AR011066A1 - Procesos para la sintesis de alfa gal(1-4) beta gal (1-4)glc-or. - Google Patents
Procesos para la sintesis de alfa gal(1-4) beta gal (1-4)glc-or.Info
- Publication number
- AR011066A1 AR011066A1 ARP980100116A ARP980100116A AR011066A1 AR 011066 A1 AR011066 A1 AR 011066A1 AR P980100116 A ARP980100116 A AR P980100116A AR P980100116 A ARP980100116 A AR P980100116A AR 011066 A1 AR011066 A1 AR 011066A1
- Authority
- AR
- Argentina
- Prior art keywords
- beta
- alpha
- lactoside
- benzoyl
- under certain
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 6
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- NNISLDGFPWIBDF-MPRBLYSKSA-N alpha-D-Gal-(1->3)-beta-D-Gal-(1->4)-D-GlcNAc Chemical compound O[C@@H]1[C@@H](NC(=O)C)C(O)O[C@H](CO)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@@H](CO)O1 NNISLDGFPWIBDF-MPRBLYSKSA-N 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 125000001424 substituent group Chemical group 0.000 abstract 3
- 125000000649 benzylidene group Chemical group [H]C(=[*])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 101000718529 Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) Alpha-galactosidase Proteins 0.000 abstract 1
- 101100393304 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GPD1 gene Proteins 0.000 abstract 1
- 125000002877 alkyl aryl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- -1 benzoyl halide Chemical class 0.000 abstract 1
- WQZGKKKJIJFFOK-FPRJBGLDSA-N beta-D-galactose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-FPRJBGLDSA-N 0.000 abstract 1
- 108010005774 beta-Galactosidase Proteins 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 239000003638 chemical reducing agent Substances 0.000 abstract 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 abstract 1
- 125000003827 glycol group Chemical group 0.000 abstract 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003944 tolyl group Chemical group 0.000 abstract 1
- 125000004953 trihalomethyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/04—Disaccharides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
- C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Saccharide Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Un proceso para la síntesis de compuestos de alfa Gal(1-4) beta Gal (1-4) Glc-OR1, cuyo proceso comprende: a) el contacto con beta-tio-R lactosido con almenos una cantidad estoiquiométrica de un alfa, alfa-dialcoxitolueno, donde el grupo tolueno es opcionalmente sustituido en el anillo de fenilo con 1 a 3sustituyentes, independientemente seleccionados de alquilo, alcoxi, ciano, halo, nitro y triahalometilo, bajo ciertas condiciones para proporcionar beta-tio-R4-6-di-O-bencilideno lactosido. Donde R es seleccionado del grupo formado por alcarilo, alquilo y arilo, opcionalmente sustituído con 1 a 2sustituyentes, seleccionados de halo, alquilo, y alcoxi y además, donde el grupo de bencilideno del beta-tio-R 4-6- di-O bencilideno lactosidoresultante, es opcionalmente sustituído en el anillo de fenilo con 1 a 3 sustituyentes seleccionados de alquilo, alcoxi, ciano, halo, nitro ytrihalometilo; b)el benzoilado del compuesto producido en a)anterior con al menos 5equivalentes de haluro de benzoilo, bajo ciertas condiciones para darbeta-tio-R46-di-O-benciliden-2,2,3,3,6-penta-O-benzoil-lactosido; c)el contacto del compuesto producido en b) anterior con un compuesto de haluroreactivo, bajo ciertas condiciones para proporcionar, ya sea alfa-cloro 4, 6-di-O-benziliden-2,2,3,3,6-penta-O-benzoil-lactosido, o, alfa-bromo 4,6-di-O-bezoil-lactosido; d) el contacto del compuesto producido en c) anterior con un compuesto de la formula HOR1 donde R1 es unaglicon de por lo menos unátomo de carbono, bajo ciertas condiciones para proporcionar beta-aglicon 4, 6-di-O-benciliden-2,23,3,6-penta-O-benzoil-lactosido; e) el contacto delcompuesto producido en d)anterior con un agente reductor, bajo ciertascondiciones que proporcionan beta-aglicon 2,2,3,3,6-penta-O-benzoil-6-O-
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78132797A | 1997-01-10 | 1997-01-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR011066A1 true AR011066A1 (es) | 2000-08-02 |
Family
ID=25122367
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980100116A AR011066A1 (es) | 1997-01-10 | 1998-01-09 | Procesos para la sintesis de alfa gal(1-4) beta gal (1-4)glc-or. |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US5910579A (es) |
| AR (1) | AR011066A1 (es) |
| AU (1) | AU5545598A (es) |
| WO (1) | WO1998030572A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA991410B (en) | 1998-02-23 | 1999-10-06 | Synsorb Biotech Inc | Compounds and methods for the treatment of bacterial dysentry using antibiotics and toxin binding oligosaccharide compositions. |
| US20020111481A1 (en) * | 2000-12-15 | 2002-08-15 | Synsorb Biotech, Inc. | Processes for the preparation of alphaGal(1-4)betaGal(1-4)Glc-OR trisaccharides |
| CN103588825B (zh) * | 2013-11-14 | 2016-06-22 | 大连九信生物化工科技有限公司 | 一种苯甲醛二甲缩醛保护d-氨基葡萄糖衍生物的方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE8203925D0 (sv) * | 1982-06-23 | 1982-06-23 | Svenska Sockerfabriks Ab | New and novel glycosides, glycoconjugates and processes for their preparation |
| US5079353A (en) * | 1987-12-02 | 1992-01-07 | Chembiomed, Ltd. | Sialic acid glycosides, antigens, immunoadsorbents, and methods for their preparation |
| CA2121604C (en) * | 1991-10-18 | 2002-01-15 | Glen D. Armstrong | Diagnosis and treatment of bacterial dysentery |
-
1997
- 1997-09-30 US US08/941,030 patent/US5910579A/en not_active Expired - Fee Related
-
1998
- 1998-01-06 WO PCT/CA1998/000008 patent/WO1998030572A1/en not_active Ceased
- 1998-01-06 AU AU55455/98A patent/AU5545598A/en not_active Abandoned
- 1998-01-09 AR ARP980100116A patent/AR011066A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU5545598A (en) | 1998-08-03 |
| US5910579A (en) | 1999-06-08 |
| WO1998030572A1 (en) | 1998-07-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |