AR011137A1 - DERIVATIVES OF 4-AMINOETOXIINDAZOL, ITS USE FOR THE PREPARATION OF A MEDICINAL PRODUCT AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM - Google Patents
DERIVATIVES OF 4-AMINOETOXIINDAZOL, ITS USE FOR THE PREPARATION OF A MEDICINAL PRODUCT AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEMInfo
- Publication number
- AR011137A1 AR011137A1 ARP980100619A ARP980100619A AR011137A1 AR 011137 A1 AR011137 A1 AR 011137A1 AR P980100619 A ARP980100619 A AR P980100619A AR P980100619 A ARP980100619 A AR P980100619A AR 011137 A1 AR011137 A1 AR 011137A1
- Authority
- AR
- Argentina
- Prior art keywords
- derivatives
- preparation
- aminoetoxiindazol
- contain
- pharmaceutical compositions
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 229940126601 medicinal product Drugs 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- UWFNMXYMTWTJAO-UHFFFAOYSA-N 2-(1h-indazol-4-yloxy)ethanamine Chemical class NCCOC1=CC=CC2=C1C=NN2 UWFNMXYMTWTJAO-UHFFFAOYSA-N 0.000 abstract 1
- -1 4-aminoethoxyindazole derivative compound Chemical class 0.000 abstract 1
- 208000007848 Alcoholism Diseases 0.000 abstract 1
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical group O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 208000000323 Tourette Syndrome Diseases 0.000 abstract 1
- 208000016620 Tourette disease Diseases 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229960003638 dopamine Drugs 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 206010013663 drug dependence Diseases 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
- 208000011117 substance-related disease Diseases 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Se relaciona con derivados de 4-aminoetoxiindazoles de la formula (I) en la cual: Y es hidrogeno, halogeno, o alcoxi C1-C6; R1 es hidrogeno o alquiloC1-C6; X es metileno, oxígeno o carbonilo; Ar es fenilo o tienilo, cada uno optativamente sustituido con 1- 2 grupos independientemente seleccionados entrealcoxi C1-C6; alquilo C1-C6, halogeno, trifluorometilo y fenilo; n = 1 - 4, o una sal farmacéuticamente aceptable del mismo. Estos compuestos son agonistasde la dopamina D2 utiles en el tratamiento de la esquizofrenia, el síndrome de Tourette, la adiccion a las drogas y al alcohol, y también sirven para eltratamiento de la enfermedad de Parkinson. También se describe el uso de un compuesto derivado de 4-aminoetoxiindazol de la reivindicacion 1 para lapreparacion de un medicamento y una composicion farmacéutica.It is related to 4-aminoethoxyindazole derivatives of formula (I) in which: Y is hydrogen, halogen, or C1-C6 alkoxy; R1 is hydrogen or C1-C6 alkyl; X is methylene, oxygen, or carbonyl; Ar is phenyl or thienyl, each optionally substituted with 1-2 groups independently selected from C1-C6alkoxy; C1-C6 alkyl, halogen, trifluoromethyl and phenyl; n = 1-4, or a pharmaceutically acceptable salt thereof. These compounds are dopamine D2 agonists useful in the treatment of schizophrenia, Tourette's syndrome, drug and alcohol addiction, and also serve for the treatment of Parkinson's disease. The use of a 4-aminoethoxyindazole derivative compound of claim 1 for the preparation of a medicament and a pharmaceutical composition is also described.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US80132597A | 1997-02-18 | 1997-02-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR011137A1 true AR011137A1 (en) | 2000-08-02 |
