AR025814A1 - Compuestos derivados de eritromicina, su procedimiento de preparacion, composiciones farmaceuticas y medicamentos - Google Patents
Compuestos derivados de eritromicina, su procedimiento de preparacion, composiciones farmaceuticas y medicamentosInfo
- Publication number
- AR025814A1 AR025814A1 ARP990105702A ARP990105702A AR025814A1 AR 025814 A1 AR025814 A1 AR 025814A1 AR P990105702 A ARP990105702 A AR P990105702A AR P990105702 A ARP990105702 A AR P990105702A AR 025814 A1 AR025814 A1 AR 025814A1
- Authority
- AR
- Argentina
- Prior art keywords
- erythromycin
- pharmaceutical compositions
- medicines
- preparation procedure
- compounds derived
- Prior art date
Links
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 title abstract 6
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 229960003276 erythromycin Drugs 0.000 title abstract 3
- 239000003814 drug Substances 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 241000193998 Streptococcus pneumoniae Species 0.000 abstract 1
- 241000193996 Streptococcus pyogenes Species 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229940031000 streptococcus pneumoniae Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
Compuestos derivados de eritromicina que comprenden los compuestos de formula (1) en la que X representa un átomo de hidrogeno o un átomo de halogeno y Zrepresenta un átomo de hidrogeno o el resto de un ácido así como sus sales de adicion con ácidos.Los compuestos de formula (1) presentan propiedadesantibioticas, son particularmente activos sobre las cepas resistentes a eritromicina como, por ejemplo, Streptococcus pyogenes y Streptococcus pneumoniae y S.aureus. Además se describe el procedimiento para su preparacion y composiciones farmacéuticas y medicamentos que los comprenden.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9814145A FR2785612A1 (fr) | 1998-11-10 | 1998-11-10 | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR025814A1 true AR025814A1 (es) | 2002-12-18 |
Family
ID=9532584
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990105702A AR025814A1 (es) | 1998-11-10 | 1999-11-10 | Compuestos derivados de eritromicina, su procedimiento de preparacion, composiciones farmaceuticas y medicamentos |
Country Status (28)
| Country | Link |
|---|---|
| US (2) | US6455505B2 (es) |
| EP (1) | EP1016669B1 (es) |
| JP (1) | JP4698783B2 (es) |
| KR (1) | KR100567695B1 (es) |
| CN (2) | CN1240708C (es) |
| AR (1) | AR025814A1 (es) |
| AT (1) | ATE232879T1 (es) |
| AU (1) | AU766138B2 (es) |
| BR (1) | BR9915236A (es) |
| CA (1) | CA2350651C (es) |
| CZ (1) | CZ20011622A3 (es) |
| DE (1) | DE69905447T2 (es) |
| DK (1) | DK1016669T3 (es) |
| EA (1) | EA200100533A1 (es) |
| ES (1) | ES2189365T3 (es) |
| FR (1) | FR2785612A1 (es) |
| HR (1) | HRP20010335B1 (es) |
| HU (1) | HUP0104035A3 (es) |
| IL (2) | IL142996A0 (es) |
| NO (1) | NO20012272L (es) |
| NZ (1) | NZ511609A (es) |
| PL (1) | PL348098A1 (es) |
| PT (1) | PT1016669E (es) |
| SI (1) | SI20640A (es) |
| TR (1) | TR200101286T2 (es) |
| TW (1) | TWI237027B (es) |
| WO (1) | WO2000027857A2 (es) |
