AR011138A1 - COMPOUNDS DERIVED FROM 4-AMINOALCOXI-1,3-DIHIDROBENZOMIDAZOLE-2-ONAS, PHARMACEUTICAL COMPOSITION THAT UNDERSTANDS THEM AND USE THEM FOR THE MANUFACTURE OF A USEFUL MEDICINAL PRODUCT, DOPAMINE SELF-RECEPTOR AGONISTS. - Google Patents
COMPOUNDS DERIVED FROM 4-AMINOALCOXI-1,3-DIHIDROBENZOMIDAZOLE-2-ONAS, PHARMACEUTICAL COMPOSITION THAT UNDERSTANDS THEM AND USE THEM FOR THE MANUFACTURE OF A USEFUL MEDICINAL PRODUCT, DOPAMINE SELF-RECEPTOR AGONISTS.Info
- Publication number
- AR011138A1 AR011138A1 ARP980100620A ARP980100620A AR011138A1 AR 011138 A1 AR011138 A1 AR 011138A1 AR P980100620 A ARP980100620 A AR P980100620A AR P980100620 A ARP980100620 A AR P980100620A AR 011138 A1 AR011138 A1 AR 011138A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- manufacture
- pharmaceutical composition
- hydrogen
- dihidrobenzomidazole
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/26—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Addiction (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Un compuesto derivado de 4-aminoalcoxi-1,3-dihidrobenzoimidazol-2-onas que tiene la formula (I), en la cual R1 es hidrogeno o alquilo C1-C6; R2 esseleccionada entre hidrogeno, alquilo C1-C10 de cadena recta y ramificada, ciclohexilmetilo o-(CH2)mAr, donde Ar es fenilo, naftilo, tienilo, furaniloo piridinilo, cada uno de ellos optativamente sustituido por uno o dos sustituyentes seleccionados independientemente entre alquilo C1-C6, halogeno,alcoxi C1-C6, y trifluorometilo; oN R1R2 es 1,2,3,4-tetrahidroquinolin-1-ilo o 1,2,3,4-tetrahidroisoquinolin-1-ilo; m es 1 - 5; n es 1 o 2; R3 es hidrogenoo alquilo C1-C6; Y es hidrogeno, halogeno, alquilo C1-C6; y alcoxi C1-C6, o una sal farmacéuticamente aceptable del mismo.Estos compuestos son agentesdopaminérgicos D2 utiles en el tratamiento de esquizofrenia, enfermedad de Parkinson, síndrome de Tourette, y adicion de drogas o alcohol. Ademés sedescribe una composicion farmacéutica y el uso de dichos compuestospara la manufactura de un medicamento.A compound derived from 4-aminoalkoxy-1,3-dihydrobenzoimidazol-2-ones having formula (I), in which R1 is hydrogen or C1-C6 alkyl; R2 is selected from hydrogen, branched and straight-chain C1-C10 alkyl, cyclohexylmethyl or- (CH2) mAr, where Ar is phenyl, naphthyl, thienyl, furanyl or pyridinyl, each optionally substituted by one or two substituents independently selected from alkyl C1-C6, halogen, C1-C6 alkoxy, and trifluoromethyl; ON R1R2 is 1,2,3,4-tetrahydroquinolin-1-yl or 1,2,3,4-tetrahydroisoquinolin-1-yl; m is 1-5; n is 1 or 2; R3 is hydrogen or C1-C6 alkyl; Y is hydrogen, halogen, C1-C6 alkyl; and C1-C6 alkoxy, or a pharmaceutically acceptable salt thereof. These compounds are D2 dopaminergic agents useful in the treatment of schizophrenia, Parkinson's disease, Tourette's syndrome, and drug or alcohol addition. In addition, a pharmaceutical composition and the use of such compounds for the manufacture of a drug are described.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US80187097A | 1997-02-18 | 1997-02-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR011138A1 true AR011138A1 (en) | 2000-08-02 |
Family
ID=25182225
