AR012437A1 - 4-AMINOPYRID [2,3-D] PIRIMIDINE 5, 6, 7-TRISUSTITUED COMPOUNDS, THE USE OF THEM FOR THE MANUFACTURE OF A MEDICINAL PRODUCT, PROCEDURE FOR SUPREPARATION, PHARMACEUTICAL COMPOSITION FOR THEM, PREPARATION AND PROCEDURE - Google Patents
4-AMINOPYRID [2,3-D] PIRIMIDINE 5, 6, 7-TRISUSTITUED COMPOUNDS, THE USE OF THEM FOR THE MANUFACTURE OF A MEDICINAL PRODUCT, PROCEDURE FOR SUPREPARATION, PHARMACEUTICAL COMPOSITION FOR THEM, PREPARATION AND PROCEDUREInfo
- Publication number
- AR012437A1 AR012437A1 ARP980101734A ARP980101734A AR012437A1 AR 012437 A1 AR012437 A1 AR 012437A1 AR P980101734 A ARP980101734 A AR P980101734A AR P980101734 A ARP980101734 A AR P980101734A AR 012437 A1 AR012437 A1 AR 012437A1
- Authority
- AR
- Argentina
- Prior art keywords
- procedure
- manufacture
- preparation
- compounds
- pharmaceutical composition
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 229940126601 medicinal product Drugs 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- -1 4-aminopyrido [2,3D] pyrimidine compound Chemical class 0.000 abstract 1
- OOXNYFKPOPJIOT-UHFFFAOYSA-N 5-(3-bromophenyl)-7-(6-morpholin-4-ylpyridin-3-yl)pyrido[2,3-d]pyrimidin-4-amine;dihydrochloride Chemical compound Cl.Cl.C=12C(N)=NC=NC2=NC(C=2C=NC(=CC=2)N2CCOCC2)=CC=1C1=CC=CC(Br)=C1 OOXNYFKPOPJIOT-UHFFFAOYSA-N 0.000 abstract 1
- 108010076278 Adenosine kinase Proteins 0.000 abstract 1
- 102100032534 Adenosine kinase Human genes 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 206010040047 Sepsis Diseases 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 210000004556 brain Anatomy 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 206010015037 epilepsy Diseases 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 208000028867 ischemia Diseases 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Transplantation (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Un compuesto de 4-aminopirido [2,3D]pirimidina 5,6,7-trisustituido o una sal o amida farmacéuticamente aceptable del mismo que tiene la formula (I),donde R1 y R2 son independienteente H, alquilo inferior, arilalquilo o acilo, pueden tomarseconj untamente con el átomo de nitrogeno al cual está unidos paraformar un anillo de 5 a 7 miembros que contiene opcionalmente 1,3 heteroátomos adicionales seleccionados de N, O o S; R3, R4 y R5 están independientementeseleccionados de alquiloinferior, alquenilo inferior, alquinilo inferior, cicloalquilo inferior, arilo, arilalquilo, heteroarilo o un grupo heterocíclicoindica que está presente opcionalmente un doble enlace; el uso de los mismos para la manufactura de unmedicamento util par a inhibir adenosina quinasa, unacomposicion farmacéutica que comprende una cantidad terapéuticamente eficaz de dichos compuestos en combinacion con un portador farmacéuticamente aceptable,eluso de los mismos para lamanufactura de un medicamento ut il para tratar isquemia cerebral, epilepsia, dolor, nocipercepcion, inflamacion y sepsis en unmamífero que necesita dicho tratamiento, procedimiento para su preparacion , compuestos intermediarios yprocedimiento para su preparacion,A 5,6,7-trisubstituted 4-aminopyrido [2,3D] pyrimidine compound or a pharmaceutically acceptable salt or amide thereof having formula (I), wherein R1 and R2 are independently H, lower alkyl, arylalkyl or acyl , can be taken in conjunction with the nitrogen atom to which they are attached to form a 5-7 membered ring optionally containing 1.3 additional heteroatoms selected from N, O, or S; R3, R4 and R5 are independently selected from lower alkyl, lower alkenyl, lower alkynyl, lower cycloalkyl, aryl, arylalkyl, heteroaryl or a heterocyclic group indicating that a double bond is optionally present; the use of the same for the manufacture of a useful medicine to inhibit adenosine kinase, a pharmaceutical composition comprising a therapeutically effective amount of said compounds in combination with a pharmaceutically acceptable carrier, the use of the same for the manufacture of a useful medicine to treat ischemia brain, epilepsy, pain, nociperception, inflammation and sepsis in a mammal that needs such treatment, procedure for its preparation, intermediate compounds and procedure for its preparation,
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84348497A | 1997-04-16 | 1997-04-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR012437A1 true AR012437A1 (en) | 2000-10-18 |
Family
ID=25290123
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980101734A AR012437A1 (en) | 1997-04-16 | 1998-04-15 | 4-AMINOPYRID [2,3-D] PIRIMIDINE 5, 6, 7-TRISUSTITUED COMPOUNDS, THE USE OF THEM FOR THE MANUFACTURE OF A MEDICINAL PRODUCT, PROCEDURE FOR SUPREPARATION, PHARMACEUTICAL COMPOSITION FOR THEM, PREPARATION AND PROCEDURE |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP0975633A1 (en) |
| JP (1) | JP2001520654A (en) |
| KR (1) | KR20010006462A (en) |
| CN (1) | CN1252069A (en) |
| AR (1) | AR012437A1 (en) |
| AU (1) | AU741033B2 (en) |
| BG (1) | BG103853A (en) |
| BR (1) | BR9809056A (en) |
| CA (1) | CA2286592A1 (en) |
| CO (1) | CO4940470A1 (en) |
| HU (1) | HUP0001443A3 (en) |
| IL (1) | IL131617A0 (en) |
| NO (1) | NO995035L (en) |
| NZ (1) | NZ337125A (en) |
| PL (1) | PL336265A1 (en) |
| SK (1) | SK140099A3 (en) |
| TR (1) | TR199902550T2 (en) |
| WO (1) | WO1998046604A1 (en) |
| ZA (1) | ZA983175B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001057040A1 (en) * | 2000-02-03 | 2001-08-09 | Abbott Laboratories | 6,7-disubstituted-4-aminopyrido[2,3-d]pyrimidine compounds |
| CN100376571C (en) | 2001-02-12 | 2008-03-26 | 霍夫曼-拉罗奇有限公司 | 6-substituted pyridopyrimidines |
| CN107744520A (en) * | 2017-10-25 | 2018-03-02 | 南京多宝生物科技有限公司 | Pyrimidines are preparing the application in promoting small bowel peristalsis medicine |
| CN112209924B (en) * | 2019-07-09 | 2022-04-05 | 中国科学院天津工业生物技术研究所 | selective adenosine A1 receptor antagonists |
| EP4343709B1 (en) * | 2022-09-23 | 2024-10-30 | Axis AB | Method and image-processing device for determining a probability value indicating that an object captured in a stream of image frames belongs to an object type |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB774094A (en) * | 1953-01-02 | 1957-05-08 | Wellcome Found | Improvements in or relating to pyrimidine compounds |
| IL112249A (en) * | 1994-01-25 | 2001-11-25 | Warner Lambert Co | Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds |
-
1998
- 1998-04-13 JP JP54408398A patent/JP2001520654A/en active Pending
- 1998-04-13 SK SK1400-99A patent/SK140099A3/en unknown
- 1998-04-13 WO PCT/US1998/007201 patent/WO1998046604A1/en not_active Ceased
- 1998-04-13 KR KR1019997009552A patent/KR20010006462A/en not_active Withdrawn
- 1998-04-13 NZ NZ337125A patent/NZ337125A/en unknown
- 1998-04-13 PL PL98336265A patent/PL336265A1/en unknown
- 1998-04-13 CA CA002286592A patent/CA2286592A1/en not_active Abandoned
- 1998-04-13 AU AU71080/98A patent/AU741033B2/en not_active Ceased
- 1998-04-13 EP EP98918091A patent/EP0975633A1/en not_active Withdrawn
- 1998-04-13 HU HU0001443A patent/HUP0001443A3/en unknown
- 1998-04-13 IL IL13161798A patent/IL131617A0/en unknown
- 1998-04-13 BR BR9809056-9A patent/BR9809056A/en not_active IP Right Cessation
- 1998-04-13 TR TR1999/02550T patent/TR199902550T2/en unknown
- 1998-04-13 CN CN98804117A patent/CN1252069A/en active Pending
- 1998-04-15 ZA ZA983175A patent/ZA983175B/en unknown
- 1998-04-15 AR ARP980101734A patent/AR012437A1/en unknown
- 1998-04-16 CO CO98020978A patent/CO4940470A1/en unknown
-
1999
- 1999-10-15 NO NO995035A patent/NO995035L/en not_active Application Discontinuation
- 1999-11-03 BG BG103853A patent/BG103853A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CO4940470A1 (en) | 2000-07-24 |
| EP0975633A1 (en) | 2000-02-02 |
| TR199902550T2 (en) | 2000-04-21 |
| KR20010006462A (en) | 2001-01-26 |
| NO995035D0 (en) | 1999-10-15 |
| WO1998046604A1 (en) | 1998-10-22 |
| ZA983175B (en) | 1998-10-21 |
| AU741033B2 (en) | 2001-11-22 |
| PL336265A1 (en) | 2000-06-19 |
| NZ337125A (en) | 2001-06-29 |
| BR9809056A (en) | 2000-08-01 |
| BG103853A (en) | 2000-06-30 |
| AU7108098A (en) | 1998-11-11 |
| NO995035L (en) | 1999-12-15 |
| HUP0001443A2 (en) | 2000-10-28 |
| HUP0001443A3 (en) | 2001-01-29 |
| SK140099A3 (en) | 2000-05-16 |
| JP2001520654A (en) | 2001-10-30 |
| CN1252069A (en) | 2000-05-03 |
| CA2286592A1 (en) | 1998-10-22 |
| IL131617A0 (en) | 2001-01-28 |
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