AR011501A1 - Una secuencia de nucleotidos aislada que codifica la 17 beta- hidroxiesteroide dehidrogenasa de tipo 5; vector de expresion recombinante;celula huesped recombinante; secuencia de oligonucleotidos; un fragmento de adn cromosomico; metodo para producir la 17 beta-hsd de tipo 5; metodo para i - Google Patents
Una secuencia de nucleotidos aislada que codifica la 17 beta- hidroxiesteroide dehidrogenasa de tipo 5; vector de expresion recombinante;celula huesped recombinante; secuencia de oligonucleotidos; un fragmento de adn cromosomico; metodo para producir la 17 beta-hsd de tipo 5; metodo para iInfo
- Publication number
- AR011501A1 AR011501A1 ARP960104447A AR10444796A AR011501A1 AR 011501 A1 AR011501 A1 AR 011501A1 AR P960104447 A ARP960104447 A AR P960104447A AR 10444796 A AR10444796 A AR 10444796A AR 011501 A1 AR011501 A1 AR 011501A1
- Authority
- AR
- Argentina
- Prior art keywords
- beta
- recombinant
- type
- nucleotide sequence
- isolated nucleotide
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 101710088194 Dehydrogenase Proteins 0.000 title abstract 2
- 239000002773 nucleotide Substances 0.000 title abstract 2
- 108091034117 Oligonucleotide Proteins 0.000 title 1
- 239000013604 expression vector Substances 0.000 title 1
- 239000012634 fragment Substances 0.000 title 1
- 238000003259 recombinant expression Methods 0.000 title 1
- 102000004190 Enzymes Human genes 0.000 abstract 4
- 108090000790 Enzymes Proteins 0.000 abstract 4
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 abstract 2
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 102000004602 Aldo-Keto Reductase Family 1 Member C3 Human genes 0.000 abstract 1
- 108091026890 Coding region Proteins 0.000 abstract 1
- 108010065942 Prostaglandin-F synthase Proteins 0.000 abstract 1
- AEMFNILZOJDQLW-QAGGRKNESA-N androst-4-ene-3,17-dione Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 AEMFNILZOJDQLW-QAGGRKNESA-N 0.000 abstract 1
- AEMFNILZOJDQLW-UHFFFAOYSA-N androstenedione Natural products O=C1CCC2(C)C3CCC(C)(C(CC4)=O)C4C3CCC2=C1 AEMFNILZOJDQLW-UHFFFAOYSA-N 0.000 abstract 1
- 230000000295 complement effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 229960003387 progesterone Drugs 0.000 abstract 1
- 239000000186 progesterone Substances 0.000 abstract 1
- 239000013589 supplement Substances 0.000 abstract 1
- 229960003604 testosterone Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Se provee un tipo novedoso de 17 beta-hidroxiesteroide dehidrogenasa del tipo 5. Una secuencia de nucleotidos aislada que codifica la 17 beta-eroide dehidrogenasa del tipo 5, siendo dicha secuencia suficientemente homologa con la SEC ID Ns 1 o uncomplemento de la misma, como para hibridizar bajocondiciones restrictivas a la region de codificacion de la SEQ ID Ns 1, o un complemento de la misma, codificando dicha secuencia una enzima que cataliza laconversion de progesterona a20a-hidroxip rogesterona y la conversion de 4- androstenediona a testosterona. Se describen métodos para la produccion de laenzima y para utilizar a la enzima con el objeto de identificar compuestos potenciales que inhiban o alteren laactividad de las enzimas.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/532,896 US6124115A (en) | 1995-09-22 | 1995-09-22 | Production and use of isolated type 5 17β-hydroxysteroid dehydrogenase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR011501A1 true AR011501A1 (es) | 2000-08-30 |
Family
ID=24123646
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP960104447A AR011501A1 (es) | 1995-09-22 | 1996-09-20 | Una secuencia de nucleotidos aislada que codifica la 17 beta- hidroxiesteroide dehidrogenasa de tipo 5; vector de expresion recombinante;celula huesped recombinante; secuencia de oligonucleotidos; un fragmento de adn cromosomico; metodo para producir la 17 beta-hsd de tipo 5; metodo para i |
| ARP990100696A AR018099A1 (es) | 1995-09-22 | 1999-02-23 | Metodo de bloqueo de sintesis de la 17beta-hidroxiesteroide dehidrogenasa del tipo 5 y metodo para interferir su expresion |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990100696A AR018099A1 (es) | 1995-09-22 | 1999-02-23 | Metodo de bloqueo de sintesis de la 17beta-hidroxiesteroide dehidrogenasa del tipo 5 y metodo para interferir su expresion |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6124115A (es) |
| EP (1) | EP0856048A1 (es) |
| JP (1) | JPH11511329A (es) |
| AR (2) | AR011501A1 (es) |
| AU (1) | AU6867896A (es) |
| CA (1) | CA2232500A1 (es) |
| IL (1) | IL119200A0 (es) |
| NZ (1) | NZ316441A (es) |
| WO (1) | WO1997011162A1 (es) |
| ZA (1) | ZA967920B (es) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2323089A1 (en) * | 1998-03-11 | 1999-09-16 | Endorecherche, Inc. | Inhibitors of type 5 and type 3 17.beta.-hydroxysteroid dehydrogenase and methods for their use |
| MXPA01007366A (es) * | 1999-01-21 | 2002-06-04 | Metamorphix Inc | Inhibidores de factores de crecimiento y diferenciacion y usos de los mismos. |
| FR2798386B1 (fr) * | 1999-09-10 | 2003-04-25 | Didier Raoult | Oligonucleotides monocatenaires, sondes, amorces et procede de detection des spirochetes |
| CN1303927A (zh) * | 1999-10-22 | 2001-07-18 | 上海博容基因开发有限公司 | 一种新的多肽——类固醇脱氢酶34和编码这种多肽的多核苷酸 |
| US7033790B2 (en) | 2001-04-03 | 2006-04-25 | Curagen Corporation | Proteins and nucleic acids encoding same |
| WO2002089802A2 (en) | 2001-05-08 | 2002-11-14 | Schering Corporation | Use of neurokinin receptor antagonists to treat androgen-dependent diseases |
| AR036492A1 (es) | 2001-09-06 | 2004-09-15 | Schering Corp | Inhibidores de la 17beta-hidroxiesteroide deshidrogenasa tipo 3, composiciones farmaceuticas y el uso de dichos inhibidores para la elaboracion de un medicamento para el tratamiento de enfermedades androgeno dependientes |
| ES2347643T3 (es) | 2001-10-17 | 2010-11-03 | Schering Corporation | Piperin- y piperazinacetamidas como inhibidores de 17beta hidroxiesteroide deshidrogenasa tipo 3 para el tratamiento de enfermedades dependientes de androgenos. |
| DE60225845D1 (de) * | 2001-12-17 | 2008-05-08 | Metabolex Inc | Zusammensetzungen und verfahren zur diagnose und behandlung von diabetes, insulinresistenz und dyslipidämie |
| JP4614770B2 (ja) | 2002-11-18 | 2011-01-19 | シェーリング コーポレイション | アンドロゲン依存性疾患を処置するための１７β−ヒドロキシステロイドデヒドロゲナーゼタイプ３インヒビター |
| AU2003293555A1 (en) | 2002-12-17 | 2004-07-29 | Schering Corporation | 17 beta-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases |
| US8088758B2 (en) * | 2003-11-12 | 2012-01-03 | Abbott Products Gmbh | 17β-hydroxysteroid dehydrogenase type I inhibitors |
| KR20130124576A (ko) | 2004-01-07 | 2013-11-14 | 앙도르쉐르슈 인코포레이티드 | 헬릭스 12 배향형 스테로이드계 약학 제품 |
| US20060073099A1 (en) * | 2004-10-01 | 2006-04-06 | Frincke James M | Treatment screening methods |
| GB0513702D0 (en) | 2005-07-04 | 2005-08-10 | Sterix Ltd | Compound |
| US8299043B2 (en) | 2006-04-28 | 2012-10-30 | Mayo Foundation For Medical Education And Research | Treating glaucoma, cardiovascular diseases, and renal diseases |
| GB0722779D0 (en) | 2007-11-20 | 2008-01-02 | Sterix Ltd | Compound |
| CN111454919B (zh) * | 2020-03-31 | 2022-08-26 | 天津大学 | 17β-羟基类固醇羟化酶3突变酶及编码基因及工程菌 |
-
1995
- 1995-09-22 US US08/532,896 patent/US6124115A/en not_active Expired - Fee Related
-
1996
- 1996-09-04 IL IL11920096A patent/IL119200A0/xx unknown
- 1996-09-12 AU AU68678/96A patent/AU6867896A/en not_active Abandoned
- 1996-09-12 WO PCT/CA1996/000605 patent/WO1997011162A1/en not_active Ceased
- 1996-09-12 EP EP96929153A patent/EP0856048A1/en not_active Withdrawn
- 1996-09-12 CA CA002232500A patent/CA2232500A1/en not_active Abandoned
- 1996-09-12 JP JP9512257A patent/JPH11511329A/ja active Pending
- 1996-09-12 NZ NZ316441A patent/NZ316441A/en unknown
- 1996-09-19 ZA ZA9607920A patent/ZA967920B/xx unknown
- 1996-09-20 AR ARP960104447A patent/AR011501A1/es not_active Application Discontinuation
-
1999
- 1999-02-23 AR ARP990100696A patent/AR018099A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NZ316441A (en) | 2000-02-28 |
| JPH11511329A (ja) | 1999-10-05 |
| US6124115A (en) | 2000-09-26 |
| AU6867896A (en) | 1997-04-09 |
| EP0856048A1 (en) | 1998-08-05 |
| AR018099A1 (es) | 2001-10-31 |
| CA2232500A1 (en) | 1997-03-27 |
| IL119200A0 (en) | 1996-12-05 |
| ZA967920B (en) | 1998-03-19 |
| WO1997011162A1 (en) | 1997-03-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |