AR018349A1 - PHARMACEUTICAL COMPOSITION THAT INCLUDES STROGENS AND ANTIESTROGENS AND ITS USE FOR THE MANUFACTURE OF A MEDICINAL PRODUCT - Google Patents
PHARMACEUTICAL COMPOSITION THAT INCLUDES STROGENS AND ANTIESTROGENS AND ITS USE FOR THE MANUFACTURE OF A MEDICINAL PRODUCTInfo
- Publication number
- AR018349A1 AR018349A1 ARP990102226A AR018349A1 AR 018349 A1 AR018349 A1 AR 018349A1 AR P990102226 A ARP990102226 A AR P990102226A AR 018349 A1 AR018349 A1 AR 018349A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- group
- unsaturated
- optionally substituted
- independently selected
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 229940046836 anti-estrogen Drugs 0.000 title 1
- 239000000328 estrogen antagonist Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 229920006395 saturated elastomer Polymers 0.000 abstract 3
- 125000004768 (C1-C4) alkylsulfinyl group Chemical group 0.000 abstract 2
- 125000004769 (C1-C4) alkylsulfonyl group Chemical group 0.000 abstract 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 125000004423 acyloxy group Chemical group 0.000 abstract 2
- 125000003282 alkyl amino group Chemical group 0.000 abstract 2
- 125000004414 alkyl thio group Chemical group 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- 239000000262 estrogen Substances 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- -1 hydroxy (C1-4) alkyl Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000004951 trihalomethoxy group Chemical group 0.000 abstract 2
- 125000004953 trihalomethyl group Chemical group 0.000 abstract 2
- 125000004070 6 membered heterocyclic group Chemical group 0.000 abstract 1
- 150000005215 alkyl ethers Chemical class 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229940011871 estrogen Drugs 0.000 abstract 1
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Composicion farmacéutica que comprende uno o más estrogenos y un compuesto que es util como agente estrogénico selectivo de tejidos, que tiene laestructura general de formulas I y II en donde R1 se selecciona entre H, OH o los alquil éteres o ésteresC1-4 de los mismos, o halogenos; R2,R3, R4 R5 y R6 son independientemente seleccionados entre H, OH o los alquil éteres o ésteres C1-4 de los mismos, halogeno, ciano, alquilo C1-6, otrifluorometilo, con la condicion que, cuando R1 es H, R2 no es OH;X es (CH2)n, n es 1 o 2, n es 2-4; Y se selecciona entre: a) la porcion, de la formulaIII en donde R7 y R8 son independientemente seleccionados entre el grupo de H, alquilo C1-6, fenilo; b) un heterociclo de cinco miembros, saturado, insaturadoo parcialmente insaturado, que contiene hasta dos heteroátomos seleccionados entre el grupo que consiste de -O-, -NH-, -N(alquilo C1-4)-, -N=, y -S(O)m-, endonde m es un entero de desde 0 - 2, opcionalmente sustituido con 1 - 3 sustituyentes independientemente seleccionados entre el grupo que consiste de hidrogeno,hidroxilo, halo, alquilo C1-4, trihalometilo, alcoxi C1-4, trihalometoxi, aciloxi C1-4, alquiltio C1-4, alquilsulfinilo C1-4, alquilsulfonilo C1-4, hidroxialquilo (C1-4), fenilo opcionalmente sustituido con 1 -3 alquilo(C1-4), -CO2H-, CN-, CONHR1-, -NH2-, alquilamino C1-4, dialquilamino C1-4, -NHSO2R1-, -NHCOR1-,-NO2-; c) un heterociclo de seis miembros, saturado, insaturado o parcialmente insaturado, que contiene hasta dos heteroátomos seleccionados entre el grupo queconsiste de -O-, -NH-, -N(alquilo C1-4)-, -N=, y -S(O)m-, en donde m es un entero de desde 0 - 2, opcionalmente sustituido con 1 -3 sustituyentesindependientemente seleccionados entre el grupo que consiste en hidrogeno, hidroxilo, halo, alquilo C1-4, trihalometilo, alcoxi C1-4, trihalometoxi, aciloxiC1-4, alquiltio C1-4, alquilsulfinilo C1-4, alquilsulfonilo C1-4, hidroxi alquilo(C1-4), fenilo opcionalmente sustituido con 1 - 3 alquilo (C1-4), -CO2H-, -CN--CONHR1-, -NH2, alquilamino C1-4 dialquilamino C1-4, -NHSO2R1-, NHCOR1-, -NO2-, d) un heterociclo de siete miembros, saturado, insaturado, o parcialmentePharmaceutical composition comprising one or more estrogens and a compound that is useful as a selective estrogenic agent of tissues, having the general structure of formulas I and II wherein R 1 is selected from H, OH or the alkyl ethers or C 1-4 esters thereof , or halogens; R2, R3, R4 R5 and R6 are independently selected from H, OH or C1-4 alkyl ethers or esters thereof, halogen, cyano, C1-6 alkyl, otrifluoromethyl, with the proviso that, when R1 is H, R2 it is not OH; X is (CH2) n, n is 1 or 2, n is 2-4; And it is selected from: a) the portion, of the formula III where R7 and R8 are independently selected from the group of H, C1-6 alkyl, phenyl; b) a five-membered, saturated, unsaturated or partially unsaturated heterocycle, containing up to two heteroatoms selected from the group consisting of -O-, -NH-, -N (C1-4 alkyl) -, -N =, and - S (O) m-, where m is an integer from 0-2, optionally substituted with 1-3 substituents independently selected from the group consisting of hydrogen, hydroxyl, halo, C1-4 alkyl, trihalomethyl, C1-4 alkoxy , trihalomethoxy, C1-4 acyloxy, C1-4 alkylthio, C1-4 alkylsulfinyl, C1-4 alkylsulfonyl, hydroxy (C1-4) alkyl, phenyl optionally substituted with 1-3 alkyl (C1-4), -CO2H-, CN- , CONHR1-, -NH2-, C1-4 alkylamino, C1-4 dialkylamino, -NHSO2R1-, -NHCOR1 -, - NO2-; c) a six-membered heterocycle, saturated, unsaturated or partially unsaturated, containing up to two heteroatoms selected from the group consisting of -O-, -NH-, -N (C1-4 alkyl) -, -N =, and - S (O) m-, wherein m is an integer from 0-2, optionally substituted with 1-3 substituents independently selected from the group consisting of hydrogen, hydroxyl, halo, C1-4 alkyl, trihalomethyl, C1-4 alkoxy , trihalomethoxy, C1-4 acyloxy, C1-4 alkylthio, C1-4 alkylsulfinyl, C1-4 alkylsulfonyl, hydroxy (C1-4) alkyl, phenyl optionally substituted with 1-3 (C1-4) alkyl, -CO2H-, -CN --CONHR1-, -NH2, C1-4 alkylamino C1-4 dialkylamino, -NHSO2R1-, NHCOR1-, -NO2-, d) a seven-membered heterocycle, saturated, unsaturated, or partially
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7671198A | 1998-05-12 | 1998-05-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR018349A1 true AR018349A1 (en) | 2001-11-14 |
Family
ID=45606461
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990102226 AR018349A1 (en) | 1998-05-12 | 1999-05-11 | PHARMACEUTICAL COMPOSITION THAT INCLUDES STROGENS AND ANTIESTROGENS AND ITS USE FOR THE MANUFACTURE OF A MEDICINAL PRODUCT |
Country Status (1)
| Country | Link |
|---|---|
| AR (1) | AR018349A1 (en) |
-
1999
- 1999-05-11 AR ARP990102226 patent/AR018349A1/en unknown
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