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AR026700A1 - CHEMICAL AND INTERMEDIARY PROCESSES - Google Patents

CHEMICAL AND INTERMEDIARY PROCESSES

Info

Publication number
AR026700A1
AR026700A1 ARP000106370A ARP000106370A AR026700A1 AR 026700 A1 AR026700 A1 AR 026700A1 AR P000106370 A ARP000106370 A AR P000106370A AR P000106370 A ARP000106370 A AR P000106370A AR 026700 A1 AR026700 A1 AR 026700A1
Authority
AR
Argentina
Prior art keywords
chemical
processes
propanoyl
phosphoryl
manufacture
Prior art date
Application number
ARP000106370A
Other languages
Spanish (es)
Original Assignee
Schuckmann Alfred Von
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schuckmann Alfred Von filed Critical Schuckmann Alfred Von
Publication of AR026700A1 publication Critical patent/AR026700A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/6574—Esters of oxyacids of phosphorus
    • C07F9/65742—Esters of oxyacids of phosphorus non-condensed with carbocyclic rings or heterocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Procesos químicos e intermediarios químicos que son utiles en la formacion selectiva de un grupo mono-fosforilo primario (-OPO(OH)2) en un sistema quecontiene un 1,2-diol-propanoilo (HO-CH2CH(OH)-CO)terminal, y procesos químicos e intermediarios quím icos (y procesos para su fabricacion) utiles en particularpara la fabricacion de agentes bacterianos de oxazolidinona anti-Gram positivas que contienen dicha funcionalidad, en particular para la preparacion de 5(R)-Isoxazol-3-iloximetil-3-(4-(1-(2(S) -hidroxi-3-fosforil-propanoil)-1,2,5,6-tetrahidropirid-4-il)-3,5-difluorofenil)oxazolidin-2-ona.Chemical processes and chemical intermediates that are useful in the selective formation of a primary mono-phosphoryl (-OPO (OH) 2) group in a system containing a 1,2-diol-propanoyl (HO-CH2CH (OH) -CO) terminal , and chemical processes and chemical intermediates (and processes for their manufacture) useful in particular for the manufacture of anti-Gram positive oxazolidinone bacterial agents containing such functionality, in particular for the preparation of 5 (R) -Isoxazol-3-yloxymethyl -3- (4- (1- (2 (S) -hydroxy-3-phosphoryl-propanoyl) -1,2,5,6-tetrahydropyrid-4-yl) -3,5-difluorophenyl) oxazolidin-2-one .

ARP000106370A 1999-12-03 2000-12-01 CHEMICAL AND INTERMEDIARY PROCESSES AR026700A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9928499.4A GB9928499D0 (en) 1999-12-03 1999-12-03 Chemical processes and intermediates

Publications (1)

Publication Number Publication Date
AR026700A1 true AR026700A1 (en) 2003-02-26

Family

ID=10865576

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP000106370A AR026700A1 (en) 1999-12-03 2000-12-01 CHEMICAL AND INTERMEDIARY PROCESSES

Country Status (22)

