AR027611A1 - 3-fenil-5-alcoxi-1,3,4-oxodiazol-2-onas substituidas, su produccion y empleo en substancias farmaceuticas - Google Patents
3-fenil-5-alcoxi-1,3,4-oxodiazol-2-onas substituidas, su produccion y empleo en substancias farmaceuticasInfo
- Publication number
- AR027611A1 AR027611A1 ARP010101037A ARP010101037A AR027611A1 AR 027611 A1 AR027611 A1 AR 027611A1 AR P010101037 A ARP010101037 A AR P010101037A AR P010101037 A ARP010101037 A AR P010101037A AR 027611 A1 AR027611 A1 AR 027611A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- substituted
- cycloalkyl
- aryl
- oxodiazol
- Prior art date
Links
- 239000000126 substance Substances 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 6
- -1 2-oxo-pyrrolidin-1-yl Chemical group 0.000 abstract 3
- 150000002431 hydrogen Chemical class 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000000041 C6-C10 aryl group Chemical group 0.000 abstract 2
- 239000004305 biphenyl Substances 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 1
- 102100026020 Hormone-sensitive lipase Human genes 0.000 abstract 1
- 102000000019 Sterol Esterase Human genes 0.000 abstract 1
- 108010055297 Sterol Esterase Proteins 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 235000010290 biphenyl Nutrition 0.000 abstract 1
- 125000006267 biphenyl group Chemical group 0.000 abstract 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N phenylbenzene Natural products C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
- C07D271/113—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
Se describen 3-fenil-5-alcoxi-1,3,4-oxodiazol-2-ona substituidos de la formula (1), en el que equivalen R1 a alquilo C1-6 u cicloalquilo C3-9 substituidos;R2, R3, R4 y R5 a hidrogeno, halogeno, nitro, alquilo C1-4, alquiloxi C1-9, arilo C6-10-alquilo xi C1-4 substituido, ariloxi C6-10, arilo C6-10, cicloalquiloC3-8 o O-cicloalquilo C3-8 o 2-oxo-pirrolidin-1-il, 2,5-dimetilpirrol-1-il o NR6-A-R7 con la condicion que R2, R3, R4 y R5 no sean hidrogenos simultáneamente yal menos uno de los radicales R2, R3, R4 y R5 sea igual al radical 2-oxo-pirrolidin-1-il, 2,5-dimetilpirrol-1-il o NR6-A-R7, con R6 = hidrogeno, alquilo C1-4 oarilo C6-10-alquilo C1-4 substituido, A = enlace simple, COn, SOn o CONH, donde n = 1 o 2; y R7 = hidrogeno, alquilo C1-1 8-alquenilo C2-18 substituido, ariloC6-10-alquilo C1-4, cicloalquilo C5-8-alquilo C1-4, cicloalquilo C5-8, arilo C6-10-alquenilo C2-6, arilo C6-10, difenilo, alquil C1-4-difenilo insanilo, o elgrupo Het-(CH2)r-, con r = 0, 1, 2 o 3 y Het = heterocicl o saturado o insaturado de 5-7 elementos, que puede tener un anillo bencénico condensado y puedesubstituirse, o pueda equivaler a un procedimiento para su produccion. Los compuestos presentan un efecto inhibidor en la lipasa sensible a hormonas, HSL.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2000110968 DE10010968A1 (de) | 2000-03-07 | 2000-03-07 | Substituierte 3-Phenyl-5-alkoxi-1,3,4-oxdiazol-2-one, ihre Herstellung und Verwendung in Arzneistoffen |
| DE2001102265 DE10102265C1 (de) | 2001-01-18 | 2001-01-18 | Substituierte 3-Phenyl-5-alkoxi-1,3,4-oxdiazol-2-one, ihre Herstellung und Verwendung in Arzneistoffen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR027611A1 true AR027611A1 (es) | 2003-04-02 |
Family
ID=26004720
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP010101037A AR027611A1 (es) | 2000-03-07 | 2001-03-05 | 3-fenil-5-alcoxi-1,3,4-oxodiazol-2-onas substituidas, su produccion y empleo en substancias farmaceuticas |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US6369088B2 (es) |
| EP (1) | EP1263745B1 (es) |
| JP (1) | JP2003525931A (es) |
| KR (1) | KR100790763B1 (es) |
| CN (1) | CN1261419C (es) |
| AR (1) | AR027611A1 (es) |
| AT (1) | ATE267184T1 (es) |
| AU (1) | AU784827B2 (es) |
| BR (1) | BR0108974A (es) |
| CA (1) | CA2401953A1 (es) |
| DE (1) | DE50102325D1 (es) |
| DK (1) | DK1263745T3 (es) |
| EE (1) | EE04877B1 (es) |
| ES (1) | ES2218383T3 (es) |
| HK (1) | HK1054036B (es) |
| HR (1) | HRP20020732A2 (es) |
| HU (1) | HUP0302772A3 (es) |
| IL (1) | IL151518A (es) |
| MX (1) | MXPA02008038A (es) |
| NO (1) | NO323483B1 (es) |
| NZ (1) | NZ521207A (es) |
| PL (1) | PL359702A1 (es) |
| PT (1) | PT1263745E (es) |
| RU (1) | RU2281283C2 (es) |
| SK (1) | SK12752002A3 (es) |
| TR (1) | TR200401217T4 (es) |
| WO (1) | WO2001066531A1 (es) |
| YU (1) | YU57802A (es) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6087350A (en) * | 1997-08-29 | 2000-07-11 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Use of pretreatment chemicals to enhance efficacy of cytotoxic agents |
| US6900233B2 (en) | 2002-02-28 | 2005-05-31 | Aventis Pharma Deutschland Gmbh | Substituted 3-phenyl-5-alkoxy-3H-(1,3,4)-oxadiazol-2-ones, pharmaceutical composition and method for treating obesity thereof |
| DE10208987A1 (de) * | 2002-02-28 | 2003-09-11 | Aventis Pharma Gmbh | Substituierte 3-Phenyl-5-alkoxi-1,3,4-oxidiazol-2-one, ihre Herstellung und Verwendung in Arzneistoffen |
| US20030236288A1 (en) * | 2002-02-28 | 2003-12-25 | Karl Schoenafinger | Use of substituted 3-phenyl-5-alkoxy-3H-(1,3,4)-oxadizol-2-ones for inhibiting pancreatic lipase |
| DE10208986A1 (de) * | 2002-02-28 | 2003-09-11 | Aventis Pharma Gmbh | Verwendung substituierter 3-Phenyl-5-alkoxi-1,3,4-oxdiazol-2-one zur Herstellung von Arzneimitteln mit hemmender Wirkung an der pankreatischen Lipase |
| SE0203754D0 (sv) * | 2002-12-17 | 2002-12-17 | Astrazeneca Ab | New compounds |
| SE0203753D0 (sv) * | 2002-12-17 | 2002-12-17 | Astrazeneca Ab | New compounds |
| WO2006116773A2 (en) * | 2005-04-28 | 2006-11-02 | The Regents Of The University Of California | Methods, compositions, and compounds for modulation of monoacylglycerol lipase, pain, and stress-related disorders |
| CN101225085B (zh) * | 2007-01-17 | 2011-09-21 | 天津天士力集团有限公司 | 苯基呋咱氮类一氧化氮供体型2-苯胺嘧啶衍生物、其制备方法、含有该化合物的组合物及其用途 |
| TW201033163A (en) * | 2008-10-20 | 2010-09-16 | Sumitomo Chemical Co | Method for manufacturing oxadiazolinone compound and intermediate thereof |
| WO2010074587A2 (en) | 2008-12-23 | 2010-07-01 | Bial - Portela & Ca., S.A. | 5-o-substituted 3-n-aryl-1,3,4-oxadiazolones for medical use |
| WO2011108724A1 (ja) * | 2010-03-04 | 2011-09-09 | 味の素株式会社 | 糖尿病又は肥満症の予防又は治療剤 |
| US8501768B2 (en) * | 2011-05-17 | 2013-08-06 | Hoffmann-La Roche Inc. | Hexahydrocyclopentapyrrolone, hexahydropyrrolopyrrolone, octahydropyrrolopyridinone and octahydropyridinone compounds |
| JP6007417B2 (ja) | 2011-05-31 | 2016-10-12 | レセプトス エルエルシー | 新規ｇｌｐ−１受容体安定剤および調節剤 |
| US8778923B2 (en) | 2011-12-12 | 2014-07-15 | Receptos, Inc. | GLP-1 receptor modulators |
| WO2014201172A1 (en) | 2013-06-11 | 2014-12-18 | Receptos, Inc. | Novel glp-1 receptor modulators |
| UA119247C2 (uk) | 2013-09-06 | 2019-05-27 | РОЙВЕНТ САЙЕНСИЗ ҐмбГ | Спіроциклічні сполуки як інгібітори триптофангідроксилази |
