | Plexxikon, Inc. | Compounds modulating c-fms and/or c-kit activity and uses therefor |
| AU2008276063B2 (en) | 2007-07-17 | 2013-11-28 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| BRPI1008709B8 (en) | 2009-04-03 | 2021-05-25 | Hoffmann La Roche | solid dispersion, formulation, composition and tablet comprising {3-[5-(4-chloro-phenyl)-1h-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide of propane-1-sulfonic acid |
| PE20120508A1 (en) | 2009-06-17 | 2012-05-09 | Vertex Pharma | INHIBITORS OF THE REPLICATION OF FLU VIRUSES |
| US20110112127A1 (en) | 2009-11-06 | 2011-05-12 | Plexxikon, Inc. | Compounds and methods for kinase modulation, and indications therefor |
| WO2012083117A1 (en) | 2010-12-16 | 2012-06-21 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
| MY162950A (en) | 2011-02-07 | 2017-07-31 | Plexxikon Inc | Compounds and methods for kinase modulation, and indications therefor |
| AR085279A1 (en) | 2011-02-21 | 2013-09-18 | Plexxikon Inc | SOLID FORMS OF {3- [5- (4-CHLORINE-PHENYL) -1H-PIRROLO [2,3-B] PIRIDINA-3-CARBONIL] -2,4-DIFLUOR-PHENIL} -AMIDE OF PROPANE ACID-1- SULFONIC |
| UA118010C2 (en) | 2011-08-01 | 2018-11-12 | Вертекс Фармасьютікалз Інкорпорейтед | INFLUENCES OF INFLUENZA VIRUS REPLICATION |
| US9150570B2 (en) | 2012-05-31 | 2015-10-06 | Plexxikon Inc. | Synthesis of heterocyclic compounds |
| SG10201804026WA (en) | 2013-11-13 | 2018-06-28 | Vertex Pharma | Inhibitors of influenza viruses replication |
| SI3421468T1 (en) | 2013-11-13 | 2021-03-31 | Vertex Pharmaceuticals Incorporated | Methods of preparing inhibitors of influenza viruses replication |
| WO2016183116A1 (en) | 2015-05-13 | 2016-11-17 | Vertex Pharmaceuticals Incorporated | Methods of preparing inhibitors of influenza viruses replication |
| EP3294735B8 (en) | 2015-05-13 | 2022-01-05 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5521197A (en) * | 1994-12-01 | 1996-05-28 | Eli Lilly And Company | 3-<1-alkylenearyl>-4-<1,2,3,6-tetrahydropyridinyl>-and 3-<1-alkylenearyl>-4-piperidinyl-1h-indoles: new 5-HT1F agonists |
| US5627196A (en) * | 1995-01-17 | 1997-05-06 | Eli Lilly And Company | Compounds having effects on serotonin-related systems |
| US5576321A (en) * | 1995-01-17 | 1996-11-19 | Eli Lilly And Company | Compounds having effects on serotonin-related systems |
-
2000
- 2000-04-19 AR ARP000101879A patent/AR028475A1/en unknown
- 2000-04-20 CN CN00806589A patent/CN1348451A/en active Pending
- 2000-04-20 BR BR0010693-3A patent/BR0010693A/en not_active Application Discontinuation
- 2000-04-20 JP JP2000614250A patent/JP2002543079A/en active Pending
- 2000-04-20 EP EP00923540A patent/EP1171439A1/en not_active Withdrawn
- 2000-04-20 AU AU43644/00A patent/AU4364400A/en not_active Abandoned
- 2000-04-20 WO PCT/US2000/010628 patent/WO2000064898A1/en not_active Ceased
- 2000-04-20 CA CA002367681A patent/CA2367681A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1171439A1 (en) | 2002-01-16 |
| BR0010693A (en) | 2002-02-05 |
| WO2000064898A1 (en) | 2000-11-02 |
| AU4364400A (en) | 2000-11-10 |
| CA2367681A1 (en) | 2000-11-02 |
| CN1348451A (en) | 2002-05-08 |
| JP2002543079A (en) | 2002-12-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR028475A1 (en) | DERIVATIVES OF AZAINDOL AND USE OF THE SAME FOR THE MANUFACTURE OF A MEDICINAL PRODUCT FOR THE TREATMENT OF DEPRESSION. | |
| AR038045A1 (en) | THERAPEUTIC AGENTS | |
| SV2002000197A (en) | NEW DERIVATIVES OF USEFUL BIARILETER AS INHIBITORS OF THE RECOVERY OF MONOAMINES REF. PC10602 / 20073 / BB | |
| AR014313A1 (en) | DERIVATIVES OF BENZOSULFONA, MEDICATION THAT CONTAINS THEM, PROCEDURE FOR THEIR PREPARATION AND ITS EMPLOYMENT FOR THE MANUFACTURE OF SUCH MEDICINAL PRODUCT | |
| CO4810373A1 (en) | ARYL-CONDENSED AZAPOLYCLIC COMPOUNDS | |
| PE20010009A1 (en) | DERIVATIVES OF PHENYL - AND PYRIDINYL AS ANTAGONISTS OF THE NEUROQUININ 1 RECEPTOR | |
| AR029454A1 (en) | PIPERAZINE DERIVATIVES REPLACED, PROCEDURES FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE IN THE DEVELOPMENT OF MEDICINES | |
| UY28059A1 (en) | NEW DERIVATIVES OF DIHYDROPIRIMIDO (4,5-D) PYRIMIDONE REPLACED BY AMINO. MANUFACTURE AND USE OF THE SAME AS PHARMACEUTICAL AGENTS. | |
| ECSP066520A (en) | DERIVATIVES OF DIHYDROBENZOFURANYL ALCANAMINE AND METHODS FOR USE | |
| AR038762A1 (en) | DERIVATIVES OF INDOLINA, A PROCESS FOR THE PREPARATION, PHARMACEUTICAL COMPOSITION, PROCESS FOR THE PREPARATION OF SUCH COMPOSITION AND THE USE OF SUCH DERIVATIVES FOR THE MANUFACTURE OF A MEDICINAL PRODUCT | |
| AR037983A1 (en) | PIRIDO DERIVATIVES [2,1-A] ISOQUINOLINE | |
| ECSP045473A (en) | DERIVATIVES OF 1- (AMINOALQUIL) -3-SULFONYLINDOL AND 1-AMINOALQUIL-3-SULFONYLINDAZOL AS 5-HYDROXYTHYRIPTAMINE-6 LIGANDS | |
| AR029215A1 (en) | DERIVATIVES OF BENZAZOL AND TAUTOMERS OF THE SAME USEFULS IN THE TREATMENT OF DISORDERS IN THE SYSTEMS OF AUTOIMMUNITY AND NEURONALS, USE OF SUCH DERIVATIVES IN THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS APPLICABLE IN THE TREATMENT OF SUCH DISORDERS INHIBIT OR PRESSED | |
| ES2067744T3 (en) | HETEROCICLIC AMINES WITH ACTIVITY ON THE CENTRAL NERVOUS SYSTEM. | |
| ES2094843T3 (en) | BENCISOTIAZOL- AND BENCISOXAZOL-3-CARBOXAMIDES, A PROCEDURE FOR THEIR PREPARATION AND USE AS ANTIPSYCHOTIC MEDICINES. | |
| AR036208A1 (en) | FLIBANSERINE STABLE POLYMORPH COMPOUND, INDUSTRIAL PROCEDURE FOR PREPARATION, AND USE OF THE SAME TO PREPARE MEDICATIONS | |
| ECSP045156A (en) | INDOLILALQUILAMINE DERIVATIVES AS LIGANDOS 5-HIDROXITRIPTAMINA-6 | |
| UY26919A1 (en) | DERIVATIVES OF QUINAZOLINE AS ALFA ADRENERGIC ANTAGONISTS - 1 | |
| UY27232A1 (en) | NEW SUBSTITUTED CYAN DIHYDROPIRIMIDINE COMPOUNDS AND THEIR USE FOR TREATMENT OF MATTERS | |
| AR005102A1 (en) | COMPOUNDS DERIVED FROM OCTAHIDRO-PIRROLO [1,2-A] -PYRAZINE 2,7-SUBSTITUTES, PHARMACEUTICAL COMPOSITIONS AND USE OF SUCH COMPOUNDS FOR THE MANUFACTURE OF A MEDICINAL PRODUCT. | |
| AR019859A1 (en) | DIAZA-ESPIRO DERIVATIVES [3,5] NONANO, A PROCEDURE FOR ITS PREPARATION, PHARMACEUTICAL COMPOSITIONS THAT INCLUDE THEM AND THE USE OF THEM FOR THE PREPARATION OF A MEDICINAL PRODUCT | |
| AR050711A1 (en) | ARILSULFONYLESTILBEN DERIVATIVES FOR THE TREATMENT AND / OR PREVENTION OF AFFECTIONS OF THE CENTRAL NERVOUS SYSTEM | |
| AR021094A1 (en) | INHIBITING HETEROCICLICAL COMPOUNDS OF PHOSPHODIESTERASE IV AND ITS USE FOR THE TREATMENT OF INFLAMMATORY DISEASES | |
| DK0888356T3 (en) | Condensed 2,3-benzodiazepine derivatives and their use as AMPA receptor inhibitors | |
| ES2172436B1 (en) | INDOLILPIPERIDINE DERIVATIVES AS ANTIHISTAMINIC AND ANTIALERGIC AGENTS. |