Country Link
EP (1) EP1237895A2 (en)
JP (1) JP2003515539A (en)
KR (1) KR20020058072A (en)
CN (1) CN1433421A (en)
AR (1) AR026700A1 (en)
AU (1) AU762241B2 (en)
BG (1) BG106728A (en)
BR (1) BR0016087A (en)
CA (1) CA2395052A1 (en)
CO (1) CO5271712A1 (en)
CZ (1) CZ20021912A3 (en)
EE (1) EE200200282A (en)
GB (1) GB9928499D0 (en)
HU (1) HUP0204052A2 (en)
IL (1) IL149641A0 (en)
IS (1) IS6401A (en)
MX (1) MXPA02005396A (en)
NO (1) NO20022605L (en)
PL (1) PL364762A1 (en)
SK (1) SK7862002A3 (en)
WO (1) WO2001040236A2 (en)
ZA (1) ZA200203876B (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9928568D0 (en) 1999-12-03 2000-02-02 Zeneca Ltd Chemical compounds
GB0009803D0 (en) 2000-04-25 2000-06-07 Astrazeneca Ab Chemical compounds
GB0113297D0 (en) * 2001-06-01 2001-07-25 Astrazeneca Ab Chemical Process
IL160739A0 (en) 2001-09-11 2004-08-31 Astrazeneca Ab Oxazolidinone and/or isoxazoline as antibacterial agents
EP1443930A1 (en) 2001-10-25 2004-08-11 AstraZeneca AB Isoxazoline derivatives useful as antimicrobials
US7141588B2 (en) 2002-02-25 2006-11-28 Pfizer, Inc. N-aryl-2-oxazolidinone-5-carboxamides and their derivatives
AR038536A1 (en) 2002-02-25 2005-01-19 Upjohn Co N-ARIL-2-OXAZOLIDINONA-5- CARBOXAMIDS AND ITS DERIVATIVES
RU2004129276A (en) 2002-02-28 2005-06-10 Астразенека Аб (Se) 3-CYCLIC-5- (NITROGEN-CONTAINING 5-MEMBER RING) METHYL-OXAZOLIDININE DERIVATIVES AND THEIR APPLICATION AS ANTIBACTERIAL MEANS
AU2003209994A1 (en) 2002-02-28 2003-09-09 Astrazeneca Ab Oxazolidinone derivatives, processes for their preparation, and pharmaceutical compositions containing them
JP2005537301A (en) 2002-08-12 2005-12-08 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー N-aryl-2-oxazolidinones and derivatives thereof
AR043050A1 (en) 2002-09-26 2005-07-13 Rib X Pharmaceuticals Inc BIFunctional HETEROCICLICAL COMPOUNDS AND METHODS TO PREPARE AND USE THE SAME
MXPA05005472A (en) 2002-11-21 2005-07-25 Pharmacia & Upjohn Co Llc N-(4-(piperazin-1-yl)-phenyl-2-oxazolidinone-5-carboxamide derivates and related compounds as antibacterial agents.
PT1656370E (en) 2003-06-03 2012-11-29 Rib X Pharmaceuticals Inc Biaryl heterocyclic compounds and methods of making and using the same
US8324398B2 (en) 2003-06-03 2012-12-04 Rib-X Pharmaceuticals, Inc. Process for the synthesis of biaryl oxazolidinones
US7304050B2 (en) 2003-09-16 2007-12-04 Pfizer Inc. Antibacterial agents
JP2007514782A (en) 2003-12-17 2007-06-07 リブ−エックス ファーマシューティカルズ，インコーポレイテッド Halogenated biaryl heterocyclic compounds and methods for making and using the same
EP2716647A3 (en) 2004-02-27 2014-08-20 Rib-X Pharmaceuticals, Inc. Macrocyclic compounds and methods of making and using the same
EP1904489B1 (en) 2005-06-08 2011-01-26 Rib-X Pharmaceuticals, Inc. Process for the synthesis of triazoles
EP2069339B1 (en) 2006-09-25 2011-05-18 Wockhardt Research Centre Substituted piperidinophenyl oxazolidinones
US9572809B2 (en) 2012-07-18 2017-02-21 Spero Trinem, Inc. Combination therapy to treat Mycobacterium diseases

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU753988B2 (en) * 1998-06-05 2002-10-31 Astrazeneca Ab Oxazolidinone derivatives, process for their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
MXPA02005396A (en) 2002-11-29
WO2001040236A2 (en) 2001-06-07
PL364762A1 (en) 2004-12-13
EP1237895A2 (en) 2002-09-11
CA2395052A1 (en) 2001-06-07
EE200200282A (en) 2003-06-16
KR20020058072A (en) 2002-07-12
CO5271712A1 (en) 2003-04-30
WO2001040236A3 (en) 2002-05-10
JP2003515539A (en) 2003-05-07
GB9928499D0 (en) 2000-02-02
IL149641A0 (en) 2002-11-10
HUP0204052A2 (en) 2003-03-28
IS6401A (en) 2002-05-28
SK7862002A3 (en) 2003-02-04
CZ20021912A3 (en) 2002-08-14
CN1433421A (en) 2003-07-30
ZA200203876B (en) 2003-08-15
AU762241B2 (en) 2003-06-19
AU1715601A (en) 2001-06-12
NO20022605L (en) 2002-06-26
BR0016087A (en) 2002-08-06
NO20022605D0 (en) 2002-05-31
BG106728A (en) 2003-02-28

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