AR010370A1 - Antagonistas de receptor vitronectina, procedimiento para su preparacion y preparados farmaceuticos. - Google Patents
Antagonistas de receptor vitronectina, procedimiento para su preparacion y preparados farmaceuticos.Info
- Publication number
- AR010370A1 AR010370A1 ARP970105995A ARP970105995A AR010370A1 AR 010370 A1 AR010370 A1 AR 010370A1 AR P970105995 A ARP970105995 A AR P970105995A AR P970105995 A ARP970105995 A AR P970105995A AR 010370 A1 AR010370 A1 AR 010370A1
- Authority
- AR
- Argentina
- Prior art keywords
- substituted
- formula
- direct bond
- r2r3n
- aryl
- Prior art date
Links
- 102100022337 Integrin alpha-V Human genes 0.000 title abstract 2
- 108010048673 Vitronectin Receptors Proteins 0.000 title abstract 2
- 239000002464 receptor antagonist Substances 0.000 title abstract 2
- 229940044551 receptor antagonist Drugs 0.000 title abstract 2
- 238000000034 method Methods 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 125000003118 aryl group Chemical group 0.000 abstract 5
- 125000006652 (C3-C12) cycloalkyl group Chemical group 0.000 abstract 2
- 102100022631 Glutamate receptor ionotropic, NMDA 2C Human genes 0.000 abstract 2
- 108020002076 NR2 subfamily Proteins 0.000 abstract 2
- 125000000732 arylene group Chemical group 0.000 abstract 2
- 125000002993 cycloalkylene group Chemical group 0.000 abstract 2
- 108091008646 testicular receptors Proteins 0.000 abstract 2
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 1
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 1
- -1 -CR2 = CR2- Chemical group 0.000 abstract 1
- 229940078581 Bone resorption inhibitor Drugs 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000002617 bone density conservation agent Substances 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 239000002319 fibrinogen receptor antagonist Substances 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 125000003367 polycyclic group Chemical group 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Ophthalmology & Optometry (AREA)
- Transplantation (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Antagonista de receptor vitronectina e inhibidores de la resorcion osea de la formula A - B - D - E - F - G , en donde: A significa A1 o A2, conA1 = R2R3N-C(= NR2C(O)-, R2R3N-C(=NR2)NR2S(O)n-, R2R3N-C(=NR2)NR2C(S)-, formula I y A2 significaformula II, en donde A1 o A2 formula III representa unsistema de anillo de 5 a 10 miembros, monocíclico o policíclico, aromático o no aromático, que contiene la agrupacion de formula IV y puede contener,adicionalmente, 1 a 4 heteroátomos de ka serieN, O, S y eventualmente puede estar sustiuido una o varias veces con R12, R13, R14, R15; B significa unenlace directo, alcanodiilo (C1-C8), -CR2=CR3-, arileno (C5-C10), cicloalquileno (C3-C8), -C=C-, que pueden estar sustituidos, encada caso una odos veces, con alquilo (C1-C8); D significa un enlace directo, alcanodiilo (C1-C8), arileno (C5-C10), -O-, -NR2-, -CO-NR2-, -NR2-CO-, -NR2-C(O)-NR2-,-NR2-C(S)-NR2-, -OC(O)-, -C(O)O-, -CO-, -CS-, -S(O)-, -S(O)2-, -S(O)2-NR2-,- S(O)-NR2-, -NR2-S(O)-, -NR2-S(O)2-, -S-, -CR2=CR3-, -C=C-, -NR2-N-CR2-,-N=CR2-, -R2C=N-, -CH(OH)-, que pueden estar sustituidos, en cada caso una o dos veces, con alquilo (C1-C8), -CR2=CR2-, arilo (C5-C6), en donde, en el casode que Brepresente u n enlace directo, D puede ser asimismo un enlace directo o un radical tal como se define en el aparato D, que está sustituido, una o dosveces, tal como se describe en el apartado D, y está enlazado a B a través de uno de estossustituyentes; E sig nifica a) una plantilla de la serie de losantagonistas de receptores de fibrinogeno; F está definido como D; G significa V, R2, R3 significan, independientemente uno de otro, H, alquilo (C1-C10) queeventualmente está sustituidouna o varias veces co n fluor, cicloalquilo (C3-C12), cicloalquil (C3-C12)-alquilo (C1-C8), arilo (C5-C14), aril (C5-C14)-
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19653647A DE19653647A1 (de) | 1996-12-20 | 1996-12-20 | Vitronectin - Rezeptorantagonisten, deren Herstellung sowie deren Verwendung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR010370A1 true AR010370A1 (es) | 2000-06-07 |
Family
ID=7815762
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970105995A AR010370A1 (es) | 1996-12-20 | 1997-12-18 | Antagonistas de receptor vitronectina, procedimiento para su preparacion y preparados farmaceuticos. |
Country Status (21)
| Country | Link |
|---|---|
| US (4) | US6011045A (es) |
| EP (1) | EP0854140B1 (es) |
| JP (1) | JP4081167B2 (es) |
| KR (1) | KR19980064656A (es) |
| CN (2) | CN1103775C (es) |
| AR (1) | AR010370A1 (es) |
| AU (1) | AU730737B2 (es) |
| BR (1) | BR9706385A (es) |
| CA (1) | CA2225273A1 (es) |
| CZ (1) | CZ411397A3 (es) |
| DE (1) | DE19653647A1 (es) |
| HU (1) | HUP9702508A3 (es) |
| ID (1) | ID19253A (es) |
| IL (1) | IL122641A0 (es) |
| MX (1) | MX9710392A (es) |
| NO (1) | NO311644B1 (es) |
| NZ (1) | NZ329430A (es) |
| PL (1) | PL323970A1 (es) |
| RU (1) | RU2198892C2 (es) |
| TW (1) | TW523510B (es) |
| ZA (1) | ZA9711316B (es) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL350291A1 (en) | 1998-12-23 | 2002-12-02 | Searle & Co | Method of using a cyclooxygenase-2 inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia |
| WO2000051998A1 (en) | 1999-03-02 | 2000-09-08 | Boehringer Ingelheim Pharmaceuticals, Inc. | Compounds useful as reversible inhibitors of cathepsin s |
| US6420364B1 (en) | 1999-09-13 | 2002-07-16 | Boehringer Ingelheim Pharmaceuticals, Inc. | Compound useful as reversible inhibitors of cysteine proteases |
| US6545032B1 (en) | 1999-09-17 | 2003-04-08 | Torrey Pines Institute For Molecular Studies | Synthesis of [3,5,7]-H-imidazo[1,5-a] imidazol-2(3H)-one compounds |
| CO5261573A1 (es) | 1999-11-19 | 2003-03-31 | Novartis Ag | Derivados de benzoxa y bezotiazol, compuesto y composicion farmaceutica que los contiene y proceso para la preparacion de la mencionada composicion |
| CA2444821C (en) | 2001-04-24 | 2012-07-10 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Combination therapy using anti-angiogenic agents and tnfa |
| CN100560131C (zh) | 2001-10-22 | 2009-11-18 | 斯克里普斯研究学院 | 抗体靶向化合物 |
| US8440217B1 (en) | 2005-06-15 | 2013-05-14 | Mawaheb M. EL-Naggar | Method and system with contact lens product for treating and preventing adverse eye conditions |
| CA2630415A1 (en) * | 2005-10-20 | 2007-04-26 | The Scripps Research Institute | Fc labeling for immunostaining and immunotargeting |
| US8618115B2 (en) * | 2005-10-26 | 2013-12-31 | Bristol-Myers Squibb Company | Substituted thieno[3,2-d]pyrimidinones as MCHR1 antagonists and methods for using them |
| US7615075B2 (en) * | 2005-11-04 | 2009-11-10 | Rush University Medical Center | Plastic implant impregnated with a degradation protector |
| EA201200560A1 (ru) | 2006-01-18 | 2012-09-28 | Мерк Патент Гмбх | Специфическая терапия, использующая интегриновые лиганды для лечения рака |
| US7553836B2 (en) * | 2006-02-06 | 2009-06-30 | Bristol-Myers Squibb Company | Melanin concentrating hormone receptor-1 antagonists |
| EP2441464B1 (en) | 2007-01-18 | 2014-04-09 | Merck Patent GmbH | Integrin ligands for use in treating colon cancer |
| DE102007012210B4 (de) * | 2007-03-08 | 2009-10-15 | Filt Lungen- Und Thoraxdiagnostik Gmbh | Transportabler Pneumotachograph zur Messung von Bestandteilen des Exspirationsvolumens sowie ein Verfahren hierzu |
| ES2576643T3 (es) | 2007-03-09 | 2016-07-08 | Second Genome, Inc. | Compuestos de bicicloheteroarilo como moduladores de P2X7 y usos de los mismos |
| PE20091928A1 (es) * | 2008-05-29 | 2009-12-31 | Bristol Myers Squibb Co | Tienopirimidinas hidroxisustituidas como antagonistas de receptor-1 de hormona concentradora de melanina no basicos |
| JP2012517447A (ja) | 2009-02-10 | 2012-08-02 | ザ スクリプス リサーチ インスティチュート | 化学的にプログラムされたワクチン接種法 |
| WO2010096722A1 (en) * | 2009-02-20 | 2010-08-26 | Takeda Pharmaceutical Company Limited | 3-oxo-2, 3-dihydro- [1,2, 4] triazolo [4, 3-a]pyridines as soluble epoxide hydrolase (seh) inhibitors |
| EP2445534A2 (en) | 2009-05-25 | 2012-05-02 | Merck Patent GmbH | Continuous administration of cilengitide in cancer treatments |
| JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
| MX2016015467A (es) | 2014-05-30 | 2017-03-23 | Pfizer | Derivados de carbonitrilo como moduladores selectivos del receptor de androgenos. |
| JOP20150177B1 (ar) | 2014-08-01 | 2021-08-17 | Janssen Pharmaceutica Nv | مركبات 6 ، 7 ثاني هيدرو بيرازولو [ 1، 5 الفا ] بيرازين – 4 (5 يد) – اون واستخدامها كمنظمات الوسترية سلبية لمستقبلات ملجور 2 |
| JOP20150179B1 (ar) | 2014-08-01 | 2021-08-17 | Janssen Pharmaceutica Nv | مركبات 6 ، 7 ثاني هيدرو بيرازولو [ 1، 5 الفا ] بيرازين – 4 (5 يد) – اون واستخدامها كمنظمات الوسترية سلبية لمستقبلات ملجور 2 |
| JP6689856B2 (ja) | 2014-12-03 | 2020-04-28 | ヤンセン ファーマシューティカ エヌ．ベー． | ６，７−ジヒドロピラゾロ［１，５−ａ］ピラジン−４（５Ｈ）−オン化合物およびＭＧＬＵＲ２受容体の負のアロステリック調節因子としてのそれらの使用 |
| AU2015357169B2 (en) | 2014-12-03 | 2021-03-04 | Janssen Pharmaceutica Nv | Radiolabelled mGluR2 PET ligands |
| US11045562B2 (en) | 2015-12-18 | 2021-06-29 | Janssen Pharmaceutica Nv | Radiolabelled mGluR2/3 PET ligands |
| PT3389727T (pt) | 2015-12-18 | 2020-10-30 | Janssen Pharmaceutica Nv | Ligantes pet de mglur2/3 radiomarcados |
| WO2023275715A1 (en) | 2021-06-30 | 2023-01-05 | Pfizer Inc. | Metabolites of selective androgen receptor modulators |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3044236A1 (de) | 1980-11-25 | 1982-06-16 | Hoechst Ag, 6000 Frankfurt | Aminosaeurederivate und verfahren zu ihrer herstellung |
| DE2937779A1 (de) | 1979-09-19 | 1981-04-09 | Hoechst Ag, 6000 Frankfurt | Aminosaeurederivate und verfahren zu ihrer herstellung |
| ZA806976B (en) | 1979-11-13 | 1981-10-28 | Ventrex Lab Inc | Method and apparatus for carrying out solid phase in vitro diagnostic assays |
| FR2503155A2 (fr) | 1980-10-02 | 1982-10-08 | Science Union & Cie | Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme |
| FR2487829A2 (fr) | 1979-12-07 | 1982-02-05 | Science Union & Cie | Nouveaux imino acides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme |
| US4350704A (en) | 1980-10-06 | 1982-09-21 | Warner-Lambert Company | Substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acids |
| DE3177311D1 (de) | 1980-08-30 | 1994-06-09 | Hoechst Ag | Aminosäurederivate, Verfahren zu ihrer Herstellung, diese enthaltende Mittel und deren Verwendung. |
| US4344949A (en) | 1980-10-03 | 1982-08-17 | Warner-Lambert Company | Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids |
| FR2492381A1 (fr) | 1980-10-21 | 1982-04-23 | Science Union & Cie | Nouveaux acides aza bicyclo alcane carboxyliques substitues leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme |
| EP0050800B2 (en) | 1980-10-23 | 1995-06-07 | Schering Corporation | Carboxyalkyl dipeptides, processes for their production and pharmaceutical compositions containing them |
| US4374847A (en) | 1980-10-27 | 1983-02-22 | Ciba-Geigy Corporation | 1-Carboxyalkanoylindoline-2-carboxylic acids |
| DE3226768A1 (de) | 1981-11-05 | 1983-05-26 | Hoechst Ag, 6230 Frankfurt | Derivate der cis, endo-2-azabicyclo-(3.3.0)-octan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung |
| IE55867B1 (en) | 1981-12-29 | 1991-02-14 | Hoechst Ag | New derivatives of bicyclic aminoacids,processes for their preparation,agents containing these compounds and their use,and new bicyclic aminoacids as intermediates and processes for their preparation |
| DE3210496A1 (de) | 1982-03-23 | 1983-10-06 | Hoechst Ag | Neue derivate bicyclischer aminsaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue bicyclische aminosaeuren als zwischenstufen und verfahren zu deren herstellung |
| DE3211397A1 (de) | 1982-03-27 | 1983-11-10 | Hoechst Ag, 6230 Frankfurt | Spiro (4.(3+n))-2-aza-3-carbonsaeure-derivate, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung |
| DE3211676A1 (de) | 1982-03-30 | 1983-10-06 | Hoechst Ag | Neue derivate von cycloalka (c) pyrrol-carbonsaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue cycloalka (c) pyrrol-carbonsaeuren als zwischenstufen und verfahren zu deren herstellung |
| DE3227055A1 (de) | 1982-07-20 | 1984-01-26 | Hoechst Ag, 6230 Frankfurt | Neue derivate der 2-aza-bicyclo(2.2.2)octan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie 2-aza-bicyclo(2.2.2)octan-3-carbonsaeure als zwischenstufe und verfahren zu deren herstellung |
| DE3242151A1 (de) | 1982-11-13 | 1984-05-17 | Hoechst Ag, 6230 Frankfurt | Neue derivate tricyclischer aminosaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung, sowie neue bicyclische aminosaeuren als zwischenstufen und verfahren zu deren herstellung |
| DE3246503A1 (de) | 1982-12-16 | 1984-06-20 | Hoechst Ag, 6230 Frankfurt | Derivate der cis, endo-2-azabicyclo-(5.3.0)-decan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung |
| ATE114473T1 (de) * | 1984-04-30 | 1994-12-15 | Procter & Gamble | Ausrüstung für die verwendung bei der behandlung von osteoporose. |
| DE3643012A1 (de) | 1986-12-17 | 1988-06-30 | Hoechst Ag | 2,3-disubstituierte isoxazolidine, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung |
| DE3818850A1 (de) | 1988-06-03 | 1989-12-07 | Hoechst Ag | Oligopeptide mit zyklischen prolin-analogen aminosaeuren |
| RU2041875C1 (ru) * | 1988-12-28 | 1995-08-20 | Такеда Кемикал Индастриз Лтд. | Серусодержащие гетероциклические соединения или их фармацевтически приемлемые соли и состав, обладающий ингибирующим действием на костную резорбацию |
| JP3497164B2 (ja) * | 1991-06-28 | 2004-02-16 | スミスクライン・ビーチャム・コーポレイション | 二環式フィブリノーゲン拮抗薬 |
| US5217994A (en) | 1991-08-09 | 1993-06-08 | Merck & Co., Inc. | Method of inhibiting osteoclast-mediated bone resorption by administration of aminoalkyl-substituted phenyl derivatives |
| US5204350A (en) | 1991-08-09 | 1993-04-20 | Merck & Co., Inc. | Method of inhibiting osteoclast-mediated bone resorption by administration of n-heterocyclicalkyl-substituted phenyl derivatives |
| DE4129603A1 (de) * | 1991-09-06 | 1993-03-11 | Thomae Gmbh Dr K | Kondensierte 5-gliedrige heterocyclen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| WO1994008577A1 (en) | 1992-10-14 | 1994-04-28 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
| GB9225141D0 (en) * | 1992-12-01 | 1993-01-20 | Smithkline Beecham Corp | Chemical compounds |
| US5648368A (en) | 1992-12-01 | 1997-07-15 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
| WO1994014776A2 (en) * | 1992-12-21 | 1994-07-07 | Smithkline Beecham Corporation | Bicyclic fibrinogen antagonists |
| WO1994018981A1 (en) * | 1993-02-22 | 1994-09-01 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
| CA2134192A1 (en) * | 1993-11-12 | 1995-05-13 | Michael L. Denney | 5, 6-bicyclic glycoprotein iib/iiia antagonists |
| US5563158A (en) * | 1993-12-28 | 1996-10-08 | The Dupont Merck Pharmaceutical Company | Aromatic compounds containing basic and acidic termini useful as fibrinogen receptor antagonists |
| US5534524A (en) * | 1994-05-09 | 1996-07-09 | Board Of Regents, The University Of Texas System | Suppression of bone resorption by quinolines |
| DE69528829T2 (de) | 1994-05-27 | 2003-08-07 | Merck & Co., Inc. | Präparate zur hemmung der durch osteoklasten vermittelten knochenresorption |
| NZ290008A (en) | 1994-06-29 | 1998-08-26 | Smithkline Beecham Corp | Vitronectin receptor antagonists, comprising a fibrinogen antagonist analogue linked to a heterocycle |
| ZA955391B (en) | 1994-06-29 | 1996-02-09 | Smithkline Beecham Corp | Vitronectin receptor antagonists |
| WO1996026190A1 (en) | 1995-02-22 | 1996-08-29 | Smithkline Beecham Corporation | Integrin receptor antagonists |
| DE19516483A1 (de) * | 1995-05-05 | 1996-11-07 | Merck Patent Gmbh | Adhäsionsrezeptor-Antagonisten |
| WO1997001540A1 (en) * | 1995-06-29 | 1997-01-16 | Smithkline Beecham Corporation | Integrin receptor antagonists |
| CZ203898A3 (cs) * | 1995-12-29 | 1999-03-17 | Smithkline Beecham Corporation | Antagonista vitronektinového receptoru, farmaceutický přípravek s jeho obsahem, způsob a použití |
| TR199801253T2 (xx) * | 1995-12-29 | 1998-12-21 | Smithkline Beecham Corporation | Vitronektin resept�r� antagonistleri. |
| BR9612378A (pt) * | 1995-12-29 | 1999-07-13 | Smithkline Beecham Corp | Antagonistas receptores de vitronectina |
| EP0796855B1 (de) | 1996-03-20 | 2002-02-06 | Hoechst Aktiengesellschaft | Inhibitoren der Knochenresorption und Vitronectinrezeptor-Antagonisten |
| DE19629816A1 (de) * | 1996-07-24 | 1998-01-29 | Hoechst Ag | Neue Cycloalkyl-Derivate als Inhibitoren der Knochenresorption und Vitronectinrezeptor-Antagonisten |
| DE19629817A1 (de) * | 1996-07-24 | 1998-01-29 | Hoechst Ag | Neue Imino-Derivate als Inhibitoren der Knochenresorption und Vitronectinrezeptor-Antagonisten |
-
1996
- 1996-12-20 DE DE19653647A patent/DE19653647A1/de not_active Withdrawn
-
1997
- 1997-12-12 EP EP97121932.4A patent/EP0854140B1/de not_active Expired - Lifetime
- 1997-12-17 ZA ZA9711316A patent/ZA9711316B/xx unknown
- 1997-12-17 BR BR9706385A patent/BR9706385A/pt not_active IP Right Cessation
- 1997-12-18 NZ NZ329430A patent/NZ329430A/xx unknown
- 1997-12-18 CZ CZ974113A patent/CZ411397A3/cs unknown
- 1997-12-18 AR ARP970105995A patent/AR010370A1/es unknown
- 1997-12-18 ID IDP973918A patent/ID19253A/id unknown
- 1997-12-18 IL IL12264197A patent/IL122641A0/xx unknown
- 1997-12-18 MX MX9710392A patent/MX9710392A/es unknown
- 1997-12-18 AU AU48465/97A patent/AU730737B2/en not_active Ceased
- 1997-12-19 CN CN97129784A patent/CN1103775C/zh not_active Expired - Fee Related
- 1997-12-19 HU HU9702508A patent/HUP9702508A3/hu unknown
- 1997-12-19 CA CA002225273A patent/CA2225273A1/en not_active Abandoned
- 1997-12-19 NO NO19975976A patent/NO311644B1/no unknown
- 1997-12-19 RU RU97122265/04A patent/RU2198892C2/ru not_active IP Right Cessation
- 1997-12-20 KR KR1019970073884A patent/KR19980064656A/ko not_active Ceased
- 1997-12-20 PL PL97323970A patent/PL323970A1/xx unknown
- 1997-12-22 US US08/995,521 patent/US6011045A/en not_active Expired - Lifetime
- 1997-12-22 JP JP36552997A patent/JP4081167B2/ja not_active Expired - Lifetime
-
1998
- 1998-02-11 TW TW086119132A patent/TW523510B/zh active
-
1999
- 1999-10-05 US US09/412,331 patent/US6207663B1/en not_active Expired - Lifetime
-
2001
- 2001-02-06 US US09/777,011 patent/US6387895B1/en not_active Expired - Lifetime
-
2002
- 2002-05-13 US US10/142,975 patent/US6867208B2/en not_active Expired - Lifetime
-
2003
- 2003-01-22 CN CN03101487A patent/CN1440971A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| HU9702508D0 (en) | 1998-03-02 |
| BR9706385A (pt) | 1999-07-20 |
| HUP9702508A3 (en) | 2001-04-28 |
| NO975976D0 (no) | 1997-12-19 |
| AU4846597A (en) | 1998-06-25 |
| TW523510B (en) | 2003-03-11 |
| NO311644B1 (no) | 2001-12-27 |
| KR19980064656A (ko) | 1998-10-07 |
| CN1103775C (zh) | 2003-03-26 |
| EP0854140A3 (de) | 2000-03-08 |
| MX9710392A (es) | 1998-06-30 |
| JP4081167B2 (ja) | 2008-04-23 |
| NZ329430A (en) | 1999-05-28 |
| PL323970A1 (en) | 1998-06-22 |
| CN1440971A (zh) | 2003-09-10 |
| JPH11147867A (ja) | 1999-06-02 |
| ID19253A (id) | 1998-06-28 |
| RU2198892C2 (ru) | 2003-02-20 |
| ZA9711316B (en) | 1998-06-22 |
| US6867208B2 (en) | 2005-03-15 |
| NO975976L (no) | 1998-06-22 |
| CA2225273A1 (en) | 1998-06-20 |
| EP0854140B1 (de) | 2013-11-06 |
| DE19653647A1 (de) | 1998-06-25 |
| US20030027807A1 (en) | 2003-02-06 |
| AU730737B2 (en) | 2001-03-15 |
| EP0854140A2 (de) | 1998-07-22 |
| CZ411397A3 (cs) | 1998-07-15 |
| US6387895B1 (en) | 2002-05-14 |
| US6207663B1 (en) | 2001-03-27 |
| HUP9702508A2 (hu) | 1999-06-28 |
| CN1200374A (zh) | 1998-12-02 |
| US6011045A (en) | 2000-01-04 |
| IL122641A0 (en) | 1998-08-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR010370A1 (es) | Antagonistas de receptor vitronectina, procedimiento para su preparacion y preparados farmaceuticos. | |
| MX9704777A (es) | Compuestos espiro tetraciclicos, procedimiento para su preparacion y composiciones que los contienen. | |
| ES2112848T3 (es) | Nuevos derivados de la n-acil-2,3-benzodiazepina. | |
| AR007118A1 (es) | 4(3h)-quinazolinonas 2,3 disustituidas y composiciones farmaceuticas que las contienen | |
| AR007961A1 (es) | Derivados de cicloalquilo como inhibidores de la resorcion osea y antagonistas de receptores de vitronectina, procedimiento para su preparacion y preparado farmaceutico. | |
| UA39168C2 (uk) | Фторалкоксифенільні похідні піперидину або хінуклідину, що є антагоністами речовини p і фармацевтична композиція на їх основі | |
| DK0490772T3 (da) | 1,4-disubstituerede piperaziner, fremgangsmåde til fremstilling heraf og farmaceutiske midler, der indeholder dem | |
| RU94040864A (ru) | Конденсированные индольные производные, их получение, фармацевтическая композиция | |
| MX9300786A (es) | Compuestos hipolipidaemicos. | |
| BR0209027A (pt) | Composto ácido carboxìlico e seu uso, medicamento, agente e método para a prevenção ou tratamento de uma doença, composição farmacêutica | |
| ECSP941122A (es) | Derivados de 5-arilindoles | |
| DE69727158D1 (de) | Pharmazeutische zusammensetzungen enthaltend eine mischung von selbstvernetzter und nichtselbstvernetzter hyaluronsäure zur behandlung von arthropathien | |
| ES2160648T3 (es) | Derivados de piridina. | |
| MX9305379A (es) | Nuevos derivados de aminoacidos, procedimiento para su preparacion y preparado farmaceutico que los contiene. | |
| AR035320A1 (es) | Compuestos activadores de hppardelta, composicion farmaceutica, su uso en la preparacion de medicamentos, metodo para el tratamiento de enfermedades mediadas por hppardelta | |
| AR035325A1 (es) | Derivados de adamantano, un proceso para su preparacion, composicion farmaceutica, un proceso para la preparacion de dicha composicion, y el uso de dichos derivados para la fabricacion de un medicamento | |
| GT199800046A (es) | Compuestos de pirazina. | |
| ES2158778B1 (es) | Compuestos de sales de paroxetina, su preparacion y uso, y composiciones farmaceuticas que los contienen. | |
| AR009985A1 (es) | Aminotiofencarboxamidas, un procedimiento para su preparacion, empleo de las mismas para preparar un medicamento, preparaciones farmaceuticas que lascontienen, y un procedimiento para obtener estas preparaciones farmaceuticas | |
| BR0311541A (pt) | indol, azaindol e 4-aquenil piperidina amidas heterocìclicas relacionadas | |
| AR030541A1 (es) | Acidos aminopropilfosfinicos, su utilizacion para la manufactura de medicamentos, y formulacion farmaceutica | |
| ES2179094T3 (es) | Derivados de amidas ciclicas como antagonistas de la neuroquinina a. | |
| ES2163407T3 (es) | Derivados piperidinilos tiaciclicos. | |
| DE3783356D1 (de) | Benzimidazolderivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische praeparate. | |
| ES2099755T3 (es) | Derivados tripeptidicos de trifluorometilcetona. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |