AR013886A1 - Proteinas utiles para tratar la obesidad y condiciones asociadas con la obesidad; composiciones farmaceuticas formuladas con dichas proteinas;compuestos polinucleoticos de dna que codifican dichas proteinas y procedimiento para pepararlas - Google Patents
Proteinas utiles para tratar la obesidad y condiciones asociadas con la obesidad; composiciones farmaceuticas formuladas con dichas proteinas;compuestos polinucleoticos de dna que codifican dichas proteinas y procedimiento para pepararlasInfo
- Publication number
- AR013886A1 AR013886A1 ARP970105941A ARP970105941A AR013886A1 AR 013886 A1 AR013886 A1 AR 013886A1 AR P970105941 A ARP970105941 A AR P970105941A AR P970105941 A ARP970105941 A AR P970105941A AR 013886 A1 AR013886 A1 AR 013886A1
- Authority
- AR
- Argentina
- Prior art keywords
- proteins
- obesity
- xaa
- useful
- conditions associated
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 10
- 108090000623 proteins and genes Proteins 0.000 title abstract 10
- 208000008589 Obesity Diseases 0.000 title abstract 6
- 235000020824 obesity Nutrition 0.000 title abstract 6
- 238000000034 method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 2
- 238000011282 treatment Methods 0.000 abstract 2
- 239000013543 active substance Substances 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/5759—Products of obesity genes, e.g. leptin, obese (OB), tub, fat
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/10—Plasmid DNA
- C12N2800/106—Plasmid DNA for vertebrates
- C12N2800/107—Plasmid DNA for vertebrates for mammalian
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Obesity (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Toxicology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Se trata de proteínas utiles para el tratamiento de la obesidad y de trastornos relacionados con estado de obesidad. Dichas proteínas respondena la secuencia de aminoácidos ID N* 1 dada la reivindicacion 1. Proteínas utiles para tratar la obesidad o condiciones asociadas con la obesidadcaracterizadas porque tienen la secuencia de aminoácidos ID N* 1, en la que: Xaa de la posicion 22 es Asn o Ser, Xaa de la posicion 28 es Gln o estáausente, Xaa de la posicion 72 es Asn, Gln, Glu oAsp y Xaa de la posicion 73 es Val o Met; teniendo la citada proteína por lo menos una de lassiguientes sustituciones: Trp de la posicion 100 está sustituido por Glu, Asp, His, Lys o Arg, o Trp de la posicion 138 está sustituido por Glu,Asp,His, Lys o Arg; o una sal farmacéuticamente aceptable de la misma. La invencion incluye además las formulaciones farmacéuticas que incluyen dichasproteínas como agente activo para dichos tratamientos; polinucleotidos de DNA codificantes de dichas proteínas y un procedimiento para obtener las proteínasmencionadas.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3356196P | 1996-12-20 | 1996-12-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR013886A1 true AR013886A1 (es) | 2001-01-31 |
Family
ID=21871119
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970105941A AR013886A1 (es) | 1996-12-20 | 1997-12-17 | Proteinas utiles para tratar la obesidad y condiciones asociadas con la obesidad; composiciones farmaceuticas formuladas con dichas proteinas;compuestos polinucleoticos de dna que codifican dichas proteinas y procedimiento para pepararlas |
Country Status (23)
| Country | Link |
|---|---|
| EP (1) | EP0849276A1 (es) |
| JP (1) | JPH10179158A (es) |
| KR (1) | KR19980064258A (es) |
| CN (1) | CN1194986A (es) |
| AR (1) | AR013886A1 (es) |
| AU (2) | AU4843297A (es) |
| BR (1) | BR9706358A (es) |
| CA (1) | CA2217698A1 (es) |
| CO (1) | CO4700343A1 (es) |
| CZ (1) | CZ407097A3 (es) |
| HU (1) | HUP9702500A3 (es) |
| ID (1) | ID19257A (es) |
| IL (1) | IL122569A0 (es) |
| NO (1) | NO975938L (es) |
| NZ (1) | NZ329413A (es) |
| PE (1) | PE47599A1 (es) |
| PL (1) | PL323956A1 (es) |
| SG (1) | SG65040A1 (es) |
| SV (1) | SV1997000107A (es) |
| TR (1) | TR199701666A3 (es) |
| WO (1) | WO1998028335A1 (es) |
| YU (1) | YU48997A (es) |
| ZA (1) | ZA9710877B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100510614B1 (ko) | 1997-04-15 | 2005-08-30 | 씨에스아이알 | 식욕 억제 활성을 갖는 화합물의 제조를 위한 중간체 및이의 제조 방법 |
| WO1999044598A2 (en) * | 1998-03-03 | 1999-09-10 | Board Of Regents, The University Of Texas System | Methods for inhibiting βcell apoptosis |
| GB9924484D0 (en) * | 1999-10-15 | 1999-12-15 | Isis Innovation | Altered polypeptide aggregation |
| GB2396815B (en) | 1999-10-27 | 2004-09-08 | Phytopharm Plc | A composition comprising a pregnenone derivative and an NSAID |
| US7022674B2 (en) | 1999-12-16 | 2006-04-04 | Eli Lilly And Company | Polypeptide compositions with improved stability |
| GB2363985B (en) | 2000-06-30 | 2004-09-29 | Phytopharm Plc | Extracts,compounds & pharmaceutical compositions having anti-diabetic activity and their use |
| EP2030628B1 (en) | 2006-06-01 | 2012-08-15 | Yun Cheng | A peptide for preventing or treating liver damage and its derivant and the use |
| US12466883B1 (en) * | 2024-05-13 | 2025-11-11 | Lumen Bioscience, Inc. | Leptin compositions and methods of making and using the same to support weight loss and/or maintenance |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6309853B1 (en) * | 1994-08-17 | 2001-10-30 | The Rockfeller University | Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof |
| US5827734A (en) * | 1995-01-20 | 1998-10-27 | University Of Washington | Materials and methods for determining ob protein in a biological sample |
| EP0725079A1 (en) * | 1995-01-31 | 1996-08-07 | Eli Lilly And Company | Anti-obesity proteins |
| AU4862396A (en) * | 1995-02-06 | 1996-08-27 | Eli Lilly And Company | Human obesity gene |
| WO1996031526A1 (en) * | 1995-04-06 | 1996-10-10 | Amylin Pharmaceuticals, Inc. | Anti-obesity agents |
| GB9509164D0 (en) * | 1995-05-05 | 1995-06-28 | Smithkline Beecham Plc | Novel compounds |
| AU6284896A (en) * | 1995-06-22 | 1997-01-22 | Eli Lilly And Company | Obesity protein intermediates and their preparation and use |
-
1997
- 1997-12-02 CA CA002217698A patent/CA2217698A1/en not_active Abandoned
- 1997-12-03 ZA ZA9710877A patent/ZA9710877B/xx unknown
- 1997-12-11 IL IL12256997A patent/IL122569A0/xx unknown
- 1997-12-16 NZ NZ329413A patent/NZ329413A/en unknown
- 1997-12-16 CO CO97073281A patent/CO4700343A1/es unknown
- 1997-12-16 PE PE1997001122A patent/PE47599A1/es not_active Application Discontinuation
- 1997-12-16 SV SV1997000107A patent/SV1997000107A/es unknown
- 1997-12-16 BR BR9706358A patent/BR9706358A/pt not_active Application Discontinuation
- 1997-12-16 EP EP97310190A patent/EP0849276A1/en not_active Withdrawn
- 1997-12-17 NO NO975938A patent/NO975938L/no not_active Application Discontinuation
- 1997-12-17 AU AU48432/97A patent/AU4843297A/en not_active Abandoned
- 1997-12-17 KR KR1019970069938A patent/KR19980064258A/ko not_active Withdrawn
- 1997-12-17 CZ CZ974070A patent/CZ407097A3/cs unknown
- 1997-12-17 AR ARP970105941A patent/AR013886A1/es unknown
- 1997-12-18 AU AU53846/98A patent/AU5384698A/en not_active Abandoned
- 1997-12-18 HU HU9702500A patent/HUP9702500A3/hu unknown
- 1997-12-18 WO PCT/US1997/023344 patent/WO1998028335A1/en not_active Ceased
- 1997-12-18 PL PL97323956A patent/PL323956A1/xx unknown
- 1997-12-18 YU YU48997A patent/YU48997A/sh unknown
- 1997-12-18 ID IDP973915A patent/ID19257A/id unknown
- 1997-12-18 SG SG1997004559A patent/SG65040A1/en unknown
- 1997-12-18 JP JP9349102A patent/JPH10179158A/ja not_active Withdrawn
- 1997-12-18 CN CN97129705A patent/CN1194986A/zh active Pending
- 1997-12-19 TR TR97/01666A patent/TR199701666A3/tr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2217698A1 (en) | 1998-06-20 |
| SV1997000107A (es) | 1999-01-18 |
| ZA9710877B (en) | 1999-06-03 |
| WO1998028335A1 (en) | 1998-07-02 |
| AU4843297A (en) | 1998-06-25 |
| PL323956A1 (en) | 1998-06-22 |
| NO975938D0 (no) | 1997-12-17 |
| ID19257A (id) | 1998-06-28 |
| NZ329413A (en) | 1999-10-28 |
| CN1194986A (zh) | 1998-10-07 |
| SG65040A1 (en) | 1999-05-25 |
| CO4700343A1 (es) | 1998-12-29 |
| TR199701666A2 (xx) | 1999-10-21 |
| KR19980064258A (ko) | 1998-10-07 |
| PE47599A1 (es) | 1999-05-14 |
| JPH10179158A (ja) | 1998-07-07 |
| HUP9702500A2 (hu) | 1998-07-28 |
| NO975938L (no) | 1998-06-22 |
| YU48997A (sh) | 1999-09-27 |
| HU9702500D0 (en) | 1998-03-02 |
| IL122569A0 (en) | 1998-06-15 |
| HUP9702500A3 (en) | 1999-07-28 |
| EP0849276A1 (en) | 1998-06-24 |
| TR199701666A3 (tr) | 1999-10-21 |
| BR9706358A (pt) | 1999-05-04 |
| AU5384698A (en) | 1998-07-17 |
| CZ407097A3 (cs) | 1998-07-15 |
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