| ZA (1) | ZA200103801B (es) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE256694T1 (de) * | 1999-01-27 | 2004-01-15 | Pfizer Prod Inc | Ketolid-antibiotika |
| CN1351608A (zh) | 1999-05-24 | 2002-05-29 | 辉瑞产品公司 | 13－甲基红霉素衍生物 |
| ES2222966T3 (es) | 2000-06-30 | 2005-02-16 | Pfizer Products Inc. | Macrolidos antibioticos. |
| JP2004017020A (ja) * | 2002-06-20 | 2004-01-22 | Sony Corp | コーティング方法および被コーティング粒子 |
| EP3738591A3 (en) * | 2003-03-10 | 2021-03-24 | Merck Sharp & Dohme Corp. | Novel antibacterial agents |
| WO2006080954A1 (en) * | 2004-07-28 | 2006-08-03 | Ranbaxy Laboratories Limited | Ketolide derivatives as antibacterial agents |
| WO2006046112A2 (en) * | 2004-10-25 | 2006-05-04 | Ranbaxy Laboratories Limited | Ketolide derivatives as antibacterial agents |
| WO2009055557A1 (en) * | 2007-10-25 | 2009-04-30 | Cempra Pharmaceuticals, Inc. | Process for the preparation of macrolide antibacterial agents |
| DK2358379T3 (en) | 2008-10-24 | 2016-03-07 | Cempra Pharmaceuticals Inc | BIOFORSVAR USING TRIAZOLHOLDIGE macrolides |
| US9937194B1 (en) | 2009-06-12 | 2018-04-10 | Cempra Pharmaceuticals, Inc. | Compounds and methods for treating inflammatory diseases |
| EP2475253B1 (en) | 2009-09-10 | 2016-10-26 | Cempra Pharmaceuticals, Inc. | Methods for treating malaria, tuberculosis and mac diseases |
| JP5711352B2 (ja) | 2010-03-22 | 2015-04-30 | センプラ ファーマシューティカルズ，インコーポレイテッド | マクロライドの結晶形、およびその使用 |
| WO2011146829A1 (en) | 2010-05-20 | 2011-11-24 | Cempra Pharmaceuticals, Inc. | Processes for preparing macrolides and ketolides and intermediates therefor |
| US9815863B2 (en) | 2010-09-10 | 2017-11-14 | Cempra Pharmaceuticals, Inc. | Hydrogen bond forming fluoro ketolides for treating diseases |
| US10188674B2 (en) | 2012-03-27 | 2019-01-29 | Cempra Pharmaceuticals, Inc. | Parenteral formulations for administering macrolide antibiotics |
| EP2968801B1 (en) | 2013-03-14 | 2018-09-26 | Cempra Pharmaceuticals, Inc. | Methods for treating respiratory diseases and formulations therefor |
| CN105188712A (zh) | 2013-03-15 | 2015-12-23 | 森普拉制药公司 | 用于制备大环内酯抗菌剂的收敛方法 |
| CA3130061C (en) | 2013-04-04 | 2024-05-28 | President And Fellows Of Harvard College | Macrolides and methods of their preparation and use |
| WO2016057798A1 (en) | 2014-10-08 | 2016-04-14 | President And Fellows Of Harvard College | 14-membered ketolides and methods of their preparation and use |
| EP3273969A4 (en) | 2015-03-25 | 2018-11-21 | President and Fellows of Harvard College | Macrolides with modified desosamine sugars and uses thereof |
| EP3190122A1 (en) * | 2016-01-08 | 2017-07-12 | LEK Pharmaceuticals d.d. | A novel synthetic pathway towards solithromycin and purification thereof |
| CN106432383A (zh) * | 2016-09-14 | 2017-02-22 | 重庆两江药物研发中心有限公司 | 索利霉素及其中间体的制备方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5671074A (en) * | 1979-11-12 | 1981-06-13 | Takeda Chem Ind Ltd | 1,2-disubstituted-4-halogenoimidazole-5-acetic acid derivative |
| FR2669337B1 (fr) * | 1990-11-21 | 1995-03-24 | Roussel Uclaf | Nouveaux derives descladinosyles de l'erythromycine, leur procede de preparation et leur application comme medicaments. |
| IL114589A (en) * | 1990-11-21 | 1999-12-22 | Roussel Uclaf | Intermediates for the preparation of erythromycin derivatives |
| US5527780A (en) * | 1992-11-05 | 1996-06-18 | Roussel Uclaf | Erythromycin derivatives |
| FR2697524B1 (fr) * | 1992-11-05 | 1994-12-23 | Roussel Uclaf | Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments. |
| FR2719587B1 (fr) * | 1994-05-03 | 1996-07-12 | Roussel Uclaf | Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments. |
| FR2727969B1 (fr) * | 1994-12-09 | 1997-01-17 | Roussel Uclaf | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
| FR2742757B1 (fr) * | 1995-12-22 | 1998-01-30 | Roussel Uclaf | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
| KR100576988B1 (ko) * | 1996-09-04 | 2006-05-10 | 아보트 러보러터리즈 | 항균 활성을 지닌 6-ｏ-치환된 케톨라이드 |
| AU4472897A (en) * | 1997-03-10 | 1998-09-29 | Taisho Pharmaceutical Co., Ltd. | Erythromycin a derivatives |
-
1998
- 1998-11-10 FR FR9814145A patent/FR2785612A1/fr active Pending
-
1999
- 1999-11-03 US US09/433,146 patent/US6455505B2/en not_active Expired - Lifetime
- 1999-11-08 TW TW088119491A patent/TWI237027B/zh not_active IP Right Cessation
- 1999-11-09 IL IL14299699A patent/IL142996A0/xx active IP Right Grant
- 1999-11-09 CZ CZ20011622A patent/CZ20011622A3/cs unknown
- 1999-11-09 DE DE69905447T patent/DE69905447T2/de not_active Expired - Lifetime
- 1999-11-09 BR BR9915236-3A patent/BR9915236A/pt active Search and Examination
- 1999-11-09 HR HR990077A patent/HRP20010335B1/xx not_active IP Right Cessation
- 1999-11-09 PT PT99402783T patent/PT1016669E/pt unknown
- 1999-11-09 EA EA200100533A patent/EA200100533A1/ru unknown
- 1999-11-09 AU AU10526/00A patent/AU766138B2/en not_active Expired
- 1999-11-09 PL PL99348098A patent/PL348098A1/xx not_active Application Discontinuation
- 1999-11-09 HU HU0104035A patent/HUP0104035A3/hu unknown
- 1999-11-09 ES ES99402783T patent/ES2189365T3/es not_active Expired - Lifetime
- 1999-11-09 CN CNB998154393A patent/CN1240708C/zh not_active Expired - Lifetime
- 1999-11-09 CA CA2350651A patent/CA2350651C/fr not_active Expired - Lifetime
- 1999-11-09 TR TR2001/01286T patent/TR200101286T2/xx unknown
- 1999-11-09 AT AT99402783T patent/ATE232879T1/de active
- 1999-11-09 KR KR1020017005854A patent/KR100567695B1/ko not_active Expired - Lifetime
- 1999-11-09 JP JP31801599A patent/JP4698783B2/ja not_active Expired - Lifetime
- 1999-11-09 CN CNB200510128838XA patent/CN100351238C/zh not_active Expired - Lifetime
- 1999-11-09 EP EP99402783A patent/EP1016669B1/fr not_active Expired - Lifetime
- 1999-11-09 DK DK99402783T patent/DK1016669T3/da active
- 1999-11-09 NZ NZ511609A patent/NZ511609A/en unknown
- 1999-11-09 WO PCT/FR1999/002718 patent/WO2000027857A2/fr not_active Ceased
- 1999-11-09 SI SI9920091A patent/SI20640A/sl not_active IP Right Cessation
- 1999-11-10 AR ARP990105702A patent/AR025814A1/es not_active Application Discontinuation
-
2000
- 2000-12-11 US US09/734,162 patent/US6407257B1/en not_active Expired - Lifetime
-
2001
- 2001-05-06 IL IL142996A patent/IL142996A/en not_active IP Right Cessation
- 2001-05-09 NO NO20012272A patent/NO20012272L/no not_active Application Discontinuation
- 2001-05-10 ZA ZA200103801A patent/ZA200103801B/en unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |