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AR019482A1 - DERIVADOS SUSTITUIDOS DEL 2-IMIDAZO(5,1-b)TIAZOL-CARBAPENEM, LAS COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN Y EL USO DE DICHOS DERIVADOS PARA LAPREPARACION DE MEDICAMENTOS - Google Patents

DERIVADOS SUSTITUIDOS DEL 2-IMIDAZO(5,1-b)TIAZOL-CARBAPENEM, LAS COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN Y EL USO DE DICHOS DERIVADOS PARA LAPREPARACION DE MEDICAMENTOS

Info

Publication number
AR019482A1
AR019482A1 ARP990103683A ARP990103683A AR019482A1 AR 019482 A1 AR019482 A1 AR 019482A1 AR P990103683 A ARP990103683 A AR P990103683A AR P990103683 A ARP990103683 A AR P990103683A AR 019482 A1 AR019482 A1 AR 019482A1
Authority
AR
Argentina
Prior art keywords
carbapenem
derivatives
imidazo
tiazol
medicines
Prior art date
Application number
ARP990103683A
Other languages
English (en)
Original Assignee
Meiji Seika Kaisha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Meiji Seika Kaisha filed Critical Meiji Seika Kaisha
Publication of AR019482A1 publication Critical patent/AR019482A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/18—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/14—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Se revela un nuevo derivado de carbapenem que posee un grupo imidazo[5,1-b]tiazol sustituido en la posicion 2-en el anillo de carbapenem que posee una granactividad antimicrobiana contra las bacterias que porducen beta-lactamasa, MRSA, Pseudomonas aeruginosa resistente, PRSP, enterococos e influenza y, una granestabilidad a DHP-1. De acuerdo con la presente invencion, se proporciona un compuesto representado por la formula (1) o una sal farmacéuticamente aceptable deéste o un éster en la posicion 3- de su anillo de carbapenem, de la formula (1) en la cual los sustituyentes R a R5 tiene los significados que constan en ladescripcion.
ARP990103683A 1998-07-27 1999-07-27 DERIVADOS SUSTITUIDOS DEL 2-IMIDAZO(5,1-b)TIAZOL-CARBAPENEM, LAS COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN Y EL USO DE DICHOS DERIVADOS PARA LAPREPARACION DE MEDICAMENTOS AR019482A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP21053498 1998-07-27

Publications (1)

Publication Number Publication Date
AR019482A1 true AR019482A1 (es) 2002-02-20

Family

ID=16590961

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP990103683A AR019482A1 (es) 1998-07-27 1999-07-27 DERIVADOS SUSTITUIDOS DEL 2-IMIDAZO(5,1-b)TIAZOL-CARBAPENEM, LAS COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN Y EL USO DE DICHOS DERIVADOS PARA LAPREPARACION DE MEDICAMENTOS

Country Status (10)

Country Link
US (2) US6458780B1 (es)
EP (1) EP1101766A4 (es)
KR (1) KR20010085302A (es)
CN (1) CN1315955A (es)
AR (1) AR019482A1 (es)
AU (1) AU771876B2 (es)
BR (1) BR9912490A (es)
CA (1) CA2338816A1 (es)
ID (1) ID29173A (es)
WO (1) WO2000006581A1 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1101766A4 (en) * 1998-07-27 2001-11-21 Meiji Seika Kaisha NEW CARBAPENEM DERIVATIVES
JP2005231997A (ja) * 2000-01-24 2005-09-02 Meiji Seika Kaisha Ltd カルバペネム誘導体の製造法
DE60106390T2 (de) * 2000-01-26 2005-02-24 Meiji Seika Kaisha Ltd. Neue carbapenem-derivate
EP1251134A4 (en) 2000-01-26 2003-01-29 Meiji Seika Kaisha NEW CARBAPENEM DERIVATIVES OF THE QUATERNARY SALT TYPE
ES2278819T3 (es) * 2000-11-24 2007-08-16 Meiji Seika Kaisha, Ltd. Nuevos derivados del carbapenem.
US8048917B2 (en) 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
JPWO2004055027A1 (ja) * 2002-12-13 2006-04-27 明治製菓株式会社 ２−置換カルバペネム誘導体の中間体および製造方法
EP1840129B1 (en) 2005-01-19 2011-03-09 Meiji Seika Kaisha Ltd. Imidazothiazole derivative and method for producing same
EP2046803A1 (en) * 2006-07-24 2009-04-15 Merck Sharp & Dohme Limited Imidazothiazole derivatives as mark inhibitors
WO2008085913A1 (en) * 2007-01-04 2008-07-17 Rib-X Pharmaceuticals, Inc. Methods for treating, preventing, or reducing the risk of opthalmic, otic, and nasal infections
US20120022040A1 (en) * 2008-12-01 2012-01-26 Mutz Mitchell W Antimicrobials
PL221806B1 (pl) * 2013-03-21 2016-05-31 Inst Chemii Bioorg Polskiej Akademii Nauk Sposób wprowadzania acetalowych i acetaloestrowych grup ochronnych oraz związki do realizacji tego sposobu
US10526343B2 (en) * 2018-03-26 2020-01-07 University Of Sharjah Heterocyclic systems and pharmaceutical applications thereof
CN114790157B (zh) * 2022-02-28 2024-06-21 开封大地农化生物科技有限公司 一种高含量乙蒜素的合成方法
CN114805280B (zh) * 2022-05-17 2023-06-02 苏州华一新能源科技股份有限公司 碳酸亚乙烯酯的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996011932A1 (en) 1994-10-14 1996-04-25 Smithkline Beecham Plc 2-(imidazol-4-yl)carbapeneme derivatives, intermediates thereof and use as antibacterials
JP3527003B2 (ja) * 1995-03-10 2004-05-17 明治製菓株式会社 新規イミダゾ［５，１−ｂ］チアゾール誘導体
WO1996028455A1 (en) 1995-03-10 1996-09-19 Meiji Seika Kabushiki Kaisha Novel carbapenem derivatives
JPH09249667A (ja) 1996-01-12 1997-09-22 Takeda Chem Ind Ltd カルバペネム化合物、その製造法および剤
KR20000070347A (ko) * 1997-01-28 2000-11-25 이치로 키타사토 신규한 카바페넴 유도체
EP1101766A4 (en) * 1998-07-27 2001-11-21 Meiji Seika Kaisha NEW CARBAPENEM DERIVATIVES
EP1251134A4 (en) * 2000-01-26 2003-01-29 Meiji Seika Kaisha NEW CARBAPENEM DERIVATIVES OF THE QUATERNARY SALT TYPE
DE60106390T2 (de) * 2000-01-26 2005-02-24 Meiji Seika Kaisha Ltd. Neue carbapenem-derivate
ES2278819T3 (es) * 2000-11-24 2007-08-16 Meiji Seika Kaisha, Ltd. Nuevos derivados del carbapenem.

Also Published As

Publication number Publication date
CA2338816A1 (en) 2000-02-10
US6677331B2 (en) 2004-01-13
KR20010085302A (ko) 2001-09-07
CN1315955A (zh) 2001-10-03
ID29173A (id) 2001-08-09
WO2000006581A1 (en) 2000-02-10
AU4802499A (en) 2000-02-21
BR9912490A (pt) 2001-06-05
AU771876B2 (en) 2004-04-01
EP1101766A1 (en) 2001-05-23
US6458780B1 (en) 2002-10-01
EP1101766A4 (en) 2001-11-21
US20030149016A1 (en) 2003-08-07

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