Family
ID=25180801
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980100619A AR011137A1 (en) | 1997-02-18 | 1998-02-11 | DERIVATIVES OF 4-AMINOETOXIINDAZOL, ITS USE FOR THE PREPARATION OF A MEDICINAL PRODUCT AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP0960101A1 (en) |
| JP (1) | JP2001512458A (en) |
| KR (1) | KR20000071125A (en) |
| CN (1) | CN1248246A (en) |
| AR (1) | AR011137A1 (en) |
| AU (2) | AU6246198A (en) |
| BR (1) | BR9807397A (en) |
| CA (1) | CA2278746A1 (en) |
| IL (1) | IL131159A0 (en) |
| WO (2) | WO1998035942A1 (en) |
| ZA (1) | ZA981307B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0511533A (en) * | 2004-05-26 | 2008-01-02 | Pfizer | indazole and indolone derivatives and their use as medicines |
| JP6701214B2 (en) | 2014-11-03 | 2020-05-27 | イオメット ファーマ リミテッド | Pharmaceutical compound |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9305623D0 (en) * | 1993-03-18 | 1993-05-05 | Merck Sharp & Dohme | Therapeutic agents |
| GB9305641D0 (en) * | 1993-03-18 | 1993-05-05 | Merck Sharp & Dohme | Therapeutic agents |
-
1998
- 1998-01-13 AU AU62461/98A patent/AU6246198A/en not_active Abandoned
- 1998-01-13 WO PCT/US1998/001167 patent/WO1998035942A1/en not_active Ceased
- 1998-02-11 AR ARP980100619A patent/AR011137A1/en unknown
- 1998-02-13 WO PCT/US1998/002413 patent/WO1998035943A1/en not_active Ceased
- 1998-02-13 CN CN98802635A patent/CN1248246A/en active Pending
- 1998-02-13 KR KR1019997007413A patent/KR20000071125A/en not_active Withdrawn
- 1998-02-13 CA CA002278746A patent/CA2278746A1/en not_active Abandoned
- 1998-02-13 BR BR9807397-4A patent/BR9807397A/en not_active Application Discontinuation
- 1998-02-13 AU AU62733/98A patent/AU6273398A/en not_active Abandoned
- 1998-02-13 JP JP53584198A patent/JP2001512458A/en active Pending
- 1998-02-13 IL IL13115998A patent/IL131159A0/en unknown
- 1998-02-13 EP EP98905000A patent/EP0960101A1/en not_active Withdrawn
- 1998-02-17 ZA ZA9801307A patent/ZA981307B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO1998035942A1 (en) | 1998-08-20 |
| AU6273398A (en) | 1998-09-08 |
| WO1998035943A1 (en) | 1998-08-20 |
| AU6246198A (en) | 1998-09-08 |
| IL131159A0 (en) | 2001-01-28 |
| CA2278746A1 (en) | 1998-08-20 |
| KR20000071125A (en) | 2000-11-25 |
| CN1248246A (en) | 2000-03-22 |
| ZA981307B (en) | 1999-08-17 |
| JP2001512458A (en) | 2001-08-21 |
| BR9807397A (en) | 2000-03-14 |
| EP0960101A1 (en) | 1999-12-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR037517A1 (en) | DERIVATIVES OF NAFTIRIDINES, A PROCESS FOR THE PREPARATION, PHARMACEUTICAL COMPOSITION AND THE USE OF THEM FOR THE PREPARATION OF A MEDICINAL PRODUCT FOR THE TREATMENT OF AN INFLAMMATORY DISEASE | |
| AR012593A1 (en) | SUBSTITUTED PYRROLYPYRIDINES, PHARMACEUTICAL COMPOSITION CONTAINING THEM, PROCEDURE FOR THE PREPARATION AND USE OF THE SAME IN THE MANUFACTURE OF A MEDICINAL PRODUCT | |
| UY27978A1 (en) | NEW OXAZOL AND TIAZOL COMPOUNDS AS INHIBITORS OF THE TRANSFORMING GROWTH FACTOR (TGF) | |
| DK2314582T3 (en) | Heterocyclic compounds as antiviral agents | |
| AR035863A1 (en) | LELAND RECEPTORS OF MELANOCORTINA | |
| PA8495101A1 (en) | DERIVATIVES OF 13-METHYLERITROMYCIN | |
| SE9904508D0 (en) | New compounds | |
| AR015768A1 (en) | PIRIDINE IMIDAZE DERIVATIVES THAT INHIBIT THE GASTRIC ACID SECRETION, PHARMACEUTICAL COMPOSITION, PROCEDURES FOR THEIR PREPARATION, PHARMACEUTICAL FORMULATION, USE OF SUCH DERIVATIVES TO PREPARE MEDICINES AND INTERMEDIATE COMPARTMENTS IN PREMISES | |
| AR029383A1 (en) | SMALL MOLECULES, THE INTERMEDIARIES FOR THEIR SYNTHESIS, THE PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THEIR USE TO PREPARE A MEDICINAL PRODUCT INTENDED FOR TREATMENT OR PROPHYLAXIS OF INFLAMMATORY DISEASES OR MEDIATIONED BY IMMUNE CELLS | |
| AR024060A1 (en) | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | |
| DOP2001000170A (en) | USEFUL THIOPHEN DERIVATIVES AS ANTI-CHANCE AGENTS | |
| AR039190A1 (en) | BENZOFURAN DERIVATIVES, PHARMACEUTICAL COMPOSITION AND MEDICINAL PRODUCT UNDERSTANDING THE COMPOUND | |
| NO20040589L (en) | Arylsulfonyl derivatives with 5-HT6 receptor affinity. | |
| UY29085A1 (en) | PIRIMIDINE DERIVATIVES 4-SULFONAMID SUBSTITUTED, INTERMEDIATE COMPOUNDS FOR PREPARATION, PREPARATION PROCEDURES, MEDICINAL COMPOSITIONS CONTAINING THEM AND APPLICATIONS | |
| AR056321A1 (en) | THERAPEUTIC COMBINATIONS FOR THE TREATMENT OR PREVENTION OF PSYCHOTIC DISORDERS | |
| FI913034A0 (en) | FOERENING MED MAGSYRAINHIBERANDE EFFEKT OCH FOERFARANDE FOER DESS FRAMSTAELLNING. | |
| AR036131A1 (en) | DERIVATIVES OF BENZO (G) QUINOLINA, A PROCESS FOR ITS PREPARATION, A PHARMACEUTICAL COMPOSITION AND THE USE OF SUCH DERIVATIVES FOR THE MANUFACTURE OF A MEDICINAL PRODUCT | |
| SV2004001419A (en) | PROCEDURES FOR THE PREPARATION OF SUBSTITUTED BICYCLE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELLULAR GROWTH "REF.PC23005 | |
| KR930006024A (en) | Imidazo indolizine derivatives and preparation method thereof | |
| AR054707A1 (en) | DERIVATIVES OF OCTAHIDROPIRROLO 3,4-C PIRROL, A PROCEDURE FOR ITS PREPARATION, A PHARMACEUTICAL COMPOSITION AND USE OF THE COMPOUND FOR THE MANUFACTURE OF A MEDICINAL PRODUCT | |
| ATE237614T1 (en) | BENZO(C)QUINOLICINE DERIVATIVES, THEIR PREPARATION AND USE AS 5-ALFA-REDUCTASE INHIBITORS | |
| AR011137A1 (en) | DERIVATIVES OF 4-AMINOETOXIINDAZOL, ITS USE FOR THE PREPARATION OF A MEDICINAL PRODUCT AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM | |
| DE602004016177D1 (en) | METHYLINDOLE AND METHYLPYRROLOPYRIDINE AS ALPHA-1-ADRENERGE AGONISTS | |
| MX9405111A (en) | NEW DERIVATIVES OF (1-PHENYL-1-HETEROCICLIL) METHANOL AND (1-PHENYL-1-HETEROCICLIL-METHYLAMINE). | |
| DE60309324D1 (en) | TETRACYCLIC ARYLCARBONYL INDOLE WITH SEROTONIN RECEPTORAFFINITY AS A MEDICAMENT, METHOD FOR ITS PREPARATION AND PHARMACEUTICAL PREPARATIONS |