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980100620A AR011138A1 (en) | 1997-02-18 | 1998-02-11 | COMPOUNDS DERIVED FROM 4-AMINOALCOXI-1,3-DIHIDROBENZOMIDAZOLE-2-ONAS, PHARMACEUTICAL COMPOSITION THAT UNDERSTANDS THEM AND USE THEM FOR THE MANUFACTURE OF A USEFUL MEDICINAL PRODUCT, DOPAMINE SELF-RECEPTOR AGONISTS. |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0964853A1 (en) |
| JP (1) | JP2001511804A (en) |
| KR (1) | KR20000071160A (en) |
| CN (1) | CN1138761C (en) |
| AR (1) | AR011138A1 (en) |
| AU (1) | AU744443B2 (en) |
| BR (1) | BR9807703A (en) |
| CA (1) | CA2278747A1 (en) |
| HU (1) | HUP0001262A3 (en) |
| IL (1) | IL131156A0 (en) |
| NZ (1) | NZ337271A (en) |
| TW (1) | TW383303B (en) |
| WO (1) | WO1998035946A1 (en) |
| ZA (1) | ZA981310B (en) |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE914003A1 (en) * | 1990-11-20 | 1992-05-20 | Astra Pharma Prod | Biologically Active Amines |
| GB9210632D0 (en) * | 1992-05-19 | 1992-07-01 | Fisons Plc | Compounds |
| DE69524528T2 (en) * | 1994-10-14 | 2002-08-01 | Merck Patent Gmbh | CNS active (R) - (-) - 2- [5- (4-fluorophenyl) -3-pyridylmethylaminomethyl] chroman |
| IL119483A (en) * | 1995-11-06 | 1999-06-20 | American Home Prod | 2-(Aminomethyl)-3,4,7,9- tetrahydro- 2H-pyrano-2[3,3-e]indol-8-ones their derivatives and pharmaceutical compositions containing them |
| EP0923576B1 (en) * | 1996-08-27 | 2002-11-06 | Wyeth | 4-aminoethoxy-indolone derivatives as dopamine d2 agonists |
| WO1998008819A1 (en) * | 1996-08-27 | 1998-03-05 | American Home Products Corporation | 4-aminoethoxy indolone derivatives |
-
1998
- 1998-01-13 IL IL13115698A patent/IL131156A0/en unknown
- 1998-01-13 AU AU60234/98A patent/AU744443B2/en not_active Ceased
- 1998-01-13 BR BR9807703-1A patent/BR9807703A/en not_active IP Right Cessation
- 1998-01-13 NZ NZ337271A patent/NZ337271A/en unknown
- 1998-01-13 JP JP53572998A patent/JP2001511804A/en active Pending
- 1998-01-13 CN CNB988041197A patent/CN1138761C/en not_active Expired - Fee Related
- 1998-01-13 EP EP98903469A patent/EP0964853A1/en not_active Withdrawn
- 1998-01-13 WO PCT/US1998/000623 patent/WO1998035946A1/en not_active Ceased
- 1998-01-13 KR KR1019997007450A patent/KR20000071160A/en not_active Withdrawn
- 1998-01-13 HU HU0001262A patent/HUP0001262A3/en unknown
- 1998-01-13 CA CA002278747A patent/CA2278747A1/en not_active Abandoned
- 1998-02-05 TW TW087101495A patent/TW383303B/en not_active IP Right Cessation
- 1998-02-11 AR ARP980100620A patent/AR011138A1/en not_active Application Discontinuation
- 1998-02-17 ZA ZA9801310A patent/ZA981310B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL131156A0 (en) | 2001-01-28 |
| HUP0001262A3 (en) | 2002-04-29 |
| AU6023498A (en) | 1998-09-08 |
| TW383303B (en) | 2000-03-01 |
| AU744443B2 (en) | 2002-02-21 |
| HUP0001262A2 (en) | 2001-04-28 |
| EP0964853A1 (en) | 1999-12-22 |
| WO1998035946A1 (en) | 1998-08-20 |
| ZA981310B (en) | 1999-08-17 |
| NZ337271A (en) | 2001-01-26 |
| JP2001511804A (en) | 2001-08-14 |
| CA2278747A1 (en) | 1998-08-20 |
| CN1138761C (en) | 2004-02-18 |
| KR20000071160A (en) | 2000-11-25 |
| CN1252060A (en) | 2000-05-03 |
| BR9807703A (en) | 2000-05-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |