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AR019817A1 - MULTIADHERENT COMPOUNDS, USE OF SUCH COMPOUNDS TO PREPARE A USEFUL MEDICINAL PRODUCT TO TREAT MAMIFERS THAT HAVE A DISEASE THAT IS RELIEFED BY TREATMENT WITH AN ANTIBACTERIAL AGENT, PROCEDURE FOR THE PREPARATION OF THESE COMPOUND COMPOSITIONS AND COMPOSITION - Google Patents

MULTIADHERENT COMPOUNDS, USE OF SUCH COMPOUNDS TO PREPARE A USEFUL MEDICINAL PRODUCT TO TREAT MAMIFERS THAT HAVE A DISEASE THAT IS RELIEFED BY TREATMENT WITH AN ANTIBACTERIAL AGENT, PROCEDURE FOR THE PREPARATION OF THESE COMPOUND COMPOSITIONS AND COMPOSITION

Info

Publication number
AR019817A1
AR019817A1 ARP990100666A AR019817A1 AR 019817 A1 AR019817 A1 AR 019817A1 AR P990100666 A ARP990100666 A AR P990100666A AR 019817 A1 AR019817 A1 AR 019817A1
Authority
AR
Argentina
Prior art keywords
compounds
disease
prepare
procedure
preparation
Prior art date
Application number
Other languages
Spanish (es)
Original Assignee
Advanced Medicine Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Advanced Medicine Inc filed Critical Advanced Medicine Inc
Publication of AR019817A1 publication Critical patent/AR019817A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
    • C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Compuestos multiadherentes que tienen la formula: (L)pXq, en la cual L es un ligando que puede ser igual o diferente cada vez que ocurre; X es un ligandoque puede ser igual o diferente cada vez que ocurre; p es un numero de 2-10; y q es un numero de1-20; donde cada uno de dichos ligandos comprende un dominiode ligando que es capaz de adherirse a un sustrato de enzima transglicosilasa; o una sal farmacéuticamente aceptable del mismo; con la condicion de que cuandoL es vancomicina, p es 2 y q es1, y el enlace es [C-C], X no es -NH-Q-HN-, donde Q es (CH2)m, -(CH2)2-NH-(CH2)n-NH-(CH2)2-, o -(CH2)n-S-S-(CH2)n-, donde m esun numero de 2-12 y n es un numero de 1-3; también con la condicion de que cuando L es vancomicina, p es 2 y q es 1, y el enlace es [V-V]; X no es alquileno,alquileno interrumpido por oxígeno, o alquileno interrumpido por fenileno a 1,4-dioxifenileno. Uso de dichos compuestos, o una sal farmacéuticamente aceptabledel mismo para preparar un medicamento util para tratar mamíferos que tienen una enfermedad que es aliviada mediante tratamiento con un agente antibacteriano.Procedimiento para la preparacion de dichos compuestos y composicion farmacéutica que los contiene.Multi-stick compounds that have the formula: (L) pXq, in which L is a ligand that can be the same or different each time it occurs; X is a ligand that may be the same or different each time it occurs; p is a number of 2-10; and q is a number of 1-20; wherein each of said ligands comprises a ligand domain that is capable of adhering to a transglycosylase enzyme substrate; or a pharmaceutically acceptable salt thereof; with the proviso that when L is vancomycin, p is 2 and q is 1, and the bond is [CC], X is not -NH-Q-HN-, where Q is (CH2) m, - (CH2) 2-NH- (CH2) n-NH- (CH2) 2-, or - (CH2) nSS- (CH2) n-, where m is a number of 2-12 and n is a number of 1-3; also on the condition that when L is vancomycin, p is 2 and q is 1, and the link is [V-V]; X is not alkylene, alkylene interrupted by oxygen, or alkylene interrupted by phenylene at 1,4-dioxyphenylene. Use of said compounds, or a pharmaceutically acceptable salt thereof to prepare a medicament useful for treating mammals that have a disease that is relieved by treatment with an antibacterial agent. Procedure for the preparation of said compounds and pharmaceutical composition containing them.

ARP990100666 1998-02-20 1999-02-23 MULTIADHERENT COMPOUNDS, USE OF SUCH COMPOUNDS TO PREPARE A USEFUL MEDICINAL PRODUCT TO TREAT MAMIFERS THAT HAVE A DISEASE THAT IS RELIEFED BY TREATMENT WITH AN ANTIBACTERIAL AGENT, PROCEDURE FOR THE PREPARATION OF THESE COMPOUND COMPOSITIONS AND COMPOSITION AR019817A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7551498P 1998-02-20 1998-02-20
US7890398P 1998-03-20 1998-03-20
US8220998P 1998-04-17 1998-04-17

Publications (1)

Publication Number Publication Date
AR019817A1 true AR019817A1 (en) 2002-03-20

Family

ID=27372700

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP990100666 AR019817A1 (en) 1998-02-20 1999-02-23 MULTIADHERENT COMPOUNDS, USE OF SUCH COMPOUNDS TO PREPARE A USEFUL MEDICINAL PRODUCT TO TREAT MAMIFERS THAT HAVE A DISEASE THAT IS RELIEFED BY TREATMENT WITH AN ANTIBACTERIAL AGENT, PROCEDURE FOR THE PREPARATION OF THESE COMPOUND COMPOSITIONS AND COMPOSITION

Country Status (7)

Country Link
EP (1) EP1060189A1 (en)
AR (1) AR019817A1 (en)
AU (1) AU3307399A (en)
CA (1) CA2318394A1 (en)
FR (1) FR2778184A1 (en)
IT (1) IT1307018B1 (en)
WO (1) WO1999042476A1 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HK1040721B (en) 1998-12-23 2003-10-17 Cumberland Pharmaceuticals Inc. Glycopeptide derivatives and pharmaceutical compositions containing the same
KR100856479B1 (en) 2000-05-02 2008-09-04 세라밴스 인코포레이티드 Reductive alkylation process
US6656694B2 (en) 2001-01-11 2003-12-02 Theravance, Inc. Method for identifying a ligand for a biological substrate
WO2003015709A2 (en) * 2001-08-17 2003-02-27 The Trustees Of Princeton University Bifunctional glycopeptides antibiotics and combinatorial libraries thereof
TWI275594B (en) 2001-08-24 2007-03-11 Theravance Inc Process for preparing vancomycin phosphonate derivatives
TWI312785B (en) 2001-08-24 2009-08-01 Theravance Inc Process for preparing vancomycin derivatives
TWI335332B (en) * 2001-10-12 2011-01-01 Theravance Inc Cross-linked vancomycin-cephalosporin antibiotics
AU2003231833A1 (en) 2002-05-24 2003-12-12 Theravance, Inc. Cross-linked glycopeptide-cephalosporin antibiotics
WO2004113350A1 (en) 2003-05-23 2004-12-29 Theravance, Inc. Cross-linked glycopeptide - cephalosporin antibiotics
ES2302034T3 (en) 2003-07-11 2008-07-01 Theravance, Inc. CEPHALOSPORINE-GLICOPEPTIDE ANTIBIOTICS RETICULATED.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997038702A1 (en) * 1996-04-12 1997-10-23 Eli Lilly And Company Covalently-linked glycopeptide dimers
CA2251086C (en) * 1996-04-12 2007-02-20 Eli Lilly And Company Glycopeptide compounds
US5977063A (en) * 1997-05-20 1999-11-02 Eli Lilly And Company Alkylated hexapeptides

Also Published As

Publication number Publication date
FR2778184A1 (en) 1999-11-05
AU3307399A (en) 1999-09-06
CA2318394A1 (en) 1999-08-26
IT1307018B1 (en) 2001-10-23
ITTO990134A1 (en) 2000-08-22
EP1060189A1 (en) 2000-12-20
WO1999042476A1 (en) 1999-08-26

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