| WO2015089137A1 (en) | 2013-12-11 | 2015-06-18 | Karos Pharmaceuticals, Inc. | Acylguanidines as tryptophan hydroxylase inhibitors |
| WO2016015014A1 (en) | 2014-07-25 | 2016-01-28 | Receptos, Inc. | Novel glp-1 receptor modulators |
| MX381977B (es) | 2014-12-10 | 2025-03-13 | Receptos Llc | Moduladores del receptor de péptido 1 tipo glucagón. |
| WO2016109501A1 (en) | 2014-12-30 | 2016-07-07 | Karos Pharmaceuticals, Inc. | Amide compounds as tryptophan hydroxylase inhibitors |
| US9611201B2 (en) | 2015-03-05 | 2017-04-04 | Karos Pharmaceuticals, Inc. | Processes for preparing (R)-1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanol and 1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanone |
| CN108863774A (zh) * | 2018-06-09 | 2018-11-23 | 石家庄市绿丰化工有限公司 | 一种2,4-二氯苯乙酰氯合成的方法 |
| US11203597B2 (en) | 2018-11-14 | 2021-12-21 | Altavant Sciences Gmbh | Crystalline spirocyclic compound, a dosage form containing, a method for using in treatment of disease, and a method for recrystallizing |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2299328A1 (fr) | 1975-02-03 | 1976-08-27 | Rhone Poulenc Ind | Derives de l'alcoyloxy-5 phenyl-3 oxyde azo |
| US4076824A (en) | 1975-02-03 | 1978-02-28 | Rhone-Poulenc Industries | Anthelmintic oxadiazolinone derivatives |
| FR2299028A1 (fr) | 1975-02-03 | 1976-08-27 | Rhone Poulenc Ind | Nouvea |
| DK156439C (da) | 1980-09-15 | 1990-01-22 | Shell Int Research | 7-substituerede 2,3-dihydrobenzofuranderivater samt pesticidpraeparater indeholdende disse og en fremgangsmaade til bekaempelse af skadelige organismer |
| EP0067471B1 (en) | 1981-06-15 | 1985-11-06 | Shell Internationale Researchmaatschappij B.V. | 7-substituted 2,3-dihydrobenzofurans, their preparation and their use as pesticides or as chemical intermediates |
| US5236939A (en) | 1989-09-23 | 1993-08-17 | Bayer Aktiengesellschaft | Substituted 1,3,4-oxa(thia)diazolinones process for their preparation and their use of combating endoparasites |
| DE3931843A1 (de) | 1989-09-23 | 1991-04-04 | Bayer Ag | Substituierte 1,3,4-oxa(thia)diazolinone verfahren zu ihrer herstellung und ihre verwendung der bekaempfung von endoparasiten |
| US5641796A (en) * | 1994-11-01 | 1997-06-24 | Eli Lilly And Company | Oral hypoglycemic agents |
-
2001
- 2001-02-20 DK DK01905805T patent/DK1263745T3/da active
- 2001-02-20 AU AU33787/01A patent/AU784827B2/en not_active Ceased
- 2001-02-20 TR TR2004/01217T patent/TR200401217T4/xx unknown
- 2001-02-20 JP JP2001565347A patent/JP2003525931A/ja not_active Abandoned
- 2001-02-20 IL IL151518A patent/IL151518A/en not_active IP Right Cessation
- 2001-02-20 PL PL35970201A patent/PL359702A1/xx not_active IP Right Cessation
- 2001-02-20 WO PCT/EP2001/001898 patent/WO2001066531A1/de not_active Ceased
- 2001-02-20 CN CNB018062156A patent/CN1261419C/zh not_active Expired - Fee Related
- 2001-02-20 CA CA002401953A patent/CA2401953A1/en not_active Abandoned
- 2001-02-20 KR KR1020027011634A patent/KR100790763B1/ko not_active Expired - Fee Related
- 2001-02-20 HU HU0302772A patent/HUP0302772A3/hu unknown
- 2001-02-20 YU YU57802A patent/YU57802A/sh unknown
- 2001-02-20 SK SK1275-2002A patent/SK12752002A3/sk unknown
- 2001-02-20 NZ NZ521207A patent/NZ521207A/en unknown
- 2001-02-20 HK HK03106394.6A patent/HK1054036B/zh not_active IP Right Cessation
- 2001-02-20 MX MXPA02008038A patent/MXPA02008038A/es active IP Right Grant
- 2001-02-20 RU RU2002126556/04A patent/RU2281283C2/ru not_active IP Right Cessation
- 2001-02-20 BR BR0108974-9A patent/BR0108974A/pt not_active IP Right Cessation
- 2001-02-20 ES ES01905805T patent/ES2218383T3/es not_active Expired - Lifetime
- 2001-02-20 DE DE50102325T patent/DE50102325D1/de not_active Expired - Lifetime
- 2001-02-20 AT AT01905805T patent/ATE267184T1/de not_active IP Right Cessation
- 2001-02-20 HR HRP20020732 patent/HRP20020732A2/hr not_active Application Discontinuation
- 2001-02-20 EE EEP200200498A patent/EE04877B1/xx not_active IP Right Cessation
- 2001-02-20 EP EP01905805A patent/EP1263745B1/de not_active Expired - Lifetime
- 2001-02-20 PT PT01905805T patent/PT1263745E/pt unknown
- 2001-03-05 AR ARP010101037A patent/AR027611A1/es not_active Application Discontinuation
- 2001-03-06 US US09/799,082 patent/US6369088B2/en not_active Expired - Lifetime
-
2002
- 2002-09-03 NO NO20024201A patent/NO323483B1/no unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR027611A1 (es) | 3-fenil-5-alcoxi-1,3,4-oxodiazol-2-onas substituidas, su produccion y empleo en substancias farmaceuticas | |
| DK0794955T3 (da) | Hindrede N-oxid-estere af rapamycin samt deres anvendelse som lægemidler | |
| ES2117400T3 (es) | Inhibidores de metaloproteinasas. | |
| NO20052469L (no) | Inhibitorer av II-beta-hydroksysteroid-dehydrogenase type 1 og type 2. | |
| AR014110A1 (es) | Compuestos de 2-aminopiridinas, composiciones farmaceuticas, procedimiento de tratamiento, prevencion e inhibicion | |
| TR200003332T2 (tr) | İzoksazolin-3-il-asil benzen üretmek için yöntem | |
| CO5700817A2 (es) | Compuesto pentaciclico heteroaromatico y uso medicinal del mismo | |
| DK0770065T3 (da) | Trisubstituerede phenylderivater nyttige som PDE IV-inhibitorer | |
| DK0730598T3 (da) | Hindrede estere af rapamycin samt deres anvendelse som lægemidler | |
| NZ506101A (en) | Tricyclic immunosupressant, anti-allergic and IgE production suppressant compounds | |
| YU34896A (sh) | Supstituisani n-(indol-2-karbonil)-glicinamidi, njihovi intermedijeri i farmaceutske kompozicije | |
| PE54294A1 (es) | Derivado de 5-aminoalquil-1,4-benzodiazepina | |
| NO970731D0 (no) | 2,3-dihydro-1-(2,2,2-trifluoretyl)-2-okso-5-fenyl-1H-1,4-benzodiazepiner | |
| HUP0002330A2 (hu) | Azetidinilpropilpiperidin-származékok, ezek intermedierjei és tachikinin antagonistaként történő alkalmazásuk | |
| DE69203797D1 (de) | Amidino-Verbindungen, ihre Herstellung und Verwendung als Arzneimittel. | |
| ES2059212T3 (es) | Antagonistas paf/h1 imidazopiridina. | |
| EP0665208A4 (es) | ||
| LV12824B (lv) | Fibrinogēnu receptoru antagonistu iegūšanas paņēmiens | |
| FI852003L (fi) | --laktamantibiotika, foerfarande foer deras framstaellning och deras anvaendning som laekemedel eller tillvaextbefraemjare vid boskapsuppfoedning eller som antioxidanter. | |
| DE59107712D1 (de) | Säurelabile Lösungsinhibitoren und darauf basierende positiv und negativ arbeitende strahlungsempfindliche Zusammensetzung | |
| DE69621651D1 (de) | Azahexan-derivate als substratisostere von retroviralen aspartat-proteasen | |
| FI910058A0 (fi) | Fungicider. | |
| ES2171306T3 (es) | Compuesto bajo la forma de isomero geometrico puro o de una mezcla de estos isomeros. | |
| PE20000734A1 (es) | Compuestos heterociclicos derivados de furopiridina y su uso terapeutico | |
| ATE300532T1 (de) | Piperazinon-derivate |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |